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4.1.1.25: tyrosine decarboxylase

This is an abbreviated version!
For detailed information about tyrosine decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.25

Reaction

L-tyrosine
=
tyramine
+
CO2

Synonyms

AADC, AtTYDC, Bradi2g51170, Decarboxylase, tyrosine, dTdc1, dTdc2, ELI5, L-(-)-Tyrosine apodecarboxylase, L-amino acid decarboxylase, L-Tyrosine decarboxylase, LbTDC, LOC100840315, MfnA protein, P0665A11.14, PcTYDC2, PF1159, PsTYDC1, PsTYDC2, TDC, tdcA, TYDC, TYDC/DODC, TYDC1, Tydc9, TYR decarboxylase, TyrDC, TyrDC-2, tyrosine decarboxylase, tyrosine decarboxylase-2, Tyrosine/Dopa decarboxylase, tyrosine/Dopa decarboxylase-1, tyrosine/Dopa decarboxylase-2, VwTYDC

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.25 tyrosine decarboxylase

Inhibitors

Inhibitors on EC 4.1.1.25 - tyrosine decarboxylase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2S)-2-amino-3-(3-hydroxyphenyl)-2-methylpropanoic acid
-
IC50: 6.37 mM
(2S)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid
-
IC50: 9.4 mM
2-mercaptoethanol
-
strong inhibition
3-hydroxybenzyl-hydrazine
-
potent inhibitor, IC50: 0.0004 mM
alpha-Difluoromethyltyrosine
-
weak
alpha-Fluoromethyl(3,4-dihydroxyphenyl)alanine
alpha-Fluoromethyltyrosine
alpha-methyl-2,4-dihydroxyphenylalanine
-
IC50: 1.8 mM
Citric acid
-
stronger inhibitory effect on strain ATCC 367 than on IOEB 9809
Cu2+
1 mM, 9.2% residual activity
ethanol
-
12%, slight inhibition of activity in cell suspension, not: up to 10%
Fe2+
1 mM, 5.7% residual activity
glycerol
-
strong inhibition
hydroxylamine
2 mM, complete inhibition
L-2-aminoxy-3-phenylpropionate
L-alpha-Aminooxy-beta-phenylpropionate
Lactic acid
-
stronger inhibitory effect on strain ATCC 367 than on IOEB 9809
Na2HPO4
1 mM, 67.2% residual activity
Ni2+
1 mM, 64.3% residual activity
O-Methylhydroxylamine
2 mM, complete inhibition
tyramine