3.9.1.3: phosphohistidine phosphatase

This is an abbreviated version!
For detailed information about phosphohistidine phosphatase, go to the full flat file.

Reaction

Synonyms

14 kDa phosphohistidine phosphatase, 14-kDa phosphohistidine phosphatase, 16 kDa protein histidine phosphatase, histidine protein phosphatase, LHPP, PGAM5, phospho-histidine phosphatase, phosphohistidine phosphatase, phosphohistidine phosphatase 1, phosphohistidine phosphatase I, phosphopolyhistidine phosphatase, PHP, PHP14, PHPT-1, PHPT1, PHPTI, PP1, PP2A, protein histidine phosphatase, protein histidine phosphatase 1, protein-histidine phosphatase, SixA

ECTree

     3 Hydrolases

         3.9 Acting on phosphorus-nitrogen bonds

             3.9.1 Acting on phosphorus-nitrogen bonds (only sub-subclass identified to date)

                3.9.1.3 phosphohistidine phosphatase

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Results	in table
3	Activating Compound
681	AA Sequence
2	Application
8	Cloned(Commentary)
4	Crystallization (Commentary)
88	Disease/ Diagnostics
4	Expression
29	General Information
19	Inhibitors
2	kcat/KM [mM/s]
3	Ki Value [mM]
2	KM Value [mM]
8	Localization
10	Metals/Ions
25	Molecular Weight [Da]
31	Natural Substrates/ Products (Substrates)
39	Organism
3	pH Optimum
2	pH Range
20	Protein Variants
17	Purification (Commentary)
1	Reaction
39	Reference
49	Source Tissue
10	Specific Activity [micromol/min/mg]
43	Substrates and Products (Substrate)
22	Subunits
74	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 3.9.1.3 - phosphohistidine phosphatase

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SYSTEMATIC NAME

IUBMB Comments

[protein]-N-phospho-L-histidine phosphohydrolase

This eukaryotic enzyme dephosphorylates phosphorylated histidine residues within proteins and peptides. The enzyme acts on phosphate groups attached to both the pros- and tele-nitrogen atoms, but the pros- position is somewhat preferred (by a factor of two at the most) [4]. The substrate specificity depends on the amino acid sequence or structural context of the phosphohistidine in a phosphoprotein. The enzyme is also active on free phosphoramidate [1,4] and peptide-bound phospholysine [5].