4.1.1.23: orotidine-5'-phosphate decarboxylase

This is an abbreviated version!
For detailed information about orotidine-5'-phosphate decarboxylase, go to the full flat file.

Reaction

Synonyms

Decarboxylase, orotidine 5'-phosphate, More, ODCase, OMP decarboxylase, OMP-DC, OMPD, OMPDC, OMPDCase, OMPdecase, Orotate decarboxylase, Orotate monophosphate decarboxylase, Orotic decarboxylase, Orotidine 5'-monophosphate decarboxylase, Orotidine 5'-phosphate decarboxylase, orotidine 5-monophosphate decarboxylase, orotidine 5-phosphate decarboxylase, Orotidine monophosphate decarboxylase, Orotidine phosphate decarboxylase, Orotidine-5'-monophosphate decarboxylase, orotidine-5'-phosphate decarboxylase, orotidine-5-monophosphate decarboxylase, Orotidylate decarboxylase, Orotidylic acid decarboxylase, Orotidylic decarboxylase, Orotodylate decarboxylase, PbrURA3, PfODCase, PfOMPDC, pm-ura3, PyrF, ScOMPDC, UMP synthase, URA3, Uridine 5'-monophosphate synthase

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.1 Carboxy-lyases

                4.1.1.23 orotidine-5'-phosphate decarboxylase

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Results	in table
14	Activating Compound
45149	AA Sequence
6	Application
1	CAS Registry Number
46	Cloned(Commentary)
12	Cofactor
37	Crystallization (Commentary)
129	Disease/ Diagnostics
10	General Information
8	General Stability
10	IC50 Value
314	Inhibitors
75	kcat/KM [mM/s]
121	Ki Value [mM]
120	KM Value [mM]
5	Localization
19	Metals/Ions
32	Molecular Weight [Da]
81	Natural Substrates/ Products (Substrates)
4	Organic Solvent Stability
163	Organism
7	Pathway
501	PDB ID
30	pH Optimum
3	pH Range
2	pH Stability
1	pI Value
2	Posttranslational Modification
130	Protein Variants
43	Purification (Commentary)
29	Reaction
28	Reaction Type
141	Reference
4	Source Tissue
24	Specific Activity [micromol/min/mg]
9	Storage Stability
233	Substrates and Products (Substrate)
43	Subunits
173	Synonyms
1	Systematic Name
27	Temperature Optimum [°C]
12	Temperature Stability [°C]
97	Turnover Number [1/s]

Temperature Stability

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Temperature Stability on EC 4.1.1.23 - orotidine-5'-phosphate decarboxylase

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TEMPERATURE STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

25

2 entries

26

Escherichia coli

-

pH 7.8, 90 min, 20% loss of activity

4178

37

Saccharomyces cerevisiae

-

half-life: 10 min. Nucleotide inhibitors stabilize against inactivation at 37°C

4169

55

Homo sapiens

-

1 min: 60% loss of the activity of the monomeric form, 10% loss of activity of the tetrameric form

4171

70

2 entries

85

2 entries

90

2 entries

additional information

Saccharomyces cerevisiae

-

the recombinant zinc-free ODCase expressed in Escherichia coli is more thermolabile than the zinc-containing ODCase expressed in yeast

651942

25

Homo sapiens

-

orotidine-5'-phosphate decarboxylase activity of UMP synthase, at low protein concentrations remains constant for 40 min

4187

25

Saccharomyces cerevisiae

-

half life: 26 min

4169

70

Methanothermobacter thermautotrophicus

-

Tm above 70°C

650145

70

Sulfolobus acidocaldarius

-

stable

651345

85

Sulfolobus acidocaldarius

-

or above, extremely thermostable in presence of substrate or product, considerable thermal inactivation in their absence

651345

85

Sulfolobus acidocaldarius

-

in the absence of substrate and product, however, a considerable thermal inactivation was observed at 85°C or above

651345

90

Sulfolobus acidocaldarius

-

10 min, 90% loss of activity

651345

90

Sulfolobus acidocaldarius

-

10 min, over 90% loss of activity, in absence of substrate and product

651345