3.7.1.7: beta-diketone hydrolase
This is an abbreviated version!
For detailed information about beta-diketone hydrolase, go to the full flat file.
Word Map on EC 3.7.1.7
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3.7.1.7
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sphingopyxis
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textile
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putida
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lipase
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sludge
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shake
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cytochemically
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ache
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desizing
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acetylacetone
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gly-x-ser-x-gly
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p-nitrophenyl
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alpha-granules
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caprylate
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industry
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wastewater
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hydrolysed
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pmsf
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sphingomonas
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depolymerases
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dt
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molecular biology
- 3.7.1.7
- sphingopyxis
-
textile
- putida
- lipase
-
sludge
-
shake
-
cytochemically
-
ache
-
desizing
- acetylacetone
-
gly-x-ser-x-gly
- p-nitrophenyl
-
alpha-granules
- caprylate
- industry
-
wastewater
-
hydrolysed
- pmsf
- sphingomonas
-
depolymerases
- dt
- molecular biology
Reaction
Synonyms
ABDH, Alr4455 protein, beta-diketone hydrolase, OPH, OPH hydrolase, oxidized polyvinyl alcohol hydrolase, oxidized PVA hydrolase, oxidized-PVA hydrolase, poly(vinyl alcohol) (PVA)-degrading enzyme, pOPH, PVA-degrading enzyme, PVAase, sOPH
ECTree
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Substrates Products
Substrates Products on EC 3.7.1.7 - beta-diketone hydrolase
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REACTION DIAGRAM
1-phenyl-2,4-butanedione + H2O
acetic acid + 1-phenyl-2-propanone
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bicyclo[2.2.2]octane-2,6-dione + H2O
[(S)-3-oxocyclohexyl]acetic acid
desymmetrization of bicyclo[2.2.2]octane-2,6-dione
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nonane-4,6-dione + H2O
pentan-2-one + butanoate
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acetic acid + 4-methyl-2-pentanone
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6-methyl-2,4-heptanedione + H2O
acetic acid + 4-methyl-2-pentanone
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6-methyl-2,4-heptanedione + H2O
acetic acid + 4-methyl-2-pentanone
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additional information
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the enzyme catalyzes the cleavage of C-C bond in beta-diketone
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additional information
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the enzyme catalyzes the cleavage of C-C bond in beta-diketone
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additional information
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the enzyme shows lipase activity with 4-nitrophenyl esters as the substrates. The wild-type enzyme shows increased Km and decreased kcat/Km with the acyl chain length, and the mutants show reduced kcat/Km for 4-nitrophenyl acetate, indicating the importance of Trp255 in sequestering the active site from solvent. The significantly lower activity for 4-nitrophenyl butyrate can be a result of product inhibition
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additional information
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the enzyme shows lipase activity with 4-nitrophenyl esters as the substrates. The wild-type enzyme shows increased Km and decreased kcat/Km with the acyl chain length, and the mutants show reduced kcat/Km for 4-nitrophenyl acetate, indicating the importance of Trp255 in sequestering the active site from solvent. The significantly lower activity for 4-nitrophenyl butyrate can be a result of product inhibition
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additional information
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the formation of hydrogen bonds between Gly65, Ser66, Val67 with ligand exert extremely important promotion effect on the reaction. Besides, significant electrostatic influence of Glu198 also contributes to the catalysis
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additional information
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no activity towards pentane-2,4-dione
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additional information
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the enzyme catalyzes the cleavage of C-C bond in beta-diketone
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-
?
additional information
?
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the enzyme shows lipase activity with 4-nitrophenyl esters as the substrates. The wild-type enzyme shows increased Km and decreased kcat/Km with the acyl chain length, and the mutants show reduced kcat/Km for 4-nitrophenyl acetate, indicating the importance of Trp255 in sequestering the active site from solvent. The significantly lower activity for 4-nitrophenyl butyrate can be a result of product inhibition
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additional information
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no activity on monoketones, diketones and esters
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additional information
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no activity on monoketones, diketones and esters
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additional information
?
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the enzyme catalyzes the cleavage of C-C bond in beta-diketone
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-
?
additional information
?
-
the enzyme shows lipase activity with 4-nitrophenyl esters as the substrates. The wild-type enzyme shows increased Km and decreased kcat/Km with the acyl chain length
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-
?