4.1.1.11: aspartate 1-decarboxylase
This is an abbreviated version!
For detailed information about aspartate 1-decarboxylase, go to the full flat file.
Word Map on EC 4.1.1.11
-
4.1.1.11
-
pantothenate
-
pyrazinamide
-
pyrazinoic
-
self-processing
-
pza-resistant
-
synthesis
-
drug development
-
pharmacology
- 4.1.1.11
- pantothenate
- pyrazinamide
-
pyrazinoic
-
self-processing
-
pza-resistant
- synthesis
- drug development
- pharmacology
Reaction
Synonyms
ACD, ADC, ADCBs, ADCC.g, ADCCg, ADCE, Aspartate alpha-decarboxylase, aspartate decarboxylase, aspartate-alpha-decarboxylase, Aspartic alpha-decarboxylase, AspDC, BmADC, BsADC, CgADC, Dgad2, GcADC, L-Aspartate alpha-decarboxylase, L-Aspartate-alpha-decarboxylase, MfnA, MJ0050, More, MtbADC, PanD, PF1159, PLP-dependent L-aspartate decarboxylase, pyruvoyl-dependent l-aspartate alpha-decarboxylase, TK1814
ECTree
Advanced search results
Cofactor
Cofactor on EC 4.1.1.11 - aspartate 1-decarboxylase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
pyridoxal 5'-phosphate
-
tautomers of the internal aldimine between PLP and enzyme, overview
pyruvoyl cofactor
-
dependent on, the enzyme contains a covalently-bound pyruvoyl cofactor
pyruvoyl cofactor
dependent on. Pathway for the formation of the pyruvoyl-dependent cofactor in ADC: the beta-hydroxyl of Ser25 attacks the carbonyl of the previous amino-acid residue (i) to form an oxyoxazolidine intermediate, which decomposes (ii) to form an ester intermediate. E1cB elimination (iii) forms a N-terminal dehydroalanyl residue which is hydrolysed (iv) to form the pyruvoyl cofactor (the alpha'-chain). The ester intermediate can also be hydrolysed to yield the inactive alpha'-chain
pyruvoyl cofactor
-
the enzyme PanD is synthesized as pro-PanD, which undergoes an auto-proteolytic cleavage at residue Ser25 to yield the catalytic pyruvoyl moiety of the enzyme
pyruvoyl cofactor
-
the enzyme PanD is synthesized as pro-PanD, which undergoes an auto-proteolytic cleavage at residue Ser25 to yield the catalytic pyruvoyl moiety of the enzyme
requires pyruvate as a covalently bound, catalytically active prosthetic group, pyruvoyl-dependent enzyme, the pyruvoyl group is generated at a specific internal serine residue of the inactive pi-protein with the coincident cleavage of the Gly-Ser bond
-
additional information
-
requires pyruvate as a covalently bound, catalytically active prosthetic group, pyruvoyl-dependent enzyme, the pyruvoyl group is generated at a specific internal serine residue of the inactive pi-protein with the coincident cleavage of the Gly-Ser bond
-
additional information
the translated inactive proenzyme, pi-enzyme, self-processes to create its own covalently bound prosthetic group, a pyruvoyl cofactor, mechanism
-
additional information
the ancillary protein PanM (formerly YhhK) is required in vitro and in vivo for cleavage of the L-aspartate-alpha-decarboxylase zymogen
-
additional information
the ancillary protein PanM (formerly YhhK) is required in vitro and in vivo for cleavage of the L-aspartate-alpha-decarboxylase zymogen
-
additional information
the ancillary protein PanM (formerly YhhK) is required in vitro and in vivo for cleavage of the L-aspartate-alpha-decarboxylase zymogen
-
additional information
the enzyme requires PanZ, an activator involved in the cleavage of ADCE
-