3.9.1.3: phosphohistidine phosphatase

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For detailed information about phosphohistidine phosphatase, go to the full flat file.

Word Map on EC 3.9.1.3

3.9.1.3

histidine-containing

phosphorelay

phosphotransfer

atp-citrate

ndpk-b

his-asp

medicine

Reaction

Synonyms

14 kDa phosphohistidine phosphatase, 14-kDa phosphohistidine phosphatase, 16 kDa protein histidine phosphatase, histidine protein phosphatase, LHPP, PGAM5, phospho-histidine phosphatase, phosphohistidine phosphatase, phosphohistidine phosphatase 1, phosphohistidine phosphatase I, phosphopolyhistidine phosphatase, PHP, PHP14, PHPT-1, PHPT1, PHPTI, PP1, PP2A, protein histidine phosphatase, protein histidine phosphatase 1, protein-histidine phosphatase, SixA

ECTree

3 Hydrolases

3.9 Acting on phosphorus-nitrogen bonds

3.9.1 Acting on phosphorus-nitrogen bonds (only sub-subclass identified to date)

3.9.1.3 phosphohistidine phosphatase

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Results	in table
3	Activating Compound
681	AA Sequence
2	Application
8	Cloned(Commentary)
4	Crystallization (Commentary)
88	Disease/ Diagnostics
4	Expression
29	General Information
19	Inhibitors
2	kcat/KM [mM/s]
3	Ki Value [mM]
2	KM Value [mM]
8	Localization
10	Metals/Ions
25	Molecular Weight [Da]
31	Natural Substrates/ Products (Substrates)
39	Organism
3	pH Optimum
2	pH Range
20	Protein Variants
17	Purification (Commentary)
1	Reaction
39	Reference
49	Source Tissue
10	Specific Activity [micromol/min/mg]
43	Substrates and Products (Substrate)
22	Subunits
74	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Turnover Number [1/s]

Expression

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Expression on EC 3.9.1.3 - phosphohistidine phosphatase

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downregulated specifically in tumours

2 entries

long-term exposure (24 h) of INS 832/13 cells or rat islets to high glucose (30 mM) increases the expression of the enzyme. Such increases in enzyme expression are also seen in islets derived from the Zucker diabetic fatty rat compared with islets from the lean control animals

Rattus norvegicus

735423

PHP14 expression is upregulated in fibrotic liver and mainly in hepatic stellate cells. TGF-beta1 can induce PHP14 expression in hepatic stellate cells accompanied with the activation of hepatic stellate cells

Homo sapiens

Q9NRX4

757452