3.7.1.11: cyclohexane-1,2-dione hydrolase
This is an abbreviated version!
For detailed information about cyclohexane-1,2-dione hydrolase, go to the full flat file.
Reaction
Synonyms
Cdh, ThDP-dependent cyclohexane-1,2-dione hydrolase, thiamine diphosphate dependent cyclohexane-1,2-dione hydrolase
ECTree
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Cofactor
Cofactor on EC 3.7.1.11 - cyclohexane-1,2-dione hydrolase
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FAD
1.0 FAD molecule per enzyme monomer, 2fold Rossmann fold for FAD binding at the C-terminal end
FAD
flavoenzyme, the redox-active cofactor FAD seems not to participate in catalysis, one FAD molecule per enzyme monomer. The FAD cofactor is bound in an extended conformation at the C-terminal end of the six-stranded betab-sheet of the domain beta
thiamine diphosphate
dependent on, 0.8 ThDP per enzyme monomer, ThDP binding motif, overview
additional information
the crystal structure shows a homotetramer with one noncovalently bound FAD and one thiamine diphosphate per monomer
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