4.1.1.103: gamma-resorcylate decarboxylase

This is an abbreviated version!
For detailed information about gamma-resorcylate decarboxylase, go to the full flat file.

Reaction

Synonyms

graF, Rdc, TsdA

ECTree

4 Lyases

4.1 Carbon-carbon lyases

4.1.1 Carboxy-lyases

4.1.1.103 gamma-resorcylate decarboxylase

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Results	in table
1	Activating Compound
4	AA Sequence
2	Application
1	Cloned(Commentary)
2	Cofactor
2	Crystallization (Commentary)
2	Expression
1	General Information
10	Inhibitors
11	kcat/KM [mM/s]
13	KM Value [mM]
3	Metals/Ions
6	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
15	Organism
4	Pathway
2	pH Optimum
1	pH Range
1	Purification (Commentary)
1	Reaction
13	Reference
1	Specific Activity [micromol/min/mg]
1	Storage Stability
48	Substrates and Products (Substrate)
5	Subunits
7	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
5	Temperature Stability [°C]
10	Turnover Number [1/s]

Crystallization

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Crystallization on EC 4.1.1.103 - gamma-resorcylate decarboxylase

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incomplex with inhibitor 2-nitroresorcinol. 2-NR is directly ligated to a Mn2+ bound in the active site, and the nitro substituent of the inhibitor is tilted significantly from the plane of the phenyl ring

Polaromonas sp. JS666

Q12BV1

747140

structures of native form, the complex with the true substrate (2,6-dihydroxybenzoate), and the complex with 2,3-dihydroxybenzaldehyde at 1.7-, 1.9-, and 1.7-A resolution, respectively. The enzyme exists as a tetramer, and the subunit consists of one (alphabeta)8 triose-phosphate isomerase-barrel domain with three functional linkers and one C-terminal tail. The native enzyme possesses one Zn2+ ion liganded by Glu8, His10, His164, Asp287, and a water molecule at the active site center. The substrate carboxylate takes the place of the water molecule and is coordinated to the Zn2+ ion. The 2-hydroxy group of the substrate is hydrogen-bonded to Asp287, which forms a triad together with His218 and Glu22

Rhizobium sp.

Q60GU1

738571