3.9.1.3: phosphohistidine phosphatase
This is an abbreviated version!
For detailed information about phosphohistidine phosphatase, go to the full flat file.
Reaction
Synonyms
14 kDa phosphohistidine phosphatase, 14-kDa phosphohistidine phosphatase, 16 kDa protein histidine phosphatase, histidine protein phosphatase, LHPP, PGAM5, phospho-histidine phosphatase, phosphohistidine phosphatase, phosphohistidine phosphatase 1, phosphohistidine phosphatase I, phosphopolyhistidine phosphatase, PHP, PHP14, PHPT-1, PHPT1, PHPTI, PP1, PP2A, protein histidine phosphatase, protein histidine phosphatase 1, protein-histidine phosphatase, SixA
ECTree
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Engineering
Engineering on EC 3.9.1.3 - phosphohistidine phosphatase
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H53A
R45A
the specific activity of the mutant is decreased by one order of magnitude compared to the wild type enzyme
R78A
the specific activity of the mutant is decreased by about 30% compared to the wild type enzyme
H105A
the mutant enzyme shows no dephosphorylation of nucleoside diphosphate kinase B
additional information
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deletion of 9 N-terminal amino acids results in inactive enzyme, while 4 C-terminal residues can be deleted without losing enzyme activity