3.7.1.4: phloretin hydrolase
This is an abbreviated version!
For detailed information about phloretin hydrolase, go to the full flat file.
Word Map on EC 3.7.1.4
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3.7.1.4
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eubacterium
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ramulus
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brush
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flavonoid
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border
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medicine
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2,4-diacetylphloroglucinol
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lactase-phlorizin
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molecular biology
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lactase
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pyridoxine
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phloridzin
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flavone
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beta-glucosidic
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carbon-carbon
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beta-glucosidase
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fluorescens
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deglycosylated
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mucosal
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5'-phosphate
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fecal
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dihydrochalcone
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pyridoxal
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abscessus
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neohesperidin
- 3.7.1.4
- eubacterium
- ramulus
-
brush
- flavonoid
- border
- medicine
- 2,4-diacetylphloroglucinol
-
lactase-phlorizin
- molecular biology
- lactase
- pyridoxine
- phloridzin
- flavone
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beta-glucosidic
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carbon-carbon
- beta-glucosidase
- fluorescens
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deglycosylated
- mucosal
- 5'-phosphate
-
fecal
- dihydrochalcone
- pyridoxal
- abscessus
- neohesperidin
Reaction
Synonyms
C-acylphenol acylhydrolase, lactase phlorizin hydrolase, lactase phlorizin-hydrolase, lactase-phlorizin hydrolase, lactase/phlorizin hydrolase, LCT, LPH, Phlg, phloretin hydrolase, Phy, PNG hydrolase
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Application
Application on EC 3.7.1.4 - phloretin hydrolase
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medicine
molecular biology
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rapid genotyping assay for LPH-13910 polymorphism based on real-time PCR, which may assist in differentiating patients with primary hypolactasia from those with secondary hypolactasia and lactose intolerance
medicine
adult-type hypolactasia is characterized by a fall of lactase activity levels to 5 - 10% of birth levels occuring during childhood and adolescence
medicine
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adult-type hypolactasia results from the progressive decline of lactase-phlorizin hydrolase activity in enterocytes after weaning, lactase nonpersistence may determine a primary lactose intolerance with reduced diary product consumption, which is possibly related to an increased risk of colon cancer
medicine
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hypolactasia seems to be strongly corretated with genotype C/C of the genetic variant C->T-13910 upstream of the lactase-phlorizin hydrolase gene
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98% similarity of the rabbit LPH precursor to PNGH sequence, LPH and PNGH enzymes have the same genomic origin, but differ in transcriptional and, possibly, post-translational processing
molecular biology
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cell specificty of LPH gene expression depends upon both positive and negative interactions among elements in the first 2kb of the LPH 5'-flanking region, generally positive activity between -74 and -37 bp, a cell-specific negative region between -210 and -95 bp, and additional elements further toward the 5' terminus that confer a highly cell-specific response in reporter activity, potential binding sites for various intestinal transcription factors, binding of HNF3beta at three sites is relevant to LPH expression
molecular biology
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LPH and PNGH enzymes have the same genomic origin, but differ in transcriptional and, possibly, post-translational processing