3.7.1.8: 2,6-dioxo-6-phenylhexa-3-enoate hydrolase
This is an abbreviated version!
For detailed information about 2,6-dioxo-6-phenylhexa-3-enoate hydrolase, go to the full flat file.
Word Map on EC 3.7.1.8
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3.7.1.8
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biphenyls
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hydrolases
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dioxygenase
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hopdas
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benzoate
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1,2-dioxygenase
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2-hydroxypenta-2,4-dienoate
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molecular biology
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cumene
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oxyanion
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2,3-dihydroxybiphenyl
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polychlorinated
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rhodococcus
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sphingomonas
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ring-hydroxylating
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2-hydroxy-6-oxohepta-2,4-dienoate
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2-hydroxymuconic
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4-chlorobiphenyl
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wittichii
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xenovorans
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extradiol
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ser-his-asp
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isopropylbenzene
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dibenzofuran
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acyl-enzyme
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carbanion
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degradation
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environmental protection
- 3.7.1.8
- biphenyls
- hydrolases
- dioxygenase
- hopdas
- benzoate
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1,2-dioxygenase
- 2-hydroxypenta-2,4-dienoate
- molecular biology
- cumene
-
oxyanion
- 2,3-dihydroxybiphenyl
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polychlorinated
- rhodococcus
- sphingomonas
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ring-hydroxylating
- 2-hydroxy-6-oxohepta-2,4-dienoate
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2-hydroxymuconic
- 4-chlorobiphenyl
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wittichii
- xenovorans
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extradiol
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ser-his-asp
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isopropylbenzene
- dibenzofuran
- acyl-enzyme
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carbanion
- degradation
- environmental protection
Reaction
Synonyms
2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoic acid hydrolase, 2-hydroxy-6-oxo-6-phenylhexa-2, 4-dienoate hydrolase, 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase, 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid hydrolase, 2-hydroxy-6-oxo-6-phenylhexa-2,4-dieonic acid hydrolase, 6-phenyl HODA hydrolase, BphD, BphD enzyme, BphDP6, CarC, HOHPDA hydrolase, HOPD hydrolase, HOPDA hydrolase, HPDA hydrolase, HsaD, hydrolase, 2,6-dioxo-6-phenylhexa-3-enoate, LigY, MCP hydrolase, meta-cleavage product hydrolase, MhpC
ECTree
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KM Value
KM Value on EC 3.7.1.8 - 2,6-dioxo-6-phenylhexa-3-enoate hydrolase
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0.00075
(2E,4E)-6-(3,4-dichlorophenyl)-2-hydroxy-6-oxohexa-2,4-dienoic acid
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-
0.00104
(2E,4E)-6-(3,5-chlorophenyl)-2-hydroxy-6-oxohexa-2,4-dienoic acid
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-
0.14
2-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate
A0A0H0ZQK0
pH 7.0, 30°C
0.0033
4,11-dicarboxy-8-hydroxy-9-methoxy-2-hydroxy-6-oxo-6-phenyl-hexa-2,4-dienoate
pH 7, 25°C
0.31
8-(2-chlorophenyl)-2-hydroxy-5-methyl-6-oxoocta-2,4-dienoic acid
pH 7.5, 25°C
0.00013
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-
0.00065
(2E,4E)-2-hydroxy-6-(4-chlorophenyl)-6-oxohexa-2,4-dienoic acid
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-
0.00019
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not chlorinated
0.00047
(2E,4E)-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid
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not chlorinated
0.00033
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-
0.0129
(2E,4E)-6-(2-chlorophenyl)-2-hydroxy-6-oxohexa-2,4-dienoic acid
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-
0.00043
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-
0.00046
(2E,4E)-6-(3-chlorophenyl)-2-hydroxy-6-oxohexa-2,4-dienoic acid
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-
0.0036
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-
0.004
(2E,4Z)-4-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid
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-
0.0049
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-
0.018
(2E,4Z)-5-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid
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-
0.00054
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-
0.0069
(2Z,4E)-3-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid
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-
0.00028
pH 7.0, 25°C, mutant M148D
0.00044
2,6-dioxo-6-phenylhexa-3-enoate
pH 7.0, 25°C, mutant M148S
0.00047
2,6-dioxo-6-phenylhexa-3-enoate
pH 7.0, 25°C, mutant M148W
0.00058
2,6-dioxo-6-phenylhexa-3-enoate
pH 7.0, 25°C, mutant M148R
0.00074
2,6-dioxo-6-phenylhexa-3-enoate
pH 7.0, 25°C, mutant M148H
0.00075
2,6-dioxo-6-phenylhexa-3-enoate
pH 7.0, 25°C, wild-type enzyme
0.00078
2,6-dioxo-6-phenylhexa-3-enoate
pH 7.0, 25°C, mutant M148I
0.00079
2,6-dioxo-6-phenylhexa-3-enoate
pH 7.0, 25°C, mutant M148T
0.00097
2,6-dioxo-6-phenylhexa-3-enoate
pH 7.0, 25°C, mutant M148C
0.0002
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pH 7.5, 25°C, recombinant wild-type BphD, without methanol
0.0003
2-Hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid
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wild-type at 3.2°C
0.00085
2-Hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid
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pH 7.5, 25°C, recombinant wild-type BphD, with 494 mM methanol
0.002
2-Hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid
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pH 7.5, 25°C, recombinant wild-type BphD, with 12940 mM methanol
0.0028
2-Hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid
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S112C mutant at 25°C
0.008
2-Hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid
pH 7.5, 25°C
0.0017
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mutant D237N
0.002
ethyl-2-acetoxy-6-keto-6-phenylhexa-2,4-dienoate
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His6-BphD
0.037
ethyl-2-acetoxy-6-keto-6-phenylhexa-2,4-dienoate
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mutant H265A
0.0373
ethyl-2-acetoxy-6-keto-6-phenylhexa-2,4-dienoate
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mutant S112A
additional information
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values between 0.00013 and 0.00106 mM for processing of the 6-acryl-2-hydroxy-6-ketohexa-2,4-dienoic acid substrates
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additional information
additional information
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in the steady-state hydrolysis of HOPDA, kcat/Km values are independent of methanol concentration, while both kcat and Km values increase with methanol concentration, stopped-flow spectrophotometry and steady-state kinetics, overview
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additional information
additional information
pre-steady-state kinetic burst of BphD
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additional information
additional information
Michaelis-Menten steady-state kinetics, stopped-flow measurements
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