3.7.1.11: cyclohexane-1,2-dione hydrolase
This is an abbreviated version!
For detailed information about cyclohexane-1,2-dione hydrolase, go to the full flat file.
Reaction
Synonyms
Cdh, ThDP-dependent cyclohexane-1,2-dione hydrolase, thiamine diphosphate dependent cyclohexane-1,2-dione hydrolase
ECTree
3.7.1.11 cyclohexane-1,2-dione hydrolaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.7.1.11 - cyclohexane-1,2-dione hydrolase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
cyclohexane-1,2-dione + H2O
6-oxohexanoate + ?
-
further conversion to adipate using NAD+ as electron acceptor
-
?
cyclohexane-1,2-dione + H2O
6-oxohexanoate + ?
degradation of cyclohexane-1,2-dione to 6-oxohexanoate comprises the cleavage of a COC bond adjacent to a carbonyl group. In the subsequent NAD-dependent reaction, 6-oxohexanoate is oxidized to adipate
further convertion to adipate using NAD+ as electron acceptor
-
?
cyclohexane-1,2-dione + H2O
6-oxohexanoate + ?
-
further conversion to adipate using NAD+ as electron acceptor
-
?
cyclohexane-1,2-dione + H2O
6-oxohexanoate + ?
degradation of cyclohexane-1,2-dione to 6-oxohexanoate comprises the cleavage of a COC bond adjacent to a carbonyl group. In the subsequent NAD-dependent reaction, 6-oxohexanoate is oxidized to adipate
further convertion to adipate using NAD+ as electron acceptor
-
?
additional information
?
-
the enzyme catalyzes C-C bond cleavage of cyclohexane-1,2-dione to produce 6-oxohexanoic acid as the primary product, presumably followed by oxidation of the latter to adipic acid
-
-
?
additional information
?
-
the enzyme catalyzes the C-C bond cleavage of cyclohexane-1,2-dione to 6-oxohexanoate, and the asymmetric benzoin condensation between benzaldehyde and pyruvate
-
-
?
additional information
?
-
the enzyme catalyzes the C-C bond cleavage of cyclohexane-1,2-dione to 6-oxohexanoate, and the asymmetric benzoin condensation between benzaldehyde and pyruvate
-
-
?
additional information
?
-
the enzyme catalyzes C-C bond cleavage of cyclohexane-1,2-dione to produce 6-oxohexanoic acid as the primary product, presumably followed by oxidation of the latter to adipic acid
-
-
?
