3.8.1.2: (S)-2-haloacid dehalogenase

This is an abbreviated version!
For detailed information about (S)-2-haloacid dehalogenase, go to the full flat file.

Word Map on EC 3.8.1.2

3.8.1.2

dehalogenation

synthesis

haloacids

l-2-haloacids

bioremediation

l-2-chloropropionate

2-chloropropionic

halide

hymeniacidon

monochloroacetic

xanthobacter

dechlorination

autotrophicus

monobromoacetic

chloroacetate

haloalkane

analysis

environmental protection

Reaction

Synonyms

2-HAD, 2-halo acid dehalogenase, 2-haloacid dehalogenase, 2-haloacid dehalogenase[ambiguous], 2-haloacid halidohydrolase[ambiguous], 2-haloalkanoate dehalogenase, 2-haloalkanoic acid dehalogenase, 2-haloalkanoid acid halidohydrolase, 2-halocarboxylic acid dehalogenase II, DEH99, dehalogenase IVa, DehL, DL-2-haloacid dehalogenase [ambiguous], HADIIBSW, HadL AJ1, L-2-DhlB, L-2-haloacid dehalogenase, L-2-MCPA dehalogenase, L-2_HAD, L-DEX, L-DEX YL, L-DEXs, L-HAD, L-HADST, L-haloacid dehalogenase, PH1421, Rhodobacteraceae family L-haloacid dehalogenase, S-2-haloacid dehalogenase, STK_25700

ECTree

3 Hydrolases

3.8 Acting on halide bonds

3.8.1 In carbon-halide compounds

3.8.1.2 (S)-2-haloacid dehalogenase

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Results	in table
10858	AA Sequence
23	Application
1	CAS Registry Number
21	Cloned(Commentary)
13	Crystallization (Commentary)
8	General Information
1	General Stability
29	Inhibitors
27	KM Value [mM]
3	Localization
7	Metals/Ions
46	Molecular Weight [Da]
90	Natural Substrates/ Products (Substrates)
28	Organic Solvent Stability
261	Organism
7	Pathway
55	PDB ID
20	pH Optimum
6	pH Range
6	pH Stability
6	pI Value
39	Protein Variants
23	Purification (Commentary)
17	Reaction
3	Reaction Type
99	Reference
4	Source Tissue
26	Specific Activity [micromol/min/mg]
4	Storage Stability
325	Substrates and Products (Substrate)
30	Subunits
68	Synonyms
1	Systematic Name
16	Temperature Optimum [°C]
9	Temperature Range [°C]
16	Temperature Stability [°C]
4	Turnover Number [1/s]

Crystallization

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Crystallization on EC 3.8.1.2 - (S)-2-haloacid dehalogenase

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alpha/beta structure

crystal structures of enzyme complexed with monochloroacetate, L-2-chlorobutyrate, L-2-chloro-3-methylbutyrate, or L-2-chloro-4-methylvalerate are determined using the complex crystals prepared with the S175A mutant

mutant S175A

mutant S175A in complex with chloroacetate, 2-L-chlorobutyrate, 2-L-chloro-3-methylbutyrate, 2-L-chloro-4-methylvalerate, and L-2-chloropropionamide, all substrates bound have D-configuration, except for chloroacetate

Pseudomonas sp.

719121

oil-microbatch method, in 200 mM NaCl and 20 mM Tris-HCl pH 8.0, 25.5% (w/v) polyethylene glycol 4000, 0.17 M ammonium acetate, 15% (w/v) glycerol and 85 mM sodium acetate buffer, pH 4.6, at 20°C

Pyrococcus horikoshii

695317

refined to 1.9 A resolution. Crystal is an orderdisorder twin by reticular merohedry with a twin index of 10

Sulfurisphaera tokodaii

677325

apoenzyme and enzyme in intermediate state with substrate L-2-monochloropropionate and monochloroacetate

2 entries

three-dimensional structure of enzyme

Xanthobacter autotrophicus

648312