Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.9.1.3: phosphohistidine phosphatase

This is an abbreviated version!
For detailed information about phosphohistidine phosphatase, go to the full flat file.

Word Map on EC 3.9.1.3

Reaction

a [protein]-N-phospho-L-histidine
+
H2O
=
a [protein]-L-histidine
+
phosphate

Synonyms

14 kDa phosphohistidine phosphatase, 14-kDa phosphohistidine phosphatase, 16 kDa protein histidine phosphatase, histidine protein phosphatase, LHPP, PGAM5, phospho-histidine phosphatase, phosphohistidine phosphatase, phosphohistidine phosphatase 1, phosphohistidine phosphatase I, phosphopolyhistidine phosphatase, PHP, PHP14, PHPT-1, PHPT1, PHPTI, PP1, PP2A, protein histidine phosphatase, protein histidine phosphatase 1, protein-histidine phosphatase, SixA

ECTree

     3 Hydrolases
         3.9 Acting on phosphorus-nitrogen bonds
             3.9.1 Acting on phosphorus-nitrogen bonds (only sub-subclass identified to date)
                3.9.1.3 phosphohistidine phosphatase

Reference

Reference on EC 3.9.1.3 - phosphohistidine phosphatase

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hamada, K.; Kato, M.; Mizuno, T.; Hakoshima, T.
Crystallographic characterization of a novel protein SixA which exhibits phospho-histidine phosphatase activity in the multistep His-Asp phosphorelay
Acta Crystallogr. Sect. D
55
269-271
1999
Escherichia coli (P76502), Escherichia coli
Manually annotated by BRENDA team
Kamath, V.; Kyathanahalli, C.N.; Jayaram, B.; Syed, I.; Olson, L.K.; Ludwig, K.; Klumpp, S.; Krieglstein, J.; Kowluru, A.
Regulation of glucose- and mitochondrial fuel-induced insulin secretion by a cytosolic protein histidine phosphatase in pancreatic beta-cells
Am. J. Physiol. Endocrinol. Metab.
299
E276-E286
2010
Rattus norvegicus
Manually annotated by BRENDA team
Klumpp, S.; Bechmann, G.; Maeurer, A.; Selke, D.; Krieglstein, J.
ATP-citrate lyase as a substrate of protein histidine phosphatase in vertebrates
Biochem. Biophys. Res. Commun.
306
110-115
2003
Oryctolagus cuniculus
Manually annotated by BRENDA team
Ma, R.; Kanders, E.; Sundh, U.B.; Geng, M.; Ek, P.; Zetterqvist, O.; Li, J.P.
Mutational study of human phosphohistidine phosphatase: effect on enzymatic activity
Biochem. Biophys. Res. Commun.
337
887-891
2005
Homo sapiens (Q9NRX4), Homo sapiens
Manually annotated by BRENDA team
Wong, C.; Faiola, B.; Wu, W.; Kennelly, P.J.
Phosphohistidine and phospholysine phosphatase activities in the rat: potential protein-lysine and protein-histidine phosphatases?
Biochem. J.
296
293-296
1993
Rattus norvegicus
Manually annotated by BRENDA team
Gong, W.; Li, Y.; Cui, G.; Hu, J.; Fang, H.; Jin, C.; Xia, B.
Solution structure and catalytic mechanism of human protein histidine phosphatase 1
Biochem. J.
418
337-344
2009
Homo sapiens (Q9NRX4), Homo sapiens
Manually annotated by BRENDA team
Attwood, P.V.; Ludwig, K.; Bergander, K.; Besant, P.G.; Adina-Zada, A.; Krieglstein, J.; Klumpp, S.
Chemical phosphorylation of histidine-containing peptides based on the sequence of histone H4 and their dephosphorylation by protein histidine phosphatase
Biochim. Biophys. Acta
1804
199-205
2010
Homo sapiens
Manually annotated by BRENDA team
Klumpp, S.; Ma, N.T.; Baeumer, N.; Bechmann, G.; Krieglstein, J.
Relevance of glycine and cysteine residues as well as N- and C-terminals for the activity of protein histidine phosphatase
Biochim. Biophys. Acta
1804
206-211
2010
Homo sapiens
Manually annotated by BRENDA team
Eissing, A.; Fischer, D.; Rauch, I.; Baumann, A.; Schebb, N.H.; Karst, U.; Rose, K.; Klumpp, S.; Krieglstein, J.
Acetylcholine content and viability of cholinergic neurons are influenced by the activity of protein histidine phosphatase
BMC Neurosci.
13
31
2012
Mus musculus
Manually annotated by BRENDA team
Klumpp, S.; Faber, D.; Fischer, D.; Litterscheid, S.; Krieglstein, J.
Role of protein histidine phosphatase for viability of neuronal cells
Brain Res.
1264
7-12
2009
Homo sapiens
Manually annotated by BRENDA team
Seeger, A.; Rose, K.; Ma, N.T.; Kremmer, E.; Klumpp, S.; Krieglstein, J.
Influence of protein histidine phosphatase overexpression and down-regulation on human umbilical-vein endothelial cell viability
Cell Biol. Int.
36
245-249
2012
Homo sapiens (Q9NRX4), Homo sapiens
Manually annotated by BRENDA team
Ek, P.; Pettersson, G.; Ek, B.; Gong, F.; Li, J.P.; Zetterqvist, O.
Identification and characterization of a mammalian 14-kDa phosphohistidine phosphatase
Eur. J. Biochem.
269
5016-5023
2002
Sus scrofa, Homo sapiens (Q9NRX4), Homo sapiens
Manually annotated by BRENDA team
Matthews, H.R.; MacKintosh, C.
Protein histidine phosphatase activity in rat liver and spinach leaves
FEBS Lett.
364
51-54
1995
Rattus norvegicus, Spinacia oleracea
Manually annotated by BRENDA team
Busam, R.D.; Thorsell, A.G.; Flores, A.; Hammarstroem, M.; Persson, C.; Hallberg, B.M.
First structure of a eukaryotic phosphohistidine phosphatase
J. Biol. Chem.
281
33830-33834
2006
Homo sapiens (Q9NRX4)
Manually annotated by BRENDA team
Klumpp, S.; Hermesmeier, J.; Selke, D.; Bechmann, G.; Van den Brulle, J.; Weidner, G.; Scharm, B.; Gussow, D.; Baumeister, R.; Kellner, R.; Krieglstein, J.
Protein histidine phosphatase: A novel enzyme with potency for neuronal signaling
J. Cereb. Blood Flow Metab.
22
1420-1424
2003
Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Oryctolagus cuniculus (P83468)
Manually annotated by BRENDA team
Shen, H.; Yang, P.; Liu, Q.; Tian, Y.
Nuclear expression and clinical significance of phosphohistidine phosphatase 1 in clear-cell renal cell carcinoma
J. Int. Med. Res.
43
747-757
2015
Homo sapiens
Manually annotated by BRENDA team
Xu, A.; Hao, J.; Zhang, Z.; Tian, T.; Jiang, S.; Hao, J.; Liu, C.; Huang, L.; Xiao, X.; He, D.
14-kDa phosphohistidine phosphatase and its role in human lung cancer cell migration and invasion
Lung Cancer
67
48-56
2010
Homo sapiens (Q9NRX4), Homo sapiens
Manually annotated by BRENDA team
Hakoshima, T.; Ichihara, H.
Structure of SixA, a histidine protein phosphatase of the ArcB histidine-containing phosphotransfer domain in Escherichia coli
Methods Enzymol.
422
288-304
2007
Escherichia coli
Manually annotated by BRENDA team
Baeumer, N.; Maeurer, A.; Krieglstein, J.; Klumpp, S.
Expression of protein histidine phosphatase in Escherichia coli, purification, and determination of enzyme activity
Methods Mol. Biol.
365
247-260
2007
Escherichia coli
Manually annotated by BRENDA team
Han, S.X.; Wang, L.J.; Zhao, J.; Zhang, Y.; Li, M.; Zhou, X.; Wang, J.; Zhu, Q.
14-kDa phosphohistidine phosphatase plays an important role in hepatocellular carcinoma cell proliferation
Oncol. Lett.
4
658-664
2012
Homo sapiens
Manually annotated by BRENDA team
Ludwig, K.; Habbach, S.; Krieglstein, J.; Klumpp, S.; Koenig, S.
MALDI-TOF high mass calibration up to 200 kDa using human recombinant 16 kDa protein histidine phosphatase aggregates
PLoS ONE
6
e23612
2011
Homo sapiens
Manually annotated by BRENDA team
Srivastava, S.; Zhdanova, O.; Di, L.; Li, Z.; Albaqumi, M.; Wulff, H.; Skolnik, E.Y.
Protein histidine phosphatase 1 negatively regulates CD4 T cells by inhibiting the K+ channel KCa3.1
Proc. Natl. Acad. Sci. USA
105
14442-14446
2008
Homo sapiens
Manually annotated by BRENDA team
Ek, P.; Ek, B.; Zetterqvist, O.e.
Phosphohistidine phosphatase 1 (PHPT1) also dephosphorylates phospholysine of chemically phosphorylated histone H1 and polylysine
Ups. J. Med. Sci.
120
20-27
2015
Homo sapiens
Manually annotated by BRENDA team
McCullough, B.S.; Barrios, A.M.
Facile, fluorogenic assay for protein histidine phosphatase activity
Biochemistry
57
2584-2589
2018
Homo sapiens (Q9NRX4)
Manually annotated by BRENDA team
Xu, A.; Li, X.; Li, S.; Sun, L.; Wu, S.; Zhang, B.; Huang, J.
A novel role for 14-kDa phosphohistidine phosphatase in lamellipodia formation
Cell Adh. Migr.
11
488-495
2017
Homo sapiens (Q9NRX4)
Manually annotated by BRENDA team
Srivastava, S.; Li, Z.; Soomro, I.; Sun, Y.; Wang, J.; Bao, L.; Coetzee, W.A.; Stanley, C.A.; Li, C.; Skolnik, E.Y.
Regulation of KATP channel trafficking in pancreatic bea-cells by protein histidine phosphorylation
Diabetes
67
849-860
2018
Mus musculus (Q9DAK9)
Manually annotated by BRENDA team
Wieland, T.; Attwood, P.V.
Alterations in reversible protein histidine phosphorylation as intracellular signals in cardiovascular disease
Front. Pharmacol.
6
173
2015
Mammalia
Manually annotated by BRENDA team
Xu, A.; Li, Y.; Zhao, W.; Hou, F.; Li, X.; Sun, L.; Chen, W.; Yang, A.; Wu, S.; Zhang, B.; Yao, J.; Wang, H.; Huang, J.
PHP14 regulates hepatic stellate cells migration in liver fibrosis via mediating TGF-beta1 signaling to PI3Kgama/AKT/Rac1 pathway
J. Mol. Med.
96
119-133
2018
Homo sapiens (Q9NRX4)
Manually annotated by BRENDA team
Schulte, J.E.; Goulian, M.
The phosphohistidine phosphatase SixA targets a phosphotransferase system
mBio
9
e01666-18
2018
Escherichia coli (P76502), Escherichia coli, Escherichia coli K12 (P76502)
Manually annotated by BRENDA team
Panda, S.; Srivastava, S.; Li, Z.; Vaeth, M.; Fuhs, S.R.; Hunter, T.; Skolnik, E.Y.
Identification of PGAM5 as a mammalian protein histidine phosphatase that plays a central role to negatively regulate CD4(+) T cells
Mol. Cell
63
457-469
2016
Mus musculus (Q8BX10)
Manually annotated by BRENDA team
Hindupur, S.K.; Colombi, M.; Fuhs, S.R.; Matter, M.S.; Guri, Y.; Adam, K.; Cornu, M.; Piscuoglio, S.; Ng, C.K.Y.; Betz, C.; Liko, D.; Quagliata, L.; Moes, S.; Jenoe, P.; Terracciano, L.M.; Heim, M.H.; Hunter, T.; Hall, M.N.
The protein histidine phosphatase LHPP is a tumour suppressor
Nature
555
678-682
2018
Mus musculus (Q9D7I5), Mus musculus, Homo sapiens (Q9H008), Homo sapiens
Manually annotated by BRENDA team
Martin, D.R.; Dutta, P.; Mahajan, S.; Varma, S.; Stevens, S.M.
Structural and activity characterization of human PHPT1 after oxidative modification
Sci. Rep.
6
23658
2016
Homo sapiens (Q9NRX4), Homo sapiens
Manually annotated by BRENDA team