3.7.1.17: 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase

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For detailed information about 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase, go to the full flat file.

Reaction

Synonyms

2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase, 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid hydrolase, HsaD, TesD

ECTree

     3 Hydrolases

         3.7 Acting on carbon-carbon bonds

             3.7.1 In ketonic substances

                3.7.1.17 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase

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Results	in table
476	AA Sequence
5	Cloned(Commentary)
2	Crystallization (Commentary)
1	IC50 Value
14	Inhibitors
4	kcat/KM [mM/s]
5	KM Value [mM]
2	Localization
2	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
582	Organism
4	Pathway
14	PDB ID
1	pH Optimum
1	Protein Variants
4	Purification (Commentary)
1	Reaction
10	Reference
13	Substrates and Products (Substrate)
4	Subunits
13	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]
5	Turnover Number [1/s]

KM Value

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KM Value on EC 3.7.1.17 - 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.019

2-hydroxy-6-oxo-6-phenyl-2,4-hexadienoic acid

Mycobacterium tuberculosis

-

in 20 mM HEPES, 80 mM NaCl, at pH 8.0 and 25°C

718315

0.008 - 0.23

2-Hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid

2 entries

0.017

4,5-9,10-diseco-3-hydroxy-5,9,17-tri-oxoandrosta-1(10),2-diene-4-oic acid

Mycobacterium tuberculosis

-

wild type enzyme, in 100 mM potassium phosphate, pH 7.5, at 25°C

717815

0.31

8-(2-chlorophenyl)-2-hydroxy-5-methyl-6-oxoocta-2,4-dienoic acid

Mycobacterium tuberculosis

-

wild type enzyme, in 100 mM potassium phosphate, pH 7.5, at 25°C

717815

0.008

2-Hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid

Mycobacterium tuberculosis

-

wild type enzyme, in 100 mM potassium phosphate, pH 7.5, at 25°C

717815

0.23

2-Hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid

Mycobacterium tuberculosis

-

apparent value, in 100 mM of phosphate buffer (pH 7.4) with 20 mM NaCl, temperature not specified in the publication

717209