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3.8.1.10: 2-haloacid dehalogenase (configuration-inverting)

This is an abbreviated version!
For detailed information about 2-haloacid dehalogenase (configuration-inverting), go to the full flat file.

Word Map on EC 3.8.1.10

Reaction

(R)-2-haloacid
+
H2O
=
(S)-2-hydroxyacid
 +
halide

Synonyms

2-HAD, 2-haloalkanoic acid dehalogenase, 2-haloalkanoid acid halidohydrolase, DL DEX 113, DL-2-haloacid dehalogenase, DL-2-haloacid dehalogenase (inversion of configuration), DL-2-haloacid halidohydrolase (inversion of configuration), DL-DEX, DL-DEX 113, DL-DEX Mb, DL-DEXi, L-2-haloacid dehalogenase, L-DEX, L-DEX YL, ps-2-HAD

ECTree

     3 Hydrolases
         3.8 Acting on halide bonds
             3.8.1 In carbon-halide compounds
                3.8.1.10 2-haloacid dehalogenase (configuration-inverting)

Inhibitors

Inhibitors on EC 3.8.1.10 - 2-haloacid dehalogenase (configuration-inverting)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-ethyl-3-(3-dimethylaminopropyl)carbodiimide
complete inactivation
2-bromo-2-methylpropionate
an inhibitor of the D194N mutant enzyme and slow substrate of the wild-type enzyme
D-2-chloropropionate
inhibits dehalogenation of L-2-chloropropionate
diethyldicarbonate
significant inactivation
L-2-chloropropionate
inhibits dehalogenation of D-2-chloropropionate
Mg2+
the enzyme activity is suppressed by Mg2+
Mn2+
-
MnSO4
N-bromosuccinimide
significant inactivation
N-ethylmaleimide
-
-
p-chloromercuribenzoate
-
-
thiol reagents
-
not
additional information
-