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4.1.1.37: uroporphyrinogen decarboxylase

This is an abbreviated version!
For detailed information about uroporphyrinogen decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.37

Reaction

uroporphyrinogen III
=
Coproporphyrinogen III
 + 4 CO2

Synonyms

ch-UroD, Decarboxylase, uroporphyrinogen, Hem12p, PCL, Porphyrinogen carboxy-lyase, rl-UroD, tobacco UROD, UORO-D, UPD, URO-D, Uro-decarboxylase, uro-III decarboxylase, UroD, UROD protein, UROD1, uroporphyrinogen decarboxylase, uroporphyrinogen decarboxylase 1, Uroporphyrinogen III decarboxylase, uroporphyrinogen-decarboxylase, uroporphyrinogen-III decarboxylase

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.37 uroporphyrinogen decarboxylase

Cloned

Cloned on EC 4.1.1.37 - uroporphyrinogen decarboxylase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cloned, sequenced and expressed in Escherichia coli
expressed in Escherichia coli
-
expressed in Escherichia coli BL21(DE3) cells
-
expressed in Escherichia coli BL21-pLysS
expressed in Escherichia coli BL21-RIL(DE3) cells
expressed in Escherichia coli Rosetta2 cells
-
expressed in Escherichia coli strain Top10
-
expression in Escherichia coli
expression in Escherichia coli as His-tagged enzyme
native enzyme and N-terminally truncated UROD are expressed in Escherichia coli Rosetta2(DE3)pLysS cells
-
overexpression in Escherichia coli
-
partial cDNA clone
-
uroporphyrinogen decarboxylase mutations G318R, D306Y and K297N
wild-type enzyme and mutants causing porphyria cutanea tarda, expression in Escherichia coli BL-21
-