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3.7.1.3: kynureninase

This is an abbreviated version!
For detailed information about kynureninase, go to the full flat file.

Word Map on EC 3.7.1.3

Reaction

L-kynurenine
+
H2O
=
anthranilate
 +
L-alanine

Synonyms

HsKynase, Kynase, KYNU, kynureninase, L-kynurenine hydrolase, PfKynase

ECTree

     3 Hydrolases
         3.7 Acting on carbon-carbon bonds
             3.7.1 In ketonic substances
                3.7.1.3 kynureninase

Disease

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Disease on EC 3.7.1.3 - kynureninase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
Comparative inhibition by substrate analogues 3-methoxy- and 3-hydroxydesaminokynurenine and an improved 3 step purification of recombinant human kynureninase.
Aneurysm
Upregulated Kynurenine Pathway Enzymes in Aortic Atherosclerotic Aneurysm: Macrophage Kynureninase Downregulates Inflammation.
Brain Injuries
Kynurenine pathway enzymes in brain: responses to ischemic brain injury versus systemic immune activation.
Brain Ischemia
Kynurenine pathway enzymes in brain: responses to ischemic brain injury versus systemic immune activation.
Breast Neoplasms
A novel role of kynureninase in the growth control of breast cancer cells and its relationships with breast cancer.
Carcinoma
Down-regulation of kynureninase restrains cutaneous squamous cell carcinoma proliferation and represses PI3K/AKT pathway.
Carcinoma, Squamous Cell
Down-regulation of kynureninase restrains cutaneous squamous cell carcinoma proliferation and represses PI3K/AKT pathway.
Dementia
Comparative inhibition by substrate analogues 3-methoxy- and 3-hydroxydesaminokynurenine and an improved 3 step purification of recombinant human kynureninase.
Encephalitis
A mechanism of quinolinic acid formation by brain in inflammatory neurological disease. Attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate.
Epilepsy
Epilepsy as a pyridoxine-dependent condition: quantified urinary biomarkers for status evaluation and monitoring antiepileptic treatment.
Essential Hypertension
A rare variant at the KYNU gene is associated with kynureninase activity and essential hypertension in the Han Chinese population.
[A polymorphism of kynureninase gene in a hypertensive candidate chromosomal region is associated with essential hypertension]
Glioma
Involvement of the kynurenine pathway in human glioma pathophysiology.
Hypertension
A rare variant at the KYNU gene is associated with kynureninase activity and essential hypertension in the Han Chinese population.
Kynureninase is a novel candidate gene for hypertension in spontaneously hypertensive rats.
Ichthyosis
Ichthyosis molecular fingerprinting shows profound TH17 skewing and a unique barrier genomic signature.
Infections
Increased mRNA expression of kynurenine pathway enzymes in human placentae exposed to bacterial endotoxin.
Ischemic Attack, Transient
Mechanism of delayed increases in kynurenine pathway metabolism in damaged brain regions following transient cerebral ischemia.
kynureninase deficiency
Biallelic variants in KYNU cause a multisystemic syndrome with hand hyperphalangism.
The urinary ratio of 3-hydroxykynurenine/3-hydroxyanthranilic acid is an index to predicting the adverse effects of D-tryptophan in rats.
Xanthurenic aciduria due to a mutation in KYNU encoding kynureninase.
[Kynureninase deficiency]
Meningitis, Pneumococcal
The cerebral protective effect and mechanism of action of vitamin B6 adjuvant ceftriaxone in experimental pneumococcal meningitis.
Metabolic Diseases
A novel role of kynureninase in the growth control of breast cancer cells and its relationships with breast cancer.
Myocardial Infarction
Sarcopenia and sarcopenic obesity as prognostic predictors in hospitalized elderly patients with acute myocardial infarction.
Neoplasms
A novel role of kynureninase in the growth control of breast cancer cells and its relationships with breast cancer.
Activatable Polymer Nanoenzymes for Photodynamic Immunometabolic Cancer Therapy.
Conformational Dynamics Contribute to Substrate Selectivity and Catalysis in Human Kynureninase.
LIVER KYNURENINASE ACTIVITY OF TUMOR BEARING ANIMALS.
Reversal of indoleamine 2,3-dioxygenase-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme.
Tryptophan PET Imaging of the Kynurenine Pathway in Patient-Derived Xenograft Models of Glioblastoma.
Tryptophan pyrrolase, kynureninase and kynurenine transaminase activities of human renal tumours.
[Importance of E-cadherin; expression in the inmunohistochemical diagnosis of breast cancer]
Neuralgia
Pharmacological Inhibition of Indoleamine 2,3-Dioxygenase-2 and Kynurenine 3-Monooxygenase, Enzymes of the Kynurenine Pathway, Significantly Diminishes Neuropathic Pain in a Rat Model.
Obesity
The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation.
Pellagra
[Inhibiting effect of amino acids on kynureninase and its significance in the pathogenesis of pellagra.]
Phenylketonurias
[Kynureninase activity and pyridoxine elimination in rats with experimental phenylketonuria]
Psoriasis
Gene expression of enzymes for tryptophan degradation pathway is upregulated in the skin lesions of patients with atopic dermatitis or psoriasis.
Ichthyosis molecular fingerprinting shows profound TH17 skewing and a unique barrier genomic signature.
Renal Insufficiency
Mechanism of increases in L-kynurenine and quinolinic acid in renal insufficiency.
Seizures
Epilepsy as a pyridoxine-dependent condition: quantified urinary biomarkers for status evaluation and monitoring antiepileptic treatment.
Skin Diseases
Effect of psoralen-induced photodermatitis on tryptophan metabolism in rats.
Spasms, Infantile
Liver kynureninase activity of an infant with infantile spasm.
Vitamin B 6 Deficiency
High-performance liquid chromatographic assay of human lymphocyte kynureninase activity levels.
Inhibition of kynureninase by oestrogen conjugates: evidence that oestrogens do not cause vitamin B6 deficiency.
LIVER kynureninase activity and tryptophan metabolism in vitamin B6 deficiency.
Multiple roles of haem in cystathionine ?-synthase activity: implications for hemin and other therapies of acute hepatic porphyria.
The relation of liver kynureninase to tryptophan metabolism in pyridoxine deficiency.
Vitamin B Deficiency
Inhibition of kynureninase (L-kynurenine hydrolase, EC 3 . 7. 1 . 3) by oestrone sulphate: an alternative explanation for abnormal results of tryptophan load tests in women receiving oestrogenic steroids.