3.8.1.9: (R)-2-haloacid dehalogenase

This is an abbreviated version!
For detailed information about (R)-2-haloacid dehalogenase, go to the full flat file.

Reaction

Synonyms

2-haloalkanoic acid dehalogenase, 2-haloalkanoid acid halidohydrolase, D-2-haloacid dehalogenase, D-2-MCPA dehalogenase, D-DEX, D-specific dehalogenase, D-specific mono chloro propionoic acid dehalogenase, DEH138, DehD, DehIII, HadD AJ1, R-2-haloacid dehalogenase

ECTree

     3 Hydrolases

         3.8 Acting on halide bonds

             3.8.1 In carbon-halide compounds

                3.8.1.9 (R)-2-haloacid dehalogenase

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Results	in table
17	AA Sequence
1	Application
1	CAS Registry Number
4	Cloned(Commentary)
2	Crystallization (Commentary)
1	General Information
2	Inhibitors
8	kcat/KM [mM/s]
16	KM Value [mM]
8	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
16	Organism
16	PDB ID
3	pH Optimum
1	pH Range
1	pI Value
29	Protein Variants
5	Purification (Commentary)
3	Reaction
14	Reference
1	Source Tissue
2	Specific Activity [micromol/min/mg]
48	Substrates and Products (Substrate)
11	Subunits
23	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
2	Temperature Stability [°C]
12	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.8.1.9 - (R)-2-haloacid dehalogenase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

(R)-2-chloropropionic acid + H2O

(S)-2-hydroxypropionic acid + chloride

Hymeniacidon perlevis

-

-

721110

-

-

?

(R)-2-haloacid + H2O

(S)-2-hydroxyacid + halide

5 entries

DL-2,3-dichloropropionate + H2O

?

Rhizobium sp.

Q8KLS9

-

733552

-

-

?

monobromoacetate + H2O

2-hydroxyacetate + bromide

Rhizobium sp.

Q8KLS9

-

733552

-

-

?

monochloroacetate + H2O

2-hydroxyacetate + chloride

Rhizobium sp.

Q8KLS9

-

733552

-

-

?

additional information

?

-

2 entries

(R)-2-haloacid + H2O

(S)-2-hydroxyacid + halide

Pseudomonas putida

-

-

648281, 648330

-

-

?

(R)-2-haloacid + H2O

(S)-2-hydroxyacid + halide

Pseudomonas putida AJ1/23

-

-

648281, 648330

-

-

?

(R)-2-haloacid + H2O

(S)-2-hydroxyacid + halide

Pseudomonas putida PP3

-

-

648281

-

-

?

(R)-2-haloacid + H2O

(S)-2-hydroxyacid + halide

Rhizobium sp.

-

-

648279, 648281

-

-

?

(R)-2-haloacid + H2O

(S)-2-hydroxyacid + halide

Rhizobium sp.

Q8KLS9

-

733999

-

-

?

additional information

?

-

Rhizobium sp.

Q8KLS9

the D-2-haloacid dehalogenase of D-specific dehalogenase (DehD) from Rhizobium sp. RC1 catalyses the hydrolytic dehalogenation of D-haloalkanoic acids, inverting the substrate-product configuration and thereby forming the corresponding L-hydroxyalkanoic acids. Molecular docking of substrates into the active site of the DehD mutants R134A and Y135A, which produce altered catalytic functions. The mutants interact strongly with substrates that wild-type DehD does not interact with or degrade. The interaction is particularly enhanced with 3-chloropropionate, in addition to monobromoacetate, monochloroacetate and D,L-2,3-dichloropropionate. The mutants exhibit a strong interaction with 3-chloropropionate at Arg134

733552

-

-

?

additional information

?

-

Rhizobium sp.

-

the D-2-haloacid dehalogenase of D-specific dehalogenase (DehD) from Rhizobium sp. RC1 catalyses the hydrolytic dehalogenation of D-haloalkanoic acids, inverting the substrate-product configuration and thereby forming the corresponding L-hydroxyalkanoic acids. Molecular docking of substrates into the active site of the DehD mutants R134A and Y135A, which produce altered catalytic functions. The mutants interact strongly with substrates that wild-type DehD does not interact with or degrade. The interaction is particularly enhanced with 3-chloropropionate, in addition to monobromoacetate, monochloroacetate and D,L-2,3-dichloropropionate. The mutants exhibit a strong interaction with 3-chloropropionate at Arg134

733552

-

-

?