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0.00002
1-(beta-D-erythrofuranosyl)-orotate
pH 7.0, 25°C, wild-type enzyme
3 - 26
1-(beta-D-erythrofuranosyl)orotic acid
0.00014
5-Fluoroorotate
pH 7.0, 25°C, wild-type enzyme
0.028 - 12000
5-Fluoroorotidine 5'-phosphate
0.0000003
Orotate
pH 7.0, 25°C, wild-type enzyme
0.000037 - 492900
orotidine 5'-phosphate
3
1-(beta-D-erythrofuranosyl)orotic acid
-
mutant Q215A/Y217F/R235A, pH 7.1, 25°C
4.2
1-(beta-D-erythrofuranosyl)orotic acid
-
mutant Q215A/R235A, pH 7.1, 25°C
4.6
1-(beta-D-erythrofuranosyl)orotic acid
-
mutant Q215A/Y217F, pH 7.1, 25°C
10
1-(beta-D-erythrofuranosyl)orotic acid
-
mutant Y217F/R235A, pH 7.1, 25°C
11
1-(beta-D-erythrofuranosyl)orotic acid
-
mutant Q215A, pH 7.1, 25°C
12
1-(beta-D-erythrofuranosyl)orotic acid
-
mutant Y217F, pH 7.1, 25°C
26
1-(beta-D-erythrofuranosyl)orotic acid
-
wild-type, pH 7.1, 25°C
26
1-(beta-D-erythrofuranosyl)orotic acid
-
mutant R235A, pH 7.1, 25°C
0.028
5-Fluoroorotidine 5'-phosphate
pH 7.1, 25°C, mutant Q215A/Y217F/R235A
0.82
5-Fluoroorotidine 5'-phosphate
pH 7.1, 25°C, mutant Y217F/R235A
7.23
5-Fluoroorotidine 5'-phosphate
pH 7.1, 25°C, mutant Q215A/R235A
13.2
5-Fluoroorotidine 5'-phosphate
pH 7.1, 25°C, mutant Y217A
53.3
5-Fluoroorotidine 5'-phosphate
pH 7.1, 25°C, mutant Q215A/Y271F
76.7
5-Fluoroorotidine 5'-phosphate
pH 7.1, 25°C, mutant S154A/Q215A
158.6
5-Fluoroorotidine 5'-phosphate
pH 7.1, 25°C, mutant R235A
160
5-Fluoroorotidine 5'-phosphate
-
mutant R235A, pH 7.1, 25°C
290.9
5-Fluoroorotidine 5'-phosphate
pH 7.1, 25°C, mutant S154A
1023.9
5-Fluoroorotidine 5'-phosphate
pH 7.1, 25°C, mutant Y217F
1979
5-Fluoroorotidine 5'-phosphate
pH 7.1, 25°C, mutant Q215A
11875
5-Fluoroorotidine 5'-phosphate
pH 7.1, 25°C, wild-type enzyme
12000
5-Fluoroorotidine 5'-phosphate
-
wild-type, pH 7.1, 25°C
0.000037 - 0.00022
orotidine 5'-phosphate
pH 7.1, 25°C, mutant Q215A/Y217F/R235A
0.00004
orotidine 5'-phosphate
-
mutant Q215A/Y217F/R235A, pH 7.1, 25°C
0.0001
orotidine 5'-phosphate
pH 7.0, 25°C, wild-type enzyme
0.0041
orotidine 5'-phosphate
-
mutant Y217F/R235A, pH 7.1, 25°C
0.0041 - 0.018
orotidine 5'-phosphate
pH 7.1, 25°C, mutant Y217F/R235A
0.013
orotidine 5'-phosphate
-
mutant Q215A/R235A, pH 7.1, 25°C
0.014 - 0.054
orotidine 5'-phosphate
pH 7.1, 25°C, mutant Q215A/R235A
0.13
orotidine 5'-phosphate
mutant T159V/V182A/Y206F, pH 7.1, 25°C
0.46
orotidine 5'-phosphate
Methanobacterium thermoautotrophicus
mutant V155D, pH 7.1, 25°C
0.61
orotidine 5'-phosphate
-
mutant R235A, pH 7.1, 25°C
0.8
orotidine 5'-phosphate
mutant T159V/V182A, pH 7.1, 25°C
0.91
orotidine 5'-phosphate
-
mutant R235A, pH 7.1, 25°C
0.91
orotidine 5'-phosphate
pH 7.1, 25°C, mutant R235A
1.5
orotidine 5'-phosphate
mutant R203A, pH 7.1, 25°C
1.7
orotidine 5'-phosphate
mutant R160A/V182A, pH 7.1, 25°C
2.3
orotidine 5'-phosphate
-
mutant Q215A/Y217F, pH 7.1, 25°C
3.4 - 17
orotidine 5'-phosphate
pH 7.1, 25°C, mutant Q215A/Y271F
3.7
orotidine 5'-phosphate
mutant T159V/Y206F, pH 7.1, 25°C
4
orotidine 5'-phosphate
Methanobacterium thermoautotrophicus
mutant D70N, pH 7.1, 25°C
8.5
orotidine 5'-phosphate
mutant R160A/Y206F, pH 7.1, 25°C
10
orotidine 5'-phosphate
Methanobacterium thermoautotrophicus
mutant I96S, pH 7.1, 25°C
13
orotidine 5'-phosphate
mutant Q185A, pH 7.1, 25°C
14
orotidine 5'-phosphate
-
mutant D71C, pH 7.2, 25°C
15
orotidine 5'-phosphate
mutant V182A/Y206F, pH 7.1, 25°C
22
orotidine 5'-phosphate
Methanobacterium thermoautotrophicus
mutant V155S, pH 7.1, 25°C
67
orotidine 5'-phosphate
mutant R160A, pH 7.1, 25°C
70
orotidine 5'-phosphate
mutant T159V, pH 7.1, 25°C
120
orotidine 5'-phosphate
Methanobacterium thermoautotrophicus
mutant L123S, pH 7.1, 25°C
130
orotidine 5'-phosphate
mutant V182A, pH 7.1, 25°C
170
orotidine 5'-phosphate
-
mutant D76C, pH 7.2, 25°C
180
orotidine 5'-phosphate
-
mutant Y217F, pH 7.1, 25°C
180
orotidine 5'-phosphate
pH 7.1, 25°C, mutant Y217F
190
orotidine 5'-phosphate
Methanobacterium thermoautotrophicus
mutant L123N, pH 7.1, 25°C
260
orotidine 5'-phosphate
-
mutant Q215A, pH 7.1, 25°C
260
orotidine 5'-phosphate
pH 7.1, 25°C, mutant Q215A
300
orotidine 5'-phosphate
Methanobacterium thermoautotrophicus
mutant I96T, pH 7.1, 25°C
559.7
orotidine 5'-phosphate
pH and temperature not specified in the publication, recombinant monofunctional enzyme, OMPDC activity
750
orotidine 5'-phosphate
mutant Y206F, pH 7.1, 25°C
2000
orotidine 5'-phosphate
Methanobacterium thermoautotrophicus
wild-type, pH 7.1, 25°C
2900
orotidine 5'-phosphate
wild-type, pH 7.1, 25°C
2923.8
orotidine 5'-phosphate
pH and temperature not specified in the publication, recombinant multienzyme complex, OMPDC activity
4500
orotidine 5'-phosphate
-
mutant D22G, pH 7.2, 25°C
5100
orotidine 5'-phosphate
-
mutant L130M, pH 7.2, 25°C
5900
orotidine 5'-phosphate
-
mutant V167N, pH 7.2, 25°C
11000
orotidine 5'-phosphate
-
wild-type, pH 7.1, 25°C
11000
orotidine 5'-phosphate
pH 7.1, 25°C, wild-type enzyme
12000
orotidine 5'-phosphate
-
mutant Q201H, pH 7.2, 25°C
15000
orotidine 5'-phosphate
-
mutant T80S, pH 7.2, 25°C
15000
orotidine 5'-phosphate
-
wild-type, pH 7.2, 25°C
492900
orotidine 5'-phosphate
pH and temperature not specified in the publication, recombinant bifunctional enzyme, OMPDC activity