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(E)-alpha-Monofluoromethyl-3-4-dehydroarginine
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irreversible inhibitor may have a potential application in chemotherapy against Trypanosoma cruzi infection
2-Nor-2-butylpyridoxal phosphate
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4-Bromo-3-hydroxybenzoyloxyamine dihydrogen phosphate
alpha-difluoromethylarginine
alpha-difluoromethylornithine
beta-(2-Methyl-3-hydroxy-4-formylpyridine-5)-propionic acid
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difluoromethyl-L-arginine
1 mM, 80 °C, 15 min, 64% loss of activity, irreversible inhibition
difluoromethyl-L-ornithine
1 mM, reduces activity by 20%
DL-alpha-difluoromethylarginine
ethylmercury
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54% inhibition at 0.005 mM
Fe2+
80% inhibition at 4 mM
Fluorescein isothiocyanate
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0.09 mM, 40% inhibition
K+
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100 mM, 50% decrease of activity
L-2-Amino-3-guanidinopropanoate
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L-2-Amino-4-guanidinobutyrate
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L-2-amino-5-guanidinopentanoate
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L-2-amino-6-guanidinohexanoate
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L-2-Chloro-5-guanidinopentanoate
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L-2-Hydroxy-5-guanidinopentanoate
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L-histidine
1 mM, 20-30% inhibition
methylglyoxal bisguanylhydrazone
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methylglyoxal-bis(guanylhydrazone)
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methylmercury
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33% inhibition at 0.005 mM
Monofluoromethylagmatine
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irreversible inhibitor may have a potential application in chemotherapy against Trypanosoma cruzi infection
N-Carbamoylputrescine
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Na+
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10 mM, 20% decrease of activity
Nalpha-acetyl-L-arginine
1 mM, 20-30% inhibition
Ngamma-methyl-D-arginine
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O-(4-nitrobenzyl)hydroxylamine
1 mM, 50% inhibition, pyruvoyl group modification
O-methyl hydroxylamine
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69% inhibition at 2 mM
O-Methylhydroxylamine
1 mM, 50% inhibition, pyruvoyl group modification
O-nitrobenzylhydroxylamine
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75% inhibition at 2 mM
p-hydroxymercuribenzoate
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phenanthrene
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concentrations above 0.5 microM cause either no change or a significant reduction in ADC activity irrespective of treatment with or without DL-alpha-difluoromethylarginine
phenylmercury
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72% inhibition at 0.005 mM
4-Bromo-3-hydroxybenzoyloxyamine dihydrogen phosphate
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4-Bromo-3-hydroxybenzoyloxyamine dihydrogen phosphate
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NSD 1055
4-Bromo-3-hydroxybenzoyloxyamine dihydrogen phosphate
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agmatine
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agmatine
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1.4 mM, 50% inhibition
agmatine
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10 mM, 57% inhibition
alpha-difluoromethylarginine
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alpha-difluoromethylarginine
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alpha-difluoromethylarginine
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DFMA, a suicide inhibitor, at 5 mM for 72 h, it inhibits ADC activity. DFMA, inhibits ADC activity in both supernatant and pellet fractions (43% and 26% respectively)
alpha-difluoromethylarginine
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alpha-difluoromethylarginine
DFMA, competitive inhibition
alpha-difluoromethylarginine
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alpha-difluoromethylarginine
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alpha-difluoromethylarginine
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alpha-difluoromethylarginine
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alpha-difluoromethylarginine
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alpha-difluoromethylarginine
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alpha-difluoromethylarginine
Paramecium bursaria Chlorella virus-1
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1 mM causes almost complete inhibition after 30 min incubation, irreversible
alpha-difluoromethylarginine
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alpha-difluoromethylarginine
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alpha-difluoromethylarginine
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alpha-difluoromethylornithine
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alpha-difluoromethylornithine
Paramecium bursaria Chlorella virus-1
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10 mM causes 74% inhibition after 30 min incubation, irreversible
Ca2+
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Ca2+
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100 mM, 90% decrease of activity
canavanine
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L-canavanine
canavanine
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L-canavanine
canavanine
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L-canavanine
citrulline
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L-citrulline
Co2+
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0.1 mM, 70% loss of activity
Cu2+
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0.1 mM, 70% loss of activity
Cu2+
87% inhibition at 4 mM, complete inhibition at 8 mM
Cu2+
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1 mM, 25% inhibition. 5 mM, 94% inhibition
D-Arg
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1 mM, 60% inhibition
D-arginine
decreases enzyme activity and inhibits growth of apple callus
D-arginine
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causes further damage to callus under salt stress, reversible by addition of putrescine
DL-alpha-difluoromethylarginine
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In the absence of phenanthrene, treatment with 1.5 mM DL-alpha-difluoromethylarginine with reduces ADC activity by 61%
DL-alpha-difluoromethylarginine
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DL-alpha-difluoromethylarginine
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irreversible inhibitor may have a potential application in chemotherapy against Trypanosoma cruzi infection
DL-alpha-difluoromethylarginine
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guanidine
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guanidine
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5-10 mM, 50% inhibition
Hg2+
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Hg2+
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85% inhibition at 0.005 mM
homoarginine
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hydroxylamine
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L-argininamide
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33% inhibition at 2 mM
L-argininamide
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5 mM, complete inhibition
L-argininamide
1 mM, almost completely abolished arginine decarboxylase activity
L-arginine methyl ester
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5 mM, complete inhibition
L-arginine methyl ester
1 mM, 70% loss of activity
L-arginine methyl ester
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L-canavanine
1 mM, 46% inhibition
L-homoarginine
1 mM, 20-30% inhibition
L-Lys
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methylguanidine
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methylguanidine
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5-10 mM, 50% inhibition
Mg2+
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Mg2+
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100 mM, 90% decrease of activity
Mn2+
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Mn2+
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100 mM, 90% decrease of activity
Mn2+
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0.01-0.1 mM, enhances activity. Inhibition at higher concentrations
NEM
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NEM
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3 mM, 65% inhibition
Orn
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PCMB
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PCMB
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dithiothreitol prevents inhibition
polyamines
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putrescine
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pyridoxal
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Pyridoxine-HCl
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spermidine
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spermine
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spermine
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1 mM, 30% loss of activity
spermine
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1 mM, 5% inhibition of the enzyme from fully developed fruit, 65% inhibition of the enzyme from the seed coat of 4-week-old fruitlets
Urea
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Urea
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4 M, 80% inhibition
urethane
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Zn2+
97% inhibition at 4 mM, complete inhibition at 8 mM
additional information
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alpha-difluoromethylornithine, DFMO, a suicide inhibitor, does not inhibit ADC activity
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additional information
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activity not affected by Mg2+ or Ca2+ at 0.1 mM
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additional information
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the mRNA level of adiA is 4fold lower in the mutants deficient in both alpha-subunit and beta-subunit of major histon-like protein HU
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additional information
no inhibition by 1 mM alpha-difluoromethylornithine
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additional information
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no inhibition by 1 mM alpha-difluoromethylornithine
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additional information
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no inhibition by DL-alpha-difluoromethylornithine
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additional information
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mercury compounds inhibits the enzyme activity but induce the enzyme expression in PC12 cells, molecular mechanism of mercury compounds' neurotoxicity and enzyme inhibition mechanism, molecular dynamics simulation, product-competitive displacement method, method optimization, overview
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additional information
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inhibition of ADC results in much greater levels of oxidative damage than seen in plants treated with 0.5 microM phenanthrene; treatment with DL-alpha-difluoromethylarginine suppresses the large increase in ADC activity observed when the plants are exposed to 0.1 or 0.5 microM phenanthrene in the absence of DL-alpha-difluoromethylarginine; treatment with methylglyoxal-bis(guanylhydrazone) does not significantly influence ADC activity
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additional information
1 mM phenylhydrazine does not inactivate the enzyme. No inhibition with D-arginine, L-citrulline, L-lysine, Nalpha-methyl-L-arginine, L-methionine, Nalpha-nitro-L-arginine methyl ester, or L-ornithine
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additional information
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1 mM phenylhydrazine does not inactivate the enzyme. No inhibition with D-arginine, L-citrulline, L-lysine, Nalpha-methyl-L-arginine, L-methionine, Nalpha-nitro-L-arginine methyl ester, or L-ornithine
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additional information
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profiles of the steady-state accumulation of Synechocystis ADC transcripts and ADC specific activities under various environmental conditions, e.g. darkness and cold reduce enzyme expression, overview
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additional information
profiles of the steady-state accumulation of Synechocystis ADC transcripts and ADC specific activities under various environmental conditions, e.g. darkness and cold reduce enzyme expression, overview
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