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4.1.1.17: ornithine decarboxylase

This is an abbreviated version!
For detailed information about ornithine decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.17

Reaction

L-ornithine
=
putrescine
+
CO2

Synonyms

AdoMetDC/ODC, BN36_1212510, bODC, DDB_G0281109, DdODC, Decarboxylase, ornithine, dODC, LDC/ODC, LdODC, lysine/ornithine decarboxylase, ODC, ODC-paralogue, ODC1, ornithine decarboxylase, PfAdoMetDC-ODC, PfODC/AdoMetDC, S-adenosylmethionine decarboxylase/ornithine decarboxylase, SpeC, XODC1, XODC2, YODC

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.17 ornithine decarboxylase

Cloned

Cloned on EC 4.1.1.17 - ornithine decarboxylase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
AdoMetDC/ODC transcriptome, proteome and metabolome analysis, overview
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DNA and amino acid sequence determination and analysis, phylogenetic analysis
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expressed in a polyamine-deficient strain of Saccharomyces cerevisiae (HNU121)
expressed in Datura innoxia
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expressed in Escherichia coli
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expressed in Escherichia coli BL21(DE3) cells
expressed in Saccharomyces cerevisiae
-
expression in Escherichia coli
expression in Escherichia coli and Saccharomyces cerevisiae
expression in Escherichia coli strain BLR(DE3)
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expression in HEK-293 cells, co-expression with wild-type mammalian ODC and the yeast/mammlian enzyme chimera
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expression in transgenic mice expressing the human MYCN gene under the control of the rat tyrosine hydroxylase promoter
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expression of cDNA in CHO cells
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expression of His6-tagged enzyme in Escherichia coli strain BLR(DE3)
expression of ODC domain, i.e. rPfODC, and ODC domain in conjunction with the preceeding part of the hinge region of the bifunctional ODC/AdoMetDC, i.e.rPfHinge-ODC, in Escherichia coli
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expression of ODC dominant-negative mutant K69/C360A in Mus musculus
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expression of ODC in transgenic mice or rats leading to altered, tumoric skin phenotypes, overview, a single nucleotide polymorphism occurs in intron 1 of the ODC gene, which results in increased ODC expression in response to Myc, expression in NIH-3T3 cells overexpressing eIF4E, alpha-difluoromethylornithine not only inhibits proliferation, but also reverts the transformed phenotype of NIH-3T3 cells overexpressing eIF4E
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expression of Strep-tactin-PfODC/AdoMetDC fusion in Escherichia coli
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expression of wild-type and chimeric mutant enzymes in COS cells
for transient transfection experiments, ODC cDNAs are cloned into the p3xFLAG-CMV-10 vector, transient transfections of COS-7 cells, used in the ODC activity assay, are performed.
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gene ODC, adenovirus-mediated expression, the virus containing the cytomegalovirus promoter and the green fluorescent protein gene, of both antisense ornithine decarboxylase and S-adenosylmethionine decarboxylase in A-549 cells, quantitative and tissue expression analysis, G1 arrest rate, overview
-
gene odc, expression as stable enzyme in Trypanosoma cruzi makes the parasite overcome the exogenous putrescine requirement for growth
-
gene ODC, HEK-293 cells are transiently transfected with yeast ODC, mammalian ODC or the chimerical proteins together with either yeast Az or mammalian Az. Overexpression of yAz in yeast cells results in polyamine depletion and growth inhibition
gene odc, located on chromosome 3 between coxadordinates 4069177 to 4070741, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic tree, domain organization, recombinant expression of a fluorescence-tagged enzyme in Dictyostelium discoideum cells
gene odc, overexpression in HL-60 cells
-
gene odc, overexpression in Leishmania guayensis
gene Odc, real-time PCR enzyme expression analysis
gene odc, recombinant expression of His-tagged enzyme in Escherichia coli strain BL21
gene ODC, sequence comparisons, recombinant expression of His-tagged wild-type and truncated mutant enzymes in Escherichia coli strain BL21(DE3)
gene ODC1, quantitative real-time PCR enzyme expression analysis
gene ODC1, recombinant expression of GST-tagged enzyme in Escherichia coli strain BL21(DE3)
gene Odc1, site-directed mutated ODC is in vitro transcribed and translated in reticulocyte lysate, recombinant expression of His-tagged wild-type enzyme, point mutants, and mutant His6-TEV (tobacco etch virus)-FLAG-ODC construct in Escherichia coli
gene speC, DNA and amino acid sequence determination and analysis, speC promoter and speC/speF expression analysis, functional expression in Escherichia coli
-
gene speF, construction of a phage library, DNA and amino acid sequence determination and analysis, genetic organization and speF locus, overview, functional complementation of an Escherichia coli ODC-defective mutant strain strain HT414, elaboration of a hypothetical pathway for the acquisition of putrescine biosynthetic genes in some Enterobacteriaceae strains, overview
genotyping
mutated ODC is in vitro transcribed and translated in reticulocyte lysate, expression of His-tagged ODC fused to the human dihydrofolate reductase, DHFR, in Escherichia coli
Myc plays a role in transcription of ODC, transcriptional regulation, overview
-
ODC expression analysis
-
ODC expression analysis, overview
-
ODC is encoded by a single-copy gene located on a 1900 kb chromosome, DNA and amino acid sequence determination and analysis, phylogenetic tree, overexpression of the His- and S-tagged enzyme in Escherichia coli
over-expression in transgenic mouse line
-
overexpression of ODC in human promyelocytic leukemia HL-60 parental cells
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overexpression of ODC, expression analysis, overview
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transfection of breast cancer cells with an adenoviral vector carrying antisense ODC, rAd-ODC/Ex3as, expression analysis
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wild type and mutant enzymes C360A, K69A, and C70S
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