4.1.1.23: orotidine-5'-phosphate decarboxylase

This is an abbreviated version!
For detailed information about orotidine-5'-phosphate decarboxylase, go to the full flat file.

Reaction

Synonyms

Decarboxylase, orotidine 5'-phosphate, More, ODCase, OMP decarboxylase, OMP-DC, OMPD, OMPDC, OMPDCase, OMPdecase, Orotate decarboxylase, Orotate monophosphate decarboxylase, Orotic decarboxylase, Orotidine 5'-monophosphate decarboxylase, Orotidine 5'-phosphate decarboxylase, orotidine 5-monophosphate decarboxylase, orotidine 5-phosphate decarboxylase, Orotidine monophosphate decarboxylase, Orotidine phosphate decarboxylase, Orotidine-5'-monophosphate decarboxylase, orotidine-5'-phosphate decarboxylase, orotidine-5-monophosphate decarboxylase, Orotidylate decarboxylase, Orotidylic acid decarboxylase, Orotidylic decarboxylase, Orotodylate decarboxylase, PbrURA3, PfODCase, PfOMPDC, pm-ura3, PyrF, ScOMPDC, UMP synthase, URA3, Uridine 5'-monophosphate synthase

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.1 Carboxy-lyases

                4.1.1.23 orotidine-5'-phosphate decarboxylase

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Results	in table
14	Activating Compound
45149	AA Sequence
6	Application
1	CAS Registry Number
46	Cloned(Commentary)
12	Cofactor
37	Crystallization (Commentary)
129	Disease/ Diagnostics
10	General Information
8	General Stability
10	IC50 Value
314	Inhibitors
75	kcat/KM [mM/s]
121	Ki Value [mM]
120	KM Value [mM]
5	Localization
19	Metals/Ions
32	Molecular Weight [Da]
81	Natural Substrates/ Products (Substrates)
4	Organic Solvent Stability
163	Organism
7	Pathway
501	PDB ID
30	pH Optimum
3	pH Range
2	pH Stability
1	pI Value
2	Posttranslational Modification
130	Protein Variants
43	Purification (Commentary)
29	Reaction
28	Reaction Type
141	Reference
4	Source Tissue
24	Specific Activity [micromol/min/mg]
9	Storage Stability
233	Substrates and Products (Substrate)
43	Subunits
173	Synonyms
1	Systematic Name
27	Temperature Optimum [°C]
12	Temperature Stability [°C]
97	Turnover Number [1/s]

General Stability

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General Stability on EC 4.1.1.23 - orotidine-5'-phosphate decarboxylase

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GENERAL STABILITY

ORGANISM

UNIPROT

LITERATURE

1-ribosyloxipurinol 5'-phosphate prevents loss of activity during preincubation in absence of substrate, when the inhibitor concentration is high enough to inhibit the enzyme substantially

Saccharomyces cerevisiae

-

4169

Asp-70 makes a crucial contribution to enzyme stability

Methanothermobacter thermautotrophicus

-

650145

conversion of the monomer to higher molecular weight forms is associated with increased stability

Homo sapiens

-

4171

glycerol, 50% v/v is an effective stabilizer of the orotidine-5'-phosphate decarboxylase domain at 4°C, -20°C or -70°C

Mus musculus

-

4180

NaCl stabilizes the dimeric active enzyme form

Saccharomyces cerevisiae

-

649921

orotidine 5'-phosphate and UMP stabilize

Sulfolobus acidocaldarius

-

651345

unliganded enzyme without bound UMP or OMP forms heavy precipitates during purification

Bacillus subtilis

P25971

653646

unstable to repeated freezing and thawing

Saccharomyces cerevisiae

-

4172