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3.8.1.10: 2-haloacid dehalogenase (configuration-inverting)

This is an abbreviated version!
For detailed information about 2-haloacid dehalogenase (configuration-inverting), go to the full flat file.

Word Map on EC 3.8.1.10

Reaction

(R)-2-haloacid
+
H2O
=
(S)-2-hydroxyacid
+
halide

Synonyms

2-HAD, 2-haloalkanoic acid dehalogenase, 2-haloalkanoid acid halidohydrolase, DL DEX 113, DL-2-haloacid dehalogenase, DL-2-haloacid dehalogenase (inversion of configuration), DL-2-haloacid halidohydrolase (inversion of configuration), DL-DEX, DL-DEX 113, DL-DEX Mb, DL-DEXi, L-2-haloacid dehalogenase, L-DEX, L-DEX YL, ps-2-HAD

ECTree

     3 Hydrolases
         3.8 Acting on halide bonds
             3.8.1 In carbon-halide compounds
                3.8.1.10 2-haloacid dehalogenase (configuration-inverting)

Substrates Products

Substrates Products on EC 3.8.1.10 - 2-haloacid dehalogenase (configuration-inverting)

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(R)-2-chloropropionate + H2O
(S)-2-hydroxypropionate + chloride
show the reaction diagram
-
-
-
?
(R)-2-chloropropionic acid + H2O
(S)-2-hydroxypropionic acid + chloride
show the reaction diagram
(R)-2-haloacid + H2O
(S)-2-hydroxyacid + halide
show the reaction diagram
(S)-2-chloropropionate + H2O
(R)-2-hydroxypropionate + chloride
show the reaction diagram
-
-
-
?
(S)-2-chloropropionic acid + H2O
(R)-2-hydroxypropionic acid + chloride
show the reaction diagram
(S)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
show the reaction diagram
2,2-dichloropropionate + H2O
?
show the reaction diagram
2,3-dichloropropionate + H2O
?
show the reaction diagram
2-bromo-2-methylpropionate + H2O
2-hydroxy-2-methylpropionate + bromide
show the reaction diagram
slow substrate for the wild-type enzyme, but inhibitory for enzyme mutant D194N
-
-
?
2-chloro-3-hydroxypropionate + H2O
glycerate + HCl
show the reaction diagram
2-chloro-n-butyrate + H2O
2-hydroxybutyrate + HCl
show the reaction diagram
2-chlorobutyrate + H2O
2-hydroxybutyrate + chloride
show the reaction diagram
bromoacetate + H2O
glycolate + bromide
show the reaction diagram
chloroacetate + H2O
glycolate + chloride
show the reaction diagram
D-2-bromopropionate + H2O
L-lactate + bromide
show the reaction diagram
D-2-chloropropionate + H2O
L-lactate + chloride
show the reaction diagram
D-2-chloropropionate + H2O
L-lactate + HCl
show the reaction diagram
D-2-monochloropropionate + H2O
L-lactate + HCl
show the reaction diagram
dichloroacetate + H2O
?
show the reaction diagram
DL-2-chloropropionate + H2O
DL-lactate + HCl
show the reaction diagram
L-2-bromopropionate + H2O
D-lactate + bromide
show the reaction diagram
Stutzerimonas chloritidismutans
-
-
-
?
L-2-chloropropionate + H2O
D-lactate + chloride
show the reaction diagram
Stutzerimonas chloritidismutans
-
-
-
?
L-2-chloropropionate + H2O
D-lactate + HCl
show the reaction diagram
L-2-monochloropropionate + H2O
D-lactate + HCl
show the reaction diagram
monobromoacetate + H2O
glycolate + HBr
show the reaction diagram
monochloroacetate + H2O
glycolate + HCl
show the reaction diagram
monoiodoacetate + H2O
glycolate + HI
show the reaction diagram
tribromoacetic acid + H2O
carbon monoxide + carbon dioxide + HBr
show the reaction diagram
-
-
-
?
trichloroacetate + H2O
?
show the reaction diagram
additional information
?
-