4.1.1.25: tyrosine decarboxylase
This is an abbreviated version!
For detailed information about tyrosine decarboxylase, go to the full flat file.
Word Map on EC 4.1.1.25
-
4.1.1.25
-
children
-
autism
-
catheter
-
taurodeoxycholate
-
biogenic
-
tunnel
-
thyroglossal
-
dopamine
-
roseus
-
faecalis
-
catharanthus
-
dielectric
-
hemodialysis
-
lymphedema
-
tryptamine
-
l-dopa
-
taurocholate
-
decarboxylases
-
forearm
-
midline
-
arteriovenous
-
aadcs
-
enterococci
-
5-hydroxytryptophan
-
octopamine
-
strictosidine
-
curvatus
-
hyoid
-
taurochenodeoxycholate
-
subdural
-
vindoline
-
cheeses
-
pharmacology
-
nephrologists
-
inattention
-
fpgas
-
tauroursodeoxycholate
-
catheter-related
-
glycocholate
-
resting-state
-
agriculture
-
synthesis
-
food industry
-
nutrition
- 4.1.1.25
- children
-
autism
-
catheter
- taurodeoxycholate
-
biogenic
-
tunnel
-
thyroglossal
- dopamine
- roseus
- faecalis
- catharanthus
-
dielectric
-
hemodialysis
- lymphedema
- tryptamine
- l-dopa
- taurocholate
- decarboxylases
-
forearm
-
midline
-
arteriovenous
-
aadcs
-
enterococci
- 5-hydroxytryptophan
- octopamine
- strictosidine
- curvatus
-
hyoid
- taurochenodeoxycholate
-
subdural
- vindoline
-
cheeses
- pharmacology
-
nephrologists
-
inattention
-
fpgas
- tauroursodeoxycholate
-
catheter-related
- glycocholate
-
resting-state
- agriculture
- synthesis
- food industry
- nutrition
Reaction
Synonyms
AADC, AtTYDC, Bradi2g51170, Decarboxylase, tyrosine, dTdc1, dTdc2, ELI5, L-(-)-Tyrosine apodecarboxylase, L-amino acid decarboxylase, L-Tyrosine decarboxylase, LbTDC, LOC100840315, MfnA protein, P0665A11.14, PcTYDC2, PF1159, PsTYDC1, PsTYDC2, TDC, tdcA, TYDC, TYDC/DODC, TYDC1, Tydc9, TYR decarboxylase, TyrDC, TyrDC-2, tyrosine decarboxylase, tyrosine decarboxylase-2, Tyrosine/Dopa decarboxylase, tyrosine/Dopa decarboxylase-1, tyrosine/Dopa decarboxylase-2, VwTYDC
ECTree
4.1.1.25 tyrosine decarboxylaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 4.1.1.25 - tyrosine decarboxylase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-aspartate
3-aminopropionic acid + CO2
95% of the activity with L-tyrosine
-
-
?
L-glutamate
4-aminobutyric acid + CO2
80% of the activity with L-tyrosine
-
-
?
L-phenylalanine + H2O
phenylethylamine + H2O2
-
reaction of mutant F338Y
-
?
L-tyrosine + H2O
4-hydroxyphenylacetaldehyde + CO2 + NH3
-
enzyme catalyzes decarboxylation and subsequent deamination of substrate
-
?
L-3,4-Dihydroxyphenylalanine
Dopamine + CO2
Thalictrum rugosum
-
at 74% of the activity with L-Tyr
-
-
?
L-Dopa
dopamine + CO2
-
preference of L-tyrosine over L-DOPA as substrate, strain IOEB 9809: 18% of activity of L-tyrosine decarboxylation, strain ATCC 367: 22% of activity of L-tyrosine decarboxylation
-
?
L-Dopa
dopamine + CO2
43.9% of the activity with L-tyrosine
-
-
?
L-Dopa
dopamine + CO2
-
shows about half of the catalytic efficiency compared to L-tyrosine
-
-
?
L-Dopa
dopamine + CO2
Levilactobacillus brevis CGMCC 1.2028
43.9% of the activity with L-tyrosine
-
-
?
L-Dopa
dopamine + CO2
-
16times lower affinity for DOPA than for tyrosine, the decarboxylation of DOPA is inhibited in the presence of the cofactor pyridoxal 5-phosphate by 50-60%, maximum activity towards DOPA in the absence of the cofactor
-
?
L-Dopa
dopamine + CO2
-
recombinant TyrDC-2, 19-28% of the specific activity with tyrosine
-
?
L-Dopa
dopamine + CO2
-
the enzyme is involved in decarboxylation of L-Dopa. L-Dopa decarboxylation activity of tyrosine decarboxylase is differentially regulated in response to stress conditions
-
-
?
L-phenylalanine
beta-phenylethylamine + CO2
-
L-phenylalanine is decarboxylated to beta-phenylethylamine (10% yield) only when tyrosine is completely depleted
-
-
?
L-phenylalanine
beta-phenylethylamine + CO2
-
L-phenylalanine is decarboxylated to beta-phenylethylamine (10% yield) only when tyrosine is completely depleted
-
-
?
L-Tyr
?
-
catalyzes an early step in the biosynthesis of isoquinoline alkaloids
-
-
?
L-Tyr
?
Thalictrum rugosum
-
inducible in late exponential and early stationary growth phases, induced by treatment with yeast glucan elicitor, may be a key enzyme between primary and secondary metabolisms in the biosynthesis of norlaudanosoline-derived alkaloids
-
-
?
L-Tyrosine
Tyramine + CO2
the recombinant protein refuses all other substrates other than L-tyrosine, suggesting TyrDC to be a specific L-tyrosine decarboxylase
-
-
?
L-Tyrosine
Tyramine + CO2
-
flies with a mutation in dTdc2 lack neural tyramine and octopamine and are female sterile due to egg retention. Dtdc2 mutants release eggs into the oviducts but are unable to deposit them
-
-
?
L-Tyrosine
Tyramine + CO2
-
highly specific for L-tyrosine
-
?
L-Tyrosine
Tyramine + CO2
-
preference of L-tyrosine over L-DOPA as substrate
-
?
L-Tyrosine
Tyramine + CO2
-
tyrosine decarboxylation in lactobacilli
-
?
L-Tyrosine
Tyramine + CO2
Levilactobacillus brevis IOEB 9809
-
tyrosine decarboxylation in lactobacilli
-
?
L-Tyrosine
Tyramine + CO2
-
16times higher affinity for tyrosine than for DOPA
-
?
L-Tyrosine
Tyramine + CO2
-
under some circumstances, enzyme activity can exert a rate-limiting control over the carbon flux allocated to the biosynthesis of hydroxycinnamic acid amides of tyramine
-
-
?
L-Tyrosine
Tyramine + CO2
-
first enzyme in poppy alkaloid biosynthesis, first biosynthetic step in the tetrahydroisoquinoline pathway, TyDC serves as a channel between the aromatic amino acids L-thyrosine and L-dopa and the biosynthesis of all of the opium poppy alkaloids
-
?
L-Tyrosine
Tyramine + CO2
-
ramification of the shikimate pathway
-
?
L-Tyrosine
Tyramine + CO2
-
ramification of the shikimate pathway
-
?
L-Tyrosine
Tyramine + CO2
-
recombinant TyrDC-2, highest specific activity with tyrosine as substrate
-
?
L-Tyrosine
Tyramine + CO2
the enzyme also catalyzes the decarboxylation of L-glutamate and L-asparate with higher efficiency. No activity with D-tyrosine
-
-
?
additional information
?
-
exclusive substrate specificity for L-amino acids with either indole or phenol side chains, but not both, inactive toward L-phenylalanine and L-tryptophan
-
?
additional information
?
-
-
exclusive substrate specificity for L-amino acids with either indole or phenol side chains, but not both, inactive toward L-phenylalanine and L-tryptophan
-
?
additional information
?
-
-
exclusive substrate specificity for L-amino acids with either indole or phenol side chains, but not both, inactive toward L-phenylalanine and L-tryptophan
-
?
additional information
?
-
-
exclusive substrate specificity for L-amino acids with either indole or phenol side chains, but not both, inactive toward L-phenylalanine and L-tryptophan
-
?
additional information
?
-
-
exclusive substrate specificity for L-amino acids with either indole or phenol side chains, but not both, inactive toward L-phenylalanine and L-tryptophan
-
?
additional information
?
-
-
exclusive substrate specificity for L-amino acids with either indole or phenol side chains, but not both, inactive toward L-phenylalanine and L-tryptophan
-
?
additional information
?
-
-
not: histidine, lysine, phenylalanine, tryptophan, ornithine
-
?
additional information
?
-
-
not: histidine, lysine, phenylalanine, tryptophan, ornithine, L-DOPA
-
?
additional information
?
-
-
agmatine deiminase pathway genes in Lactobacillus brevis are linked to the tyrosine decarboxylation operon in a putative acid resistance locus, overview
-
-
?
additional information
?
-
no substrates: L-phenylalanine, L-tryptophan
-
-
?
additional information
?
-
-
no substrates: L-phenylalanine, L-tryptophan
-
-
?
additional information
?
-
-
key residues involved in conformational swing and substrate binding, e.g. H241, K240, or S586, molecular docking and mutational analysis, overview. Residue S586 is a critical residue for substrate binding
-
-
?
additional information
?
-
Levilactobacillus brevis CGMCC 1.2028
no substrates: L-phenylalanine, L-tryptophan
-
-
?
additional information
?
-
Levilactobacillus brevis IOEB 9809
-
agmatine deiminase pathway genes in Lactobacillus brevis are linked to the tyrosine decarboxylation operon in a putative acid resistance locus, overview
-
-
?
additional information
?
-
Levilactobacillus brevis IOEB 9809
-
not: histidine, lysine, phenylalanine, tryptophan, ornithine, L-DOPA
-
?
additional information
?
-
exclusive substrate specificity for L-amino acids with either indole or phenol side chains, but not both, inactive toward L-phenylalanine and L-tryptophan
-
?
additional information
?
-
-
TDC catalyzes the decarboxylation of tryptophan to tryptamine and 5-hydroxytryptophan to serotonin. Tryptophan is a good ligand showing the highest binding affinity. Tyrosine and dopa show the same binding affinity only slightly lower as tryptophan
-
-
?
additional information
?
-
-
exclusive substrate specificity for L-amino acids with either indole or phenol side chains, but not both, inactive toward L-phenylalanine and L-tryptophan
-
?
additional information
?
-
-
exclusive substrate specificity for L-amino acids with either indole or phenol side chains, but not both, inactive toward L-phenylalanine and L-tryptophan
-
?
additional information
?
-
-
exclusive substrate specificity for L-amino acids with either indole or phenol side chains, but not both, inactive toward L-phenylalanine and L-tryptophan
-
?
additional information
?
-
-
exclusive substrate specificity for L-amino acids with either indole or phenol side chains, but not both, inactive toward L-phenylalanine and L-tryptophan
-
?
