3.8.1.10: 2-haloacid dehalogenase (configuration-inverting)
This is an abbreviated version!
For detailed information about 2-haloacid dehalogenase (configuration-inverting), go to the full flat file.
Word Map on EC 3.8.1.10
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3.8.1.10
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lymphedema
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bioimpedance
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cancer-related
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dehalogenation
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l-2-haloalkanoic
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2-haloacids
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l-2-chloropropionate
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alpha-carbon
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monochloroacetate
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decongestive
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autotrophicus
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xanthobacter
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synthesis
- 3.8.1.10
- lymphedema
-
bioimpedance
-
cancer-related
-
dehalogenation
-
l-2-haloalkanoic
-
2-haloacids
- l-2-chloropropionate
-
alpha-carbon
- monochloroacetate
-
decongestive
- autotrophicus
- xanthobacter
- synthesis
Reaction
Synonyms
2-HAD, 2-haloalkanoic acid dehalogenase, 2-haloalkanoid acid halidohydrolase, DL DEX 113, DL-2-haloacid dehalogenase, DL-2-haloacid dehalogenase (inversion of configuration), DL-2-haloacid halidohydrolase (inversion of configuration), DL-DEX, DL-DEX 113, DL-DEX Mb, DL-DEXi, L-2-haloacid dehalogenase, L-DEX, L-DEX YL, ps-2-HAD
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Reaction
Reaction on EC 3.8.1.10 - 2-haloacid dehalogenase (configuration-inverting)
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Dehalogenates both (S)- and (R)-2-haloalkanoic acids to the corresponding (R)- and (S)-hydroxyalkanoic acids, respectively, with inversion of configuration at C-2. The enzyme from Pseudomonas sp. 113 acts on 2-haloalkanoic acids whose carbon chain lengths are five or less. See also EC 3.8.1.2 (S)-2-haloacid dehalogenase, EC 3.8.1.9 (R)-2-haloacid dehalogenase and EC 3.8.1.11 2-haloacid dehalogenase (configuration-retaining)
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(R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide
group I enzymes, including DL-2-haloacid dehalogenase and D-2-haloacid dehalogenase, catalyze the reaction without forming an ester intermediate. Instead, a solvent water molecule directly attacks the alpha-carbon atom of the substrate to release the halide ion. DL-2-haloacid dehalogenase acts on both enantiomers of the substrate
Dehalogenates both (S)- and (R)-2-haloalkanoic acids to the corresponding (R)- and (S)-hydroxyalkanoic acids, respectively, with inversion of configuration at C-2. The enzyme from Pseudomonas sp. 113 acts on 2-haloalkanoic acids whose carbon chain lengths are five or less. See also EC 3.8.1.2 (S)-2-haloacid dehalogenase, EC 3.8.1.9 (R)-2-haloacid dehalogenase and EC 3.8.1.11 2-haloacid dehalogenase (configuration-retaining)
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(S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide
group I enzymes, including DL-2-haloacid dehalogenase and D-2-haloacid dehalogenase, catalyze the reaction without forming an ester intermediate. Instead, a solvent water molecule directly attacks the alpha-carbon atom of the substrate to release the halide ion. DL-2-haloacid dehalogenase acts on both enantiomers of the substrate