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4.1.1.48: indole-3-glycerol-phosphate synthase

This is an abbreviated version!
For detailed information about indole-3-glycerol-phosphate synthase, go to the full flat file.

Word Map on EC 4.1.1.48

Reaction

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
=
1-C-(indol-3-yl)glycerol 3-phosphate
 +
CO2
 +
H2O

Synonyms

eIGPS, IGP synthase, IGPS, indole-3-glycerol phosphate synthase, Indole-3-glycerol phosphate synthetase, Indole-3-glycerol-phosphate synthase, indole-3-glycerolphosphate synthase, Indole-3-glycerophosphate synthase, Indoleglycerol phosphate synthase, Indoleglycerol phosphate synthetase, Indoleglycerolphosphate synthetase, InGP synthase, InGP synthetase, InGPS, mIGPS, MtIGPS, Phosphoribosylanthranilate isomerase-indoleglycerol phosphate synthetase, Pk-trpC, PRAI, PRAI-InGPS, sIGPS, SSO0895, Synthase, indole-3-glycerol phosphate, TrpC

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.48 indole-3-glycerol-phosphate synthase

Inhibitors

Inhibitors on EC 4.1.1.48 - indole-3-glycerol-phosphate synthase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ATB107
geomycine
-
0.5 mg/ml
H2O2
-
0.001% H2O2 inactivates the enzyme almost completely
kanamycin
-
0.5 mg/ml
L-tryptophan
tryptophan at high concentrations has definite inhibitory activity against Mycobacterium tuberculosis but does not antagonize the activity of ATB107
methanol
-
enzyme activity is gradually lost in the presence of increasing concentrations of methanol and completely lost at 65%
phosphate
-
-
Reduced 1-[2-carboxyphenyl)amino]-1-deoxyribulose 5-phosphate
-
-
-
streptomycin
-
0.5 mg/ml
tryptophan
tryptophan at high concentrations has definite inhibitory activity against Mycobacterium tuberculosis but does not antagonize the activity of ATB107
additional information
-