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3.8.1.6: 4-chlorobenzoate dehalogenase

This is an abbreviated version!
For detailed information about 4-chlorobenzoate dehalogenase, go to the full flat file.

Word Map on EC 3.8.1.6

Reaction

4-Chlorobenzoate
+
H2O
=
4-hydroxybenzoate
+
chloride

Synonyms

FcbB

ECTree

     3 Hydrolases
         3.8 Acting on halide bonds
             3.8.1 In carbon-halide compounds
                3.8.1.6 4-chlorobenzoate dehalogenase

Engineering

Engineering on EC 3.8.1.6 - 4-chlorobenzoate dehalogenase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
A154R
84% of wild-type activity with 1-chloro-2,4-dinitrobenzene, 57% of wild-type activity with 4-chlorobenzoate
A154S
84% of wild-type activity with 1-chloro-2,4-dinitrobenzene, 47% of wild-type activity with 4-chlorobenzoate
D155Y
no decrease in glutathione S-transferase actvitiy, affected in thermostability, 96% of wild-type activity with 1-chloro-2,4-dinitrobenzene, 95% of wild-type activity with 4-chlorobenzoate
L158P
56% of wild-type activity with 1-chloro-2,4-dinitrobenzene, 50% of wild-type activity with 4-chlorobenzoate
S152G
4% of wild-type activity with 1-chloro-2,4-dinitrobenzene, 3% of wild-type activity with 4-chlorobenzoate
S152I
53% of wild-type activity with 1-chloro-2,4-dinitrobenzene, 156% of wild-type activity with 4-chlorobenzoate
V153I
56% of wild-type activity with 1-chloro-2,4-dinitrobenzene, 52% of wild-type activity with 4-chlorobenzoate
V153R
4% of wild-type activity with 1-chloro-2,4-dinitrobenzene, 39% of wild-type activity with 4-chlorobenzoate
Y157W
49% of wild-type activity with 1-chloro-2,4-dinitrobenzene, 59% of wild-type activity with 4-chlorobenzoate
L158P
-
56% of wild-type activity with 1-chloro-2,4-dinitrobenzene, 50% of wild-type activity with 4-chlorobenzoate
-
S152G
-
4% of wild-type activity with 1-chloro-2,4-dinitrobenzene, 3% of wild-type activity with 4-chlorobenzoate
-
S152I
-
53% of wild-type activity with 1-chloro-2,4-dinitrobenzene, 156% of wild-type activity with 4-chlorobenzoate
-
V153I
-
56% of wild-type activity with 1-chloro-2,4-dinitrobenzene, 52% of wild-type activity with 4-chlorobenzoate
-
V153R
-
4% of wild-type activity with 1-chloro-2,4-dinitrobenzene, 39% of wild-type activity with 4-chlorobenzoate
-