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4.1.1.15: glutamate decarboxylase

This is an abbreviated version!
For detailed information about glutamate decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.15

Reaction

L-glutamate
=
4-aminobutanoate
 +
CO2

Synonyms

42 kDa biotin-coupled protein, 65 kDa glutamic acid decarboxylase, 67 kDa glutamic acid decarboxylase, Aspartate 1-decarboxylase, Aspartic alpha-decarboxylase, AtGAD1, BmGAD, BmGadB, BMI_II334, Cysteic acid decarboxylase, Decarboxylase, glutamate, ERT D1, GAD, GAD B, GAD-65, GAD-67, GAD-alpha, GAD-beta, GAD-gamma, GAD1, GAD2, GAD3, Gad56, GAD65, GAD67, GadA, GadB, GADB1, gadB2, GADbeta, GADCase, gadlbhye1, gamma-Glutamate decarboxylase, GDC, GDCase, Glt decarboxylase, glutamate decarboxylase, glutamate decarboxylase 1, glutamate decarboxylase 65, glutamate decarboxylase 67, glutamate decarboxylase A, glutamate decarboxylase B, Glutamic acid decarboxylase, glutamic acid decarboxylase 65, glutamic acid decarboxylase 67, glutamic acid decarboxylase-65, glutamic acid decarboxylase-67, glutamic acid decarboxylase67, Glutamic decarboxylase, hGAD65, hGAD67, L-Aspartate-alpha-decarboxylase, L-glutamate 1-carboxylyase, L-Glutamate alpha-decarboxylase, L-Glutamate decarboxylase, L-glutamate decarboxylase 65, L-glutamate decarboxylase 67, L-Glutamic acid decarboxylase, L-Glutamic decarboxylase, LbGAD, LbGadB, MGAD, More, p42, PF1159, PfGAD, ScGAD, sll1641

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.15 glutamate decarboxylase

pH Stability

pH Stability on EC 4.1.1.15 - glutamate decarboxylase

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pH STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
10
beyond pH range 5.0-9.0 a sharp decline in enzyme stability is observed, and negligible activity is detected at pH above 10
705391
3 - 7
recombinant enzyme, 4°C, 24 h, both GAD-C and GAD-V retain more than 70% of their maximal activity at pH 3.0-5.0 and more than 80% at pH 5.0-7.0
749087
3.5
purified enzyme, loss of about 35% activity at 40°C after 5 h
699147
3.5 - 6
purified recombinant enzyme, the enzyme is stable within a pH range of pH 4.5 to pH 5.0, but is unstable below pH 4.0 and above pH 5.5
696826
4 - 7
purified recombinant BmGAD, stable at around pH 7.0, but retains only 66 % activity of its initial activity after incubation for 6 h at pH 4.0
747386
4.5 - 8
-
-
679946
5 - 7
-
24 h, 8°C, stable
3972
5.5
purified enzyme, loss of about 40% activity at 40°C after 5 h
699147
8
-
24 h, 8°C, 90% loss of activity
3972