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4.1.1.28: aromatic-L-amino-acid decarboxylase

This is an abbreviated version!
For detailed information about aromatic-L-amino-acid decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.28

Reaction

5-hydroxy-L-tryptophan
=
5-hydroxytryptamine
 +
CO2

Synonyms

3,4-dihydroxyphenylalanine carboxylase, 3,4-Dihydroxyphenylalanine decarboxylase, 5-Hydroxy-L-tryptophan decarboxylase, 5-Hydroxytryptophan decarboxylase, 5-hydroxytryptophan hydroxylase, 5HTP decarboxylase, AAAC, AAAD, AACD, AADC, AADC1A, AADC1B, AADC393, AADC438, AADC486, Alt-DDC, aromatic acid acid decarboxylase, Aromatic amino acid decarboxylase, aromatic amino acid decarboxylase 1A, aromatic amino acid decarboxylase 1B, Aromatic L-amino acid decarboxylase, aromatic L-aminoacid decarboxylase, aromatic-L-amino-acid decarboxylase, CrTDC, DDC, Decarboxylase, aromatic amino acid, Di-ADC, Dihydroxyphenylalanine-5-hydroxytryptophan decarboxylase, DOPA DC, dopa decarboxilase, DOPA decarboxylase, DOPA-5-hydroxytryptophan decarboxylase, DOPA/5HTP decarboxylase, dopamine decarboxylase, EC 4.1.1.26, EC 4.1.1.27, HsDDC, Hydroxytryptophan decarboxylase, L-3,4-Dihydroxyphenylalanine decarboxylase, L-5-Hydroxytryptophan decarboxylase, L-amino acid decarboxylase, L-amino-acid decarboxylase, L-Aromatic amino acid decarboxylase, L-aromatic aminoacid decarboxylase, L-DOPA decarboxylase, L-Tryptophan decarboxylase, neural-type DDC, non-neural DDC, PP_2552, TDC, TDC2, Tenebrio Dopa decarboxylase, Trp decarboxylase, Tryptophan decarboxylase, tryptophan decarboxylase-1, tryptophan decarboxylase-2, TYDC, Tydc9, Tyrosine/Dopa decarboxylase

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.28 aromatic-L-amino-acid decarboxylase

Cloned

Cloned on EC 4.1.1.28 - aromatic-L-amino-acid decarboxylase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cDNA, alternative mRNA splice variants, neuronal and nonneuronal
-
cloning and expression of wild-type DDC and Y332F and T246A mutants in SVS370 Escherichia coli cells.
coexpression of tyrosine hydroxylase, GTP cyclohydrolase I, aromatic amino acid decarboxylase, and vesicular monoamine transporter 2 from a helper virus-free herpes simplex virus type 1 vector supports high-level, long-term biochemical and behavioral correction of a rat model of Parkinson's disease
-
DDC genotyping
-
developed an adeno-associated virus vector that contains human AADC cDNA under the control of the cytomegalovirus promoter. Infusion of this vector into the striatum of parkinsonian rats and monkeys improves L-DOPA responsiveness by improving AADC-mediated conversion of L-DOPA to dopamine
-
expressed in Escherichia coli
expressed in Escherichia coli BL21 (DE3)-Transetta cells
expressed in Escherichia coli expression vector pFLAG-1
expressed in Escherichia coli XL-1 Blue cells
-
expressed in LNCaP cells
-
expressed in MN-9D cells
-
expression in a mouse cell line using a bovine papilloma virus-derived expression vector containg the full coding region of the bovine enzyme
-
expression in COS cells
-
expression in Escherichia coli
expression in Escherichia coli using a T7 RNA polymerase expression system
-
gene ddc, located on chromosome 7p12.2, sequence comparisons, in addition to a TATA box, a strong promoter is detectedin the human DDC gene. It contains three positive regulatory elements located from position -560 bp to -1. Another two negative regulatory cis-elements are detected in between -9000 and 560 and 396-31. An alternative-promoter mechanism for regulating tissue-specific expression of DDC gene is observed
human AADC gene is cloned into a Adeno-associated virus type 2 shuttle plasmid, and a recombinant Adeno-associated virus type 2 containing hAADC under the control of the cytomegalovirus promoter is generated by a triple transfection technique
-
in a primate model of Parkinson disease, intrastriatal infusion of an adeno-associated viral vector containing the AADC gene results in robust gene expression
-
knockdown (silencing) of gene expression (RNA interference) results in a significant reduction of melanization of Sephadex beads at 24 h after injection. The average proportion of mosquitoes that completely melanized beads is 28% compared with 64% when the control green fluorescent protein is injected
mutant enzyme K303A is expressed in Escherichia coli SVS370 cells
-
plant expression vectors introduced into Agrobacterium tumefaciens GV3101
-
prediction and cloning of the promoter, a 3 kbp fragment flanking the Ddc gene. Development of a simple method combining a green fluorescent protein-reporter assay in vivo with TA-cloning
recombinant expression in Escherichia coli
splice variant of L-Dopa decarboxylase lacking exons 10-15 of the full-length transcript but includes an alternative exon 10
-
TDC encoded by a single-copy gene,TDC gene used to transform tobacco, Canola and potato plants and callus and root cultures from Peganum harmala
two autonomously regulated genes, TDC1 and TDC2