Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

4.1.1.15: glutamate decarboxylase

This is an abbreviated version!
For detailed information about glutamate decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.15

Reaction

L-glutamate
=
4-aminobutanoate
+
CO2

Synonyms

42 kDa biotin-coupled protein, 65 kDa glutamic acid decarboxylase, 67 kDa glutamic acid decarboxylase, Aspartate 1-decarboxylase, Aspartic alpha-decarboxylase, AtGAD1, BmGAD, BmGadB, BMI_II334, Cysteic acid decarboxylase, Decarboxylase, glutamate, ERT D1, GAD, GAD B, GAD-65, GAD-67, GAD-alpha, GAD-beta, GAD-gamma, GAD1, GAD2, GAD3, Gad56, GAD65, GAD67, GadA, GadB, GADB1, gadB2, GADbeta, GADCase, gadlbhye1, gamma-Glutamate decarboxylase, GDC, GDCase, Glt decarboxylase, glutamate decarboxylase, glutamate decarboxylase 1, glutamate decarboxylase 65, glutamate decarboxylase 67, glutamate decarboxylase A, glutamate decarboxylase B, Glutamic acid decarboxylase, glutamic acid decarboxylase 65, glutamic acid decarboxylase 67, glutamic acid decarboxylase-65, glutamic acid decarboxylase-67, glutamic acid decarboxylase67, Glutamic decarboxylase, hGAD65, hGAD67, L-Aspartate-alpha-decarboxylase, L-glutamate 1-carboxylyase, L-Glutamate alpha-decarboxylase, L-Glutamate decarboxylase, L-glutamate decarboxylase 65, L-glutamate decarboxylase 67, L-Glutamic acid decarboxylase, L-Glutamic decarboxylase, LbGAD, LbGadB, MGAD, More, p42, PF1159, PfGAD, ScGAD, sll1641

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.15 glutamate decarboxylase

pH Range

pH Range on EC 4.1.1.15 - glutamate decarboxylase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2.5 - 7.5
-
activity range, profile overview
3 - 6
activity range, profile overview
3 - 7
purified recombinant enzyme, the activity decreases dramatically between pH 5.0 and pH 7.0. GAD-V exhibits a much higher activity than GAD-C below pH 5.0. More than 80% of the maximum catalytic activity is observed for GAD-V between pH 4.0 and pH 5.0, while GAD-C exhibits 98.3% and 38% of the activity shown by GAD-V at pH 5.0 and 4.0, respectively
3 - 9
activity range, profile overview
3.3 - 5.8
-
pH 3.3: about 20% of maximal activity, pH 3.5: about 65% of maximal activity, pH 5.2: about 55% of maximal activity, pH 5.8: about 20% of maximal activity
3.5 - 5.2
pH 3.5: about 40% of maximal activity, pH 4.5: about 65% of maximal activity, pH 5.0: about 50% of maximal activity pH 5.2: about 40% of maximal activity
3.5 - 5.5
GAD is active in the range pH 3.5 to pH 5.5 with optimal pH at 4.6, inactive above pH 6.0
3.5 - 6
4
-
40% residual activity
4 - 6.2
activity range, inactive below and above, profile overview
4 - 6.5
-
pH 4.0: about 75% of maximal activity, pH 6.5: about 55% of maximal activity
4 - 7.5
pH 4.0: about 40% of maximal activity, pH 7.5: about 45% of maximal activity
4.5 - 6
-
pH 4.5: about 50% of maximal activity, pH 6.0: about 75% of maximal activity
4.5 - 7
5 - 9
retains 80% of its original activity in the pH range 5-9
5.2 - 7.8
-
pH 5.2: about 55% of maximal activity, pH 7.8: about 35% of maximal activity
6 - 7.5
-
pH 6.0: about 80% of maximal activity, pH 7.5: about 65% of maximal activity
6 - 7.8
-
pH 6.0: about 65% of maximal activity, pH 7.8: about 35% of maximal activity
6.4 - 7.8
-
pH 6.4: about 50% of maximal activity, pH 7.8: about 70% of maximal activity
9
-
20% residual activity
additional information