4.1.1.2: oxalate decarboxylase
This is an abbreviated version!
For detailed information about oxalate decarboxylase, go to the full flat file.
Word Map on EC 4.1.1.2
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4.1.1.2
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hyperoxaluria
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velutipes
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oxalate-degrading
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flammulina
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mniii
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mn-dependent
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bicupins
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collybia
-
medicine
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agriculture
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paper production
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industry
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biotechnology
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degradation
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synthesis
- 4.1.1.2
- hyperoxaluria
- velutipes
-
oxalate-degrading
-
flammulina
-
mniii
-
mn-dependent
-
bicupins
-
collybia
- medicine
- agriculture
- paper production
- industry
- biotechnology
- degradation
- synthesis
Reaction
Synonyms
AnODC, AtuOXDC, Decarboxylase, oxalate, FvOXDC, More, ODC, ODC B, ODC C, ODC E, ODC F, odc2, oxalate carboxy-lyase, oxalate-decarboxylase, oxazyme, OXD, OXDC, OxDc-CLEC, OxDcase, OxdD, pBy, TOXDC, YoaN, YvrK
ECTree
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Reference on EC 4.1.1.2 - oxalate decarboxylase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Magro, P.; Marciano, P.; Di Lenna, P.
Enzymatic oxalate decarboxylase isolates of Sclerotinia sclerotium
FEMS Microbiol. Lett.
49
49-52
1988
Sclerotinia sclerotiorum
-
Murthy, M.S.R.; Talwar, H.S.; Nath, R.; Thind, S.K.
Oxalate decarboxylase from guinea pig liver
IRCS Med. Sci. Libr. Compend.
9
683-684
1981
Cavia porcellus
-
Emiliani, E.; Riera, B.
Enzymatic oxalate dcarboxylase in Aspergillus niger. II. Hydrogen peroxide formation and other characteristics of the oxalate decarboxylase
Biochim. Biophys. Acta
167
414-421
1968
Aspergillus niger
Labrou, N.E.; Clonis, Y.D.
Biomimetic dye-ligands for oxalate-recognizing enzymes. Studies with oxalate oxidase and oxalate decarboxylase
J. Biotechnol.
40
59-70
1995
Aspergillus phoenicis
-
Dutton, M.V.; Kathiara, M.; Gallagher, I.M.; Evans, C.S.
Purification and characterization of oxalate decarboxylase from Coriolus versicolor
FEMS Microbiol. Lett.
116
321-326
1994
Trametes versicolor
-
Mehta, A.; Datta, A.
Oxalate decarboxylase from Collybia velutipes. Purification, characterization, and cDNA cloning
J. Biol. Chem.
266
23548-23553
1991
Flammulina velutipes
Anand, R.; Dorrestein, P.C.; Kinsland, C.; Begley, T.P.; Ealick, S.E.
Structure of oxalate decarboxylase from Bacillus subtilis at 1.75 A resolution
Biochemistry
41
7659-7669
2002
Bacillus subtilis (O34714), Bacillus subtilis, Bacillus subtilis 168 / CU1065 (O34714)
Makela, M.; Galkin, S.; Hatakka, A.; Lundell, T.
Production of organic acids and oxalate decarboxylase in lignin-degrading white rot fungi
Enzyme Microb. Technol.
30
542-549
2002
Trametes versicolor, Trametes ochracea, Dichomitus squalens, no activity in Phanerochaete chrysosporium, no activity in Phlebiopsis gigantea, no activity in Radulodon erikssonii, no activity in Trichaptum fusco-violaceum, Atheliachaete sanguinea, no activity in Ceriporiopsis subvermispora, no activity in Haploporus odorus strain T154, no activity in Nematoloma frowardii, no activity in Ceriporiopsis subvermispora CZ-3, Trametes ochracea T7, Atheliachaete sanguinea T51, no activity in Radulodon erikssonii T84, no activity in Trichaptum fusco-violaceum T21, no activity in Phlebiopsis gigantea T55, no activity in Phanerochaete chrysosporium F1767, Dichomitus squalens PO114, no activity in Nematoloma frowardii b19
-
Reinhardt, L.A.; Svedruzic, D.; Chang, C.H.; Cleland, W.W.; Richards, N.G.J.
Heavy atom isotope effects on the reaction catalyzed by the oxalate decarboxylase from Bacillus subtilis
J. Am. Chem. Soc.
125
1244-1252
2003
Bacillus subtilis, Bacillus subtilis 168
Tanner, A.; Bornemann, S.
Bacillus subtilis YvrK is an acid-induced oxalate decarboxylase
J. Bacteriol.
182
5271-5273
2000
Bacillus subtilis, Bacillus subtilis 168
Costa, T.; Steil, L.; Martins, L.O.; Volker, U.; Henriques, A.O.
Assembly of an oxalate decarboxylase produced under sigmaK control into the Bacillus subtilis spore coat
J. Bacteriol.
186
1462-1474
2004
Bacillus subtilis
Kesarwani, M.; Azam, M.; Natarajan, K.; Mehta, A.; Datta, A.
Oxalate decarboxylase from Collybia velutipes. Molecular cloning and its overexpression to confer resistance to fungal infection in transgenic tobacco and tomato
J. Biol. Chem.
275
7230-7238
2000
Flammulina velutipes (Q9UVK4), Flammulina velutipes
Tanner, A.; Bowater, L.; Fairhurst, S.A.; Bornemann, S.
Oxalate decarboxylase requires manganese and dioxygen for activity. Overexpression and characterization of Bacillus subtilis YvrK and YoaN
J. Biol. Chem.
276
43627-43634
2001
Bacillus subtilis (O34714), Bacillus subtilis (O34767), Bacillus subtilis, Bacillus subtilis 168 (O34714), Bacillus subtilis 168 (O34767)
Just, V.J.; Stevenson, C.E.M.; Bowater, L.; Tanner, A.; Lawson, D.M.; Bornemann, S.
A closed conformation of Bacillus subtilis oxalate decarboxylase OxdC provides evidence for the true identity of the active site
J. Biol. Chem.
279
19867-19874
2004
Bacillus subtilis (O34714), Bacillus subtilis, Bacillus subtilis 168 (O34714)
Kathiara, M.; Wood, D.A.; Evans, C.S.
Detection and partial characterization of oxalate decarboxylase from Agaricus bisporus
Mycol. Res.
104
345-350
2000
Agaricus bisporus
Chang, C.H.; Svedruzic, D.; Ozarowski, A.; Walker, L.; Yeagle, G.; Britt, R.D.; Angerhofer, A.; Richards, N.G.
EPR spectroscopic characterization of the manganese center and a free radical in the oxalate decarboxylase reaction: identification of a tyrosyl radical during turnover
J. Biol. Chem.
279
52840-52849
2004
Bacillus subtilis
Svedruzic, D.; Liu, Y.; Reinhardt, L.A.; Wroclawska, E.; Cleland, W.W.; Richards, N.G.
Investigating the roles of putative active site residues in the oxalate decarboxylase from Bacillus subtilis
Arch. Biochem. Biophys.
464
36-47
2007
Bacillus subtilis
Just, V.J.; Burrell, M.R.; Bowater, L.; McRobbie, I.; Stevenson, C.E.; Lawson, D.M.; Bornemann, S.
The identity of the active site of oxalate decarboxylase and the importance of the stability of active-site lid conformations
Biochem. J.
407
397-406
2007
Bacillus subtilis (O34714), Bacillus subtilis 168 (O34714)
Muthusamy, M.; Burrell, M.R.; Thorneley, R.N.; Bornemann, S.
Real-time monitoring of the oxalate decarboxylase reaction and probing hydron exchange in the product, formate, using fourier transform infrared spectroscopy
Biochemistry
45
10667-10673
2006
Bacillus subtilis
Burrell, M.R.; Just, V.J.; Bowater, L.; Fairhurst, S.A.; Requena, L.; Lawson, D.M.; Bornemann, S.
Oxalate decarboxylase and oxalate oxidase activities can be interchanged with a specificity switch of up to 282,000 by mutating an active site lid
Biochemistry
46
12327-12336
2007
Bacillus subtilis (O34714), Bacillus subtilis
Angerhofer, A.; Moomaw, E.W.; Garcia-Rubio, I.; Ozarowski, A.; Krzystek, J.; Weber, R.T.; Richards, N.G.
Multifrequency EPR studies on the Mn(II) centers of oxalate decarboxylase
J. Phys. Chem. B
111
5043-5046
2007
Bacillus subtilis
Dias, B.B.; Cunha, W.G.; Morais, L.S.; Vianna, G.R.; Rech, E.L.; de Capdeville, G.; Aragao, F.J.
Expression of an oxalate decarboxylase gene from Flammulina sp. in transgenic lettuce (Lactuca sativa) plants and resistance to Sclerotinia sclerotiorum
Plant Pathol.
55
187-193
2006
Flammulina sp. (Q870M8), Flammulina sp. IJF 140502 (Q870M8)
Scarpellini, M.; Gaetjens, J.; Martin, O.J.; Kampf, J.W.; Sherman, S.E.; Pecoraro, V.L.
Modeling the resting state of oxalate oxidase and oxalate decarboxylase enzymes
Inorg. Chem.
47
3584-3593
2008
Bacillus subtilis, Thermotoga maritima
Grujic, D.; Salido, E.C.; Shenoy, B.C.; Langman, C.B.; McGrath, M.E.; Patel, R.J.; Rashid, A.; Mandapati, S.; Jung, C.W.; Margolin, A.L.
Hyperoxaluria is reduced and nephrocalcinosis prevented with an oxalate-degrading enzyme in mice with hyperoxaluria
Am. J. Nephrol.
29
86-93
2009
Mus musculus
Kolandaswamy, A.; George, L.; Sadasivam, S.
Heterologous expression of oxalate decarboxylase in Lactobacillus plantarum NC8
Curr. Microbiol.
58
117-121
2009
Bacillus subtilis
Walz, A.; Zingen-Sell, I.; Theisen, S.; Kortekamp, A.
Reactive oxygen intermediates and oxalic acid in the pathogenesis of the necrotrophic fungus Sclerotinia sclerotiorum
Eur. J. Plant Pathol.
120
317-330
2008
Trametes versicolor
MacLellan, S.R.; Helmann, J.D.; Antelmann, H.
The YvrI alternative sigma factor is essential for acid stress induction of oxalate decarboxylase in Bacillus subtilis
J. Bacteriol.
191
931-939
2009
Bacillus subtilis, Bacillus subtilis 168 / CU1065
Shen, Y.H.; Liu, R.J.; Wang, H.Q.
Oxalate decarboxylase from Agrobacterium tumefaciens C58 is translocated by a twin arginine translocation system
J. Microbiol. Biotechnol.
18
1245-1251
2008
Agrobacterium tumefaciens, Agrobacterium tumefaciens C58 / ATCC 33970
MacLellan, S.R.; Wecke, T.; Helmann, J.D.
A previously unidentified sigma factor and two accessory proteins regulate oxalate decarboxylase expression in Bacillus subtilis
Mol. Microbiol.
69
954-967
2008
Bacillus subtilis, Bacillus subtilis 168 / CU1065
Cassland, P.; Sjoede, A.; Winestrand, S.; Joensson, L.J.; Nilvebrant, N.O.
Evaluation of oxalate decarboxylase and oxalate oxidase for industrial applications
Appl. Biochem. Biotechnol.
161
255-263
2010
Aspergillus niger
Zhu, C.X.; Hong, F.
Induction of an oxalate decarboxylase in the filamentous fungus Trametes versicolor by addition of inorganic acids
Appl. Biochem. Biotechnol.
160
655-664
2010
Trametes versicolor, Trametes versicolor PRL572
Moomaw, E.W.; Angerhofer, A.; Moussatche, P.; Ozarowski, A.; Garcia-Rubio, I.; Richards, N.G.
Metal dependence of oxalate decarboxylase activity
Biochemistry
48
6116-6125
2009
Bacillus subtilis (O34714), Bacillus subtilis
Cowley, A.B.; Poage, D.W.; Dean, R.R.; Meschter, C.L.; Ghoddusi, M.; Li, Q.S.; Sidhu, H.
14-day repeat-dose oral toxicity evaluation of oxazyme in rats and dogs
Int. J. Toxicol.
29
20-31
2010
Bacillus subtilis
Tabares, L.C.; Gaetjens, J.; Hureau, C.; Burrell, M.R.; Bowater, L.; Pecoraro, V.L.; Bornemann, S.; Un, S.
pH-Dependent structures of the manganese binding sites in oxalate decarboxylase as revealed by high-field electron paramagnetic resonance
J. Phys. Chem. B
113
9016-9025
2009
Bacillus subtilis
Maekelae, M.R.; Hilden, K.; Lundell, T.K.
Oxalate decarboxylase: biotechnological update and prevalence of the enzyme in filamentous fungi
Appl. Microbiol. Biotechnol.
87
801-814
2010
Agaricus bisporus, Aspergillus niger, Aspergillus sp., Bacillus subtilis, Dichomitus squalens, Flammulina sp., Flammulina sp. IJF 140502, Flammulina velutipes, Pandorea sp., Pandorea sp. OXJ-11a, Phanerodontia chrysosporium, Trametes versicolor
Moral, M.E.; Tu, C.; Imaram, W.; Angerhofer, A.; Silverman, D.N.; Richards, N.G.
Nitric oxide reversibly inhibits Bacillus subtilis oxalate decarboxylase
Chem. Commun. (Camb. )
47
3111-3113
2011
Bacillus subtilis
Imaram, W.; Saylor, B.T.; Centonze, C.P.; Richards, N.G.; Angerhofer, A.
EPR spin trapping of an oxalate-derived free radical in the oxalate decarboxylase reaction
Free Radic. Biol. Med.
50
1009-1015
2011
Bacillus subtilis (O34714), Bacillus subtilis
Wolfenden, R.; Lewis, C.A.; Yuan, Y.
Kinetic challenges facing oxalate, malonate, acetoacetate, and oxaloacetate decarboxylases
J. Am. Chem. Soc.
133
5683-5685
2011
Bacillus subtilis
Lin, R.; Wu, R.; Huang, X.; Xie, T.
Immobilization of oxalate decarboxylase to Eupergit and properties of the immobilized enzyme
Prep. Biochem. Biotechnol.
41
154-165
2011
Bacillus subtilis
Saylor, B.T.; Reinhardt, L.A.; Lu, Z.; Shukla, M.S.; Nguyen, L.; Cleland, W.W.; Angerhofer, A.; Allen, K.N.; Richards, N.G.
A structural element that facilitates proton-coupled electron transfer in oxalate decarboxylase
Biochemistry
51
2911-2920
2012
Bacillus subtilis (O34714), Bacillus subtilis, Bacillus subtilis 168 (O34714)
Sasikumar, P.; Gomathi, S.; Anbazhagan, K.; Selvam, G.S.
Secretion of biologically active heterologous oxalate decarboxylase (OxdC) in Lactobacillus plantarum WCFS1 using homologous signal peptides
BioMed Res. Int.
2013
280432
2013
Bacillus subtilis
Winestrand, S.; Sjoede, A.; Cassland, P.; Hilden, L.; Nilvebrant, N.; Joensson, L.
Evaluation of oxalate decarboxylases in industrial bleaching filtrates and in pulp-mill experiments
Ind. Biotechnol.
10
126-129
2014
Aspergillus niger, uncultured fungus
-
Campomanes, P.; Kellett, W.F.; Easthon, L.M.; Ozarowski, A.; Allen, K.N.; Angerhofer, A.; Rothlisberger, U.; Richards, N.G.
Assigning the EPR fine structure parameters of the Mn(II) centers in Bacillus subtilis oxalate decarboxylase by site-directed mutagenesis and DFT/MM calculations
J. Am. Chem. Soc.
136
2313-2323
2014
Bacillus subtilis (O34714), Bacillus subtilis
Anbazhagan, K.; Sasikumar, P.; Gomathi, S.; Priya, H.P.; Selvam, G.S.
In vitro degradation of oxalate by recombinant Lactobacillus plantarum expressing heterologous oxalate decarboxylase
J. Appl. Microbiol.
115
880-887
2013
Bacillus subtilis
Karmakar, T.; Periyasamy, G.; Balasubramanian, S.
CO2 migration pathways in oxalate decarboxylase and clues about its active site
J. Phys. Chem. B
117
12451-12460
2013
Bacillus subtilis
da Silva, L.F.; Dias, C.V.; Cidade, L.C.; Mendes, J.S.; Pirovani, C.P.; Alvim, F.C.; Pereira, G.A.; Aragao, F.J.; Cascardo, J.C.; Costa, M.G.
Expression of an oxalate decarboxylase impairs the necrotic effect induced by Nep1-like protein (NLP) of Moniliophthora perniciosa in transgenic tobacco
Mol. Plant Microbe Interact.
24
839-848
2011
Flammulina velutipes
Chakraborty, N.; Ghosh, R.; Ghosh, S.; Narula, K.; Tayal, R.; Datta, A.; Chakraborty, S.
Reduction of oxalate levels in tomato fruit and consequent metabolic remodeling following overexpression of a fungal oxalate decarboxylase
Plant Physiol.
162
364-378
2013
Flammulina velutipes, no activity in Solanum lycopersicum
Twahir, U.T.; Ozarowski, A.; Angerhofer, A.
Redox cycling, pH dependence, and ligand effects of Mn(III) in oxalate decarboxylase from Bacillus subtilis
Biochemistry
55
6505-6516
2016
Bacillus subtilis (O34714), Bacillus subtilis, Bacillus subtilis 168 (O34714)
Zhu, W.; Reinhardt, L.A.; Richards, N.G.J.
Second-shell hydrogen bond impacts transition-state structure in Bacillus subtilis oxalate decarboxylase
Biochemistry
57
3425-3432
2018
Bacillus subtilis (O34714), Bacillus subtilis, Bacillus subtilis 168 (O34714)
Lee, E.; Jeong, B.C.; Park, Y.H.; Kim, H.H.
Expression of the gene encoding oxalate decarboxylase from Bacillus subtilis and characterization of the recombinant enzyme
BMC Res. Notes
7
598
2014
Bacillus subtilis (O34714), Bacillus subtilis, Bacillus subtilis 128 (O34714)
Sasikumar, P.; Gomathi, S.; Anbazhagan, K.; Baby, A.E.; Sangeetha, J.; Selvam, G.S.
Genetically engineered Lactobacillus plantarum WCFS1 constitutively secreting heterologous oxalate decarboxylase and degrading oxalate under in vitro
Curr. Microbiol.
69
708-715
2014
Lactiplantibacillus plantarum
Kotb, E.
Production, purification and partial characterization for an oxalate decarboxylase (OxDcase) from the probiote Lactobacillus plantarum KSK-II
Curr. Sci.
114
835-844
2018
Lactiplantibacillus plantarum, Lactiplantibacillus plantarum KSK-II
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Twahir, U.T.; Stedwell, C.N.; Lee, C.T.; Richards, N.G.; Polfer, N.C.; Angerhofer, A.
Observation of superoxide production during catalysis of Bacillus subtilis oxalate decarboxylase at pH 4
Free Radic. Biol. Med.
80
59-66
2015
Bacillus subtilis (O34714), Bacillus subtilis, Bacillus subtilis 168 (O34714)
Sasikumar, P.; Gomathi, S.; Anbazhagan, K.; Abhishek, A.; Paul, E.; Vasudevan, V.; Sasikumar, S.; Selvam, G.S.
Recombinant Lactobacillus plantarum expressing and secreting heterologous oxalate decarboxylase prevents renal calcium oxalate stone deposition in experimental rats
J. Biomed. Sci.
21
86
2014
Lactiplantibacillus plantarum
Albert, A.; Tiwari, V.; Paul, E.; Ganesan, D.; Ayyavu, M.; Kujur, R.; Ponnusamy, S.; Shanmugam, K.; Saso, L.; Govindan Sadasivam, S.
Expression of heterologous oxalate decarboxylase in HEK293 cells confers protection against oxalate induced oxidative stress as a therapeutic approach for calcium oxalate stone disease
J. Enzyme Inhib. Med. Chem.
32
426-433
2017
Bacillus subtilis
Liang, X.; Moomaw, E.W.; Rollins, J.A.
Fungal oxalate decarboxylase activity contributes to Sclerotinia sclerotiorum early infection by affecting both compound appressoria development and function
Mol. Plant Pathol.
16
825-836
2015
Sclerotinia sclerotiorum, Sclerotinia sclerotiorum 1980
Koni, T.; Rusma, R.; Hanim, C.; Zupriza, Z.
Effect of pH and temperature on Bacillus subtilis FNCC 0059 oxalate decarboxylase activity
Pak. J. Biol. Sci.
20
436-441
2017
Bacillus subtilis, Bacillus subtilis FNCC 0059
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