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4.1.1.23: orotidine-5'-phosphate decarboxylase

This is an abbreviated version!
For detailed information about orotidine-5'-phosphate decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.23

Reaction

orotidine 5'-phosphate
=
UMP
 +
CO2

Synonyms

Decarboxylase, orotidine 5'-phosphate, More, ODCase, OMP decarboxylase, OMP-DC, OMPD, OMPDC, OMPDCase, OMPdecase, Orotate decarboxylase, Orotate monophosphate decarboxylase, Orotic decarboxylase, Orotidine 5'-monophosphate decarboxylase, Orotidine 5'-phosphate decarboxylase, orotidine 5-monophosphate decarboxylase, orotidine 5-phosphate decarboxylase, Orotidine monophosphate decarboxylase, Orotidine phosphate decarboxylase, Orotidine-5'-monophosphate decarboxylase, orotidine-5'-phosphate decarboxylase, orotidine-5-monophosphate decarboxylase, Orotidylate decarboxylase, Orotidylic acid decarboxylase, Orotidylic decarboxylase, Orotodylate decarboxylase, PbrURA3, PfODCase, PfOMPDC, pm-ura3, PyrF, ScOMPDC, UMP synthase, URA3, Uridine 5'-monophosphate synthase

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.23 orotidine-5'-phosphate decarboxylase

Molecular Weight

Molecular Weight on EC 4.1.1.23 - orotidine-5'-phosphate decarboxylase

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
105000 - 115000
-
bifunctional enzyme that contains activities of EC 2.4.2.10 and EC 4.1.1.23, sucrose density gradient centrifugation with 30% dimethyl sulfoxide and 5% glycerol
115000
-
dimeric enzyme form, gel filtration
14000
-
multienzyme complex of orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase with two subunits each of orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase
158000
recombinant bifunctional OMPDC-OPRT enzyme, gel filtration
22000
-
2 * 22000, SDS-PAGE
22800
calculated from sequence
250000
-
tetrameric enzyme form, gel filtration
26000
-
2 * 26000, SDS-PAGE
27000
29500
-
sucrose density gradient centrifugation, at low protein concentration, in absence of ligands that bind at the catalytic site. The enzyme exists as dimer at high protein concentrations
30000
x * 30000, about, sequence calculation
31100
x * 31100, calculation from amino acid sequence
31710
-
-
38000
46000
51000
-
gel filtration
54000
-
gel filtration
62000
64000
-
sucrose density gradient centrifugation, at high protein concentration, in presence of 0.05 mM 6-azauridine 5'-phosphate or 0.002 1-(5'-phospho-beta-D-ribofuranosyl)barbituric acid. The enzyme exists as monomer at low protein concentrations
76000
additional information
-
the orotidine-5'-phosphate decarboxylase domain of the bifunctional enzyme UMP synthase has a MW of 27814, calculation from amino acid sequence