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3.9.1.3: phosphohistidine phosphatase

This is an abbreviated version!
For detailed information about phosphohistidine phosphatase, go to the full flat file.

Word Map on EC 3.9.1.3

Reaction

a [protein]-N-phospho-L-histidine
+
H2O
=
a [protein]-L-histidine
 +
phosphate

Synonyms

14 kDa phosphohistidine phosphatase, 14-kDa phosphohistidine phosphatase, 16 kDa protein histidine phosphatase, histidine protein phosphatase, LHPP, PGAM5, phospho-histidine phosphatase, phosphohistidine phosphatase, phosphohistidine phosphatase 1, phosphohistidine phosphatase I, phosphopolyhistidine phosphatase, PHP, PHP14, PHPT-1, PHPT1, PHPTI, PP1, PP2A, protein histidine phosphatase, protein histidine phosphatase 1, protein-histidine phosphatase, SixA

ECTree

     3 Hydrolases
         3.9 Acting on phosphorus-nitrogen bonds
             3.9.1 Acting on phosphorus-nitrogen bonds (only sub-subclass identified to date)
                3.9.1.3 phosphohistidine phosphatase

Substrates Products

Substrates Products on EC 3.9.1.3 - phosphohistidine phosphatase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-nitrophenylphosphate + H2O
4-nitrophenol + phosphate
show the reaction diagram
-
-
-
?
6,8-difluoromethylumbelliferyl phosphate + H2O
6,8-difluoromethylumbelliferone + phosphate
show the reaction diagram
-
-
-
?
a [CheA protein]-N-phospho-L-histidine + H2O
a [CheA protein]-L-histidine + phosphate
show the reaction diagram
a [protein]-N-phospho-L-histidine + H2O
a [protein]-L-histidine + phosphate
show the reaction diagram
AKR-N-phospho-HKV + H2O
AKRHKV + phosphate
show the reaction diagram
-
-
-
-
?
succinyl-L-Ala-N-phospho-L-His-L-Pro-L-Phe 4-nitroanilide + H2O
succinyl-L-Ala-L-His-L-Pro-L-Phe 4-nitroanilide + phosphate
show the reaction diagram
VIFIE-N-phospho-HAKRKG + H2O
VIFIEHAKRKG + phosphate
show the reaction diagram
-
-
-
-
?
[ATP-citrate lyase]-N-phospho-L-histidine + H2O
[ATP-citrate lyase]-L-histidine + phosphate
show the reaction diagram
[beta-subunit of heterotrimeric G-protein]-N-phospho-L-histidine + H2O
[beta-subunit of heterotrimeric G-protein]-L-histidine + phosphate
show the reaction diagram
-
-
-
-
?
[cation channel SK4]-N-phospho-L-histidine + H2O
[cation channel SK4]-L-histidine + phosphate
show the reaction diagram
-
-
-
-
?
[Escherichia coli histidine kinase ArcB]-N-phospho-L-histidine + H2O
[Escherichia coli histidine kinase ArcB]-L-histidine + phosphate
show the reaction diagram
[histidine kinase ArcB]-N-phospho-L-histidine + H2O
[histidine kinase ArcB]-L-histidine + phosphate
show the reaction diagram
-
-
-
-
?
[histone H4]-N-phospho-L-histidine + H2O
[histone H4]-L-histidine + phosphate
show the reaction diagram
[KCa3.1 channel protein]-N-phospho-L-histidine + H2O
[KCa3.1 channel protein]-L-histidine + phosphate
show the reaction diagram
-
the enzyme directly binds and inhibits KCa3.1 by dephosphorylating histidine 358
-
-
?
[nucleoside diphosphate kinase B]-N-phospho-L-histidine + H2O
[nucleoside diphosphate kinase B]-L-histidine + phosphate
show the reaction diagram
the enzyme (PGAM5) specifically associates with and dephosphorylates the catalytic histidine (H118) on nucleoside diphosphate kinase B (NDPK-B). By dephosphorylating NDPK-B, the enzyme (PGAM5) negatively regulates CD4+ T cells by inhibiting NDPK-B mediated histidine phosphorylation and activation of the K+ channel KCa3.1, which is required for T cell receptor stimulated Ca2+ influx and cytokine production
-
-
?
[peptide]-N-phospho-L-histidine + H2O
[peptide]-L-histidine + phosphate
show the reaction diagram
H2O2 exposure induces selective oxidation of hPHPT1 at Met95, a residue within the substrate binding region. H2O2-induced oxidation does not impact hPHPT1 function negatively
-
-
?
[protein]-N-phospho-L-histidine + H2O
[protein]-L-histidine + phosphate
show the reaction diagram
-
-
-
-
?
[TRP channel protein TRPV5]-N-phospho-L-histidine + H2O
[TRP channel protein TRPV5]-L-histidine + phosphate
show the reaction diagram
-
-
-
-
?
additional information
?
-