4.1.1.48: indole-3-glycerol-phosphate synthase

This is an abbreviated version!
For detailed information about indole-3-glycerol-phosphate synthase, go to the full flat file.

Reaction

Synonyms

eIGPS, IGP synthase, IGPS, indole-3-glycerol phosphate synthase, Indole-3-glycerol phosphate synthetase, Indole-3-glycerol-phosphate synthase, indole-3-glycerolphosphate synthase, Indole-3-glycerophosphate synthase, Indoleglycerol phosphate synthase, Indoleglycerol phosphate synthetase, Indoleglycerolphosphate synthetase, InGP synthase, InGP synthetase, InGPS, mIGPS, MtIGPS, Phosphoribosylanthranilate isomerase-indoleglycerol phosphate synthetase, Pk-trpC, PRAI, PRAI-InGPS, sIGPS, SSO0895, Synthase, indole-3-glycerol phosphate, TrpC

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.1 Carboxy-lyases

                4.1.1.48 indole-3-glycerol-phosphate synthase

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Results	in table
41425	AA Sequence
5	Application
1	CAS Registry Number
12	Cloned(Commentary)
10	Crystallization (Commentary)
3	Expression
5	General Information
6	General Stability
15	Inhibitors
43	kcat/KM [mM/s]
1	Ki Value [mM]
89	KM Value [mM]
4	Metals/Ions
48	Molecular Weight [Da]
38	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
301	Organism
6	Pathway
46	PDB ID
7	pH Optimum
3	pH Range
3	pH Stability
1	Posttranslational Modification
69	Protein Variants
20	Purification (Commentary)
4	Reaction
1	Reaction Type
82	Reference
1	Renatured (Commentary)
2	Source Tissue
9	Specific Activity [micromol/min/mg]
3	Storage Stability
109	Substrates and Products (Substrate)
22	Subunits
77	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
2	Temperature Range [°C]
20	Temperature Stability [°C]
59	Turnover Number [1/s]

KCat KM Value

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KCat KM Value on EC 4.1.1.48 - indole-3-glycerol-phosphate synthase

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kcat/KM VALUE [1/mMs^-1]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

1.36 - 20000

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

35 entries

100 - 14200

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate

8 entries

1.36

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Saccharolobus solfataricus

Q06121

pH 7.5, 25°C

4615

2.9

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Mycobacterium tuberculosis

-

25°C, pH 7.5

701916

10

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Saccharolobus solfataricus

Q06121

mutant G212E, pH 7.5, 25°C

747143

13.3

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Escherichia coli

-

pH 7.5, 25°C

4615

30

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Saccharolobus solfataricus

Q06121

pH 7.5, 75°C, mutant enzyme K53R

725533

50

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Saccharolobus solfataricus

-

pH 7.0, 75°C, mutant enzyme F89A

726453

60

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Saccharolobus solfataricus

Q06121

mutant L236Q, pH 7.5, 25°C

747143

80

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Saccharolobus solfataricus

Q06121

mutant M237T, pH 7.5, 25°C

747143

240

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Saccharolobus solfataricus

Q06121

mutant F246S, pH 7.5, 25°C

747143

380

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Saccharolobus solfataricus

Q06121

pH 7.5, 75°C, mutant enzyme R182A

725533

540

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Saccharolobus solfataricus

Q06121

pH 7.5, 75°C, mutant enzyme E51Q

725533

596

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Saccharolobus solfataricus

Q06121

pH 7.5, 25°C, mutant enzyme D61C labeled with the fluorescent dye Alexa Fluor 555

721686

826

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Saccharolobus solfataricus

Q06121

pH 7.5, 25°C, mutant enzyme D61C labeled with the fluorescent dye PyMPO

721686

840

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Saccharolobus solfataricus

Q06121

pH 7.5, 25°C, mutant enzyme R18C labeled with the fluorescent dye PyMPO

721686

888

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Saccharolobus solfataricus

Q06121

pH 7.5, 25°C, mutant enzyme R18C labeled with the fluorescent dye Alexa Fluor 555

721686

980

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Pseudomonas aeruginosa

-

at 37°C and pH 8.0

728750

1000

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Saccharolobus solfataricus

-

pH 7.0, 25°C, mutant enzyme N90A

726453

1180

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Saccharolobus solfataricus

Q06121

wild-type, pH 7.5, 25°C

747143

1215

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Saccharolobus solfataricus

Q06121

pH 7.5, 25°C, wild-type enzyme

721686

2200

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Saccharolobus solfataricus

-

pH 7.0, 25°C, mutant enzyme R54A

726453

2200

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Saccharolobus solfataricus

-

pH 7.0, 25°C, wild-type enzyme

726453

2300

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Saccharolobus solfataricus

-

pH 7.0, 37°C, mutant enzyme N90A

726453

2300

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Saccharolobus solfataricus

-

pH 7.0, 37°C, mutant enzyme N90Q

726453

2500

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Saccharolobus solfataricus

Q06121

pH 7.5, 75°C, mutant enzyme E210Q

725533

3700

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Saccharolobus solfataricus

-

pH 7.0, 37°C, mutant enzyme R54A

726453

4800

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Saccharolobus solfataricus

-

pH 7.0, 37°C, wild-type enzyme

726453

4800

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Saccharolobus solfataricus

-

pH 7.0, 75°C, mutant enzyme R54A/N90Q

726453

5700

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Escherichia coli

-

at pH 7.5 and 37°C

726866

7000

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Saccharolobus solfataricus

-

pH 7.0, 75°C, mutant enzyme N90A

726453

7600

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Saccharolobus solfataricus

-

pH 7.0, 75°C, mutant enzyme N90Q

726453

8200

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Saccharolobus solfataricus

-

pH 7.0, 37°C, mutant enzyme R54A/N90Q

726453

15000

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Saccharolobus solfataricus

-

pH 7.0, 75°C, wild-type enzyme

726453

15230

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Saccharolobus solfataricus

Q06121

pH 7.5, 75°C, wild-type enzyme

725533

16000

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Saccharolobus solfataricus

-

pH 7.0, 75°C, mutant enzyme R54A

726453

20000

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Saccharolobus solfataricus

Q06121

wild-type, pH 7.5, 60°C

747143

100

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate

Saccharolobus solfataricus

-

pH 7.5, 25°C, mutant enzyme P2S/G212E

724261

100

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate

Saccharolobus solfataricus

-

pH 7.5, 37°C, mutant enzyme G212E

724261

600

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate

Saccharolobus solfataricus

-

pH 7.5, 25°C, mutant enzyme P2S/F246S

724261

750

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate

Saccharolobus solfataricus

-

pH 7.5, 25°C, wild-type enzyme

724261

900

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate

Saccharolobus solfataricus

-

pH 7.5, 37°C, mutant enzyme F246S

724261

3000

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate

Saccharolobus solfataricus

-

pH 7.5, 37°C, wild-type enzyme

724261

3200

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate

Saccharolobus solfataricus

-

pH 7.5, 37°C, mutant enzyme P2S

724261

14200

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate

Saccharolobus solfataricus

-

pH 7.5, 60°C, wild-type enzyme

724261