4.1.1.45: aminocarboxymuconate-semialdehyde decarboxylase

This is an abbreviated version!
For detailed information about aminocarboxymuconate-semialdehyde decarboxylase, go to the full flat file.

Reaction

Synonyms

2-amino 3-carboxymuconate 6-semialdehyde decarboxylase, 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase, 3-(3-oxoprop-2-enyl)-2-aminobut-2-endioate carboxy-lyase, ACMS decarboxylase, ACMSD, ACMSD I, ACMSDase, alpha-amino beta-carboxymuconate epsilon-semialdehyde decarboxylase, alpha-Amino-beta-carboxymuconate-epsilon-semialdehade decarboxylase, alpha-Amino-beta-carboxymuconate-epsilon-semialdehyde beta-decarboxylase, alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase, alpha-amino-beta-carboxymuconic-epsilon-semialdehyde decarboxylase, Amino-carboxymuconate-semialdehyde decarboxylase, Decarboxylase, aminocarboxymuconate semialdehyde, hACMSD, NbaD enzyme, Picolinic acid carboxylase, Picolinic acid decarboxylase, picolinic carboxylase, Picolinic decarboxylase

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.1 Carboxy-lyases

                4.1.1.45 aminocarboxymuconate-semialdehyde decarboxylase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
2	Activating Compound
1722	AA Sequence
10	Application
1	CAS Registry Number
17	Cloned(Commentary)
6	Crystallization (Commentary)
29	Disease/ Diagnostics
3	Expression
3	General Information
1	IC50 Value
50	Inhibitors
1	Ki Value [mM]
21	KM Value [mM]
25	Metals/Ions
11	Molecular Weight [Da]
31	Natural Substrates/ Products (Substrates)
47	Organism
7	Pathway
33	PDB ID
7	pH Optimum
1	pH Range
2	pH Stability
14	Protein Variants
15	Purification (Commentary)
2	Reaction
2	Reaction Type
46	Reference
24	Source Tissue
17	Specific Activity [micromol/min/mg]
6	Storage Stability
70	Substrates and Products (Substrate)
5	Subunits
75	Synonyms
1	Systematic Name
2	Temperature Stability [°C]
16	Turnover Number [1/s]

Crystallization

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Crystallization on EC 4.1.1.45 - aminocarboxymuconate-semialdehyde decarboxylase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide Go to Crystallization (commentary) Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

EPR spectroscopic study on the Cu-substituted enzyme and crystal structure in the native catalytically active state at 1.99 A resolution, a substrate analogue-bound form at 2.50 A resolution, and a selected active site mutant form with one of the putative substrate binding residues altered at 2.32 A resolution. Each asymmetric unit contains three pairs of dimers. The substrate analogue does not directly coordinate to the metal ion but is bound to the active site by two arginine residues through noncovalent interactions

Homo sapiens

Q8TDX5

749250

molecular docking of inhibitor 3-[[[5-cyano-1,6-dihydro-6-oxo-4-(2-thienyl)-2-pyrimidinyl]thio]methyl]phenylacetic acid. The 2-thiophene ring fits the hydrophobic cleft defined by the Trp191 and Met180 residues

Homo sapiens

Q8TDX5

748372

vapour diffusion technique in hanging drop, crystal structure of human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase in complex with the glycolytic intermediate 1,3-dihydroxyacetonephosphate (DHAP), refined to an R-factor of 0.19, 1 mM DHAP, 2% poly(ethylene glycol) (PEG 400), 0.1 M Na/Hepes pH 7.5, 2.0 M ammonium sulphate, mixed with the same amount of a protein solution at a concentration of 12.7 mg/ml, and equilibrated against 500 microL of the reservoir solution, at 20°C

Homo sapiens

Q8TDX5

703670

-

Pseudomonas fluorescens

-

691974

hanging drop vapour diffusion method with 0.1 M Tris (pH 8.75), 15% PEG 5000, and 0.2 M MgCl2, at 20°C

Pseudomonas fluorescens

-

678137

mutant enzymes Co(II)-H228Y, Zn(II)-H228Y, and Zn(II)-H228G, hanging drop vapor diffusion method, using 0.1 M Tris-HCl (pH 8.75), 0.2 M MgCl2, and 15% (w/v) PEG 5000

Pseudomonas fluorescens

Q83V25

726993