3.7.1.11: cyclohexane-1,2-dione hydrolase

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For detailed information about cyclohexane-1,2-dione hydrolase, go to the full flat file.

Reaction

Synonyms

Cdh, ThDP-dependent cyclohexane-1,2-dione hydrolase, thiamine diphosphate dependent cyclohexane-1,2-dione hydrolase

ECTree

3 Hydrolases

3.7 Acting on carbon-carbon bonds

3.7.1 In ketonic substances

3.7.1.11 cyclohexane-1,2-dione hydrolase

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Results	in table
1	Activating Compound
12	AA Sequence
4	Application
2	Cloned(Commentary)
13	Cofactor
2	Crystallization (Commentary)
16	General Information
4	Inhibitors
1	kcat/KM [mM/s]
2	KM Value [mM]
4	Metals/Ions
6	Molecular Weight [Da]
16	Natural Substrates/ Products (Substrates)
48	Organism
2	Pathway
4	PDB ID
5	pH Optimum
11	Protein Variants
2	Purification (Commentary)
10	Reaction
16	Reference
2	Source Tissue
1	Specific Activity [micromol/min/mg]
36	Substrates and Products (Substrate)
8	Subunits
12	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
1	Turnover Number [1/s]

Reference

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Reference on EC 3.7.1.11 - cyclohexane-1,2-dione hydrolase

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695911

Harder, J.

Anaerobic degradation of cyclohexane-1,2-diol by a new Azoarcus species

Arch. Microbiol.

168

199-204

1997

Azoarcus sp., Azoarcus sp. 22Lin

699603

Fraas, S.; Steinbach, A.; Tabbert, A.; Harder, J.; Ermler, U.; Tittmann, K.; Meyer, A.; Kroneck, P.

Cyclohexane-1,2-dione hydrolase: A new tool to degrade alicyclic compounds

J. Mol. Catal. B

47-49

2009

Azoarcus sp., Azoarcus sp. 22Lin

719464

Steinbach, A.; Fraas, S.; Harder, J.; Warkentin, E.; Kroneck, P.M.; Ermler, U.

Crystal structure of a ring-cleaving cyclohexane-1,2-dione hydrolase, a novel member of the thiamine diphosphate enzyme family

FEBS J.

279

1209-1219

2012

Azoarcus sp. (P0CH62), Azoarcus sp., Azoarcus sp. 22Lin (P0CH62)

22309255

719735

Steinbach, A.K.; Fraas, S.; Harder, J.; Tabbert, A.; Brinkmann, H.; Meyer, A.; Ermler, U.; Kroneck, P.M.

Cyclohexane-1,2-dione hydrolase from denitrifying Azoarcus sp. strain 22Lin, a novel member of the thiamine diphosphate enzyme family

J. Bacteriol.

193

6760-6769

2011

Azoarcus sp. (P0CH62), Azoarcus sp., Azoarcus sp. 22Lin (P0CH62)

21965568

733089

Loschonsky, S.; Wacker, T.; Waltzer, S.; Giovannini, P.P.; McLeish, M.J.; Andrade, S.L.; Mueller, M.

Extended reaction scope of thiamine diphosphate dependent cyclohexane-1,2-dione hydrolase: from C-C bond cleavage to C-C bond ligation

Angew. Chem. Int. Ed. Engl.

14402-14406

2014

Azoarcus sp. (P0CH62), Azoarcus sp. 22Lin (P0CH62)

25382418

733657

Loschonsky, S.; Waltzer, S.; Fraas, S.; Wacker, T.; Andrade, S.L.; Kroneck, P.M.; Mueller, M.

Catalytic scope of the thiamine-dependent multifunctional enzyme cyclohexane-1,2-dione hydrolase

ChemBioChem

389-392

2014

Azoarcus sp. (P0CH62), Azoarcus sp. 22Lin (P0CH62)

24436243

733660

Loschonsky, S.; Waltzer, S.; Brecht, V.; Mueller, M.

Elucidation of the enantioselective cyclohexane-1,2-dione hydrolase catalyzed formation of (S)-acetoin

ChemCatChem

969-972

2014

Azoarcus sp., Azoarcus sp. 22Lin

735301

Zhu, W.; Liu, Y.

QM/MM study on the catalytic mechanism of cyclohexane-1,2-dione hydrolase (CDH)

Theoret. Chem. Accounts

133

1-9

2014

Azoarcus sp. (P0CH62), Azoarcus sp. 22Lin (P0CH62)