4.1.1.23: orotidine-5'-phosphate decarboxylase
This is an abbreviated version!
For detailed information about orotidine-5'-phosphate decarboxylase, go to the full flat file.
Word Map on EC 4.1.1.23
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4.1.1.23
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pyrimidine
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phosphoribosyltransferase
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uracil
-
auxotrophic
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dihydroorotase
-
5-fluoroorotic
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2.4.2.10
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phosphoribosyl
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6-azauridine
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pyrazofurin
-
transcarbamoylase
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carbanions
-
oprtase
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aciduria
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5-fluorouridine
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dianion
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prototrophy
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barbituric
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succinate-grown
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phosphite
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phosphodianion
-
pyre
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molecular biology
-
pharmacology
-
medicine
-
biotechnology
- 4.1.1.23
- pyrimidine
-
phosphoribosyltransferase
- uracil
-
auxotrophic
- dihydroorotase
-
5-fluoroorotic
-
2.4.2.10
-
phosphoribosyl
- 6-azauridine
- pyrazofurin
-
transcarbamoylase
-
carbanions
- oprtase
-
aciduria
- 5-fluorouridine
- dianion
-
prototrophy
-
barbituric
-
succinate-grown
- phosphite
-
phosphodianion
-
pyre
- molecular biology
- pharmacology
- medicine
- biotechnology
Reaction
Synonyms
Decarboxylase, orotidine 5'-phosphate, More, ODCase, OMP decarboxylase, OMP-DC, OMPD, OMPDC, OMPDCase, OMPdecase, Orotate decarboxylase, Orotate monophosphate decarboxylase, Orotic decarboxylase, Orotidine 5'-monophosphate decarboxylase, Orotidine 5'-phosphate decarboxylase, orotidine 5-monophosphate decarboxylase, orotidine 5-phosphate decarboxylase, Orotidine monophosphate decarboxylase, Orotidine phosphate decarboxylase, Orotidine-5'-monophosphate decarboxylase, orotidine-5'-phosphate decarboxylase, orotidine-5-monophosphate decarboxylase, Orotidylate decarboxylase, Orotidylic acid decarboxylase, Orotidylic decarboxylase, Orotodylate decarboxylase, PbrURA3, PfODCase, PfOMPDC, pm-ura3, PyrF, ScOMPDC, UMP synthase, URA3, Uridine 5'-monophosphate synthase
ECTree
4.1.1.23 orotidine-5'-phosphate decarboxylaseAdvanced search results
results (
results (KI Value
KI Value on EC 4.1.1.23 - orotidine-5'-phosphate decarboxylase
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Ki VALUE [mM] 
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.022 - 0.028
(5-(4-amino-3-oxido-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl)-methyl dihydrogen phosphate
0.00132
6-carbamoyl-UMP
-
in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C
0.0000035
6-thiocarboxamidouridine 5'-phosphate
-
recombinant ODCase expressed in Escherichia coli
0.000000009
barbiturate ribonucleoside 5'-monophosphate
-
in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C
0.022
(5-(4-amino-3-oxido-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl)-methyl dihydrogen phosphate
pH 7.5, 22°C
0.028
(5-(4-amino-3-oxido-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl)-methyl dihydrogen phosphate
pH 7.5, 22°C
0.36
5-cyano-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate
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in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C
0.759
5-cyano-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate
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in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C
9.1
5-cyano-UMP
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in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C
290
5-cyano-UMP
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in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C
550
5-cyano-UMP
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in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C
3.322
6-amido-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate
-
in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C
4
6-amido-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate
-
Ki above 4 mM, in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C
0.0001
6-aza-UMP
pH and temperature not specified in the publication, recombinant multienzyme complex, versus OMPDC activity
0.001
6-aza-UMP
pH and temperature not specified in the publication, recombinant monofunctional enzyme, versus OMPDC activity
0.0195
6-aza-UMP
pH and temperature not specified in the publication, recombinant bifunctional enzyme, versus OMPDC activity
0.000064
6-azauridine 5'-phosphate
pH 7.4, 25°C, wild-type enzyme
0.037
6-cyano-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate
-
in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C
2
6-cyano-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate
-
Ki above 2 mM, in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C
0.0286
6-cyanouridine
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in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C
0.204
6-cyanouridine
-
in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C
0.000005
pyrazofurin-5'-monophosphate
-
in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C
0.000017
pyrazofurin-5'-monophosphate
-
in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C
0.00013
pyrazofurin-5'-monophosphate
-
in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C
0.0062
pyrazofurin-5'-monophosphate
-
in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C
0.078
UMP
pH and temperature not specified in the publication, recombinant bifunctional enzyme, versus OMPDC activity
0.12
UMP
pH and temperature not specified in the publication, recombinant multienzyme complex, versus OMPDC activity
0.25
UMP
pH and temperature not specified in the publication, recombinant monofunctional enzyme, versus OMPDC activity
0.00041
xanthosine 5'-phosphate
pH 7.4, 25°C, wild-type enzyme
additional information
additional information
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inhibition kinetics
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additional information
additional information
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inhibition kinetics, isothermal calorimetry
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