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3.6.5.6: tubulin GTPase

This is an abbreviated version!
For detailed information about tubulin GTPase, go to the full flat file.

Word Map on EC 3.6.5.6

Reaction

GTP
+
H2O
=
GDP
 +
phosphate

Synonyms

atypical GTPase, BtubB, cell division protein, EC 3.6.1.51, eFtsZ, FtsZ, FtsZ tubulin-like protein, FtsZDr, gamma-tubulin, GTP phosphohydrolase, GTPase, guanine triphosphatase, guanosine 5'-triphosphatase, guanosine triphosphatase, mFtsZ, ORF156, ribosomal GTPase, TUBG1, tubulin, tubulin FtsZ, tubulin GTPase, tubulin homolog FtsZ, tubulin-colchicine GTPase

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.5 Acting on GTP to facilitate cellular and subcellular movement
                3.6.5.6 tubulin GTPase

Disease

topprint

Disease on EC 3.6.5.6 - tubulin GTPase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
Crystal structure of the open conformation of the mammalian chaperonin CCT in complex with tubulin.
Detection of natural autoantibodies in the serum of anti-HIV-positive individuals.
HIV-1 Tat protein enhances microtubule polymerization.
Incorporation of (14C) leucine into protein and tubulin by brain slices from young and old mice.
Mechanism of defective natural killer cell activity in patients with AIDS is associated with defective distribution of tubulin.
Adenocarcinoma
Customized Adjuvant Chemotherapy Based on Biomarker Examination May Improve Survival of Patients Completely Resected for Non-small-cell Lung Cancer.
Determinants of anti-vascular action by combretastatin A-4 phosphate: role of nitric oxide.
Evidence for downregulation of calcium signaling proteins in advanced mouse adenocarcinoma.
Immunohistochemical analysis of beta-tubulin isotypes in human prostate carcinoma and benign prostatic hypertrophy.
Involvement of the Tubulin Tyrosine Ligase-Like Family Member 4 Polyglutamylase in PELP1 Polyglutamylation and Chromatin Remodeling in Pancreatic Cancer Cells.
Novel combretastatin analogues effective against murine solid tumors: design and structure-activity relationships.
Proteomics indicates modulation of tubulin polymerization by L-menthol inhibiting human epithelial colorectal adenocarcinoma cell proliferation.
Adenocarcinoma of Lung
Ampelopsin-sodium induces apoptosis in human lung adenocarcinoma cell lines by promoting tubulin polymerization in vitro.
betaIII-tubulin is a multifunctional protein involved in drug sensitivity and tumorigenesis in non-small cell lung cancer.
Effect of taxol on vinblastine sulfate-induced crystallization of tubulin.
Linobiflavonoid inhibits human lung adenocarcinoma A549 cells: effect on tubulin protein.
Adenoma, Pleomorphic
Immunohistochemical distribution of tubulin beta II in human normal and neoplastic tissues.
Adenomatous Polyposis Coli
BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes.
Characterization of Hap/BAG-1 variants as RP1 binding proteins with antiapoptotic activity.
Chromosomal localization and promoter analysis of the adenomatous polyposis coli binding protein RP1.
Microtubule self-organization via protein-RNA network crosstalk.
Ageusia
Chronic impairment of axonal transport eliminates taste responses and taste buds.
AIDS-Related Complex
Detection of natural autoantibodies in the serum of anti-HIV-positive individuals.
Albinism, Oculocutaneous
A closer look at evolution: Variants (SNPs) of genes involved in skin pigmentation, including EXOC2, TYR, TYRP1, and DCT, are associated with 25(OH)D serum concentration.
Alzheimer Disease
Acute decrease in alkaline phosphatase after brain injury: A potential mechanism for tauopathy.
Alzheimer disease specific phosphoepitopes of Tau interfere with assembly of tubulin but not binding to microtubules.
Analysis of microtubule-associated protein tau glycation in paired helical filaments.
Antigenic characteristics of neurofibrillary tangles in progressive supranuclear palsy.
Autoantibodies in neurodegenerative diseases: antigen-specific frequencies and intrathecal analysis.
Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: a radioimmuno-slot-blot assay for nanograms of the protein.
Brain t-complex polypeptide 1 (TCP- 1) related to its natural substrate beta1 tubulin is decreased in Alzheimer's disease.
Brain ubiquitin is markedly elevated in Alzheimer disease.
Change in the cytoskeletal system in fibroblasts from patients with familial Alzheimer's disease.
Cytoskeletal neurofilament gene expression in brain tissue from Alzheimer's disease patients. I. Decrease in NF-L and NF-M message.
Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress.
Defective brain microtubule assembly in Alzheimer's disease.
Diminished taxol/GTP-stimulated tubulin polymerization in diseased region of brain from patients with late-onset or inherited Alzheimer's disease or frontotemporal dementia with parkinsonism linked to chromosome-17 but not individuals with mild cognitive impairment.
Direct interaction between selenoprotein P and tubulin.
Do We Need Anti-Prion Compounds to Treat Alzheimer's Disease?
Effect of tacrine, amiridine, akatinol memantine, and triazolam on phosphorylation, structure, and assembly of microtubules from brain microtubular proteins in Alzheimer diseases.
Exchangeable GTP binding site of the beta-subunit of brain tubulin in Alzheimer disease.
Functional studies of Alzheimer's disease tau protein.
Guanosine triphosphate binding to beta-subunit of tubulin in Alzheimer's disease brain: role of microtubule-associated protein tau.
High level of aspartic acid-bond isomerization during the synthesis of an N-linked tau glycopeptide.
Imbalanced Expression of Tau and Tubulin Induces Neuronal Dysfunction in C. elegans Models of Tauopathy.
Impaired tau-microtubule interactions are prevalent among pathogenic tau variants arising from missense mutations.
Incorporation of (14C) leucine into protein and tubulin by brain slices from young and old mice.
Involvement of clusterin and the aggresome in abnormal protein deposits in myofibrillar myopathies and inclusion body myositis.
Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons.
Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels.
Neurofibrillary tangles in Alzheimer's disease and progressive supranuclear palsy: antigenic similarities and differences. Microtubule-associated protein tau antigenicity is prominent in all types of tangles.
Phosphorylated tau can promote tubulin assembly.
PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma.
Real-Time Tau Protein Detection by Sandwich-Based Piezoelectric Biosensing: Exploring Tubulin as a Mass Enhancer.
Reduced proteins in temporal cortex in Alzheimer's disease: an electrophoretic study.
Reduction of neuronal intranuclear rodlets immunoreactive for tubulin and glucocorticoid receptor in Alzheimer's disease.
Reductions in soluble brain proteins in older subjects with Down's syndrome.
Selectively increased oxidative modifications mapped to detergent-insoluble forms of Abeta and beta-III tubulin in Alzheimer's disease.
Sequestration of tubulin in neurons in Alzheimer's disease.
Tau--an inhibitor of deacetylase HDAC6 function.
Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau.
Tubulin and Tau: Possible targets for diagnosis of Parkinson's and Alzheimer's diseases.
Tubulin: Structure, Functions and Roles in Disease.
Ubiquitination and abnormal phosphorylation of paired helical filaments in Alzheimer's disease.
[The pathogenesis of Alzheimer's disease: the effect of aluminum ions on the cytoskeletal protein tubulin]
Ameloblastoma
?TAT1-induced tubulin acetylation promotes ameloblastoma migration and invasion.
Amyotrophic Lateral Sclerosis
Assessing the role of TUBA4A gene in frontotemporal degeneration.
Autoantibodies in neurodegenerative diseases: antigen-specific frequencies and intrathecal analysis.
Brain-specific knockin of the pathogenic Tubb5 E401K allele causes defects in motor coordination and prepulse inhibition.
Kennedy's disease: a triplet repeat disorder or a motor neuron disease?
VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle.
Anemia
Isolation, characterization and sequence of a cDNA encoding gamma-tubulin protein from the fern Anemia phyllitidis L. Sw.
Preliminary investigation about the expression of tubulin in platelets from patients with iron deficiency anemia and thrombocytosis.
Anemia, Iron-Deficiency
Preliminary investigation about the expression of tubulin in platelets from patients with iron deficiency anemia and thrombocytosis.
Anthrax
Insights Into SMAD4 Loss in Pancreatic Cancer From Inducible Restoration of TGF-? Signaling.
Aortic Valve Stenosis
Cytoskeletal role in the transition from compensated to decompensated hypertrophy during adult canine left ventricular pressure overloading.
Arrhythmias, Cardiac
Tubulin polymerization modifies cardiac sodium channel expression and gating.
Arthritis
Antibodies to tubulin and microtubule-associated proteins. A study in diabetes mellitus, systemic lupus erythematosus, and rheumatoid arthritis.
Arthritis, Rheumatoid
Antibodies to tubulin and microtubule-associated proteins. A study in diabetes mellitus, systemic lupus erythematosus, and rheumatoid arthritis.
In silico design of colchicine-based bioisosteric inhibitors of tubulin for the treatment of rheumatoid arthritis.
Asthenozoospermia
A missense mutation in IFT74, encoding for an essential component for intraflagellar transport of Tubulin, causes asthenozoospermia and male infertility without clinical signs of Bardet-Biedl syndrome.
Correction to: A missense mutation in IFT74, encoding for an essential component for intraflagellar transport of Tubulin, causes asthenozoospermia and male infertility without clinical signs of Bardet-Biedl syndrome.
Asthma
Genetic risk factors for decreased bone mineral accretion in children with asthma receiving multiple oral corticosteroid bursts.
Neural autoantibodies in patients with neurological symptoms and histories of chemical/mold exposures.
Neurokinin 1 receptor promotes rat airway smooth muscle cell migration in asthmatic airway remodelling by enhancing tubulin expression.
Astrocytoma
Altered cellular distribution and subcellular sorting of gamma-tubulin in diffuse astrocytic gliomas and human glioblastoma cell lines.
Anti-neoplastic agent thymoquinone induces degradation of ? and ? tubulin proteins in human cancer cells without affecting their level in normal human fibroblasts.
Association of Aurora A and gamma-tubulin expression in astrocytomas and patient survival.
Cell-cycle specific cytotoxicity mediated by stizophyllin (2 alpha,3 beta,12 beta-trihydroxypregna-4,7,16-trien-20-one), a novel electrophilic pregnane isolated from Stizophyllum riparium.
Class III beta-tubulin and gamma-tubulin are co-expressed and form complexes in human glioblastoma cells.
In vivo antitumor activity of 6-benzyl-1,3-benzodioxole derivatives against the P388, L1210, B16, and M5076 murine models.
Integrated proteomic platforms for the comparative characterization of medulloblastoma and pilocytic astrocytoma pediatric brain tumors: a preliminary study.
Ataxia
Longitudinal Evaluation of Cerebellar Signs of H-ABC Tubulinopathy in a Patient and in the taiep Model.
TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development.
Ataxia Telangiectasia
ATM is activated by mitotic stress and suppresses centrosome amplification in primary but not in tumor cells.
Atherosclerosis
Pentoxifylline administration changes protein expression profile of coronary artery disease patients.
Bardet-Biedl Syndrome
A missense mutation in IFT74, encoding for an essential component for intraflagellar transport of Tubulin, causes asthenozoospermia and male infertility without clinical signs of Bardet-Biedl syndrome.
Correction to: A missense mutation in IFT74, encoding for an essential component for intraflagellar transport of Tubulin, causes asthenozoospermia and male infertility without clinical signs of Bardet-Biedl syndrome.
Protein profile of Dabry's sturgeon (Acipenser dabryanus) spermatozoa and relationship to sperm quality.
Bile Duct Neoplasms
Centrosome abnormalities in human carcinomas of the gallbladder and intrahepatic and extrahepatic bile ducts.
Blister
Disruption of microtubules in vivo by vincristine induces large membrane complexes and other cytoplasmic abnormalities in megakaryocytes and platelets of normal rats like those in human and Wistar Furth rat hereditary macrothrombocytopenias.
Ganglioside GM3 is essential for the structural integrity and function of cochlear hair cells.
Myosin IIB and F-Actin Control Apical Vacuolar Morphology and Histamine-Induced Trafficking of H,K-ATPase-Containing Tubulovesicles in Gastric Parietal Cells.
Nocodazole and taxol affect subcellular compartments but not secretory activity of GH3B6 prolactin cells.
Photodynamic therapy-induced apoptosis of HeLa cells.
Rapid and transient reorganization of the cytoskeleton in GH3B6 cells during short-term exposure to thyroliberin.
Substance P induces rapid and transient membrane blebbing in U373MG cells in a p21-activated kinase-dependent manner.
Surface blebbing and cytoskeletal changes induced in vitro by toxin B from Clostridium difficile: an immunochemical and ultrastructural study.
Brain Diseases
Biallelic Mutations in TBCD, Encoding the Tubulin Folding Cofactor D, Perturb Microtubule Dynamics and Cause Early-Onset Encephalopathy.
Effect of experimental colchicine encephalopathy on brain protein synthesis and tubulin metabolism.
Mutation of Ser172 in Yeast ? Tubulin Induces Defects in Microtubule Dynamics and Cell Division.
Reduction of protein kinase MARK4 in the brains of experimental scrapie rodents and human prion disease correlates with deposits of PrP(Sc).
Structural basis of tubulin detyrosination by the vasohibin-SVBP enzyme complex.
The Game of Tubulins.
Brain Injuries, Traumatic
PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma.
Brain Ischemia
Immunohistochemical investigation of ischemic and postischemic damage after bilateral carotid occlusion in gerbils.
Immunohistochemical investigation of regional cerebral ischemia in the gerbil: occlusion of the posterior communicating artery.
Brain Neoplasms
?III-Tubulin Regulates Breast Cancer Metastases to the Brain.
Investigation of structural requirements of anticancer activity at the paclitaxel/tubulin binding site using CoMFA and CoMSIA.
PET: brain tumor biochemistry.
Breast Neoplasms
1,3-Benzodioxole-Modified Noscapine Analogues: Synthesis, Antiproliferative Activity, and Tubulin-Bound Structure.
15-Deoxi-Delta(12,14)-prostaglandin J2 is a tubulin-binding agent that destabilizes microtubules and induces mitotic arrest.
3-Vinylazetidin-2-Ones: Synthesis, Antiproliferative and Tubulin Destabilizing Activity in MCF-7 and MDA-MB-231 Breast Cancer Cells.
4'-Demethyl-deoxypodophyllotoxin glucoside isolated from Podophyllum hexandrum exhibits potential anticancer activities by altering Chk-2 signaling pathway in MCF-7 breast cancer cells.
9-Arylimino noscapinoids as potent tubulin binding anticancer agent: chemical synthesis and cellular evaluation against breast tumour cells.
?-Lactam estrogen receptor antagonists and a dual-targeting estrogen receptor/tubulin ligand.
?III-Tubulin Regulates Breast Cancer Metastases to the Brain.
A new microtubule-targeting compound PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin.
A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs.
A semisynthetic taxane Yg-3-46a effectively evades P-glycoprotein and ?-III tubulin mediated tumor drug resistance in vitro.
An Orally Available Tubulin Inhibitor, VERU-111, Suppresses Triple-Negative Breast Cancer Tumor Growth and Metastasis and Bypasses Taxane Resistance.
Antiproliferative mechanism of action of the novel taxane cabazitaxel as compared with the parent compound docetaxel in MCF7 breast cancer cells.
Antitumor activity of TZT-1027 (Soblidotin).
Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2',3',4'-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a new class of antimitotic antitumor agents.
Antitumor Effect of KX-01 through Inhibiting Src Family Kinases and Mitosis.
Arylthioindoles, potent inhibitors of tubulin polymerization.
Assessing associations between the AURKA-HMMR-TPX2-TUBG1 functional module and breast cancer risk in BRCA1/2 mutation carriers.
Association of ABCB1, ? tubulin I, and III with multidrug resistance of MCF7/DOC subline from breast cancer cell line MCF7.
Association of estrogen receptor alpha and histone deacetylase 6 causes rapid deacetylation of tubulin in breast cancer cells.
Autophagy, cell death and sustained senescence arrest in B16/F10 melanoma cells and HCT-116 colon carcinoma cells in response to the novel microtubule poison, JG-03-14.
BCIRG 001 molecular analysis: prognostic factors in node-positive breast cancer patients receiving adjuvant chemotherapy.
Beta class II tubulin predominates in normal and tumor breast tissues.
Centrosome-related genes, genetic variation, and risk of breast cancer.
Characterization of the pharmacokinetics of a liposomal formulation of eribulin mesylate (E7389) in mice.
Clinical analysis of 21-gene recurrence score test in hormone receptor-positive early-stage breast cancer.
Combinations of paclitaxel and vinblastine and their effects on tubulin polymerization and cellular cytotoxicity: characterization of a synergistic schedule.
CoMFA and docking studies of 2-phenylindole derivatives with anticancer activity.
Conformationally restricted analogs of Combretastatin A-4 derived from SU5416.
CRMP2 is a therapeutic target that suppresses the aggressiveness of breast cancer cells by stabilizing RECK.
Delocalization of gamma-tubulin due to increased solubility in human breast cancer cell lines.
Design, synthesis and biological evaluation of a novel library of antimitotic C2-aroyl/arylimino tryptamine derivatives that are also potent inhibitors of indoleamine-2, 3-dioxygenase (IDO).
Design, synthesis and biological studies of novel tubulin inhibitors.
Design, synthesis and molecular modeling of new 4-phenylcoumarin derivatives as tubulin polymerization inhibitors targeting MCF-7 breast cancer cells.
Design, synthesis, molecular modeling, and biological evaluation of pyrazole-naphthalene derivatives as potential anticancer agents on MCF-7 breast cancer cells by inhibiting tubulin polymerization.
Discovery and structure-activity relationships of (2-(arylthio)benzylideneamino)guanidines as a novel series of potent apoptosis inducers.
Dose-intense taxol: high response rate in patients with platinum-resistant recurrent ovarian cancer.
Effect of an aryl chloroethyl urea on tubulin and vimentin syntheses in a human breast cancer cell line.
Effect of CH-35, a novel anti-tumor colchicine analogue, on breast cancer cells overexpressing the ?III isotype of tubulin.
Effect of stathmin on the sensitivity to antimicrotubule drugs in human breast cancer.
Effects of tubulin-inhibiting agents in human lung and breast cancer cell lines with different multidrug resistance phenotypes.
Electrochemical approach for monitoring the effect of anti tubulin drugs on breast cancer cells based on silicon nanograss electrodes.
Epithelial-to-mesenchymal transition promotes tubulin Detyrosination and Microtentacles that enhance endothelial engagement.
Eribulin in the Management of Advanced Breast Cancer: Implications of Current Research Findings.
Ferulin C triggers potent PAK1 and p21-mediated anti-tumor effects in breast cancer by inhibiting Tubulin polymerization in vitro and in vivo.
G-1 inhibits breast cancer cell growth via targeting colchicine-binding site of tubulin to interfere with microtubule assembly.
Gallic acid based steroidal phenstatin analogues for selective targeting of breast cancer cells through inhibiting tubulin polymerization.
Genetics and Expression Profile of the Tubulin Gene Superfamily in Breast Cancer Subtypes and Its Relation to Taxane Resistance.
Growth arrest by the antitumor steroidal lactone withaferin A in human breast cancer cells is associated with down-regulation and covalent binding at cysteine 303 of ?-tubulin.
Identification by mass spectrometry of a new alpha-tubulin isotype expressed in human breast and lung carcinoma cell lines.
Identification of gallic acid based glycoconjugates as a novel tubulin polymerization inhibitors.
In silico design of novel tubulin binding 9-arylimino derivatives of noscapine, their chemical synthesis and cellular activity as potent anticancer agents against breast cancer.
In vivo measurement of microtubule dynamics using stable isotope labeling with heavy water. Effect of taxanes.
Inhibition of centromere dynamics by eribulin (E7389) during mitotic metaphase.
Inhibition of tubulin polymerization by 5,6-dihydroindolo[2,1-alpha]isoquinoline derivatives.
Inhibition of tumor-associated fatty acid synthase activity enhances vinorelbine (Navelbine)-induced cytotoxicity and apoptotic cell death in human breast cancer cells.
Kinesin-1 translocation: Surprising differences between bovine brain and MCF7-derived microtubules.
Lead identification of conformationally restricted ?-lactam type combretastatin analogues: Synthesis, antiproliferative activity and tubulin targeting effects.
Local anesthetics inhibit kinesin motility and microtentacle protrusions in human epithelial and breast tumor cells.
Long non-coding RNA Tubulin Alpha 4B (TUBA4B) inhibited breast cancer proliferation and invasion by directly targeting miR-19.
MCF7 microtubules: Cancer microtubules with relatively slow and stable dynamic in vitro.
Measuring the persistence length of MCF7 cell microtubules in vitro.
Metastatic breast tumors express increased tau, which promotes microtentacle formation and the reattachment of detached breast tumor cells.
Methoxy-substituted 3-formyl-2-phenylindoles inhibit tubulin polymerization.
Methyl 5-[(1H-indol-3-yl)selanyl]-1H-benzoimidazol-2-ylcarbamate (M-24), a novel tubulin inhibitor, causes G2/M arrest and cell apoptosis by disrupting tubulin polymerization in human cervical and breast cancer cells.
Microtubule depolymerization and phosphorylation of c-Jun N-terminal kinase-1 and p38 were involved in gambogic acid induced cell cycle arrest and apoptosis in human breast carcinoma MCF-7 cells.
Microtubule-targeted chemotherapeutic agents inhibit signal transducer and activator of transcription 3 (STAT3) signaling.
Mitotic arrest of endometrial epithelium after paclitaxel therapy for breast cancer.
New Colchicine-Derived Triazoles and Their Influence on Cytotoxicity and Microtubule Morphology.
Novel chemotypes targeting tubulin at the colchicine binding site and unbiasing P-glycoprotein.
Novel mutations involving ?I-, ?IIA-, or ?IVB-tubulin isotypes with functional resemblance to ?III-tubulin in breast cancer.
Novel second generation analogs of eribulin. Part III: Blood-brain barrier permeability and in vivo activity in a brain tumor model.
Occurrence of nuclear beta(II)-tubulin in cultured cells.
Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-?B inhibition.
Perturbation of tubulin structure by stellate gold nanoparticles retards MDA-MB-231 breast cancer cell viability.
Phase I-II study of vorinostat plus paclitaxel and bevacizumab in metastatic breast cancer: evidence for vorinostat-induced tubulin acetylation and Hsp90 inhibition in vivo.
Pilot study of vinorelbine (Navelbine) and paclitaxel (Taxol) in patients with refractory breast cancer and lung cancer.
Pyranocarbazole derivatives as potent anti-cancer agents triggering tubulin polymerization stabilization induced activation of caspase-dependent apoptosis and downregulation of Akt/mTOR in breast cancer cells.
Rational design, chemical synthesis and cellular evaluation of novel 1,3-diynyl derivatives of noscapine as potent tubulin binding anticancer agents.
Resveratrol analog trans 3,4,5,4'-tetramethoxystilbene (DMU-212) mediates anti-tumor effects via mechanism different from that of resveratrol.
Reversible posterior leukoencephalopathy syndrome induced by vinorelbine.
Self-assembled supramolecular nanomicelles from a bile acid-docetaxel conjugate are highly tolerable with improved therapeutic efficacy.
Septin cooperation with tubulin polyglutamylation contributes to cancer cell adaptation to taxanes.
Septin filament coalignment with microtubules depends on SEPT9_i1 and tubulin polyglutamylation, and is an early feature of acquired cell resistance to paclitaxel.
Silencing of tubulin binding cofactor C modifies microtubule dynamics and cell cycle distribution and enhances sensitivity to gemcitabine in breast cancer cells.
SPIKET and COBRA compounds as novel tubulin modulators with potent anticancer activity.
Spongistatins as tubulin targeting agents.
Structure-activity analysis of the interaction of curacin A, the potent colchicine site antimitotic agent, with tubulin and effects of analogs on the growth of MCF-7 breast cancer cells.
Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode.
Structure-based design of a novel synthetic spiroketal pyran as a pharmacophore for the marine natural product spongistatin 1.
Sulforaphane inhibits human MCF-7 mammary cancer cell mitotic progression and tubulin polymerization.
Synergistic Anticancer Effect of Peptide-Docetaxel Nanoassembly Targeted to Tubulin: Toward Development of Dual Warhead Containing Nanomedicine.
Synthesis and Biochemical Evaluation of 3-Phenoxy-1,4-diarylazetidin-2-ones as Tubulin-Targeting Antitumor Agents.
Synthesis and biological evaluation of 1,1-dichloro-2,3-diarylcyclopropanes as antitubulin and anti-breast cancer agents.
Synthesis and biological evaluation of imidazo[1,5-a]pyridine-benzimidazole hybrids as inhibitors of both tubulin polymerization and PI3K/Akt pathway.
Synthesis and biological evaluation of new 2-methoxyestradiol derivatives: Potent inhibitors of angiogenesis and tubulin polymerization.
Synthesis and biological evaluation of oxazinonaphthalene-3-one derivatives as potential anticancer agents and tubulin inhibitors.
Synthesis and evaluation of azetidinone analogues of combretastatin A-4 as tubulin targeting agents.
Synthesis and in Vitro Bioactivity of Polyunsaturated Fatty Acid Conjugates of Combretastatin A-4.
Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site.
Synthesis, biological evaluation, and molecular modelling of new naphthalene-chalcone derivatives as potential anticancer agents on MCF-7 breast cancer cells by targeting tubulin colchicine binding site.
Synthesis, Evaluation for Cytotoxicity and Molecular Docking Studies of Benzo[c]furan-Chalcones for Potential to Inhibit Tubulin Polymerization and/or EGFR-Tyrosine Kinase Phosphorylation.
Targeting the autophagy promoted antitumor effect of T-DM1 on HER2-positive gastric cancer.
The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly.
TITAN: phase III study of doxorubicin/cyclophosphamide followed by ixabepilone or paclitaxel in early-stage triple-negative breast cancer.
Total synthesis and anti-tubulin activity of epi-c3 analogues of cryptophycin-24.
Total synthesis and antitubulin activity of c10 analogues of cryptophycin-24.
Total synthesis and evaluation of C25-benzyloxyepothilone C for tubulin assembly and cytotoxicity against MCF-7 breast cancer cells.
Tubulin binding cofactor C (TBCC) suppresses tumor growth and enhances chemosensitivity in human breast cancer cells.
Tubulin detyrosination is a frequent occurrence in breast cancers of poor prognosis.
Validation of the pharmacodynamics of BMS-247550, an analogue of epothilone B, during a phase I clinical study.
Vimentin filaments support extension of tubulin-based microtentacles in detached breast tumor cells.
Vinflunine: a new active drug for second-line treatment of advanced breast cancer. Results of a phase II and pharmacokinetic study in patients progressing after first-line anthracycline/taxane-based chemotherapy.
Vinorelbine-induced neurotoxicity in patients with advanced breast cancer pretreated with paclitaxel--a phase II study.
[A quantitative immuno-fluorescence analysis of alpha-tubulin and gamma-tubulin proteins in precancerous lesion and carcinoma of the breast and their clinical significance]
[Expression of alpha-tubulin and gamma-tubulin in premalignant lesion and carcinoma of breast and the significance thereof]
[F-actin aggregates and aberrations of cytoskeletal organization of microfilaments and microtubules in human breast carcinoma cells]
[Recent development of new anticancer drugs in Japan]
Bronchiolitis Obliterans
Circulating exosomes with lung self-antigens as a biomarker for chronic lung allograft dysfunction: A retrospective analysis.
Bulbo-Spinal Atrophy, X-Linked
Kennedy's disease: a triplet repeat disorder or a motor neuron disease?
Burkholderia Infections
Chemical, Metabolic, and Cellular Characterization of a FtsZ Inhibitor Effective Against Burkholderia cenocepacia.
Burkitt Lymphoma
A new anti-tubulin agent containing the benzo[b]thiophene ring system.
Antitumor agents--CLXXV. Anti-tubulin action of (+)-thiocolchicine prepared by partial synthesis.
Antitumor agents. 172. Synthesis and biological evaluation of novel deacetamidothiocolchicin-7-ols and ester analogs as antitubulin agents.
Carcinogenesis
A novel tubulin inhibitor STK899704 induces tumor regression in DMBA/TPA-induced skin carcinogenesis model.
Beta class II tubulin predominates in normal and tumor breast tissues.
Cadmium-induced multistep transformation of cultured Indian muntjac skin fibroblasts.
Covalent binding of reactive estrogen metabolites to microtubular protein as a possible mechanism of aneuploidy induction and neoplastic cell transformation.
Deregulated DNA polymerase beta induces chromosome instability and tumorigenesis.
HDAC6: Physiological function and its selective inhibitors for cancer treatment.
Identification of a gamma-tubulin-binding domain in BRCA1.
Identification of a novel transcript isoform of the TTLL12 gene in human cancers.
Increased levels of a unique post-translationally modified betaIVb-tubulin isotype in liver cancer.
Potential role of tubulin tyrosine ligase-like enzymes in tumorigenesis and cancer cell resistance.
STMN1 is Overexpressed in Adrenocortical Carcinoma and Promotes a More Aggressive Phenotype In Vitro.
The Aneugenicity of Ketone Bodies in Colon Epithelial Cells Is Mediated by Microtubule Hyperacetylation and Is Blocked by Resveratrol.
Time- and dose-dependent effects of curcumin on gene expression in human colon cancer cells.
Tubulin targets in the pathobiology and therapy of glioblastoma multiforme. II. gamma-tubulin.
Tubulin tyrosine ligase like 12, link to prostate cancer through tubulin post-translational modification and chromosome ploidy.
[A quantitative immuno-fluorescence analysis of alpha-tubulin and gamma-tubulin proteins in precancerous lesion and carcinoma of the breast and their clinical significance]
Carcinoma
A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells.
Acetylated Tubulin (AT) as a Prognostic Marker in Squamous Cell Carcinoma of the Head and Neck.
Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)).
Anaplastic thyroid carcinoma: palliation or treatment?
Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2',3',4'-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a new class of antimitotic antitumor agents.
Apoptotic-like death occurs through a caspase-independent route in colon carcinoma cells undergoing mitotic catastrophe.
Application of ensemble pharmacophore-based virtual screening to the discovery of novel antimitotic tubulin inhibitors.
Arsenic trioxide produces polymerization of microtubules and mitotic arrest before apoptosis in human tumor cell lines.
Association of estramustine resistance in human prostatic carcinoma cells with modified patterns of tubulin expression.
Bcl-xL is phosphorylated in malignant cells following microtubule disruption.
beta tubulin mutations are rare in human ovarian carcinoma.
Beta-tubulin epitope expression in normal and malignant epithelial cells.
Centrosomal abnormality is common in and a potential biomarker for bladder cancer.
Clinical pharmacology and metabolism of Taxol (paclitaxel): update 1993.
Comparative proteomic analysis of esophageal squamous cell carcinoma.
Delineating the interaction of combretastatin A-4 with ?? tubulin isotypes present in drug resistant human lung carcinoma using a molecular modeling approach.
Design, synthesis, biological evaluation, and molecular docking of new benzofuran and indole derivatives as tubulin polymerization inhibitors.
Distribution of the cytoskeletal protein beta-tubulin in normal lung, cryptogenic fibrosing alveolitis and lung tumours.
Estramustine-based chemotherapy.
Exploring the interaction of Peloruside-A with drug resistant ??II and ??III tubulin isotypes in human ovarian carcinoma using a molecular modeling approach.
Expression of class II beta-tubulin in non-melanoma cutaneous tumors.
FB-15 inhibits MGC-803 cells growth by regulating energy metabolism.
Gamma tubulin: a promising indicator of recurrence in squamous cell carcinoma of the larynx.
GAPD and tubulin are suitable internal controls for qPCR analysis of oral squamous cell carcinoma cell lines.
Human papillomavirus infection, centrosome aberration, and genetic stability in cervical lesions.
Immunohistochemical distribution of tubulin beta II in human normal and neoplastic tissues.
Immunohistochemistry of the cytoskeleton of human prostatic epithelium. Evidence for disturbed organization in neoplasia.
Increased expression of centrosomal alpha, gamma-tubulin in atypical ductal hyperplasia and carcinoma of the breast.
Increased gamma-tubulin expression and P16INK4A promoter methylation occur together in preinvasive lesions and carcinomas of the breast.
Interaction of estramustine with tubulin isotypes.
Microsatellite analysis of the APC gene and immunoexpression of E-cadherin, catenin, and tubulin in esophageal squamous cell carcinoma.
Mitotic arrest of endometrial epithelium after paclitaxel therapy for breast cancer.
Modulation of endogenous beta-tubulin isotype expression as a result of human beta(III)cDNA transfection into prostate carcinoma cells.
Nanomolar concentrations of epothilone D inhibit the proliferation of glioma cells and severely affect their tubulin cytoskeleton.
Novel antimitotic agents related to tubuloclustin: synthesis and biological evaluation.
Occurrence of nuclear beta(II)-tubulin in cultured cells.
Oncoprotein 18 overexpression increases the sensitivity to vindesine in the human lung carcinoma cells.
Overexpression of kalpha1 tubulin mRNA in thyroid anaplastic carcinoma.
Paclitaxel selects for mutant or pseudo-null p53 in drug resistance associated with tubulin mutations in human cancer.
Paclitaxel-resistant human ovarian cancer cells undergo c-Jun NH2-terminal kinase-mediated apoptosis in response to noscapine.
Phase 3 Trials of Tirbanibulin Ointment for Actinic Keratosis.
Polyploidisation of metastatic colon carcinoma cells by microtubule and tubulin interacting drugs: effect on proteolytic activity and invasiveness.
Pretreatment by tubulin agents decreases C-MYC induction in human colon carcinoma cell line HT29-D4.
Resistance to the tubulin-binding agents in renal cell carcinoma: no mutations in the class I beta-tubulin gene but changes in tubulin isotype protein expression.
Sulforaphane: a naturally occurring mammary carcinoma mitotic inhibitor, which disrupts tubulin polymerization.
Synergistic antitumor effects of novel HDAC inhibitors and paclitaxel in vitro and in vivo.
Synergistic interaction between cisplatin and taxol in human ovarian carcinoma cells in vitro.
Synthesis and antiproliferative activity of 6-phenylaminopurines.
Synthesis and biological assessment of simplified analogues of the potent microtubule stabilizer (+)-discodermolide.
Synthesis and cytotoxic activity of 2-acyl-1H-indole-4,7-diones on human cancer cell lines.
Targeting Src and tubulin in mucinous ovarian carcinoma.
The potent microtubule-stabilizing agent (+)-discodermolide induces apoptosis in human breast carcinoma cells--preliminary comparisons to paclitaxel.
The pro-oxidant buthionine sulfoximine (BSO) reduces tumor growth of implanted Lewis lung carcinoma in mice associated with increased protein carbonyl, tubulin abundance, and aminopeptidase activity.
The von Hippel-Lindau tumor suppressor protein influences microtubule dynamics at the cell periphery.
Theaflavins depolymerize microtubule network through tubulin binding and cause apoptosis of cervical carcinoma HeLa cells.
Tubal origin of 'ovarian' low-grade serous carcinoma.
Tubulin ?-6 chain is a stably expressed reference gene in archival samples of normal oral tissue and oral squamous cell carcinoma.
Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin.
Tubulin Beta Chain, Filamin A Alpha Isoform 1, and Cytochrome b-c1 Complex Subunit 1 As Serological Diagnostic Biomarkers of Esophageal Squamous Cell Carcinoma: A Proteomics Study.
Tubulin from paclitaxel-resistant cells as a probe for novel antimicrotubule agents.
[A quantitative immuno-fluorescence analysis of alpha-tubulin and gamma-tubulin proteins in precancerous lesion and carcinoma of the breast and their clinical significance]
[Conjugate of podophyllotoxin with chlorambucil: synthesis, biological testing and molecular modeling].
[Expression of alpha-tubulin and gamma-tubulin in premalignant lesion and carcinoma of breast and the significance thereof]
Carcinoma, Basal Cell
Expression of class II beta-tubulin in non-melanoma cutaneous tumors.
Immunohistochemical distribution of tubulin beta II in human normal and neoplastic tissues.
Carcinoma, Ductal
Epithelial-to-mesenchymal transition promotes tubulin Detyrosination and Microtentacles that enhance endothelial engagement.
Increased expression of centrosomal alpha, gamma-tubulin in atypical ductal hyperplasia and carcinoma of the breast.
[A quantitative immuno-fluorescence analysis of alpha-tubulin and gamma-tubulin proteins in precancerous lesion and carcinoma of the breast and their clinical significance]
[Expression of alpha-tubulin and gamma-tubulin in premalignant lesion and carcinoma of breast and the significance thereof]
Carcinoma, Ehrlich Tumor
Assembly of nonneural microtubules in the absence of glycerol and microtubule-associated proteins.
Catecholamine-induced stimulation of adenylate cyclase in parallel with a change in tubulin assembly in Ehrlich ascites tumor cells.
Comparison of tyrosine protein kinases in membrane fractions from mouse liver and Ehrlich ascites tumor.
In vitro formation of different tubulin polymers from purified tubulin of Ehrlich ascites tumor cells.
Interaction of triethyl lead chloride with microtubules in vitro and in mammalian cells.
Carcinoma, Embryonal
Complexes of gamma-tubulin with nonreceptor protein tyrosine kinases Src and Fyn in differentiating P19 embryonal carcinoma cells.
Differential sorting of beta tubulin isotypes into colchicine-stable microtubules during neuronal and muscle differentiation of embryonal carcinoma cells.
Effects of methylmercury on retinoic acid-induced neuroectodermal derivatives of embryonal carcinoma cells.
Regulation of microtubule nucleation from membranes by complexes of membrane-bound gamma-tubulin with Fyn kinase and phosphoinositide 3-kinase.
The effects of methylmercury on the cytoskeleton of murine embryonal carcinoma cells.
Carcinoma, Hepatocellular
1,3,4-oxadiazole-2-thione Derivatives; Novel Approach for Anticancer and Tubulin Polymerization Inhibitory Activities.
A Chimeric Cetuximab-Functionalized Corona as a Potent Delivery System for Microtubule-Destabilizing Nanocomplexes to Hepatocellular Carcinoma Cells: A Focus on EGFR and Tubulin Intracellular Dynamics.
A highly potent maytansinoid analogue and its use as a cytotoxic therapeutic agent in gold nanoparticles for the treatment of hepatocellular carcinoma.
Antitumor and antivascular effects of AC-7700, a combretastatin A-4 derivative, against rat liver cancer.
Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity.
Enhanced anticancer effect of Combretastatin A-4 phosphate when combined with vincristine in the treatment of hepatocellular carcinoma.
Identification of differentially expressed proteins between human hepatoma and normal liver cell lines by two-dimensional electrophoresis and liquid chromatography-ion trap mass spectrometry.
MIL-1, a novel antitumor agent derived from natural product millepachine, acts as tubulin polymerization inhibitor for the treatment of hepatocellular carcinoma.
Phenylazoxycyanide damages microtubular protein more than its reference antibiotic, calvatic acid.
Phosphorylation of voltage-dependent anion channel by serine/threonine kinases governs its interaction with tubulin.
Regulation of mitochondrial function by voltage dependent anion channels in ethanol metabolism and the Warburg effect.
Synthesis and activity evaluation of benzoylurea derivatives as potential antiproliferative agents.
Synthesis and biological evaluation of 2,4,5-substituted pyrimidines as a new class of tubulin polymerization inhibitors.
Tivantinib induces G2/M arrest and apoptosis by disrupting tubulin polymerization in hepatocellular carcinoma.
Tubulin alpha 8 is expressed in hepatic stellate cells and is induced in transformed hepatocytes.
Up-regulation of 42 kDa tubulin alpha-6 chain fragment in well-differentiated hepatocellular carcinoma tissues from patients infected with hepatitis C virus.
Vacuole formation and cytokeratin rearrangement of hepatoma cells induced by teleocidin are not associated with down-regulation of protein kinase C.
Carcinoma, Intraductal, Noninfiltrating
Epithelial-to-mesenchymal transition promotes tubulin Detyrosination and Microtentacles that enhance endothelial engagement.
Increased expression of centrosomal alpha, gamma-tubulin in atypical ductal hyperplasia and carcinoma of the breast.
[A quantitative immuno-fluorescence analysis of alpha-tubulin and gamma-tubulin proteins in precancerous lesion and carcinoma of the breast and their clinical significance]
Carcinoma, Large Cell
Distribution of the cytoskeletal protein beta-tubulin in normal lung, cryptogenic fibrosing alveolitis and lung tumours.
Carcinoma, Lewis Lung
The pro-oxidant buthionine sulfoximine (BSO) reduces tumor growth of implanted Lewis lung carcinoma in mice associated with increased protein carbonyl, tubulin abundance, and aminopeptidase activity.
Carcinoma, Non-Small-Cell Lung
Anti-tumor selectivity of a novel tubulin and HSP90 dual-targeting inhibitor in non-small cell lung cancer models.
Docetaxel in non-small cell lung cancer: a review.
Emerging treatment using tubulin inhibitors in advanced non-small cell lung cancer.
Expression of class III beta tubulin in non-small cell lung cancer is correlated with resistance to taxane chemotherapy.
Expression of ERCC1 and class IIIbeta tubulin for predicting effect of carboplatin/paclitaxel in patients with advanced inoperable non-small cell lung cancer.
Inhalable nanostructured lipid particles of 9-bromo-noscapine, a tubulin-binding cytotoxic agent: Invitro and in vivo studies.
Mitotic arrest of endometrial epithelium after paclitaxel therapy for breast cancer.
New Colchicine-Derived Triazoles and Their Influence on Cytotoxicity and Microtubule Morphology.
PAQR3 suppresses the growth of non-small cell lung cancer cells via modulation of EGFR-mediated autophagy.
Synergistic interaction of gemcitabine and paclitaxel by modulating acetylation and polymerization of tubulin in non-small cell lung cancer cell lines.
The anthelmintic drug mebendazole induces mitotic arrest and apoptosis by depolymerizing tubulin in non-small cell lung cancer cells.
The newly synthesized 2-arylnaphthyridin-4-one, CSC-3436, induces apoptosis of non-small cell lung cancer cells by inhibiting tubulin dynamics and activating CDK1.
The role of betaIII tubulin in predicting chemoresistance in non-small cell lung cancer.
Tubulin inhibitors in non-small cell lung cancer: looking back and forward.
[Class III beta tubulin expression in nonsmall cell lung cancer]
[Recent development of new anticancer drugs in Japan]
Carcinoma, Ovarian Epithelial
Eribulin mesylate (halichondrin B analog E7389) in platinum-resistant and platinum-sensitive ovarian cancer: A 2-cohort, phase 2 study.
Carcinoma, Papillary
Overexpression of kalpha1 tubulin mRNA in thyroid anaplastic carcinoma.
Carcinoma, Renal Cell
Resistance to the tubulin-binding agents in renal cell carcinoma: no mutations in the class I beta-tubulin gene but changes in tubulin isotype protein expression.
The von Hippel-Lindau tumor suppressor protein influences microtubule dynamics at the cell periphery.
Carcinoma, Squamous Cell
Acetylated Tubulin (AT) as a Prognostic Marker in Squamous Cell Carcinoma of the Head and Neck.
Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2',3',4'-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a new class of antimitotic antitumor agents.
Beta-tubulin epitope expression in normal and malignant epithelial cells.
Comparative proteomic analysis of esophageal squamous cell carcinoma.
Expression of class II beta-tubulin in non-melanoma cutaneous tumors.
Gamma tubulin: a promising indicator of recurrence in squamous cell carcinoma of the larynx.
Trafficking of beta2-adrenergic receptors: insulin and beta-agonists regulate internalization by distinct cytoskeletal pathways.
Carcinosarcoma
Evaluation of the anti-vascular effects of combretastatin in rodent tumours by dynamic contrast enhanced MRI.
Cardiomegaly
Cardiac hypertrophic and developmental regulation of the beta-tubulin multigene family.
Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: II. Cytoskeletal remodeling.
Role of microtubules in myocyte contractile dysfunction during cardiac hypertrophy in the rat.
Cardiomyopathies
Modulation of Ca(2+) signaling by microtubule disruption in rat ventricular myocytes and its dependence on the ruptured patch-clamp configuration.
Role of microtubules in the contractile dysfunction of myocytes from tachycardia-induced dilated cardiomyopathy.
Cardiomyopathy, Dilated
Impairment of the myocardial ultrastructure and changes of the cytoskeleton in dilated cardiomyopathy.
Cardiomyopathy, Hypertrophic
Proteomic and Functional Studies Reveal Detyrosinated Tubulin as Treatment Target in Sarcomere Mutation-Induced Hypertrophic Cardiomyopathy.
Tubulin Detyrosination: An Emerging Therapeutic Target in Hypertrophic Cardiomyopathy.
Cardiotoxicity
Primary endothelial damage is the mechanism of cardiotoxicity of tubulin-binding drugs.
[Cardiac toxicity of cancer treatment regimes in children and adolescents: physiopathology, clinical data and the paediatric oncologist's point of view]
Cardiovascular Diseases
Tubulin hyperacetylation is adaptive in cardiac proteotoxicity by promoting autophagy.
Cat-Scratch Disease
Use of the cell division protein FtsZ as a means of differentiating among Bartonella species.
Cataract
Activation of aldose reductase by interaction with tubulin and involvement of this mechanism in diabetic cataract formation.
Cervical Intraepithelial Neoplasia
Human papillomavirus infection, centrosome aberration, and genetic stability in cervical lesions.
Chagas Disease
Novel drug design for Chagas disease via targeting Trypanosoma cruzi tubulin: Homology modeling and binding pocket prediction on Trypanosoma cruzi tubulin polymerization inhibition by naphthoquinone derivatives.
Charcot-Marie-Tooth Disease
Altered neurofilament phosphorylation and beta tubulin isotypes in Charcot-Marie-Tooth disease type 1.
Chediak-Higashi Syndrome
Tubulin tyrosinolation in human polymorphonuclear leukocytes: studies in normal subjects and in patients with the Chediak-Higashi syndrome.
Cholangiocarcinoma
Centrosome abnormalities in human carcinomas of the gallbladder and intrahepatic and extrahepatic bile ducts.
Tubulin ?-III: a novel immunohistochemical marker for intrahepatic peripheral cholangiocarcinoma.
Cholera
Adenine nucleotides directly stimulate pertussis toxin.
ADP-ribosylation of microtubule proteins as catalyzed by cholera toxin.
ADPRibosylation of chicken red cell tubulin and inhibition of microtubule self-assembly in vitro by the NAD(+)-dependent avian ADPRibosyl transferase.
Changes of GTP binding proteins, not neurofilament-associated proteins, in the brain of the neurofilament-deficient quail, "Quiver".
Cyclic AMP-independent stimulation of steroidogenesis in Y-1 adrenal tumor cells by antimitotic agents.
Cytosolic G{alpha}s Acts as an Intracellular Messenger to Increase Microtubule Dynamics and Promote Neurite Outgrowth.
Differential role of microtubules in the control of prostaglandin E2 and beta-adrenergic stimulation of cyclic AMP accumulation in the rat myometrium.
GD3 ganglioside is prevalent in fully differentiated neurons from rat retina.
Microtubule assembly in cultivated Greene melanoma cells is stimulated by dibutyryl adenosine 3':5'-cyclic monophosphate or cholera toxin.
Microtubule protein ADP-ribosylation in vitro leads to assembly inhibition and rapid depolymerization.
Natural flavonoid morin showed anti-bacterial activity against Vibrio cholera after binding with cell division protein FtsA near ATP binding site.
Regulation of acetyl-CoA carboxylase by ADP-ribosylation.
Tubulin adenosine diphosphate ribosylation is catalyzed by cholera toxin.
Cholestasis
Trimethylcolchicinic acid decreases liver fibrosis and cholestasis induced by prolonged biliary obstruction in the rat.
Chondroblastoma
Expression of tau proteins and tubulin in extraskeletal myxoid chondrosarcoma, chordoma, and other chondroid tumors.
Chondrosarcoma
Expression of tau proteins and tubulin in extraskeletal myxoid chondrosarcoma, chordoma, and other chondroid tumors.
Extraskeletal myxoid chondrosarcoma characterized by microtubular aggregates in the rough endoplasmic reticulum and tubulin immunoreactivity.
Chordoma
Expression of tau proteins and tubulin in extraskeletal myxoid chondrosarcoma, chordoma, and other chondroid tumors.
Microtubular aggregates in the rough endoplasmic reticulum of sacrococcygeal chordoma.
Chorea
Anti-streptococcal, tubulin, and dopamine receptor 2 antibodies in children with PANDAS and Tourette syndrome: Single-point and longitudinal assessments.
Tubulin is a neuronal target of autoantibodies in Sydenham's chorea.
Ciliopathies
Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules.
Cytoplasmic carboxypeptidase 5 regulates tubulin glutamylation and zebrafish cilia formation and function.
Mutation of NEKL-4/NEK10 and TTLL genes suppress neuronal ciliary degeneration caused by loss of CCPP-1 deglutamylase function.
Role of tubulin acetylation in cellular functions and diseases.
Classical Lissencephalies and Subcortical Band Heterotopias
Refining the phenotype of alpha-1a Tubulin (TUBA1A) mutation in patients with classical lissencephaly.
Colitis
Simultaneous quantification of enterotoxins tilimycin and tilivalline in biological matrices using HPLC high resolution ESMS2 based on isotopically 15N-labeled internal standards.
Colonic Neoplasms
1-Phenyl-dihydrobenzoindazoles as novel colchicine site inhibitors: Structural basis and antitumor efficacy.
?-III tubulin modulates the behavior of Snail overexpressed during the epithelial-to-mesenchymal transition in colon cancer cells.
Antitumor Activity of Asperphenin A, a Lipopeptidyl Benzophenone from Marine-Derived Aspergillus sp. Fungus, by Inhibiting Tubulin Polymerization in Colon Cancer Cells.
Apicularen A acetate induces cell death via AIF translocation and disrupts the microtubule network by down-regulating tubulin in HM7 human colon cancer cells.
Apicularen A Induces Cell Death through Fas Ligand Up-Regulation and Microtubule Disruption by Tubulin Down-Regulation in HM7 Human Colon Cancer Cells.
Discovery of oxyepiberberine as a novel tubulin polymerization inhibitor and an anti-colon cancer agent against LS-1034 cells.
Dual inhibition of topoisomerase II and tubulin polymerization by azatoxin, a novel cytotoxic agent.
Epothilones induce human colon cancer SW620 cell apoptosis via the tubulin polymerization independent activation of the nuclear factor-kappaB/IkappaB kinase signal pathway.
Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4.
Synthesis and biological evaluation of 7-methoxy-1-(3,4,5-trimethoxyphenyl)-4,5-dihydro-2H-benzo[e]indazoles as new colchicine site inhibitors.
Synthesis and biological evaluation of new 3-amino-2-azetidinone derivatives as anti-colorectal cancer agents.
Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon.
Tubulin inhibitory activity of a novel colchicine-binding compounds based on a dinaphthospiropyranran scaffold.
Colorectal Neoplasms
5-(3,4,5-trimethoxybenzoyl)-4-methyl-2-(p-tolyl) imidazol (BZML) targets tubulin and DNA to induce anticancer activity and overcome multidrug resistance in colorectal cancer cells.
CircTUBGCP3 Contributes to the Malignant Progression of Rectal Cancer.
Identification alpha-2-HS-glycoprotein precursor and tubulin beta chain as serology diagnosis biomarker of colorectal cancer.
Inhibition of microtubule assembly and cytotoxic effect of graphene oxide on human colorectal carcinoma cell HCT116.
Knockdown of Tubulin Polymerization Promoting Protein Family Member 3 inhibits cell proliferation and invasion in human colorectal cancer.
Liposomes as Delivery System of a Sn(IV) Complex for Cancer Therapy.
Low expression of lncRNA TUBA4B promotes proliferation and inhibits apoptosis of colorectal cancer cells via regulating P15 and P16 expressions.
Moscatilin induces apoptosis in human colorectal cancer cells: a crucial role of c-Jun NH2-terminal protein kinase activation caused by tubulin depolymerization and DNA damage.
MPT0B169 and MPT0B002, New Tubulin Inhibitors, Induce Growth Inhibition, G2/M Cell Cycle Arrest, and Apoptosis in Human Colorectal Cancer Cells.
Nucleation capacity and presence of centrioles define a distinct category of centrosome abnormalities that induces multipolar mitoses in cancer cells.
Numerical and structural centrosome aberrations are an early and stable event in the adenoma-carcinoma sequence of colorectal carcinomas.
PMN inhibits colorectal cancer cells through inducing mitotic arrest and p53-dependent apoptosis via the inhibition of tubulin polymerization.
PPARgamma Inhibitors as Novel Tubulin-Targeting Agents.
PPARgamma inhibitors reduce tubulin protein levels by a PPARgamma, PPARdelta and proteasome-independent mechanism, resulting in cell cycle arrest, apoptosis and reduced metastasis of colorectal carcinoma cells.
Synthesis and antiproliferative evaluation of pyrazolo[1,5-a]-1,3,5-triazine myoseverin derivatives.
Up-regulation of hnRNP A1, Ezrin, tubulin ?-2C and Annexin A1 in sentinel lymph nodes of colorectal cancer.
[BETA-III TUBULIN AS A POTENTIAL TARGET FOR BLOCKING INVASIVE GROWTH OF MALIGNANT EPITHELIAL TUMORS].
Cone Dystrophy
Novel TTLL5 Variants Associated with Cone-Rod Dystrophy and Early-Onset Severe Retinal Dystrophy.
Cone-Rod Dystrophies
Novel TTLL5 Variants Associated with Cone-Rod Dystrophy and Early-Onset Severe Retinal Dystrophy.
Confusion
Altered Loyalties of Neuronal Markers in Cultured Slices of Resected Human Brain Tissue.
Plasmodium chaperonin TRiC/CCT identified as a target of the antihistamine clemastine using parallel chemoproteomic strategy.
Variations of chromatin, tubulin and actin structures in primate oocytes arrested during in vitro maturation and fertilization-what is this telling us about the relationships between cytoskeletal and chromatin meiotic defects?
Congenital Abnormalities
Effects of sodium fluoride (NaF) on the cilia and microtubular system of Tetrahymena.
Contracture
Flow cytometric analysis of isolated adult cardiomyocytes: vinculin and tubulin fluorescence during metabolic inhibition and ischemia.
[Isoproterenol induced changes of protein expression and myocardial ultrastructure]
Coronary Disease
Colchicine for prevention of vascular inflammation in Non-CardioEmbolic stroke (CONVINCE) - study protocol for a randomised controlled trial.
Cough
Noscapine inhibits human prostate cancer progression and metastasis in a mouse model.
Cystic Fibrosis
Actin and tubulin in normal and cystic fibrosis fibroblasts.
Colchicine binding activity and tyrosyl tubulin ligase activity in normal and cystic fibrosis fibroblasts.
Localised mutagenesis of the fts YEX operon: conditionally lethal missense substitutions in the FtsE cell division protein of Escherichia coli are similar to those found in the cystic fibrosis transmembrane conductance regulator protein (CFTR) of human patients.
The cell division protein FtsZ as a cellular target to hit cystic fibrosis pathogens.
Cysticercosis
Immunodiagnosis of porcine cysticercosis: identification of candidate antigens through immunoproteomics.
Cysts
A high-throughput screening platform for Polycystic Kidney Disease (PKD) drug repurposing utilizing murine and human ADPKD cells.
Actin and tubulin cytoskeletons in germlings of the oomycete fungus Phytophthora infestans.
Cytoplasmic carboxypeptidase 5 regulates tubulin glutamylation and zebrafish cilia formation and function.
Expression of beta 1 tubulin (beta Tub56D) in Drosophila testis stem cells is regulated by a short upstream sequence while intron elements guide expression in somatic cells.
Genesis of newt sperm axial fiber: cDNA cloning and expression of a 29 kDa protein, a major component of the axial fiber, during spermatogenesis.
Lineage tracing suggests that ovarian endosalpingiosis does not result from escape of oviductal epithelium.
Long double-stranded RNA produces specific gene downregulation in Giardia lamblia.
Mucin-histochemical and immunohistochemical profiles of epithelial cells of several types of hepatic cysts.
Presence of a tubulin pool in the resting cyst of the hypotrich ciliate, Histriculus muscorum.
Transcription by RNA polymerase II during Acanthamoeba differentiation.
Decompression Sickness
Are the local adjustments of the relative spatial frequencies of the dynein arms and the beta-tubulin monomers involved in the regulation of the "9+2" axoneme?
Detailed Per-residue Energetic Analysis Explains the Driving Force for Microtubule Disassembly.
Dehydration
Changes in DNA and microtubules during loss and re-establishment of desiccation tolerance in germinating Medicago truncatula seeds.
Dehydration and embedding temperatures affect the antigenic specificity of tubulin and immunolabeling by the protein A-colloidal gold technique.
Improved immunoelectron microscopic method for localizing cytoskeletal proteins in Lowicryl K4M embedded tissues.
Dementia
Diminished taxol/GTP-stimulated tubulin polymerization in diseased region of brain from patients with late-onset or inherited Alzheimer's disease or frontotemporal dementia with parkinsonism linked to chromosome-17 but not individuals with mild cognitive impairment.
Dementia, Vascular
Autoantibodies in neurodegenerative diseases: antigen-specific frequencies and intrathecal analysis.
Demyelinating Diseases
A new myelin protein, TPPP/p25, reduced in demyelinated lesions is enriched in cerebrospinal fluid of multiple sclerosis.
Axonal lesions and PDGF-enhanced remyelination in the rat corpus callosum after lysolecithin demyelination.
Immunological myelin disruption does not alter expression of regeneration-associated genes in intact or axotomized rubrospinal neurons.
Role of advanced glycation end products in diabetic neuropathy.
Serum IgM monoclonal autoantibody binding to the 301 to 314 amino acid epitope of beta-tubulin: clinical association with slowly progressive demyelinating polyneuropathy.
Dengue
Differential expression of aldolase, alpha tubulin and thioredoxin peroxidase in peripheral blood mononuclear cells from dengue fever and dengue hemorrhagic fever patients.
Identification of a 48kDa tubulin or tubulin-like C6/36 mosquito cells protein that binds dengue virus 2 using mass spectrometry.
Synthesis, Biological Evaluation, and Molecular Docking of Combretastatin and Colchicine Derivatives and their hCE1-Activated Prodrugs as Antiviral Agents.
Dermatitis, Allergic Contact
SAR modelling of complex phenomena: probing methodological limitations.
Dermoid Cyst
Centrioles, microtubules and microfilaments in activated mononuclear and multinucleate macrophages from rat peritoneum: electron-microscopic and immunofluorescence microscopic studies.
Diabetes Complications
Prevention of tubulin/aldose reductase association delays the development of pathological complications in diabetic rats.
Diabetes Mellitus
Antibodies to tubulin and microtubule-associated proteins. A study in diabetes mellitus, systemic lupus erythematosus, and rheumatoid arthritis.
Prevention of tubulin/aldose reductase association delays the development of pathological complications in diabetic rats.
Proteins of slow axonal transport in sciatic motoneurones of rats with streptozotocin-induced diabetes or galactosaemia.
Structural and functional consequences of increased tubulin glycosylation in diabetes mellitus.
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Diabetes Mellitus, Experimental
Glycation of rat sciatic nerve tubulin in experimental diabetes mellitus.
Diabetes Mellitus, Type 2
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Diabetic Ketoacidosis
Cardiac antibody production to self-antigens in children and adolescents during and following the correction of severe diabetic ketoacidosis.
Diabetic Neuropathies
Role of advanced glycation end products in diabetic neuropathy.
Down Syndrome
Brain t-complex polypeptide 1 (TCP- 1) related to its natural substrate beta1 tubulin is decreased in Alzheimer's disease.
Reductions in soluble brain proteins in older subjects with Down's syndrome.
Dysarthria
Longitudinal Evaluation of Cerebellar Signs of H-ABC Tubulinopathy in a Patient and in the taiep Model.
Dysautonomia, Familial
Potential role of tubulin acetylation and microtubule-based protein trafficking in familial dysautonomia.
Dyskinesias
Longitudinal Evaluation of Cerebellar Signs of H-ABC Tubulinopathy in a Patient and in the taiep Model.
Dyslipidemias
Associations between TUBB-WWOX SNPs, their haplotypes, gene-gene, and gene-environment interactions and dyslipidemia.
Dystonia
A novel TUBB4A mutation G96R identified in a patient with hypomyelinating leukodystrophy onset beyond adolescence.
Dystonin-A3 upregulation is responsible for maintenance of tubulin acetylation in a less severe dystonia musculorum mouse model for hereditary sensory and autonomic neuropathy type VI.
Whispering dysphonia (DYT4 dystonia) is caused by a mutation in the TUBB4 gene.
Echinococcosis
Recombinant ?- and ?-tubulin from Echinococcus granulosus: expression, purification and polymerization.
Ectromelia
Ectromelia virus induces tubulin cytoskeletal rearrangement in immune cells accompanied by a loss of the microtubule organizing center and increased ?-tubulin acetylation.
Endometrial Neoplasms
Expression of tubulin, p53, ki67, receptors for estrogen, and progesterone in endometrial cancer.
Progestin regulation of protein synthesis in endometrial cancer.
Rapamycin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and induction of apoptosis.
Tubulin inhibitor AEZS 112 inhibits the growth of experimental human ovarian and endometrial cancers irrespective of caspase inhibition.
Endometriosis
Characterization of exosomes in peritoneal fluid of endometriosis patients.
Organization of the Cytoskeleton in Ectopic Foci of the Endometrium with Rare Localization.
Epilepsy
A novel TUBG1 mutation with neurodevelopmental disorder caused by malformations of cortical development.
Case reports: novel TUBG1 mutations with milder neurodevelopmental presentations.
Down-regulation of protein L-isoaspartyl methyltransferase in human epileptic hippocampus contributes to generation of damaged tubulin.
Lissencephaly in an epilepsy cohort: Molecular, radiological and clinical aspects.
Nestin-expressing cell types in the temporal lobe and hippocampus: Morphology, differentiation, and proliferative capacity.
Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramide.
TUBG1 missense variants underlying cortical malformations disrupt neuronal locomotion and microtubule dynamics but not neurogenesis.
Tubulin ?-III modulates seizure activity in epilepsy.
Epilepsy, Temporal Lobe
Down-regulation of protein L-isoaspartyl methyltransferase in human epileptic hippocampus contributes to generation of damaged tubulin.
Esophageal Neoplasms
PPMP, a novel tubulin-depolymerizing agent against esophageal cancer in patient-derived tumor xenografts.
Synthesis and biological evaluation of novel 9-functional heterocyclic coupled 7-deoxy-9-dihydropaclitaxel analogue.
Esophageal Squamous Cell Carcinoma
Microsatellite analysis of the APC gene and immunoexpression of E-cadherin, catenin, and tubulin in esophageal squamous cell carcinoma.
Tubulin Beta Chain, Filamin A Alpha Isoform 1, and Cytochrome b-c1 Complex Subunit 1 As Serological Diagnostic Biomarkers of Esophageal Squamous Cell Carcinoma: A Proteomics Study.
Familial Mediterranean Fever
Analysis of polymorphisms in the colchicine binding site of tubulin in colchicine-resistant familial Mediterranean fever patients.
Familial Primary Pulmonary Hypertension
Targets of anti-endothelial cell antibodies in pulmonary hypertension and scleroderma.
Fibroma
Infantile digital fibromatosis. Immunohistochemical and ultrastructural observations of cytoplasmic inclusions.
Fibrosarcoma
3-(3-Hydroxy-4-methoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-1,2,5-selenadiazole (G-1103), a novel combretastatin A-4 analog, induces G2/M arrest and apoptosis by disrupting tubulin polymerization in human cervical HeLa cells and fibrosarcoma HT-1080 cells.
Glycosylated podophyllotoxin congeners: loss of microtubule inhibition and permission of invasion in vitro.
New microtubule polymerization inhibitors comprising a nitrooxymethylphenyl group.
Frontotemporal Dementia
Aberrant molecular properties shared by familial Parkinson's disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1.
Diminished taxol/GTP-stimulated tubulin polymerization in diseased region of brain from patients with late-onset or inherited Alzheimer's disease or frontotemporal dementia with parkinsonism linked to chromosome-17 but not individuals with mild cognitive impairment.
Extended investigation of tau and mutation screening of other candidate genes on chromosome 17q21 in a Swedish FTDP-17 family.
Impaired tau-microtubule interactions are prevalent among pathogenic tau variants arising from missense mutations.
The role of tau (MAPT) in frontotemporal dementia and related tauopathies.
VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle.
Frontotemporal Lobar Degeneration
Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress.
Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration.
Gallbladder Neoplasms
Centrosome abnormalities in human carcinomas of the gallbladder and intrahepatic and extrahepatic bile ducts.
Gastroenteritis
Tubulins interact with porcine and human S proteins of the genus Alphacoronavirus and support successful assembly and release of infectious viral particles.
Gastroenteritis, Transmissible, of Swine
Tubulins interact with porcine and human S proteins of the genus Alphacoronavirus and support successful assembly and release of infectious viral particles.
Gastrointestinal Stromal Tumors
Plocabulin, a novel tubulin inhibitor, has potent antitumor activity in patient-derived xenograft models of gastrointestinal stromal tumors.
Genetic Diseases, Inborn
A TUBB6 mutation is associated with autosomal dominant non-progressive congenital facial palsy, bilateral ptosis and velopharyngeal dysfunction.
An essential quality control mechanism at the eukaryotic Basal body prior to intraflagellar transport.
Giant Cell Tumor of Bone
Centrosome abnormalities in giant cell tumour of bone: possible association with chromosomal instability.
Giant Cell Tumors
Centrosome abnormalities in giant cell tumour of bone: possible association with chromosomal instability.
Glaucoma
Acto-myosin drug effects and aqueous outflow function.
Glioblastoma
6-MOMIPP, a novel brain-penetrant anti-mitotic indolyl-chalcone, inhibits glioblastoma growth and viability.
Altered cellular distribution and subcellular sorting of gamma-tubulin in diffuse astrocytic gliomas and human glioblastoma cell lines.
Bioinformatics Analysis Discovers Microtubular Tubulin Beta 6 Class V (TUBB6) as a Potential Therapeutic Target in Glioblastoma.
Class III beta-tubulin and gamma-tubulin are co-expressed and form complexes in human glioblastoma cells.
Confocal investigation on colocalization between tubulin posttranslational modifications and associated proteins in rat C6 glioma cells.
Differential expression and cellular distribution of gamma-tubulin and betaIII-tubulin in medulloblastomas and human medulloblastoma cell lines.
Emerging microtubule targets in glioma therapy.
Epothilone B induces glioblastoma cell death via survivin down-regulation.
Glioblastoma CUSA Fluid Protein Profiling: A Comparative Investigation of the Core and Peripheral Tumor Zones.
KX2-361: a novel orally bioavailable small molecule dual Src/tubulin inhibitor that provides long term survival in a murine model of glioblastoma.
Lower Tubulin Expression in Glioblastoma Stem Cells Attenuates Efficacy of Microtubule-Targeting Agents.
Morphological and quantitative analysis on ?-tubulin modifications in glioblastoma cells.
Novel chalcones derivatives with potential antineoplastic activity investigated by docking and molecular dynamics simulations.
Novel chemotypes targeting tubulin at the colchicine binding site and unbiasing P-glycoprotein.
Pharmacology of novel small-molecule tubulin inhibitors in glioblastoma cells with enhanced EGFR signalling.
Preclinical and Early Clinical Development of PTC596, a Novel Small-Molecule Tubulin-Binding Agent.
Proteomic Analysis on Anti-Proliferative and Apoptosis Effects of Curcumin Analog, 1,5-bis(4-Hydroxy-3-Methyoxyphenyl)-1,4-Pentadiene-3-One-Treated Human Glioblastoma and Neuroblastoma Cells.
Sulforaphane-cysteine downregulates CDK4 /CDK6 and inhibits tubulin polymerization contributing to cell cycle arrest and apoptosis in human glioblastoma cells.
Tubulin targets in the pathobiology and therapy of glioblastoma multiforme. I. class III beta-tubulin.
Tubulin targets in the pathobiology and therapy of glioblastoma multiforme. II. gamma-tubulin.
Glioma
A novel cholchicine/gadolinium-loading tubulin self-assembly nanocarrier for MR imaging and chemotherapy of glioma.
A software application for comparing large numbers of high resolution MALDI-FTICR MS spectra demonstrated by searching candidate biomarkers for glioma blood vessel formation.
A tubulin binding peptide targets glioma cells disrupting their microtubules, blocking migration, and inducing apoptosis.
AlphaB-crystallin phosphorylated at Ser-59 is localized in centrosomes and midbodies during mitosis.
Biphasic regulation by dibutyryl cyclic AMP of tubulin and actin mRNA levels in neuroblastoma cells.
Change of morphology and cytoskeletal protein gene expression during dibutyryl cAMP-induced differentiation in C6 glioma cells.
Comparative study of microtubule inhibitors - Estramustine and natural podophyllotoxin conjugated PAMAM dendrimer on glioma cell proliferation.
Confocal investigation on colocalization between tubulin posttranslational modifications and associated proteins in rat C6 glioma cells.
Differential expression of centrosomal proteins at different stages of human glioma.
Effects of methylmercury and some metal ions on microtubule networks in mouse glioma cells and in vitro tubulin polymerization.
Fibroblast growth factor 13 regulates glioma cell invasion and is important for bevacizumab-induced glioma invasion.
Glioma cell proliferation controlled by ERK activity-dependent surface expression of PDGFRA.
Induction of matrix metalloproteinase-9 requires a polymerized actin cytoskeleton in human malignant glioma cells.
Investigating the Structural Variability and Binding Modes of the Glioma Targeting NFL-TBS.40-63 Peptide on Tubulin.
KX2-361: a novel orally bioavailable small molecule dual Src/tubulin inhibitor that provides long term survival in a murine model of glioblastoma.
Localization of NGF and TrkA at mitotic apparatus in human glioma cell line U251.
Mechanism of cytotoxicity of methylmercury. With special reference to microtubule disruption.
Methylmercury-induced microtubule depolymerization leads to inhibition of tubulin synthesis.
Nanomolar concentrations of epothilone D inhibit the proliferation of glioma cells and severely affect their tubulin cytoskeleton.
Occurrence of nuclear beta(II)-tubulin in cultured cells.
Proteins from morphologically differentiated neuroblastoma cells promote tubulin polymerization.
Role of microtubules in glucose uptake by C6 glioma cells.
Selective antimitotic effects of estramustine correlate with its antimicrotubule properties on glioblastoma and astrocytes.
Single doublecortin gene therapy significantly reduces glioma tumor volume.
SIRT2 downregulation confers resistance to microtubule inhibitors by prolonging chronic mitotic arrest.
Synaptic membrane G proteins are complexed with tubulin in situ.
The molecular biology of mammalian SIRT proteins: SIRT2 in cell cycle regulation.
Tubulin constancy during morphological differentiation of mouse neuroblastoma cells.
Tubulin microheterogeneity in neuroblastoma and glioma cell lines differs from that of the brain.
Tubulin nitration in human gliomas.
Tubulin stimulates adenylyl cyclase activity in C6 glioma cells by bypassing the beta-adrenergic receptor: a potential mechanism of G protein activation.
Tubulin stimulates adenylyl cyclase activity in rat striatal membranes via transfer of guanine nucleotide to Gs protein.
Tubulin targets in the pathobiology and therapy of glioblastoma multiforme. II. gamma-tubulin.
Glomerulonephritis
[Role of tubulin in the pathogenesis of fibrillary glomerulonephritis].
Gout
Colchicine in Gout: an update.
Colchicine to decrease NLRP3-activated inflammation and improve obesity-related metabolic dysregulation.
Comparative modelling of human ? tubulin isotypes and implications for drug binding.
Novel analogue of colchicine induces selective pro-death autophagy and necrosis in human cancer cells.
Granuloma
Asteroid bodies: products of unusual microtubule dynamics in monocyte-derived giant cells. An immunohistochemical study.
Expression of mycobacterial cell division protein, FtsZ, and dormancy proteins, DevR and Acr, within lung granulomas throughout guinea pig infection.
Granulomatous Disease, Chronic
Studies in normal and chronic granulomatous disease neutrophils indicate a correlation of tubulin tyrosinolation with the cellular redox state.
Gray Platelet Syndrome
The organization of microtubules and microtubule coils in giant platelet disorders.
Guillain-Barre Syndrome
Autoantibodies in neurodegenerative diseases: antigen-specific frequencies and intrathecal analysis.
Head and Neck Neoplasms
An Orally Bioavailable, Indole-3-glyoxylamide Based Series of Tubulin Polymerization Inhibitors Showing Tumor Growth Inhibition in a Mouse Xenograft Model of Head and Neck Cancer.
Hearing Loss
Age-related changes in microtubules in the guinea pig organ of Corti. Tubulin isoform shifts with increasing age suggest changes in micromechanical properties of the sensory epithelium.
Heart Failure
Adenosine regulation of microtubule dynamics in cardiac hypertrophy.
Cardiocyte cytoskeleton in patients with left ventricular pressure overload hypertrophy.
Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: II. Cytoskeletal remodeling.
Effect of long-term monotherapy with the aldosterone receptor blocker eplerenone on cytoskeletal proteins and matrix metalloproteinases in dogs with heart failure.
Post-translational modifications of cardiac tubulin during chronic heart failure in the rat.
The Effects of Guizhi Gancao Decoction on Pressure Overload-Induced Heart Failure and Posttranslational Modifications of Tubulin in Mice.
Tubulin polymerization modifies cardiac sodium channel expression and gating.
Helminthiasis
A review of chemotherapeutic approaches to the treatment of cryptosporidiosis.
Non-disjunction events induced by albendazole in human cells.
Hemangiosarcoma
The radiation response of sarcomas by histologic subtypes: a review with special emphasis given to results achieved with razoxane.
Hematologic Neoplasms
A novel class of tubulin inhibitors that exhibit potent antiproliferation and in vitro vessel-disrupting activity.
Microtubule changes in hematologic malignant cells treated with paclitaxel and comparison with vincristine cytotoxicity.
PBOX-15 induces apoptosis and improves the efficacy of oxaliplatin in human colorectal cancer cell lines.
Hemimegalencephaly
Introduction: Brain malformations.
Hepatitis
Sera with high levels of anti-smooth muscle and anti-mitochondrial antibodies frequently bind to cytoskeleton proteins.
Hepatitis B
Autoantibodies and circulating immune complexes in sera from patients with hepatitis B virus-related chronic liver disease.
Sirtuin 2 Isoform 1 Enhances Hepatitis B Virus RNA Transcription and DNA Synthesis via the AKT/GSK-3?/?-Catenin Signaling Pathway.
Hepatitis C
Interaction of hepatitis C virus F protein with prefoldin 2 perturbs tubulin cytoskeleton organization.
Up-regulation of 42 kDa tubulin alpha-6 chain fragment in well-differentiated hepatocellular carcinoma tissues from patients infected with hepatitis C virus.
Hepatitis, Chronic
Sera with high levels of anti-smooth muscle and anti-mitochondrial antibodies frequently bind to cytoskeleton proteins.
Herpes Simplex
Heat-shock protein 90 promotes nuclear transport of herpes simplex virus 1 capsid protein by interacting with acetylated tubulin.
Intracellular maturation and sorting of two herpes simplex virus type 1 glycoproteins. Immunogold staining of ultrathin cryosections.
Organization of cytoskeleton elements during herpes simplex virus type 1 infection of human fibroblasts: an immunofluorescence study.
Herpes Zoster
Dietary cysteamine hydrochloride protects against oxidation, inflammation, and mucosal barrier disruption of broiler chickens challenged with Clostridium perfringens.
Multiwalled carbon nanotubes induce altered morphology and loss of barrier function in human bronchial epithelium at noncytotoxic doses.
Patterns of intercellular connectivity in the mammalian cumulus-oocyte complex.
Hirschsprung Disease
Calretinin, ? Tubulin Immunohistochemistry And Submucosal Nerve Trunks Morphology In Hirschsprung Disease: Possible Applications In Clinical Practice.
HIV Infections
HIV-1 Tat protein enhances microtubule polymerization.
Huntington Disease
Correction: SIRT2 Ablation Has No Effect on Tubulin Acetylation in Brain, Cholesterol Biosynthesis or the Progression of Huntington's Disease Phenotypes In Vivo.
Genetic deletion of the Histone Deacetylase 6 exacerbates selected behavioral deficits in the R6/1 mouse model for Huntington's disease.
Hdac6 knock-out increases tubulin acetylation but does not modify disease progression in the R6/2 mouse model of Huntington's disease.
Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation.
Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels.
SIRT2 ablation has no effect on tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington's disease phenotypes in vivo.
The cytoskeleton of cultured skin fibroblasts from patients with Huntington's chorea.
Hydrocephalus
Cytoplasmic carboxypeptidase 5 regulates tubulin glutamylation and zebrafish cilia formation and function.
Hypereosinophilic Syndrome
RhoH is a negative regulator of eosinophilopoiesis.
Hypersensitivity
Kinesin-13 regulates the quantity and quality of tubulin inside cilia.
Hypertension
Effects of detyrosinated tubulin on Na+,K+-ATPase activity and erythrocyte function in hypertensive subjects.
Exaggerated hypertensive response to combretastatin A-4 phosphate in hypertensive rats: Effective pharmacological inhibition by diltiazem.
Inhibition of flippase-like activity by tubulin regulates phosphatidylserine exposure in erythrocytes from hypertensive and diabetic patients.
Reversible posterior leukoencephalopathy syndrome induced by vinorelbine.
Targets of anti-endothelial cell antibodies in pulmonary hypertension and scleroderma.
Hyperthyroidism
Effects of fetal thyroid states on RNA, DNA, and tubulin content in neonatal rat brain.
Hypoparathyroidism
Hypoparathyroidism, retardation, and dysmorphism syndrome: impaired early growth and increased susceptibility to severe infections due to hyposplenism and impaired polymorphonuclear cell functions.
Tubulin chaperone E binds microtubules and proteasomes and protects against misfolded protein stress.
Hypothyroidism
Biology of the congenitally hypothyroid hyt/hyt mouse.
Hypothyroidism reduces the rate of slow component A (SCa) axonal transport and the amount of transported tubulin in the hyt/hyt mouse optic nerve.
Regulation of tubulin by triiodothyronine in hypothyroid rat brain.
Thyroid hormones and neurotubule assembly in vitro during brain development.
Idiopathic Pulmonary Fibrosis
Distribution of the cytoskeletal protein beta-tubulin in normal lung, cryptogenic fibrosing alveolitis and lung tumours.
Infarction, Middle Cerebral Artery
Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons.
Infections
African swine fever virus infection disrupts centrosome assembly and function.
An evaluation of potential reference genes for stability of expression in two salmonid cell lines after infection with either Piscirickettsia salmonis or IPNV.
Antibodies to tubulin in patients with parasitic infections.
Behaviour of microtubules in cells infected with Toxoplasma gondii.
Blue Native/SDS-PAGE and iTRAQ-Based Chloroplasts Proteomics Analysis of Nicotiana tabacum Leaves Infected with M Strain of Cucumber Mosaic Virus Reveals Several Proteins Involved in Chlorosis Symptoms.
Changes in corneal innervation and pain responses in fungal keratitis.
Characterization of the beta-tubulin gene of Pneumocystis carinii.
Comparison between autoantibodies arising during Trypanosoma cruzi infection in mice and natural autoantibodies.
Differential expression of aldolase, alpha tubulin and thioredoxin peroxidase in peripheral blood mononuclear cells from dengue fever and dengue hemorrhagic fever patients.
Differential Proteome Analysis of Host Cells Infected with Porcine Circovirus Type 2.
Drug discovery targeting cell division proteins, microtubules and FtsZ.
Expression of both Arabidopsis ?-tubulin genes is essential for development of a functional syncytium induced by Heterodera schachtii.
Expression of mycobacterial cell division protein, FtsZ, and dormancy proteins, DevR and Acr, within lung granulomas throughout guinea pig infection.
Foot-and-mouth disease virus, but not bovine enterovirus, targets the host cell cytoskeleton via the nonstructural protein 3Cpro.
Helicobacter pylori infection and infertility.
Hepatitis C virus and alcohol: Same mitotic targets but different signaling pathways.
Impact of FtsZ Inhibition on the Localization of the Penicillin Binding Proteins in Methicillin-Resistant Staphylococcus aureus.
Initiation of Hepatitis C Virus Infection Requires the Dynamic Microtubule Network: ROLE OF THE VIRAL NUCLEOCAPSID PROTEIN.
Internalization of Candida albicans and cytoskeletal organization in macrophages and fibroblasts treated with concanavalin A.
Intracellular Organization by Jumbo Bacteriophages.
Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons.
iTRAQ-based proteomic study of the effects of Spiroplasma eriocheiris on Chinese mitten crab Eriocheir sinensis hemocytes.
Knockdown of BmTCP-1? Delays BmNPV Infection in vitro.
Legionella pneumophila invasion of MRC-5 cells induces tyrosine protein phosphorylation.
Localization and immunogenicity of tubulin in the filarial nematodes Brugia malayi and B. pahangi.
Loss of corneal sensory nerve fibers in SIV-infected macaques: an alternate approach to investigate HIV-induced PNS damage.
Microtubules as antifungal and antiparasitic drug targets.
Morphologic, immunohistochemical, immunologic, ultrastructural, and time-related study of herpes simplex virus type 1-infected cultured human fibroblasts.
Nuclear localizations of the herpes simplex virus type 1 tegument proteins VP13/14, vhs, and VP16 precede VP22-dependent microtubule reorganization and VP22 nuclear import.
Organization of cytoskeleton elements during herpes simplex virus type 1 infection of human fibroblasts: an immunofluorescence study.
Phosphodiesterase-induced cAMP degradation restricts hepatitis B virus infection.
Plasma phosphoproteome and differential plasma phosphoproteins with opisthorchis viverrini-related cholangiocarcinoma.
Quantitative comparison of HTLV-1 and HIV-1 cell-to-cell infection with new replication dependent vectors.
Rabies Virus Infection Induces Microtubule Depolymerization to Facilitate Viral RNA Synthesis by Upregulating HDAC6.
Remodeling of tick cytoskeleton in response to infection with Anaplasma phagocytophilum.
Role of cytoskeleton components in measles virus replication.
Rotavirus infection of cells in culture induces activation of RhoA and changes in the actin and tubulin cytoskeleton.
Stathmin recruits tubulin to Listeria monocytogenes-induced actin comets and promotes bacterial dissemination.
Synchronised infection identifies early rate-limiting steps in the hepatitis B virus life cycle.
The HrpB-HrpA two-partner secretion system is essential for intracellular survival of Neisseria meningitidis.
Therapeutic targets for the treatment of microsporidiosis in humans.
Tropism and Induction of Cytokines in Human Embryonic-Stem Cells-Derived Neural Progenitors upon Inoculation with Highly- Pathogenic Avian H5N1 Influenza Virus.
Trypanosoma brucei: anti-tubulin antibodies specifically inhibit trypanosome growth in culture.
Vaccinia virus infection induces a stress response that leads to association of Hsp70 with viral proteins.
Verifying the stability of selected genes for normalization in Q PCR experiments of Spodoptera frugiperda cells during AcMNPV infection.
[Effect of wild-type p53 gene on the number and proteins of centrosome in leukemic K562 cells]
Infectious Mononucleosis
Antitubulin antibody in healthy adults and patients with infectious mononucleosis and its relationship to smooth muscle antibody (SMA).
Infertility
Immunocytochemistry and sperm pathology.
Insights of the tubulin code in gametes and embryos: from basic research to potential clinical applications in humans.
Infertility, Female
Mutation analysis of tubulin beta 8 class VIII in infertile females with oocyte or embryonic defects.
Infertility, Male
A missense mutation in IFT74, encoding for an essential component for intraflagellar transport of Tubulin, causes asthenozoospermia and male infertility without clinical signs of Bardet-Biedl syndrome.
Correction to: A missense mutation in IFT74, encoding for an essential component for intraflagellar transport of Tubulin, causes asthenozoospermia and male infertility without clinical signs of Bardet-Biedl syndrome.
Tubulin cytoskeleton during microsporogenesis in the male-sterile genotype of Allium sativum and fertile Allium ampeloprasum L.
Influenza, Human
Mammalian Diaphanous-related formin-1 restricts early phases of influenza A/NWS/33 virus (H1N1) infection in LLC-MK2 cells by affecting cytoskeleton dynamics.
Intellectual Disability
A novel TUBG1 mutation with neurodevelopmental disorder caused by malformations of cortical development.
Clinical variability of TUBB-associated disorders: Diagnosis through reanalysis.
Overlapping phenotype comprising Kenny-Caffey type 2 and Sanjad-Sakati syndromes: The first case report.
TUBG1 missense variants underlying cortical malformations disrupt neuronal locomotion and microtubule dynamics but not neurogenesis.
Intervertebral Disc Degeneration
HIF1A Alleviates compression-induced apoptosis of nucleus pulposus derived stem cells via upregulating autophagy.
Intestinal Neoplasms
Antiproliferative effect of benzimidazole anthelmintics albendazole, ricobendazole, and flubendazole in intestinal cancer cell lines.
Intestinal Volvulus
Classical ligands interact with native and recombinant tubulin from Onchocerca volvulus with similar rank order of magnitude.
Ischemic Attack, Transient
Immunoelectron microscopic study of tubulin and microtubule-associated proteins after transient cerebral ischemia in gerbils.
Keratoacanthoma
Expression of class II beta-tubulin in non-melanoma cutaneous tumors.
Keratosis, Actinic
Phase 3 Trials of Tirbanibulin Ointment for Actinic Keratosis.
Tirbanibulin Ointment 1% as a Novel Treatment for Actinic Keratosis: Phase 1 and 2 Results.
Tirbanibulin: First Approval.
Kidney Neoplasms
Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2',3',4'-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a new class of antimitotic antitumor agents.
Labyrinth Diseases
TUNEL-positive labeling in mouse inner ear caused by tubulin immunization is not apoptosis.
Leiomyosarcoma
Preclinical and Early Clinical Development of PTC596, a Novel Small-Molecule Tubulin-Binding Agent.
Leishmaniasis
Antileishmanial activity and tubulin polymerization inhibition of podophyllotoxin derivatives on Leishmania infantum.
Leishmaniasis, Visceral
Antiactin and antitubulin antibodies in canine visceral leishmaniasis.
Identification of immune complex antigens in sera of Indian kala-azar patients.
Leprosy
Effects of anti-endothelial cell antibodies in leprosy and malaria.
Leukemia
(4-Methoxyphenyl)(3,4,5-trimethoxyphenyl)methanone inhibits tubulin polymerization, induces G2/M arrest, and triggers apoptosis in human leukemia HL-60 cells.
A novel isoflavone, ME-344, targets the cytoskeleton in acute myeloid leukemia.
Aberrant protein expression in cerebral cortex of fetus with Down syndrome.
Antiproliferative 4-(1,2,4-oxadiazol-5-yl)piperidine-1-carboxamides, a new tubulin inhibitor chemotype.
Antiproliferative activity and mechanism of action of DZ-3358, a novel pyrimidinyl pyrazole derivative.
Antitubulin effects of derivatives of 3-demethylthiocolchicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine. Comparison with colchicinoids.
AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo.
Cell surface tubulin in leukemic cells: molecular structure, surface binding, turnover, cell cycle expression, and origin.
Cytoskeletal disruption accelerates caspase-3 activation and alters the intracellular membrane reorganization in DNA damage-induced apoptosis.
Denbinobin-mediated anticancer effect in human K562 leukemia cells: role in tubulin polymerization and Bcr-Abl activity.
Derivatives of 5,6-diphenylpyridazin-3-one: synthetic antimitotic agents which interact with plant and mammalian tubulin at a new drug-binding site.
Design and synthesis of novel 5-(4-chlorophenyl)furan derivatives with inhibitory activity on tubulin polymerization.
Effects of extremely low frequency magnetic fields on NGF induced neuronal differentiation of PC12 cells.
Effects of modulators of protein kinases on taxol-induced apoptosis of human leukemic cells possessing disparate levels of p26BCL-2 protein.
Enhancement of in vivo antitumor activity of a novel antimitotic 1-phenylpropenone derivative, AM-132, by tumor necrosis factor-alpha or interleukin-6.
Establishment and characterization of embryonic stem-like cells from porcine somatic cell nuclear transfer blastocysts.
Estimation of changes in tubulin induced with etoposide in human leukemia cells line K-562 by immunofluorescence microscope.
Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data.
High-Complexity shRNA Libraries and PI3 Kinase Inhibition in Cancer: High-Fidelity Synthetic Lethality Predictions.
Increase in the chemically-induced differentiation of human leukemia cell lines by tubulin disruptors.
Indole: A privileged scaffold for the design of anti-cancer agents.
Intranuclear rodlets in human pancreatic islet cells.
Isolation, structure, synthesis, and antimitotic properties of combretastatins B-3 and B-4 from Combretum caffrum.
Mechanisms by which Synthetic 6,7-Annulated-4-substituted Indole Compounds with Anti-proliferative Activity Disrupt Mitosis and Block Cytokinesis in Human HL-60 Tumor Cells In Vitro.
Microtubule changes and cytotoxicity in leukemic cell lines treated with taxol.
MJ-29 inhibits tubulin polymerization, induces mitotic arrest, and triggers apoptosis via cyclin-dependent kinase 1-mediated Bcl-2 phosphorylation in human leukemia U937 cells.
MPT0B169 and MPT0B002, New Tubulin Inhibitors, Induce Growth Inhibition, G2/M Cell Cycle Arrest, and Apoptosis in Human Colorectal Cancer Cells.
MPT0B169, a New Tubulin Inhibitor, Inhibits Cell Growth and Induces G2/M Arrest in Nonresistant and Paclitaxel-Resistant Cancer Cells.
Mutations of oncoprotein 18/stathmin identify tubulin-directed regulatory activities distinct from tubulin association.
Op18/stathmin mediates multiple region-specific tubulin and microtubule-regulating activities.
Phase I and pharmacodynamic study of taxol in refractory acute leukemias.
Phase I pharmacologic study of a new Vinca alkaloid: navelbine.
Protein tyrosine kinase p53/p56(lyn) forms complexes with gamma-tubulin in rat basophilic leukemia cells.
Resistance to microtubule-targeted cytotoxins in a K562 leukemia cell variant associated with altered tubulin expression and polymerization.
Selective inhibition of human leukemia cell growth and induction of cell cycle arrest and apoptosis by pseudolaric acid B.
Structure-activity studies with chiral isomers and with segments of the antimitotic marine peptide dolastatin 10.
Syntheses of 5a'-homo-vinblastine and congeners designed to establish structural determinants for isolation of atropisomers.
Synthesis and biological effects of novel thiocolchicines. 3. Evaluation of N-acyldeacetylthiocolchicines, N-(alkoxycarbonyl) deacetylthiocolchicines, and O-ethyldemethylthiocolchicines. New synthesis of thiodemecolcine and antileukemic effects of 2-demethyl- and 3-demethylthiocolchicine.
Synthesis and biological evaluation of 2-styrylquinazolin-4(3H)-ones, a new class of antimitotic anticancer agents which inhibit tubulin polymerization.
Synthesis and biological evaluation of phenstatin metabolites.
Synthesis and Evaluation of 2-Naphthaleno trans-Stilbenes and Cyanostilbenes as Anticancer agents.
Synthesis of alkoxy-substituted diaryl compounds and correlation of ring separation with inhibition of tubulin polymerization: differential enhancement of inhibitory effects under suboptimal polymerization reaction conditions.
Synthesis, antiproliferative activity and inhibition of tubulin polymerization by anthracenone-based oxime derivatives.
Synthesis, tubulin binding, antineoplastic evaluation, and structure-activity relationship of oncodazole analogues.
The influence of etoposide on the distribution of tubulin in human leukemia cell line HL-60.
Visualization of tubulin in lymphocytes. I. Comparison of normal and chronic lymphocytic leukemia (CLL) lymphocytes.
[The cytoskeleton reorganization and differentiation of HL-60 and K-562 human leukemia cell lines]
Leukemia, Lymphocytic, Chronic, B-Cell
Human lymphocyte tubulin. Purification and characterization in normal and leukemic cells.
Rapid induction of apoptosis in chronic lymphocytic leukemia cells by the microtubule disrupting agent BNC105.
Visualization of tubulin in lymphocytes. I. Comparison of normal and chronic lymphocytic leukemia (CLL) lymphocytes.
Leukemia, Lymphoid
A pinacol rearrangement/oxidation synthetic route to hydroxyphenstatin.
Antitubulin effects of derivatives of 3-demethylthiocolchicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine. Comparison with colchicinoids.
Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4.
Synthesis and biological effects of novel thiocolchicines. 3. Evaluation of N-acyldeacetylthiocolchicines, N-(alkoxycarbonyl) deacetylthiocolchicines, and O-ethyldemethylthiocolchicines. New synthesis of thiodemecolcine and antileukemic effects of 2-demethyl- and 3-demethylthiocolchicine.
Visualization of tubulin in lymphocytes. I. Comparison of normal and chronic lymphocytic leukemia (CLL) lymphocytes.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
3-Aroyl-1,4-diarylpyrroles Inhibit Chronic Myeloid Leukemia Cell Growth through an Interaction with Tubulin.
Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia.
Tubulin-binding dibenz[c,e]oxepines as colchinol analogues for targeting tumour vasculature.
Leukemia, Myeloid
Antiproliferative and differentiating activities of a novel series of histone deacetylase inhibitors.
Leukemia, Myeloid, Acute
Efficacy of the novel tubulin polymerization inhibitor PTC-028 for myelodysplastic syndrome.
MPT0B169, a novel tubulin inhibitor, induces apoptosis in taxol-resistant acute myeloid leukemia cells through mitochondrial dysfunction and Mcl-1 downregulation.
Synthesis and evaluation of a series of resveratrol analogues as potent anti-cancer agents that target tubulin.
Synthesis of 1,2-benzisoxazole tethered 1,2,3-triazoles that exhibit anticancer activity in acute myeloid leukemia cell lines by inhibiting histone deacetylases, and inducing p21 and tubulin acetylation.
Lewy Body Disease
The presence of tau distinguishes Lewy bodies of diffuse Lewy body disease from those of idiopathic Parkinson disease.
Lipidoses
A Proteomic Study of Atherosclerotic Plaques in Men with Coronary Atherosclerosis.
Lissencephaly
A case of TUBA1A mutation presenting with lissencephaly and Hirschsprung disease.
Brain-specific knockin of the pathogenic Tubb5 E401K allele causes defects in motor coordination and prepulse inhibition.
In vitro characterization of neurite extension using induced pluripotent stem cells derived from lissencephaly patients with TUBA1A missense mutations.
Large spectrum of lissencephaly and pachygyria phenotypes resulting from de novo missense mutations in tubulin alpha 1A (TUBA1A).
Lissencephaly in an epilepsy cohort: Molecular, radiological and clinical aspects.
Mutations in ?- and ?-tubulin encoding genes: Implications in brain malformations.
Mutations in the ?-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities.
Platelet-activating factor (PAF) acetylhydrolase activity, LIS1 expression, and seizures.
Recognizable cerebellar dysplasia associated with mutations in multiple tubulin genes.
The wide spectrum of tubulinopathies: what are the key features for the diagnosis?
TUBA1A mutation-associated lissencephaly: case report and review of the literature.
Tubulin-related cortical dysgeneses: microtubule dysfunction underlying neuronal migration defects.
Tubulinopathies continued: refining the phenotypic spectrum associated with variants in TUBG1.
Liver Cirrhosis
Trimethylcolchicinic acid decreases liver fibrosis and cholestasis induced by prolonged biliary obstruction in the rat.
Liver Cirrhosis, Biliary
Sera with high levels of anti-smooth muscle and anti-mitochondrial antibodies frequently bind to cytoskeleton proteins.
Liver Diseases
Autoantibodies and circulating immune complexes in sera from patients with hepatitis B virus-related chronic liver disease.
Changes of hepatic microtubules and secretory proteins in human alcoholic liver disease.
Liver Diseases, Alcoholic
Changes of hepatic microtubules and secretory proteins in human alcoholic liver disease.
The Altered Hepatic Tubulin Code in Alcoholic Liver Disease.
Liver Neoplasms
An orally antitumor chalcone hybrid inhibited HepG2 cells growth and migration as the tubulin binding agent.
COH-203, a novel microtubule inhibitor, exhibits potent anti-tumor activity via p53-dependent senescence in hepatocellular carcinoma.
Design, synthesis and biological evaluation of a novel library of antimitotic C2-aroyl/arylimino tryptamine derivatives that are also potent inhibitors of indoleamine-2, 3-dioxygenase (IDO).
Discovery of novel vinyl sulfone derivatives as anti-tumor agents with microtubule polymerization inhibitory and vascular disrupting activities.
Enhanced anticancer effect of Combretastatin A-4 phosphate when combined with vincristine in the treatment of hepatocellular carcinoma.
Increased levels of a unique post-translationally modified betaIVb-tubulin isotype in liver cancer.
Mitochondrial-targeted prodrug cancer therapy using a rhodamine B labeled fluorinated docetaxel.
Novel chemotypes targeting tubulin at the colchicine binding site and unbiasing P-glycoprotein.
Synthesis and biological evaluation of novel 9-functional heterocyclic coupled 7-deoxy-9-dihydropaclitaxel analogue.
Tertiary sulphonamide derivatives as dual acting small molecules that inhibit LSD1 and suppress tubulin polymerisation against liver cancer.
Lung Diseases
Lung Injury Combined with Loss of Regulatory T Cells Leads to De Novo Lung-Restricted Autoimmunity.
Lung Neoplasms
5-Demethylnobiletin promotes the formation of polymerized tubulin, leads to G2/M phase arrest and induces autophagy via JNK activation in human lung cancer cells.
Anti-tumor selectivity of a novel tubulin and HSP90 dual-targeting inhibitor in non-small cell lung cancer models.
Cancer preventive isothiocyanates induce selective degradation of cellular alpha- and beta-tubulins by proteasomes.
Covalent binding to tubulin by isothiocyanates. A mechanism of cell growth arrest and apoptosis.
Cytotoxicity, in silico predictions and molecular studies for androstane heterocycle compounds revealed potential antitumor agent against lung cancer cells.
Design, synthesis and biological evaluation of a novel library of antimitotic C2-aroyl/arylimino tryptamine derivatives that are also potent inhibitors of indoleamine-2, 3-dioxygenase (IDO).
Design, synthesis and biological evaluation of imidazopyridine-propenone conjugates as potent tubulin inhibitors.
Docetaxel in non-small cell lung cancer: a review.
Drug resistance to paclitaxel is not only associated with ABCB1 mRNA expression but also with drug accumulation in intracellular compartments in human lung cancer cell lines.
Effects of cytoskeletal inhibitors on the accumulation of vincristine in a resistant human lung cancer cell line with high level of polymerized tubulin.
Emerging treatment using tubulin inhibitors in advanced non-small cell lung cancer.
Enhancement of in vivo antitumor activity of a novel antimitotic 1-phenylpropenone derivative, AM-132, by tumor necrosis factor-alpha or interleukin-6.
Eribulin mesilate, a halichondrin B analogue, in the treatment of breast cancer.
Expression of class III beta tubulin in non-small cell lung cancer is correlated with resistance to taxane chemotherapy.
Expression of ERCC1 and class IIIbeta tubulin for predicting effect of carboplatin/paclitaxel in patients with advanced inoperable non-small cell lung cancer.
Genome-wide cDNA microarray screening of genes related to survival in patients after curative resection of non-small cell lung cancer.
Identification by mass spectrometry of a new alpha-tubulin isotype expressed in human breast and lung carcinoma cell lines.
Imetelstat (a telomerase antagonist) exerts off?target effects on the cytoskeleton.
Imidazopyridine linked triazoles as tubulin inhibitors, effectively triggering apoptosis in lung cancer cell line.
Induction of tubulin by docetaxel is associated with p53 status in human non small cell lung cancer cell lines.
Inhalable nanostructured lipid particles of 9-bromo-noscapine, a tubulin-binding cytotoxic agent: Invitro and in vivo studies.
Knockdown of Tubulin Polymerization Promoting Protein Family Member 3 Suppresses Proliferation and Induces Apoptosis in Non-Small-Cell Lung Cancer.
New Colchicine-Derived Triazoles and Their Influence on Cytotoxicity and Microtubule Morphology.
Novel hybrid nocodazole analogues as tubulin polymerization inhibitors and their antiproliferative activity.
Orally available tubulin inhibitor VERU-111 enhances antitumor efficacy in paclitaxel-resistant lung cancer.
P-glycoprotein-evading anti-tumor activity of a novel tubulin and HSP90 dual inhibitor in a non-small-cell lung cancer model.
PAQR3 suppresses the growth of non-small cell lung cancer cells via modulation of EGFR-mediated autophagy.
Photo-Uncaging of a Microtubule-Targeted Rigidin Analogue in Hypoxic Cancer Cells and in a Xenograft Mouse Model.
Pilot study of vinorelbine (Navelbine) and paclitaxel (Taxol) in patients with refractory breast cancer and lung cancer.
Randomized phase II study of ixabepilone or paclitaxel plus carboplatin in patients with non-small-cell lung cancer prospectively stratified by beta-3 tubulin status.
Synergistic interaction of gemcitabine and paclitaxel by modulating acetylation and polymerization of tubulin in non-small cell lung cancer cell lines.
Synthesis and mechanism of action of novel pyrimidinyl pyrazole derivatives possessing antiproliferative activity.
Synthesis, Evaluation of Cytotoxicity and Molecular Docking Studies of the 7-Acetamido Substituted 2-Aryl-5-bromo-3-trifluoroacetylindoles as Potential Inhibitors of Tubulin Polymerization.
The anthelmintic drug mebendazole induces mitotic arrest and apoptosis by depolymerizing tubulin in non-small cell lung cancer cells.
The newly synthesized 2-arylnaphthyridin-4-one, CSC-3436, induces apoptosis of non-small cell lung cancer cells by inhibiting tubulin dynamics and activating CDK1.
The novel toluidine sulphonamide EL102 shows pre-clinical in vitro and in vivo activity against prostate cancer and circumvents MDR1 resistance.
The role of betaIII tubulin in predicting chemoresistance in non-small cell lung cancer.
Tubulin acetylation enhances lung cancer resistance to paclitaxel-induced cell death through Mcl-1 stabilization.
Tubulin inhibitors in non-small cell lung cancer: looking back and forward.
[Class III beta tubulin expression in nonsmall cell lung cancer]
[Recent development of new anticancer drugs in Japan]
Lupus Erythematosus, Systemic
Antibodies to tubulin and microtubule-associated proteins. A study in diabetes mellitus, systemic lupus erythematosus, and rheumatoid arthritis.
Natural autoantibodies in systemic lupus erythematosus.
Lupus Nephritis
Pathogenic autoantibodies from patients with lupus nephritis cause reduced tyrosine phosphorylation of podocyte proteins, including tubulin.
Lymphatic Metastasis
Microsatellite analysis of the APC gene and immunoexpression of E-cadherin, catenin, and tubulin in esophageal squamous cell carcinoma.
Lymphoma
Aberrant protein expression in cerebral cortex of fetus with Down syndrome.
Clinicopathological observation of primary lung enteric adenocarcinoma and its response to chemotherapy: A case report and review of the literature.
Cytosine arabinoside, vinblastine, 5-fluorouracil and 2-aminoanthracene testing in the in vitro micronucleus assay with L5178Y mouse lymphoma cells at Sanofi Aventis, with different cytotoxicity measurements, in support of the draft OECD Test Guideline on In Vitro Mammalian Cell Micronucleus Test.
Etoposide, cadmium chloride, benzo[a]pyrene, cyclophosphamide and colchicine tested in the in vitro mammalian cell micronucleus test (MNvit) in the presence and absence of cytokinesis block using L5178Y mouse lymphoma cells and 2-aminoanthracene tested in MNvit in the absence of cytokinesis block using TK6 cells at AstraZeneca UK, in support of OECD draft Test Guideline 487.
MPT0B169, a New Tubulin Inhibitor, Inhibits Cell Growth and Induces G2/M Arrest in Nonresistant and Paclitaxel-Resistant Cancer Cells.
Novel aminochromone derivative inhibits tumor growth on xenograft model of lung cancer in mice.
Purification and characterization of tubulin from parental and vincristine-resistant HOB1 lymphoma cells.
Lymphoma, B-Cell
LncRNA MEG3 inhibits proliferation and promotes apoptosis of synovial cells in rats with knee osteoarthritis by regulating PTEN.
Molecular targets for the management of gastrointestinal cancer using melatonin, a natural endogenous body hormone.
Macular Degeneration
Retinal tubulin binds macular carotenoids.
Malaria
An Antiparasitic Compound from the Medicines for Malaria Venture Pathogen Box Promotes Leishmania Tubulin Polymerization.
Antimitotic herbicides bind to an unidentified site on malarial parasite tubulin and block development of liver-stage Plasmodium parasites.
Combination Assays and Molecular Docking Can Identify Binding Sites of Anti-Microtubule Drugs on Plasmodium falciparum tubulin.
Comparative Gene Expression Profiling of P. falciparum Malaria Parasites Exposed to Three Different Histone Deacetylase Inhibitors.
Microtubule inhibitors as potential antimalarial agents.
Mode of action of tubulozoles against Plasmodium falciparum in vitro.
The gamma-tubulin gene of the malaria parasite Plasmodium falciparum.
The tubulin genes of the human malaria parasite Plasmodium falciparum, their chromosomal location and sequence analysis of the alpha-tubulin II gene.
Malaria, Cerebral
IgG autoantibody to brain beta tubulin III associated with cytokine cluster-II discriminate cerebral malaria in central India.
Malformations of Cortical Development
A novel TUBG1 mutation with neurodevelopmental disorder caused by malformations of cortical development.
Beta tubulin isoforms are not interchangeable for rescuing impaired radial migration due to Tubb3 knockdown.
Brain malformations and mutations in ?- and ?-tubulin genes: a review of the literature and description of two new cases.
Cerebral palsy and seizures in a child with tubulinopathy pattern dysgenesis and focal cortical dysplasia.
Investigation of the most common clinical and imaging findings and the role of Tubulin genes in the etiology Of malformations of cortical development.
Mutations in ?- and ?-tubulin encoding genes: Implications in brain malformations.
Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly.
Mutations in tubulin genes are frequent causes of various foetal malformations of cortical development including microlissencephaly.
Novel variants in TUBA1A cause congenital fibrosis of the extraocular muscles with or without malformations of cortical brain development.
Recognizable cerebellar dysplasia associated with mutations in multiple tubulin genes.
The wide spectrum of tubulinopathies: what are the key features for the diagnosis?
TUBG1 missense variants underlying cortical malformations disrupt neuronal locomotion and microtubule dynamics but not neurogenesis.
Tubulin genes and malformations of cortical development.
Two unique TUBB3 mutations cause both CFEOM3 and malformations of cortical development.
Malformations of Cortical Development, Group II
Epilepsy in Tubulinopathy: Personal Series and Literature Review.
Posterior Neocortex-Specific Regulation of Neuronal Migration by CEP85L Identifies Maternal Centriole-Dependent Activation of CDK5.
Malnutrition
Malnutrition increases insoluble-to-soluble tubulin ratio and in vitro incorporation of 32ATP in rat cerebral cortex.
Measles
Host cell proteins required for measles virus reproduction.
Medulloblastoma
Differential expression and cellular distribution of gamma-tubulin and betaIII-tubulin in medulloblastomas and human medulloblastoma cell lines.
Integrated proteomic platforms for the comparative characterization of medulloblastoma and pilocytic astrocytoma pediatric brain tumors: a preliminary study.
Megalencephaly
Introduction: Brain malformations.
Melanoma
3'-Hydroxy-3,4'-dimethoxyflavone blocks tubulin polymerization and is a potent apoptotic inducer in human SK-MEL-1 melanoma cells.
An autophagic deficit in the uterine vessel microenvironment provokes hyperpermeability through deregulated VEGFA, NOS1, and CTNNB1.
Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2',3',4'-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a new class of antimitotic antitumor agents.
Colchicine Binding Site Agent DJ95 Overcomes Drug Resistance and Exhibits Antitumor Efficacy.
Cytoplasmic microtubules in two different mouse melanoma cell lines: a qualitative and quantitative analysis using confocal laser scanning microscopy and computer-assisted image analysis.
Cytoskeletal tubulin competes with actin to increase deformability of metastatic melanoma cells.
Evaluation of tubulin ?-3 as a novel senescence-associated gene in melanocytic malignant transformation.
Exploring the Influence of the Aromaticity on the Anticancer and Antivascular Activities of Organoplatinum(II) Complexes.
Expression of cytoskeletal components in melanocytic skin lesions. An immunohistochemical study.
Gold(I)-NHC complexes of antitumoral diarylimidazoles: structures, cellular uptake routes and anticancer activities.
Imidazoquinoxaline anticancer derivatives and imiquimod interact with tubulin: Characterization of molecular microtubule inhibiting mechanisms in correlation with cytotoxicity.
Mechanism of action of the third generation benzopyrans and evaluation of their broad anti-cancer activity in vitro and in vivo.
New imidazoquinoxaline derivatives: Synthesis, biological evaluation on melanoma, effect on tubulin polymerization and structure-activity relationships.
Novel Tubulin Polymerization Inhibitors Overcome Multidrug Resistance and Reduce Melanoma Lung Metastasis.
Postembedding immunogold electron microscopy for S100, tubulin, and cytoskeletal proteins in an amelanotic malignant melanoma.
RAC1 induces nuclear alterations through the LINC complex to enhance melanoma invasiveness.
Requirement of calcium ions for cell degeneration with a toxin (vibriolysin) from Vibrio parahaemolyticus.
Structural Optimization of Indole Derivatives Acting at Colchicine Binding Site as Potential Anticancer Agents.
Structure-Activity Relationship Study of Novel 6-Aryl-2-benzoyl-pyridines as Tubulin Polymerization Inhibitors with Potent Antiproliferative Properties.
Synergistic combination of novel tubulin inhibitor ABI-274 and vemurafenib overcome vemurafenib acquired resistance in BRAFV600E melanoma.
Systemic delivery of nanoparticle formulation of novel tubulin inhibitor for treating metastatic melanoma.
The Tubulin Inhibitor VERU-111 in Combination With Vemurafenib Provides an Effective Treatment of Vemurafenib-Resistant A375 Melanoma.
Tubulin expression in melanocytic skin tumors. An immunohistochemical study.
Melanoma, Experimental
A systematic SAR study of C10 modified paclitaxel analogues using a combinatorial approach.
Butitaxel analogues: synthesis and structure-activity relationships.
Cellular uptake and tubulin binding properties of four Vinca alkaloids.
In vitro and in vivo biological evaluation of new 4,5-disubstituted 1,2,3-triazoles as cis-constrained analogs of combretastatin A4.
Metastasis associated MTS1 and NM23 genes affect tubulin polymerisation in B16 melanomas: a possible mechanism of their regulation of metastatic behaviour of tumours.
Structure-activity relationships of indole compounds derived from combretastatin A4: synthesis and biological screening of 5-phenylpyrrolo[3,4-a]carbazole-1,3-diones as potential antivascular agents.
Synthesis and biological evaluation of (3,4,5-trimethoxyphenyl)indol-3-ylmethane derivatives as potential antivascular agents.
Synthesis and biological evaluation of new disubstituted analogues of 6-methoxy-3-(3',4',5'-trimethoxybenzoyl)-1H-indole (BPR0L075), as potential antivascular agents.
Synthesis and biological evaluation of novel ferrocenyl curcuminoid derivatives.
Synthesis of biologically active taxol analogues with modified phenylisoserine side chains.
YoshixolTR inhibits B16 melanoma cell growth in vivo and induces apoptosis-like (quantum thermodynamic) cell death.
Memory Disorders
Pharmocologic treatment with histone deacetylase 6 inhibitor (ACY-738) recovers Alzheimer's disease phenotype in amyloid precursor protein/presenilin 1 (APP/PS1) mice.
Spastin depletion increases tubulin polyglutamylation and impairs kinesin-mediated neuronal transport, leading to working and associative memory deficits.
Meningeal Carcinomatosis
Pathology of brain parenchyma in meningeal carcinomatosis; immunohistochemical study with astroprotein (GFAP) and tubulin.
Reversible posterior leukoencephalopathy syndrome induced by vinorelbine.
Mesothelioma
Preclinical Activity of New [1,2]Oxazolo[5,4-e]isoindole Derivatives in Diffuse Malignant Peritoneal Mesothelioma.
Synergistic activity of the c-Met and tubulin inhibitor tivantinib (ARQ197) with pemetrexed in mesothelioma cells.
Mesothelioma, Malignant
Immunohistochemical distribution of tubulin beta II in human normal and neoplastic tissues.
Induction of tubulin polymerization and apoptosis in malignant mesothelioma cells by a new compound JBIR-23.
Microcephaly
Bi-allelic Pathogenic Variants in TUBGCP2 Cause Microcephaly and Lissencephaly Spectrum Disorders.
Case reports: novel TUBG1 mutations with milder neurodevelopmental presentations.
Clinical variability of TUBB-associated disorders: Diagnosis through reanalysis.
De novo TUBB2B mutation causes fetal akinesia deformation sequence with microlissencephaly: An unusual presentation of tubulinopathy.
Disorders of Microtubule Function in Neurons: Imaging Correlates.
Mutations in the ?-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities.
Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly.
Mutations in tubulin genes are frequent causes of various foetal malformations of cortical development including microlissencephaly.
Overlapping phenotype comprising Kenny-Caffey type 2 and Sanjad-Sakati syndromes: The first case report.
The wide spectrum of tubulinopathies: what are the key features for the diagnosis?
Tubulinopathies continued: refining the phenotypic spectrum associated with variants in TUBG1.
Microsporidiosis
Therapeutic targets for the treatment of microsporidiosis in humans.
microtubule-severing atpase deficiency
Graded Control of Microtubule Severing by Tubulin Glutamylation.
Mobius Syndrome
An exome sequencing study of Moebius syndrome including atypical cases reveals an individual with CFEOM3A and a TUBB3 mutation.
Motor Neuron Disease
A missense mutation in Tbce causes progressive motor neuronopathy in mice.
AAV9-Stathmin1 gene delivery improves disease phenotype in an intermediate mouse model of Spinal Muscular Atrophy.
Mouth Neoplasms
?- and ?-Santalols Directly Interact with Tubulin and Cause Mitotic Arrest and Cytotoxicity in Oral Cancer Cells.
Resveratrol in Various Pockets: A Review.
Movement Disorders
MPTP induces intranuclear rodlet formation in midbrain dopaminergic neurons.
TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development.
Multiple Myeloma
MIR145-3p promotes autophagy and enhances bortezomib sensitivity in multiple myeloma by targeting HDAC4.
Natural antibodies against tubulin, actin myoglobin, thyroglobulin, fetuin, albumin and transferrin are present in normal human sera, and monoclonal immunoglobulins from multiple myeloma and Waldenström's macroglobulinemia may express similar antibody specificities.
Ricolinostat, the First Selective Histone Deacetylase 6 Inhibitor, in Combination with Bortezomib and Dexamethasone for Relapsed or Refractory Multiple Myeloma.
Targeting the 'garbage-bin' to fight cancer: HDAC6 inhibitor WT161 has an anti-tumor effect on osteosarcoma and synergistically interacts with 5-FU.
Multiple Sclerosis
A new myelin protein, TPPP/p25, reduced in demyelinated lesions is enriched in cerebrospinal fluid of multiple sclerosis.
Autoantibodies in neurodegenerative diseases: antigen-specific frequencies and intrathecal analysis.
Axon cytoskeleton proteins specifically modulate oligodendrocyte growth and differentiation in vitro.
Beta4 tubulin identifies a primitive cell source for oligodendrocytes in the mammalian brain.
Cerebrospinal fluid antibodies to tubulin are elevated in the patients with multiple sclerosis.
Comparative study of natural autoantibodies in the serum and cerebrospinal fluid of normal individuals and patients with multiple sclerosis and other neurological diseases.
Serum antibodies against central nervous system proteins in human demyelinating disease.
Tubulin polymerization promoting protein (TPPP/p25) as a marker for oligodendroglial changes in multiple sclerosis.
[Lesion mechanism dependent, differential changes in neurofilaments and microtubules: a pathological and experimental study]
Multiple System Atrophy
?-III Tubulin Fragments Inhibit ?-Synuclein Accumulation in Models of Multiple System Atrophy.
Binding of neuronal ?-synuclein to ?-III tubulin and accumulation in a model of multiple system atrophy.
Interactions of pathological hallmark proteins: Tubulin polymerization promoting protein/p25, {beta}-amyloid and {alpha}-synuclein.
Loss of DJ-1 protein stability and cytoprotective function by Parkinson's disease-associated proline-158 deletion.
TPPP/p25: from unfolded protein to misfolding disease: prediction and experiments.
Tubulin polymerization promoting protein (TPPP/p25) as a marker for oligodendroglial changes in multiple sclerosis.
Muscle Hypotonia
[Reorganization of the tubulin and vimentin components of the cytoskeleton as affected by the action of hypotonia on L cells]
Muscular Atrophy
Effect of an Adipose-Derived Stem Cell and Nerve Growth Factor-Incorporated Hydrogel on Recovery of Erectile Function in a Rat Model of Cavernous Nerve Injury.
The decrease of the cytoskeleton tubulin follows the decrease of the associating molecular chaperone alphaB-crystallin in unloaded soleus muscle atrophy without stretch.
Muscular Diseases
VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle.
Muscular Dystrophies
Distribution of cytoskeletal elements in cultured skin fibroblasts of patients with Duchenne's muscular dystrophy.
Muscular Dystrophy, Facioscapulohumeral
Identification of a novel beta-tubulin subfamily with one member (TUBB4Q) located near the telomere of chromosome region 4q35.
Myelodysplastic Syndromes
Efficacy of the novel tubulin polymerization inhibitor PTC-028 for myelodysplastic syndrome.
Nasopharyngeal Carcinoma
Antimitotic and cytotoxic flavonols from Zieridium pseudobtusifolium and Acronychia porteri.
Autoantibodies to tubulin are specifically associated with the young age onset of the nasopharyngeal carcinoma.
Nasopharyngeal Neoplasms
EBV-miR-BART12 accelerates migration and invasion in EBV-associated cancer cells by targeting tubulin polymerization-promoting protein 1.
Nematode Infections
Expression of both Arabidopsis ?-tubulin genes is essential for development of a functional syncytium induced by Heterodera schachtii.
Neoplasm Metastasis
?III-Tubulin Regulates Breast Cancer Metastases to the Brain.
An Orally Available Tubulin Inhibitor, VERU-111, Suppresses Triple-Negative Breast Cancer Tumor Growth and Metastasis and Bypasses Taxane Resistance.
Bax/Tubulin/Epithelial-Mesenchymal Pathways Determine the Efficacy of Silybin Analog HM015k in Colorectal Cancer Cell Growth and Metastasis.
Challenges in treating advanced disease.
Differential expression of glu-tubulin in relation to mammary gland disease.
Expression of cytoskeletal components in melanocytic skin lesions. An immunohistochemical study.
HDAC6: Physiological function and its selective inhibitors for cancer treatment.
Increased levels of a unique post-translationally modified betaIVb-tubulin isotype in liver cancer.
Induction of 18A2/mts1 gene expression and its effects on metastasis and cell cycle control.
Metastasis associated MTS1 and NM23 genes affect tubulin polymerisation in B16 melanomas: a possible mechanism of their regulation of metastatic behaviour of tumours.
Microsatellite analysis of the APC gene and immunoexpression of E-cadherin, catenin, and tubulin in esophageal squamous cell carcinoma.
Novel Molecular Targets for the Therapy of Castration-Resistant Prostate Cancer.
Novel Tubulin Polymerization Inhibitors Overcome Multidrug Resistance and Reduce Melanoma Lung Metastasis.
Oblongifolin C inhibits metastasis by up-regulating keratin 18 and tubulins.
Pharmacophore-based virtual screening for identification of potential selective inhibitors of human histone deacetylase 6.
PPARgamma inhibitors reduce tubulin protein levels by a PPARgamma, PPARdelta and proteasome-independent mechanism, resulting in cell cycle arrest, apoptosis and reduced metastasis of colorectal carcinoma cells.
Reversible posterior leukoencephalopathy syndrome induced by vinorelbine.
Synthesis and biological evaluation of new 2-methoxyestradiol derivatives: Potent inhibitors of angiogenesis and tubulin polymerization.
Systemic delivery of nanoparticle formulation of novel tubulin inhibitor for treating metastatic melanoma.
Tektin4 loss promotes triple-negative breast cancer metastasis through HDAC6-mediated tubulin deacetylation and increases sensitivity to HDAC6 inhibitor.
Tubulin cofactor a functions as a novel positive regulator of ccRCC progression, invasion and metastasis.
Tubulin-binding agents down-regulate matrix metalloproteinase-2 and -9 in human hormone-refractory prostate cancer cells - A critical role of Cdk1 in mitotic entry.
Up-regulation of hnRNP A1, Ezrin, tubulin ?-2C and Annexin A1 in sentinel lymph nodes of colorectal cancer.
Vasohibin-2 plays an essential role in metastasis of pancreatic ductal adenocarcinoma.
Neoplasms
(4-Methoxyphenyl)(3,4,5-trimethoxyphenyl)methanone inhibits tubulin polymerization, induces G2/M arrest, and triggers apoptosis in human leukemia HL-60 cells.
(E)-N-Aryl-2-oxo-2-(3,4,5-trimethoxyphenyl)acetohydrazonoyl cyanides as tubulin polymerization inhibitors: Structure-based bioisosterism design, synthesis, biological evaluation, molecular docking and in silico ADME prediction.
1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase.
10-(2-oxo-2-Phenylethylidene)-10H-anthracen-9-ones as Highly Active Antimicrotubule Agents: Synthesis, Antiproliferative Activity, and Inhibition of Tubulin Polymerization.
10-(4-Phenylpiperazine-1-carbonyl)acridin-9(10H)-ones and related compounds: Synthesis, antiproliferative activity and inhibition of tubulin polymerization.
11-Substituted Benzo[c]phenanthridines: New Structures and Insight into Their Mode of Antiproliferative Action.
2-APCAs, the Novel Microtubule Targeting Agents Active Against Distinct Cancer Cell Lines.
2-Phenyl-5-(pyrrolidin-1-yl)-1-(3,4,5-trimethoxybenzyl)-1H-benzimidazole, a benzimidazole derivative, inhibits growth of human prostate cancer cells by affecting tubulin and c-Jun N-terminal kinase.
2D-PAGE of ovarian cancer: analysis of soluble and insoluble fractions using medium-range immobilized pH gradients.
3-(Iodoacetamido)-benzoylurea: a novel cancericidal tubulin ligand that inhibits microtubule polymerization, phosphorylates bcl-2, and induces apoptosis in tumor cells.
3-Aroyl-1,4-diarylpyrroles Inhibit Chronic Myeloid Leukemia Cell Growth through an Interaction with Tubulin.
50 years on … the discovery of tubulin continues to advance cancer treatment.
?- and ?-Santalols Directly Interact with Tubulin and Cause Mitotic Arrest and Cytotoxicity in Oral Cancer Cells.
?-Cyclodextrin Interacts Close to Vinblastine Site of Tubulin and Delivers Curcumin Preferentially to the Tubulin Surface of Cancer Cell.
?-Taxilin Interacts with Sorting Nexin 4 and Participates in the Recycling Pathway of Transferrin Receptor.
?-tubulin as a signal-transducing molecule and meshwork with therapeutic potential.
?III-tubulin enhances efficacy of cabazitaxel as compared with docetaxel.
?III-Tubulin is required for interphase microtubule dynamics in untransformed human mammary epithelial cells.
A boronic acid chalcone analog of combretastatin A-4 as a potent anti-proliferation agent.
A Cell-Level Systems PK-PD Model to Characterize In Vivo Efficacy of ADCs.
A class of novel tubulin polymerization inhibitors exert effective anti-tumor activity via mitotic catastrophe.
A closer look at evolution: Variants (SNPs) of genes involved in skin pigmentation, including EXOC2, TYR, TYRP1, and DCT, are associated with 25(OH)D serum concentration.
A collective motion description of tubulin ?T7 loop dynamics.
A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells.
A cryptic tubulin-binding domain links MEKK1 to curved tubulin protomers.
A DM1-doped porous gold nanoshell system for NIR accelerated redox-responsive release and triple modal imaging guided photothermal synergistic chemotherapy.
A drug repositioning success: The repositioned therapeutic applications and mechanisms of action of thalidomide.
A highly potent maytansinoid analogue and its use as a cytotoxic therapeutic agent in gold nanoparticles for the treatment of hepatocellular carcinoma.
A malignant and metastasizing feline cardiac ganglioneuroma.
A method for determination of dimethyl benzoylphenyl urea (BPU) in human plasma by using LC/UV.
A new anti-tubulin agent containing the benzo[b]thiophene ring system.
A new C,N-cyclometalated osmium(ii) arene anticancer scaffold with a handle for functionalization and antioxidative properties.
A new cytotoxic epothilone from modified polyketide synthases heterologously expressed in Myxococcus xanthus.
A New Inhibitor of Tubulin Polymerization Kills Multiple Cancer Cell Types and Reveals p21-Mediated Mechanism Determining Cell Death after Mitotic Catastrophe.
A new tubulin polymerization inhibitor, auristatin PE, induces tumor regression in a human Waldenstrom's macroglobulinemia xenograft model.
A novel anti-microtubule agent with carbazole and benzohydrazide structures suppresses tumor cell growth in vivo.
A novel candidate compound with urethane structure for anticancer drug development.
A novel class of tubulin inhibitors that exhibit potent antiproliferation and in vitro vessel-disrupting activity.
A Novel Dual HDAC6 and Tubulin Inhibitor, MPT0B451, Displays Anti-tumor Ability in Human Cancer Cells
A novel dual inhibitor of microtubule and Bruton's tyrosine kinase inhibits survival of multiple myeloma and osteoclastogenesis.
A novel microtubule inhibitor, MT3-037, causes cancer cell apoptosis by inducing mitotic arrest and interfering with microtubule dynamics.
A novel orally active microtubule destabilizing agent S-40 targets the colchicine-binding site and shows potent antitumor activity.
A Novel Resveratrol Based Tubulin Inhibitor Induces Mitotic Arrest and Activates Apoptosis in Cancer Cells.
A novel synthetic microtubule inhibitor, MPT0B214 exhibits antitumor activity in human tumor cells through mitochondria-dependent intrinsic pathway.
A novel tubulin inhibitor STK899704 induces tumor regression in DMBA/TPA-induced skin carcinogenesis model.
A perspective on vascular disrupting agents that interact with tubulin: preclinical tumor imaging and biological assessment.
A phase 1 study of ABT-751, an orally bioavailable tubulin inhibitor, administered daily for 7 days every 21 days in pediatric patients with solid tumors.
A phase 2 study of epothilone B analog BMS-247550 (NSC 710428) in patients with relapsed aggressive non-Hodgkin lymphomas.
A phase I study of ABT-751, an orally bioavailable tubulin inhibitor, administered daily for 21 days every 28 days in pediatric patients with solid tumors.
A phase I study of paclitaxel, estramustine phosphate and vinorelbine (Pacl-E-Vin) in advanced malignancies: triple tubulin targeting.
A phase I-II study of the histone deacetylase inhibitor vorinostat plus sequential weekly paclitaxel and doxorubicin-cyclophosphamide in locally advanced breast cancer.
A phase II clinical trial of the Vascular Disrupting Agent BNC105P as second line chemotherapy for advanced Malignant Pleural Mesothelioma.
A phase II evaluation of ixabepilone in the treatment of recurrent/persistent carcinosarcoma of the uterus, an NRG Oncology/Gynecologic Oncology Group study.
A radioligand binding assay for antitubulin activity in tumor cells.
A rapid and sensitive method for determination of dimethyl benzoylphenyl urea in human plasma by using LC/MS/MS.
A Rationale for Drug Design Provided by Co-Crystal Structure of IC261 in Complex with Tubulin.
A Review on Mechanisms of Anti Tumor Activity of Chalcones.
A role for the RASSF1A tumor suppressor in the regulation of tubulin polymerization and genomic stability.
A scalable high-content cytotoxicity assay insensitive to changes in mitochondrial metabolic activity.
A semisynthetic taxane Yg-3-46a effectively evades P-glycoprotein and ?-III tubulin mediated tumor drug resistance in vitro.
A Stilbenoid Isorhapontigenin as a Potential Anti-Cancer Agent against Breast Cancer through Inhibiting Sphingosine Kinases/Tubulin Stabilization.
A study of the cross-resistance of vincristine and vindesine in reinduction therapy for acute lymphocytic leukemia in relapse. A report for Children's Cancer Study Group.
A tale of two tumor targets: topoisomerase I and tubulin. The Wall and Wani contribution to cancer chemotherapy.
A Theoretical Study on the Biophysical Mechanisms by Which Tumor Treating Fields Affect Tumor Cells during Mitosis.
A TOGL domain specifically targets yeast CLASP to kinetochores to stabilize kinetochore microtubules.
A tubulin polymerization microassay used to compare ligand efficacy.
Aberrations of centrosomes in adrenocortical tumors.
Abilities of 3,4-diarylfuran-2-one analogs of combretastatin A-4 to inhibit both proliferation of tumor cell lines and growth of relevant tumors in nude mice.
Acetonitrile-assisted enzymatic digestion can facilitate the bottom-up identification of proteins of cancer origin.
Activated carbon/Brønsted acid-promoted aerobic benzylic oxidation under "on-water" condition: Green and efficient synthesis of 3-benzoylquinoxalinones as potent tubulin inhibitors.
Affinity Purification and Characterization of Functional Tubulin from Cell Suspension Cultures of Arabidopsis and Tobacco.
Alterations in vascular architecture and permeability following OXi4503 treatment.
Altered cellular distribution and subcellular sorting of gamma-tubulin in diffuse astrocytic gliomas and human glioblastoma cell lines.
An Amino-Benzosuberene Analogue That Inhibits Tubulin Assembly and Demonstrates Remarkable Cytotoxicity.
An Emerging Role for Tubulin Isotypes in Modulating Cancer Biology and Chemotherapy Resistance.
An Orally Available Tubulin Inhibitor, VERU-111, Suppresses Triple-Negative Breast Cancer Tumor Growth and Metastasis and Bypasses Taxane Resistance.
An Orally Bioavailable, Indole-3-glyoxylamide Based Series of Tubulin Polymerization Inhibitors Showing Tumor Growth Inhibition in a Mouse Xenograft Model of Head and Neck Cancer.
Analysis of Tubulin Alpha-1A/1B C-Terminal Tail Post-translational Poly-glutamylation Reveals Novel Modification Sites.
Androgen receptor signalling impairs docetaxel efficacy in castration-resistant prostate cancer.
Anti-neoplastic agent thymoquinone induces degradation of ? and ? tubulin proteins in human cancer cells without affecting their level in normal human fibroblasts.
Anti-tubulin agents of natural origin: Targeting taxol, vinca, and colchicine binding domains.
Anti-tumor activity evaluation of novel tubulin and HDAC dual-targeting inhibitors.
Anti-tumor efficacy of CKD-516 in combination with radiation in xenograft mouse model of lung squamous cell carcinoma.
Anticancer activity of bisindole alkaloids derived from natural sources and synthetic bisindole hybrids.
Antifungal and cancer cell growth inhibitory activities of 1-(3',4',5'-trimethoxyphenyl)-2-nitro-ethylene.
Antimitotic antifungal compound benomyl inhibits brain microtubule polymerization and dynamics and cancer cell proliferation at mitosis, by binding to a novel site in tubulin.
Antineoplastic agents 337. Synthesis of dolastatin 10 structural modifications.
Antineoplastic agents 360. Synthesis and cancer cell growth inhibitory studies of dolastatin 15 structural modifications.
Antineoplastic agents 365. Dolastatin 10 SAR probes.
Antineoplastic agents 440. Asymmetric synthesis and evaluation of the combretastatin A-1 SAR probes (1S,2S)- and (1R,2R)-1, 2-dihydroxy- 1-(2',3'-dihydroxy-4'-methoxyphenyl)-2-(3' ',4' ',5' '-trimethoxyphenyl)-ethane.
Antineoplastic agents. 410. Asymmetric hydroxylation of trans-combretastatin A-4.
Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41.
Antiproliferative Activity of 8-methoxy Ciprofloxacin-Hydrozone/Acylhydrazone Scaffolds.
Antiproliferative and proapoptotic effects of a pyrrole containing arylthioindole in human Jurkat leukemia cell line and multidrug-resistant Jurkat/A4 cells.
Antitumor Activity of Asperphenin A, a Lipopeptidyl Benzophenone from Marine-Derived Aspergillus sp. Fungus, by Inhibiting Tubulin Polymerization in Colon Cancer Cells.
Antitumor Activity of IMC-038525, a Novel Oral Tubulin Polymerization Inhibitor.
Antitumor activity of tricyclic pyrone analogs, a new synthetic class of microtubule de-stabilizing agents, in the murine EMT-6 mammary tumor cell line in vitro.
Antitumor activity of TZT-1027 (Soblidotin).
Antitumor agents. 139. Synthesis and biological evaluation of thiocolchicine analogs 5,6-dihydro-6(S)-(acyloxy)- and 5,6-dihydro-6(S)-[(aroyloxy)methyl]-1,2,3-trimethoxy-9-(methylthio)-8H- cyclohepta[a]naphthalen-8-ones as novel cytotoxic and antimitotic agents.
Antitumor agents. 141. Synthesis and biological evaluation of novel thiocolchicine analogs: N-acyl-, N-aroyl-, and N-(substituted benzyl)deacetylthiocolchicines as potent cytotoxic and antimitotic compounds.
Antitumor agents. 150. 2',3',4',5',5,6,7-substituted 2-phenyl-4-quinolones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2',3',4'-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a new class of antimitotic antitumor agents.
Antitumor agents. Part 226: synthesis and cytotoxicity of 2-phenyl-4-quinolone acetic acids and their esters.
Antitumor agents. Part 236: Synthesis of water-soluble colchicine derivatives.
Antitumor and antivascular effects of AC-7700, a combretastatin A-4 derivative, against rat liver cancer.
Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells.
Antitumor effect of the vascular-disrupting agent ZD6126 in a murine renal cell carcinoma model.
Antivascular approaches to solid tumour therapy: evaluation of tubulin binding agents.
Antivascular effects of TZT-1027 (Soblidotin) on murine Colon26 adenocarcinoma.
Application of GA-MLR for QSAR modeling of the arylthioindole class of tubulin polymerization inhibitors as anticancer agents.
Application of the McMurry coupling reaction in the synthesis of tri- and tetra-arylethylene analogues as potential cancer chemotherapeutic agents.
Array-based structure and gene expression relationship study of antitumor sulfonamides including N-[2-[(4-hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide and N-(3-chloro-7-indolyl)-1,4-benzenedisulfonamide.
Arsenic trioxide produces polymerization of microtubules and mitotic arrest before apoptosis in human tumor cell lines.
Arylurea Derivatives: a Class of Potential Cancer Targeting Agents.
Assembly of nonneural microtubules in the absence of glycerol and microtubule-associated proteins.
Assessing the utility of in vitro microtubule assays for studying mechanisms of peripheral neuropathy with the microtubule inhibitor class of cancer chemotherapy.
Association of Aurora A and gamma-tubulin expression in astrocytomas and patient survival.
Asymmetric synthesis of 2,3-dihydro-2-arylquinazolin-4-ones: methodology and application to a potent fluorescent tubulin inhibitor with anticancer activity.
ATP/ADP ratio, the missed connection between mitochondria and the Warburg effect.
Attachment and invasion of high- and low-metastatic clones of RCT sarcoma in a three-dimensional culture system.
Augmentation of the anticancer activity of CYT997 in human prostate cancer by inhibiting Src activity.
Autophagy drives fibroblast senescence through MTORC2 regulation.
Autophagy inhibition with chloroquine reverts paclitaxel resistance and attenuates metastatic potential in human nonsmall lung adenocarcinoma A549 cells via ROS mediated modulation of ?-catenin pathway.
Azatoxin derivatives with potent and selective action on topoisomerase II.
B-ring-modified isocombretastatin A-4 analogues endowed with interesting anticancer activities.
BCIRG 001 molecular analysis: prognostic factors in node-positive breast cancer patients receiving adjuvant chemotherapy.
Beta class II tubulin predominates in normal and tumor breast tissues.
beta(III)-tubulin at the invasive margin of colorectal cancer: possible link to invasion.
Beta-tubulin III expression in prostate cancer.
BetaIII-tubulin induces paclitaxel resistance in association with reduced effects on microtubule dynamic instability.
betaIII-tubulin is a multifunctional protein involved in drug sensitivity and tumorigenesis in non-small cell lung cancer.
Bifidenone: Structure-Activity Relationship and Advanced Preclinical Candidate.
Bioelectrical impedimetric sensor for single cell analysis based on nanoroughened quartz substrate; suitable for cancer therapeutic purposes.
Biological activity of 4-substituted methoxybenzoyl-aryl-thiazole: an active microtubule inhibitor.
Biological Characterization of an Improved Pyrrole-Based Colchicine Site Agent Identified through Structure-Based Design.
Biological evaluation on different human cancer cell lines of novel colchicine analogs.
Biophysical and Structural Characterization of the Centriolar Protein Cep104 Interaction Network.
Bioreductively Activatable Prodrug Conjugates of Combretastatin A-1 and Combretastatin A-4 as Anticancer Agents Targeted toward Tumor-Associated Hypoxia.
Biosynthesis of radiolabeled curacin A and its rapid and apparently irreversible binding to the colchicine site of tubulin.
Blocking Blood Flow to Solid Tumors by Destabilizing Tubulin: An Approach to Targeting Tumor Growth.
BNC105: a novel tubulin polymerization inhibitor that selectively disrupts tumor vasculature and displays single-agent antitumor efficacy.
Bone marrow CFU-GM and human tumor xenograft efficacy of three tubulin binding agents.
BPR0C305, an orally active microtubule-disrupting anticancer agent.
BRCA1 Regulates g-Tubulin Binding to Centrosomes.
Breast cancer cells evade paclitaxel-induced cell death by developing resistance to dasatinib.
BubR1 is required for the mitotic block induced by combretastatin-A4 and a novel cis-restricted ß-lactam analogue in human cancer cells.
Butterfly Structure: A Privileged Scaffold Targeting Tubulin-Colchicine Binding Site.
CA-1H, a novel oxazole bearing analogue of combretastatin A-4, disrupts the tumor vasculatures and inhibits the tumor growth via inhibiting tubulin polymerization.
Carbendazim inhibits cancer cell proliferation by suppressing microtubule dynamics.
Catecholamine-induced stimulation of adenylate cyclase in parallel with a change in tubulin assembly in Ehrlich ascites tumor cells.
Caulerpenyne binding to tubulin: structural modifications by a non conventional pharmacological agent.
CD13 as a new tumor target for antibody-drug conjugates: validation with the conjugate MI130110.
Cell cycle arrest through inhibition of tubulin polymerization by withaphysalin F, a bioactive compound isolated from Acnistus arborescens.
Cellular Effects of Curcumin on Plasmodium falciparum Include Disruption of Microtubules.
Cellular targets of the anti-breast cancer agent Z-1,1-dichloro-2,3-diphenylcyclopropane: type II estrogen binding sites and tubulin.
Centrosomal aberrations in primary invasive breast cancer are associated with nodal status and hormone receptor expression.
Centrosome abnormalities in giant cell tumour of bone: possible association with chromosomal instability.
Centrosome abnormalities in human carcinomas of the gallbladder and intrahepatic and extrahepatic bile ducts.
Centrosome abnormalities in ovarian cancer.
Changes in cell morphology guide identification of tubulin as the off-target for protein kinase inhibitors.
Characterization of Ceap-11 and Ceap-16, two novel splicing-variant-proteins, associated with centrosome, microtubule aggregation and cell proliferation.
Chemical synthesis and biological properties of pyridine epothilones.
Chemical targeting of GAPDH moonlighting function in cancer cells reveals its role in tubulin regulation.
Chemistry and biology of curacin A.
Chemoprotection by sulforaphane: Keep one eye beyond Keap1.
Chemoresistance in non-small cell lung cancer.
Chromosomal localization and promoter analysis of the adenomatous polyposis coli binding protein RP1.
Cink4T, a quinazolinone-based dual inhibitor of Cdk4 and tubulin polymerization, identified via ligand-based virtual screening, for efficient anticancer therapy.
Clinical outcome in children with recurrent neuroblastoma treated with ABT-751 and effect of ABT-751 on proliferation of neuroblastoma cell lines and on tubulin polymerization in vitro.
Colchicine Binding Site Agent DJ95 Overcomes Drug Resistance and Exhibits Antitumor Efficacy.
Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent.
Combretastatin A-4 Analogue: A Dual-Targeting and Tubulin Inhibitor Containing Antitumor Pt(IV) Moiety with a Unique Mode of Action.
Combretastatin A-4 derived 5-(1-methyl-4-phenyl-imidazol-5-yl)indoles with superior cytotoxic and anti-vascular effects on chemoresistant cancer cells and tumors.
Combretastatin A-4 derived imidazoles show cytotoxic, antivascular, and antimetastatic effects based on cytoskeletal reorganisation.
Combretastatin A-4 phosphate as a tumor vascular-targeting agent: early effects in tumors and normal tissues.
Combretastatin A-4 phosphate suppresses development and induces regression of choroidal neovascularization.
Combretastatin dinitrogen-substituted stilbene analogues as tubulin-binding and vascular-disrupting agents.
Combretastatin-like chalcones as inhibitors of microtubule polymerisation. Part 2: Structure-based discovery of alpha-aryl chalcones.
Comparative preclinical pharmacokinetic and metabolic studies of the combretastatin prodrugs combretastatin A4 phosphate and A1 phosphate.
Comparative profiling of the novel epothilone, sagopilone, in xenografts derived from primary non-small cell lung cancer.
Comparative proteomic analysis of esophageal squamous cell carcinoma.
Comparison of beta-tubulin mRNA and protein levels in 12 human cancer cell lines.
Comparison of tyrosine protein kinases in membrane fractions from mouse liver and Ehrlich ascites tumor.
Complementary isonitrile-based multicomponent reactions for the synthesis of diversified cytotoxic hemiasterlin analogues.
Concise syntheses of 7-anilino-indoline-N-benzenesulfonamides as antimitotic and vascular disrupting agents.
Confocal investigation on colocalization between tubulin posttranslational modifications and associated proteins in rat C6 glioma cells.
Conformational Flexibility of A Highly Conserved Helix Controls Cryptic Pocket Formation in FtsZ.
Constitutive production of 92-kDa gelatinase B can be suppressed by alterations in cell shape.
Convergent Synthesis and Biological Evaluation of 2-Amino-4-(3',4',5'-trimethoxyphenyl)-5-aryl Thiazoles as Microtubule Targeting Agents.
Copper(I) mediated facile synthesis of potent tubulin polymerization inhibitor, 9-amino-?-noscapine from natural ?-noscapine.
Correlation of tubulin-binding and antitumor activities of podophyllotoxin analogs.
CRA-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivo.
CRA-026440: a potent, broad-spectrum, hydroxamic histone deacetylase inhibitor with antiproliferative and antiangiogenic activity in vitro and in vivo.
Current advances of tubulin inhibitors as dual acting small molecules for cancer therapy.
Current Advances of Tubulin Inhibitors in Nanoparticle Drug Delivery and Vascular Disruption/Angiogenesis.
CXI-benzo-84 reversibly binds to tubulin at colchicine site and induces apoptosis in cancer cells.
Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites.
Cytoskeleton and motility: an immunohistological and computer simulation analysis of melanocytic skin tumors.
Cytoskeleton targeting value in prostate cancer treatment.
Cytotoxic 3,4,5-trimethoxychalcones as mitotic arresters and cell migration inhibitors.
Cytotoxic activity of the histone deacetylase inhibitor panobinostat (LBH589) in anaplastic thyroid cancer in vitro and in vivo.
Cytotoxic and antivascular 1-methyl-4-(3-fluoro-4-methoxyphenyl)-5-(halophenyl)-imidazoles.
Delineating the interaction of combretastatin A-4 with ?? tubulin isotypes present in drug resistant human lung carcinoma using a molecular modeling approach.
Delocalization of gamma-tubulin due to increased solubility in human breast cancer cell lines.
Deoxypodophyllotoxin triggers necroptosis in human non-small cell lung cancer NCI-H460 cells.
Deregulated DNA polymerase beta induces chromosome instability and tumorigenesis.
Design and synthesis of dual-action inhibitors targeting histone deacetylases and 3-hydroxy-3-methylglutaryl coenzyme A reductase for cancer treatment.
Design and synthesis of piperazine acetate podophyllotoxin ester derivatives targeting tubulin depolymerization as new anticancer agents.
Design and synthesis of silicon-containing tubulin polymerization inhibitors: replacement of the ethylene moiety of combretastatin A-4 with a silicon linker.
Design, synthesis and anticancer properties of 5-arylbenzoxepins as conformationally restricted isocombretastatin A-4 analogs.
Design, synthesis and antiproliferative activity of the new conjugates of E7010 and resveratrol as tubulin polymerization inhibitors.
Design, synthesis and antiproliferative evaluation of novel sulfanilamide-1,2,3-triazole derivatives as tubulin polymerization inhibitors.
Design, synthesis and bioevaluation of 2,7-diaryl-pyrazolo[1,5-a]pyrimidines as tubulin polymerization inhibitors.
Design, synthesis and biological evaluation of a novel library of antimitotic C2-aroyl/arylimino tryptamine derivatives that are also potent inhibitors of indoleamine-2, 3-dioxygenase (IDO).
Design, synthesis and biological evaluation of a novel tubulin inhibitor 7a3 targeting the colchicine binding site.
Design, synthesis and biological evaluation of a series of pyrano chalcone derivatives containing indole moiety as novel anti-tubulin agents.
Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors.
Design, synthesis and biological evaluation of combretastatin A-4 sulfamate derivatives as potential anti-cancer agents.
Design, synthesis and biological evaluation of dihydronaphthalene and benzosuberene analogs of the combretastatins as inhibitors of tubulin polymerization in cancer chemotherapy.
Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors.
Design, synthesis and biological evaluation of resveratrol-cinnamoyl derivates as tubulin polymerization inhibitors targeting the colchicine binding site.
Design, Synthesis and Cancer Cell Growth Inhibition Evaluation of New Aminoquinone Hybrid Molecules.
Design, synthesis and molecular modeling of new 4-phenylcoumarin derivatives as tubulin polymerization inhibitors targeting MCF-7 breast cancer cells.
Design, synthesis and structure-activity relationship of 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of tubulin polymerization.
Design, synthesis, and bioevaluation of pyrazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site with potent anticancer activities.
Design, synthesis, and biological evaluation of combretastatin nitrogen-containing derivatives as inhibitors of tubulin assembly and vascular disrupting agents.
Design, synthesis, and biological evaluation of novel benzodiazepine derivatives as anticancer agents through inhibition of tubulin polymerization in vitro and in vivo.
Design, Synthesis, and Biological Evaluation of the First Podophyllotoxin Analogues as Potential Vascular-Disrupting Agents.
Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents.
Design, Synthesis, and in?vitro Evaluation of Tubulin-Targeting Dibenzothiazines with Antiproliferative Activity as a Novel Heterocycle Building Block.
Design, synthesis, and SAR studies of 4-substituted methoxylbenzoyl-aryl-thiazoles analogues as potent and orally bioavailable anticancer agents.
Design, synthesis, biochemical, and biological evaluation of nitrogen-containing trifluoro structural modifications of combretastatin A-4.
Design, Synthesis, in vitro and in vivo Evaluation of (Z)-3,4,5-Trimethoxystyryl Benzenesulfonamides/Sulfonates as Highly Potent Tubulin Polymerization Inhibitors.
Design, synthesis, in vitro, and in vivo anticancer and antiangiogenic activity of novel 3-arylaminobenzofuran derivatives targeting the colchicine site on tubulin.
Designing and Testing of Novel Taxanes to Probe the Highly Complex Mechanisms by Which Taxanes Bind to Microtubules and Cause Cytotoxicity to Cancer Cells.
Detection of human betaV-tubulin expression in epithelial cancer cell lines by tubulin proteomics.
Determinants of anti-vascular action by combretastatin A-4 phosphate: role of nitric oxide.
Determination of the optimal tubulin isotype target as a method for the development of individualized cancer chemotherapy.
Development of a novel class of tubulin inhibitors with promising anticancer activities.
Development of a novel in vitro human tissue-based angiogenesis assay to evaluate the effect of antiangiogenic drugs.
Development of a novel near-infrared fluorescent theranostic combretastain A-4 analogue, YK-5-252, to target triple negative breast cancer.
Development of a novel nitro-derivative of noscapine for the potential treatment of drug-resistant ovarian cancer and T-cell lymphoma.
Development of combretastatins as potent tubulin polymerization inhibitors.
Development of novel derivatives of stilbene and macrocyclic compounds as potent of anti-microtubule factors.
Development of Taccalonolide AJ-Hydroxypropyl-?-Cyclodextrin Inclusion Complexes for Treatment of Clear Cell Renal-Cell Carcinoma.
Developments of combretastatin A-4 derivatives as anticancer agents.
Diaminothiazoles evade multidrug resistance in cancer cells and xenograft tumour models and develop transient specific resistance: understanding the basis of broad-spectrum versus specific resistance.
Diarylmethyloxime and hydrazone derivatives with 5-indolyl moieties as potent inhibitors of tubulin polymerization.
Dietary cysteamine hydrochloride protects against oxidation, inflammation, and mucosal barrier disruption of broiler chickens challenged with Clostridium perfringens.
Differential expression and cellular distribution of gamma-tubulin and betaIII-tubulin in medulloblastomas and human medulloblastoma cell lines.
Differential expression of glu-tubulin in relation to mammary gland disease.
Differential protein expression using proteomics from a crustacean brine shrimp (Artemia sinica) under CO2-driven seawater acidification.
Diphenyl ether derivatives occupy the expanded binding site of cyclohexanedione compounds at the colchicine site in tubulin by movement of the ?T5 loop.
Direct analysis of tubulin expression in cancer cell lines by electrospray ionization mass spectrometry.
Discover 4?-NH-(6-aminoindole)-4-desoxy-podophyllotoxin with nanomolar-potency antitumor activity by improving the tubulin binding affinity on the basis of a potential binding site nearby colchicine domain.
Discovery and hit to lead optimization of novel combretastatin A-4 analogues: dependence of C-linker length and hybridization.
Discovery and optimization of a series of 2-aryl-4-amino-5-(3',4',5'-trimethoxybenzoyl)thiazoles as novel anticancer agents.
Discovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple-acting angiokinase inhibition as antitumor agents.
Discovery of 3-(((9H-purin-6-yl)amino)methyl)-4,6-dimethylpyridin-2(1H)-one derivatives as novel tubulin polymerization inhibitors for treatment of cancer.
Discovery of 7-Hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a Tubulin Polymerization Inhibitor with Potent Antiproliferative and Tumor Vascular Disrupting Properties.
Discovery of a chiral fluorinated azetidin-2-one as a tubulin polymerisation inhibitor with potent antitumour efficacy.
Discovery of a Novel Microtubule Targeting Agent as an Adjuvant for Cancer Immunotherapy.
Discovery of a potent tubulin polymerization inhibitor: synthesis and evaluation of water-soluble prodrugs of benzophenone analog.
Discovery of antitubulin agents with antiangiogenic activity as single entities with multitarget chemotherapy potential.
Discovery of CYT997: a structurally novel orally active microtubule targeting agent.
Discovery of Dual VEGFR-2 and Tubulin Inhibitors with in Vivo Efficacy.
Discovery of Hedgehog Antagonists for Cancer Therapy.
Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities.
Discovery of novel antitumor antimitotic agents that also reverse tumor resistance.
Discovery of novel CA-4 analogs as dual inhibitors of tubulin polymerization and PD-1/PD-L1 interaction for cancer treatment.
Discovery of Novel Diarylamide N-Containing Heterocyclic Derivatives as New Tubulin Polymerization Inhibitors with Anti-Cancer Activity.
Discovery of novel quinoline-based analogues of combretastatin A-4 as tubulin polymerisation inhibitors with apoptosis inducing activity and potent anticancer effect.
Discovery of novel tubulin inhibitors targeting taxanes site by virtual screening, molecular dynamic simulation, and biological evaluation.
Discovery of novel tubulin/HDAC dual-targeting inhibitors with strong antitumor and antiangiogenic potency.
Discovery of novel vinyl sulfone derivatives as anti-tumor agents with microtubule polymerization inhibitory and vascular disrupting activities.
Discovery of oxyepiberberine as a novel tubulin polymerization inhibitor and an anti-colon cancer agent against LS-1034 cells.
Discovery of potential anticancer multi-targeted ligustrazine based cyclohexanone and oxime analogs overcoming the cancer multidrug resistance.
Discovery of tertiary amide derivatives incorporating benzothiazole moiety as anti-gastric cancer agents in vitro via inhibiting tubulin polymerization and activating the Hippo signaling pathway.
Disparate SAR data of griseofulvin analogues for the dermatophytes Trichophyton mentagrophytes, T. rubrum, and MDA-MB-231 cancer cells.
Distinct tubulin dynamics in cancer cells explored using a highly tubulin-specific fluorescent probe.
Distinctive roles of syntaxin binding protein 4 and its action target, TP63, in lung squamous cell carcinoma: a theranostic study for the precision medicine.
Distribution of the cytoskeletal protein beta-tubulin in normal lung, cryptogenic fibrosing alveolitis and lung tumours.
Dolastatin 15 from a Marine Cyanobacterium Suppresses HIF-1? Mediated Cancer Cell Viability and Vascularization.
Dose-intense taxol: high response rate in patients with platinum-resistant recurrent ovarian cancer.
Drug target interaction of tubulin-binding drugs in cancer therapy.
Dual-Fluorescence Isogenic High-Content Screening for MUC16/CA125 Selective Agents.
Dual-functional conjugates improving cancer immunochemotherapy by inhibiting tubulin polymerization and indoleamine-2,3-dioxygenase.
Dual-targeting antitumor conjugates derived from platinum(IV) prodrugs and microtubule inhibitor CA-4 significantly exhibited potent ability to overcome cisplatin resistance.
DYZ-2-90, a novel neo-tanshinlactone ring-opened compound, induces ERK-mediated mitotic arrest and subsequent apoptosis by activating JNK in human colorectal cancer cells.
Early investigational tubulin inhibitors as novel cancer therapeutics.
Eaton's reagent-mediated domino ?-cationic arylations of aromatic carboxylic acids to Iasi-red polymethoxylated polycyclic aromatic hydrocarbons: products with unprecedented biological activities as tubulin polymerization inhibitors.
EBV-miR-BART12 accelerates migration and invasion in EBV-associated cancer cells by targeting tubulin polymerization-promoting protein 1.
Effect of paclitaxel administration on P wave duration and dispersion.
Effect of TTLL12 on tubulin tyrosine nitration as a novel target for screening anticancer drugs in vitro.
Effects of altering the electronics of 2-methoxyestradiol on cell proliferation, on cytotoxicity in human cancer cell cultures, and on tubulin polymerization.
Effects of Black Raspberries and Their Ellagic Acid and Anthocyanin Constituents on Taxane Chemotherapy of Castration-Resistant Prostate Cancer Cells.
Effects of combretastatin A4 phosphate on endothelial cell morphology in vitro and relationship to tumour vascular targeting activity in vivo.
Effects of lithium gammalinolenate on the perfusion of liver and pancreatic tissues in pancreatic cancer.
Effects of novel and conventional anti-cancer agents on human endothelial permeability: influence of tumour secreted factors.
Efficacy of the novel tubulin polymerization inhibitor PTC-028 for myelodysplastic syndrome.
Efficient Synthetic Methodology for the Construction of Dihydronaphthalene and Benzosuberene Molecular Frameworks.
Eleutherobin, a novel cytotoxic agent that induces tubulin polymerization, is similar to paclitaxel (Taxol).
Emerging microtubule targets in glioma therapy.
Endowing Indole-Based Tubulin Inhibitors with an Anchor for Derivatization: Highly Potent 3-Substituted Indolephenstatins and Indoleisocombretastatins.
Enhanced anticancer effect of Combretastatin A-4 phosphate when combined with vincristine in the treatment of hepatocellular carcinoma.
Enhanced antitumor activities of TZT-1027 against TNF-alpha or IL-6 secreting Lewis lung carcinoma in vivo.
Enhanced target gene knockdown by a bifunctional shRNA: a novel approach of RNA interference.
Enhancement of in vivo antitumor activity of a novel antimitotic 1-phenylpropenone derivative, AM-132, by tumor necrosis factor-alpha or interleukin-6.
Enhancing major histocompatibility complex class I antigen presentation by targeting antigen to centrosomes.
Epithelial-to-mesenchymal transition promotes tubulin Detyrosination and Microtentacles that enhance endothelial engagement.
EPO906 (epothilone B): a promising novel microtubule stabilizer.
Erastin-Like Anti-Warburg Agents Prevent Mitochondrial Depolarization Induced by Free Tubulin and Decrease Lactate Formation in Cancer Cells.
ErbB2 Targeted Epigenetic Modulation: Anti-tumor Efficacy of the ADC Trastuzumab-HDACi ST8176AA1.
Eribulin mesilate, a halichondrin B analogue, in the treatment of breast cancer.
Eribulin, a simplified ketone analog of the tubulin inhibitor halichondrin B, for the potential treatment of cancer.
Estradiol dimer inhibits tubulin polymerization and microtubule dynamics.
Estrogen mediates Aurora-A overexpression, centrosome amplification, chromosomal instability, and breast cancer in female ACI rats.
Ethyl-2-amino-pyrrole-3-carboxylates are active against imatinib-resistant gastrointestinal stromal tumors in vitro and in vivo.
Ethyl-2-amino-pyrrole-3-carboxylates are novel potent anticancer agents that affect tubulin polymerization, induce G2/M cell-cycle arrest, and effectively inhibit soft tissue cancer cell growth in vitro.
Evading Pgp activity in drug-resistant cancer cells: a structural and functional study of antitubulin furan metotica compounds.
Evaluation of antivascular and antimitotic effects of tubulin binding agents in solid tumor therapy.
Evaluation of epothilone B analog in advanced soft tissue sarcoma: a phase II study of the phase II consortium.
Evaluation of glycosylated docetaxel-encapsulated liposomes prepared by remote loading under solubility gradient.
Evaluation of ligustrazine based synthetic compounds for mechanism based antiproliferative effects.
Evidence for microtubule target engagement in tumors of patients receiving ixabepilone.
Evolution of the Systems Pharmacokinetics-Pharmacodynamics Model for Antibody-Drug Conjugates to Characterize Tumor Heterogeneity and In Vivo Bystander Effect.
Evolving Approaches to Metastatic Breast Cancer Patients Pre-treated with Anthracycline and Taxane.
Examination of the 1,4-disubstituted azetidinone ring system as a template for combretastatin A-4 conformationally restricted analogue design.
Exploiting Mitochondrial Vulnerabilities to Trigger Apoptosis Selectively in Cancer Cells.
Exploring natural product chemistry and biology with multicomponent reactions. 5. Discovery of a novel tubulin-targeting scaffold derived from the rigidin family of marine alkaloids.
Exploring the size adaptability of the B ring binding zone of the colchicine site of tubulin with para-nitrogen substituted isocombretastatins.
Expression of ?V-Tubulin in Secretory Cells of the Fallopian Tube Epithelium Marks Cellular Atypia.
Expression of Arl2 is associated with p53 localization and chemosensitivity in a breast cancer cell line.
Expression of CCT6A mRNA in chicken granulosa cells is regulated by progesterone.
Expression of class II beta-tubulin in non-melanoma cutaneous tumors.
Expression of class III beta tubulin in cervical cancer patients administered preoperative radiochemotherapy: correlation with response to treatment and clinical outcome.
Expression of class III beta tubulin in non-small cell lung cancer is correlated with resistance to taxane chemotherapy.
Expression of class III beta-tubulin in colorectal carcinomas: an immunohistochemical study using TU-20 & TuJ-1 antibody.
Expression of cytoskeletal components in melanocytic skin lesions. An immunohistochemical study.
Expression of oncogenic epidermal growth factor receptor family kinases induces paclitaxel resistance and alters beta-tubulin isotype expression.
Expression of tau proteins and tubulin in extraskeletal myxoid chondrosarcoma, chordoma, and other chondroid tumors.
Expression of tubulin, p53, ki67, receptors for estrogen, and progesterone in endometrial cancer.
Expression profiling of tubulin isotypes and microtubule-interacting proteins using real-time polymerase chain reaction.
Extraskeletal myxoid chondrosarcoma characterized by microtubular aggregates in the rough endoplasmic reticulum and tubulin immunoreactivity.
FASN Inhibition and Taxane Treatment Combine to Enhance Anti-tumor Efficacy in Diverse Xenograft Tumor Models through Disruption of Tubulin Palmitoylation and Microtubule Organization and FASN Inhibition-Mediated Effects on Oncogenic Signaling and Gene Expression.
Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways.
Fibroblast growth factor 13 regulates glioma cell invasion and is important for bevacizumab-induced glioma invasion.
Fluorescent taxoid probes for microtubule research.
Fluorine Substituted Proline Enhances the Tubulin Binding Potential of a Tetrapeptide at the GTP Binding Pocket Causing the Inhibition of Microtubule Motility and an Antimitotic Effect.
Formation of extra centrosomal structures is dependent on beta-catenin.
Free tubulin modulates mitochondrial membrane potential in cancer cells.
From amino acid sequence to bioactivity: The biomedical potential of antitumor peptides.
From fighting depression to conquering tumors: a novel tricyclic thiazepine compound as a tubulin polymerization inhibitor.
Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety.
Gamma tubulin: a promising indicator of recurrence in squamous cell carcinoma of the larynx.
Gene expression patterns define pathways correlated with loss of differentiation in lung adenocarcinomas.
Gene expression profiling of exposure to TZT-1027, a novel microtubule-interfering agent, in non-small cell lung cancer PC-14 cells and astrocytes.
Genetics and Expression Profile of the Tubulin Gene Superfamily in Breast Cancer Subtypes and Its Relation to Taxane Resistance.
Genistein-induced neuroendocrine differentiation of prostate cancer cells.
Genome-wide cDNA microarray screening of genes related to survival in patients after curative resection of non-small cell lung cancer.
Giant cell glioblastoma and pleomorphic xanthoastrocytoma show different immunohistochemical profiles for neuronal antigens and p53 but share reactivity for class III beta-tubulin.
Glioblastoma CUSA Fluid Protein Profiling: A Comparative Investigation of the Core and Peripheral Tumor Zones.
Glioma cell proliferation controlled by ERK activity-dependent surface expression of PDGFRA.
Gliosarcoma with ependymal and PNET-like differentiation.
Glyceraldehyde-3-phosphate dehydrogenase is a microtubule binding protein in a human colon tumor cell line.
Gold(I) Biscarbene Complexes Derived from Vascular-Disrupting Combretastatin A-4 Address Different Targets and Show Antimetastatic Potential.
Gold(I)-NHC complexes of antitumoral diarylimidazoles: structures, cellular uptake routes and anticancer activities.
Green Approaches for Cancer Management: an Effective Tool for Health Care.
Halichondrin B amide acts as tubulin binding agent to exhibit anti-tumor efficacy in hematologic cancers.
Heroin-Induces Differential Protein Expression by Normal Human Astrocytes (NHA).
Heterogeneous and homogeneous nucleation of Taxol crystals in aqueous solutions and gels: effect of tubulin proteins.
HIC1 and RassF1A Methylation Attenuates Tubulin Expression and Cell Stiffness in Cancer.
High content screening of diverse compound libraries identifies potent modulators of tubulin dynamics.
High-Complexity shRNA Libraries and PI3 Kinase Inhibition in Cancer: High-Fidelity Synthetic Lethality Predictions.
Highly potent triazole-based tubulin polymerization inhibitors.
HMGB1 release and redox regulates autophagy and apoptosis in cancer cells.
Human papillomavirus infection, centrosome aberration, and genetic stability in cervical lesions.
Hybridized quinoline derivatives as anticancer agents: Design, Synthesis, biological evaluation and molecular docking.
Hydropathic analysis and biological evaluation of stilbene derivatives as colchicine site microtubule inhibitors with anti-leukemic activity.
Identification and Characterization of an Intermediate Taxol Binding Site Within Microtubule Nanopores and a Mechanism for Tubulin Isotype Binding Selectivity.
Identification and characterization of an intermediate taxol binding site within microtubule nanopores and a mechanism for tubulin isotype binding selectivity.
Identification of a new CRMP5 isoform present in the nucleus of cancer cells and enhancing their proliferation.
Identification of a novel transcript isoform of the TTLL12 gene in human cancers.
Identification of CKD-516: a potent tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors.
Identification of differentially expressed proteins in spontaneous thymic lymphomas from knockout mice with deletion of p53.
Identification of glycan structure alterations on cell membrane proteins in desoxyepothilone B resistant leukemia cells.
Identification of metastasis-related proteins and their clinical relevance to triple-negative human breast cancer.
Identification of novel 1-indolyl acetate-5-nitroimidazole derivatives of combretastatin A-4 as potential tubulin polymerization inhibitors.
Identification of potent virtual leads and ADME prediction of isoxazolidine podophyllotoxin derivatives as topoisomerase II and tubulin inhibitors.
Identification of selective tubulin inhibitors as potential anti-trypanosomal agents.
Imidazoles and benzimidazoles as tubulin-modulators for anti-cancer therapy.
Immunohistochemical analysis of beta-tubulin isotypes in human prostate carcinoma and benign prostatic hypertrophy.
Immunohistochemical Characterization of Canine Neuroepithelial Tumors.
Immunohistochemical distribution of tubulin beta II in human normal and neoplastic tissues.
Implications of Nanoscale Based Drug Delivery Systems in Delivery and Targeting Tubulin Binding Agent, Noscapine in Cancer Cells.
In silico design of peptide inhibitors of tubulin: Amyloid-? as a lead compound.
In silico Investigations of the Mode of Action of Novel Colchicine Derivatives Targeting ?-Tubulin Isotypes: A Search for a Selective and Specific ?-III Tubulin Ligand.
In vitro and in vivo biological characterization of the anti-proliferative potential of a cyclic trinuclear organotin(iv) complex.
In vitro assembly of tubulin from nonneural cells (Ehrlich ascites tumor cells).
In vitro cross-resistance and collateral sensitivity in seven resistant small-cell lung cancer cell lines: preclinical identification of suitable drug partners to taxotere, taxol, topotecan and gemcitabin.
In vitro formation of different tubulin polymers from purified tubulin of Ehrlich ascites tumor cells.
In vitro Metabolism of Phenstatin: Potential Pharmacological Consequences.
In vivo measurement of microtubule dynamics using stable isotope labeling with heavy water. Effect of taxanes.
In vivo tumor growth inhibition produced by a novel sulfonamide, E7010, against rodent and human tumors.
Increased gamma-tubulin expression and P16INK4A promoter methylation occur together in preinvasive lesions and carcinomas of the breast.
Indanocine, a microtubule-binding indanone and a selective inducer of apoptosis in multidrug-resistant cancer cells.
Indibulin dampens microtubule dynamics and produces synergistic antiproliferative effect with vinblastine in MCF-7 cells: Implications in cancer chemotherapy.
Indolizine-phenothiazine hybrids as the first dual inhibitors of tubulin polymerization and farnesyltransferase with synergistic antitumor activity.
Indomethacin derivatives as tubulin stabilizers to inhibit cancer cell proliferation.
Induction of apoptosis through tubulin inhibition in human cancer cells by new chromene-based chalcones.
Induction of microtubule hyper stabilization and robust G2 /M arrest by N-4-CN in human breast carcinoma MDA-MB-231 cells.
Induction of tumor cell death through targeting tubulin and evoking dysregulation of cell cycle regulatory proteins by multifunctional cinnamaldehydes.
Influence of guanine nucleotides on vincristine binding in tumor cytosols and purified tubulin: evidence for an inhibitor of vincristine binding.
Influence of hormones and hormone metabolites on the growth of schwann cells derived from embryonic stem cells and on tumor cell lines expressing variable levels of neurofibromin.
Inhibition of SIRT2 potentiates the anti-motility activity of taxanes: implications for antineoplastic combination therapies.
Inhibitors of kinesin Eg5: antiproliferative activity of monastrol analogues against human glioblastoma cells.
Inhibitors of tubulin assembly identified through screening a compound library.
Inorganic nanoparticles as tubulin binding agents for cancer therapy.
Integrated Analysis Reveals That Long Non-Coding RNA TUBA4B Can Be Used as a Prognostic Biomarker in Various Cancers.
Integration of NMR studies, computational predictions, and in vitro assays in the search of marine diterpenes with antitumor activity.
Interaction between cisplatin-treated macrophages and Dalton's lymphoma cells in vitro.
Interaction of A? peptide with tubulin causes an inhibition of tubulin polymerization and the apoptotic death of cancer cells.
Interaction of microtubule depolymerizing agent indanocine with different human ?? tubulin isotypes.
Interaction of triethyl lead chloride with microtubules in vitro and in mammalian cells.
Interleukin-6 inhibits the growth of prostate cancer xenografts in mice by the process of neuroendocrine differentiation.
Intrinsic and Extrinsic Factors Affecting Microtubule Dynamics in Normal and Cancer Cells.
Investigation of HMN-176 anticancer activity in human tumor specimens in vitro and the effects of HMN-176 on differential gene expression.
Investigation of podophyllotoxin esters as potential anticancer agents: synthesis, biological studies and tubulin inhibition properties.
In vitro and in vivo biological evaluation of new 4,5-disubstituted 1,2,3-triazoles as cis-constrained analogs of combretastatin A4.
IRC-083927 is a new tubulin binder that inhibits growth of human tumor cells resistant to standard tubulin-binding agents.
IsoCombretaQuinazolines: Potent Cytotoxic Agents with Antitubulin Activity.
Isolation of a taxol-resistant Leishmania donovani promastigote mutant that exhibits a multidrug-resistant phenotype.
Ixabepilone, a novel epothilone analog in the treatment of breast cancer.
Jerantinine A induces tumor-specific cell death through modulation of splicing factor 3b subunit 1 (SF3B1).
JWA enhances As(2)O (3)-induced tubulin polymerization and apoptosis via p38 in HeLa and MCF-7 cells.
Kinetic stabilization of microtubule dynamics by indanocine perturbs EB1 localization, induces defects in cell polarity and inhibits migration of MDA-MB-231 cells.
Knockdown of Tubulin Polymerization Promoting Protein Family Member 3 inhibits cell proliferation and invasion in human colorectal cancer.
Ligand- and structural-based discovery of potential small molecules that target the colchicine site of tubulin for cancer treatment.
LncRNA TUBA4B functions as a competitive endogenous RNA to inhibit gastric cancer progression by elevating PTEN via sponging miR-214 and miR-216a/b.
Low expression of human tubulin tyrosine ligase and suppressed tubulin tyrosination/detyrosination cycle are associated with impaired neuronal differentiation in neuroblastomas with poor prognosis.
Making epothilones fluoresce: design, synthesis, and biological characterization of a fluorescent n12-aza-epothilone (azathilone).
MALDI in-source decay of high mass protein isoforms: application to alpha- and beta-tubulin variants.
Mana-Hox displays anticancer activity against prostate cancer cells through tubulin depolymerization and DNA damage stress.
Marine Derived Anticancer Drugs Targeting Microtubule.
Mebendazole as a Candidate for Drug Repurposing in Oncology: An Extensive Review of Current Literature.
Mechanism of action of ixabepilone and its interactions with the ?III-tubulin isotype.
Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability.
Mechanisms by which Synthetic 6,7-Annulated-4-substituted Indole Compounds with Anti-proliferative Activity Disrupt Mitosis and Block Cytokinesis in Human HL-60 Tumor Cells In Vitro.
Mechanisms of action and resistance to tubulin-binding agents.
Mechanisms of antitumor action of methyl-3,5-diiodo-4-(4'-methoxyphenoxy)benzoate: drug-induced protein dephosphorylations and inhibition of the permissive action of ceramide on growth factor induced cell proliferation.
Mechanisms of multidrug resistance: the potential role of microtubule-stabilizing agents.
Mechanisms of Tubulin Binding Ligands to Target Cancer Cells: Updates on Their Therapeutic Potential and Clinical Trials.
Mechano-induced cell metabolism promotes microtubule glutamylation to force metastasis.
Mertansine Inhibits mRNA Expression and Enzyme Activities of Cytochrome P450s and Uridine 5'-Diphospho-Glucuronosyltransferases in Human Hepatocytes and Liver Microsomes.
Metastasis associated MTS1 and NM23 genes affect tubulin polymerisation in B16 melanomas: a possible mechanism of their regulation of metastatic behaviour of tumours.
Methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino)benzoate (GN39482) as a tubulin polymerization inhibitor identified by MorphoBase and ChemProteoBase profiling methods.
Methylsulfanylpyridine based diheteroaryl isocombretastatin analogs as potent anti-proliferative agents.
Microsatellite analysis of the APC gene and immunoexpression of E-cadherin, catenin, and tubulin in esophageal squamous cell carcinoma.
Microtubins: a novel class of small synthetic microtubule targeting drugs that inhibit cancer cell proliferation.
Microtubular aggregates in the rough endoplasmic reticulum of sacrococcygeal chordoma.
Microtubule alterations and resistance to tubulin-binding agents (review).
Microtubule and MAPs: thermodynamics of complex formation by AUC, ITC, fluorescence, and NMR.
Microtubule binding and disruption and induction of premature senescence by disorazole C(1).
Microtubule inhibitor-based antibody-drug conjugates for cancer therapy.
Microtubule inhibitors containing immunostimulatory agents promote cancer immunochemotherapy by inhibiting tubulin polymerization and tryptophan-2,3-dioxygenase.
Microtubule network and microtubule-associated proteins in leukemic T lymphocytes.
Microtubule organization in lymphoid malignancies.
Microtubule polymerase and processive plus-end tracking functions originate from distinct features within TOG domain arrays.
Microtubule Targeting Agents as Cancer Chemotherapeutics: An Overview of Molecular Hybrids as Stabilizing and Destabilizing Agents.
Microtubule-binding agents: a dynamic field of cancer therapeutics.
Microtubule-disrupting chemotherapeutics result in enhanced proteasome-mediated degradation and disappearance of tubulin in neural cells.
Microtubule-targetable fluorescent probe: site-specific detection and super-resolution imaging of ultratrace tubulin in microtubules of living cancer cells.
Microtubule-targeted chemotherapeutic agents inhibit signal transducer and activator of transcription 3 (STAT3) signaling.
Microtubule-Targeted Self-Assembly Triggers Prometaphase-Metaphase Oscillations Suppressing Tumor Growth.
Microtubules and their role in cellular stress in cancer.
Migrastatin analogues target fascin to block tumour metastasis.
Mitosis is not a key target of microtubule agents in patient tumors.
Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules.
MLN8054, an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo.
Molecular dissection of the inhibitor binding pocket of mitotic kinesin Eg5 reveals mutants that confer resistance to antimitotic agents.
Molecular dynamics simulation and free energy landscape methods in probing L215H, L217R and L225M ?I-tubulin mutations causing paclitaxel resistance in cancer cells.
Molecular insight of isotypes specific ?-tubulin interaction of tubulin heterodimer with noscapinoids.
Molecular recognition pattern of cytotoxic alkaloid vinblastine with multiple targets.
Morphological and quantitative analysis on ?-tubulin modifications in glioblastoma cells.
MPC-6827: a small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps.
MPT0B169, a New Tubulin Inhibitor, Inhibits Cell Growth and Induces G2/M Arrest in Nonresistant and Paclitaxel-Resistant Cancer Cells.
MR22388, a novel anti-cancer agent with a strong FLT-3 ITD kinase affinity.
MT119, a new planar-structured compound, targets the colchicine site of tubulin arresting mitosis and inhibiting tumor cell proliferation.
Mutagenicity screening with fungal systems.
Mutations in Traf3ip1 reveal defects in ciliogenesis, embryonic development, and altered cell size regulation.
N,N-bis-heteroaryl methylamines: Potent anti-mitotic and highly cytotoxic agents.
N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)arylamide as a new scaffold that provides rapid access to antimicrotubule agents: synthesis and evaluation of antiproliferative activity against select cancer cell lines.
N-(2,6-Dimeth-oxy-pyridin-3-yl)-9-methyl-9H-carbazole-3-sulfonamide.
N-(2,6-dimethoxypyridine-3-yl)-9-methylcarbazole-3-sulfonamide as a novel tubulin ligand against human cancer.
N-(2-methyl-indol-1H-5-yl)-1-naphthalenesulfonamide: A novel reversible antimitotic agent inhibiting cancer cell motility.
N-Heterocyclic (4-Phenylpiperazin-1-yl)methanones Derived from Phenoxazine and Phenothiazine as Highly Potent Inhibitors of Tubulin Polymerization.
Nakiterpiosin targets tubulin and triggers mitotic catastrophe in human cancer cells.
Naphthylphenstatins as tubulin ligands: synthesis and biological evaluation.
Natural products as antimitotic agents.
New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors.
New antitubulin derivatives in the combretastatin A4 series: synthesis and biological evaluation.
New C5-alkylated indolobenzazepinones acting as inhibitors of tubulin polymerization: cytotoxic and antitumor activities.
New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer.
New indole-based chalconoids as tubulin-targeting antiproliferative agents.
New insights into mechanisms of resistance to microtubule inhibitors.
New ligands of the tubulin colchicine site based on X-ray structures.
New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer.
New tubulin targeting agents currently in clinical development.
Nitric oxide-dependent cytoskeletal changes and inhibition of endothelial cell migration contribute to the suppression of angiogenesis by RAD50 gene transfer.
NK cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule network.
Non-Invasive Evaluation of Acute Effects of Tubulin Binding Agents: A Review of Imaging Vascular Disruption in Tumors.
Novel agents that target tublin and related elements.
Novel aminochromone derivative inhibits tumor growth on xenograft model of lung cancer in mice.
Novel Colchicine Derivatives and their Anti-cancer Activity.
Novel derivatives of 1,3,4-oxadiazoles are potent mitostatic agents featuring strong microtubule depolymerizing activity in the sea urchin embryo and cell culture assays.
Novel diarylsulfonylurea derivatives as potent antimitotic agents.
Novel mutations involving ?I-, ?IIA-, or ?IVB-tubulin isotypes with functional resemblance to ?III-tubulin in breast cancer.
Novel nicotinoyl pyrazoline derivates bearing N-methyl indole moiety as antitumor agents: Design, synthesis and evaluation.
Novel piperidine derivatives as colchicine binding site inhibitors induce apoptosis and inhibit epithelial-mesenchymal transition against prostate cancer PC3 cells.
Novel Podophyllotoxin Derivatives as Potential Tubulin Inhibitors: Design, Synthesis and Anti-proliferative Activity Evaluation.
Novel pyrrolizines bearing 3,4,5-trimethoxyphenyl moiety: design, synthesis, molecular docking, and biological evaluation as potential multi-target cytotoxic agents.
Novel quinolone chalcones targeting colchicine-binding pocket kill multidrug-resistant cancer cells by inhibiting tubulin activity and MRP1 function.
Novel suicide ligands of tubulin arrest cancer cells in S-phase.
Novel third-generation water-soluble noscapine analogs as superior microtubule-interfering agents with enhanced antiproliferative activity.
Novel tubulin-targeted cell penetrating antimitotic octapeptide.
Novel Water-Soluble Substituted Pyrrolo[3,2-d]pyrimidines: Design, Synthesis, and Biological Evaluation as Antitubulin Antitumor Agents.
NPI-2358 is a tubulin-depolymerizing agent: in-vitro evidence for activity as a tumor vascular-disrupting agent.
Nuclear gamma-tubulin associates with nucleoli and interacts with tumor suppressor protein C53.
Nucleocytoplasmic shuttling of soluble tubulin in mammalian cells.
Oblongifolin C inhibits metastasis by up-regulating keratin 18 and tubulins.
Occurrence of nuclear beta(II)-tubulin in cultured cells.
Oligomannurarate sulfate, a novel antimitotic agent, exerts anti-cancer activity by binding to tubulin on novel site.
Oncoprotein 18 overexpression increases the sensitivity to vindesine in the human lung carcinoma cells.
Opening of voltage dependent anion channels promotes reactive oxygen species generation, mitochondrial dysfunction and cell death in cancer cells.
Optimisation of estrogen receptor subtype-selectivity of a 4-Aryl-4H-chromene scaffold previously identified by virtual screening.
Optimising the Delivery of Tubulin Targeting Agents through Antibody Conjugation.
Orally available tubulin inhibitor VERU-111 enhances antitumor efficacy in paclitaxel-resistant lung cancer.
Orally Bioavailable Tubulin Antagonists for Paclitaxel-Refractory Cancer.
Over-Expression of ?II-Tubulin and Especially Its Localization in Cell Nuclei Correlates with Poorer Outcomes in Colorectal Cancer.
Overcoming P-Glycoprotein-Mediated Drug Resistance with Noscapine Derivatives.
Overexpression of ?-tubulin in non-small cell lung cancer.
Overexpression of a hexa-histidine and T7 peptide-tagged human ribonucleotide reductase small subunit, R2 in Escherichia coli and the generation of human R2 antibodies.
Overexpression of class III beta tubulin and amplified HER2 gene predict good response to paclitaxel and trastuzumab therapy.
Oxadiazole derivatives as a novel class of antimitotic agents: Synthesis, inhibition of tubulin polymerization, and activity in tumor cell lines.
Oxazole-Bridged Combretastatin A-4 Derivatives with Tethered Hydroxamic Acids: Structure?Activity Relations of New Inhibitors of HDAC and/or Tubulin Function.
Oxidative metabolism of combretastatin A-1 produces quinone intermediates with the potential to bind to nucleophiles and to enhance oxidative stress via free radicals.
p53 Down-regulates SETDB1 gene expression during paclitaxel induced-cell death.
p53-dependent and p53-independent anticancer activity of a new indole derivative in human osteosarcoma cells.
Paclitaxel selects for mutant or pseudo-null p53 in drug resistance associated with tubulin mutations in human cancer.
Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of {beta}-tubulin (Asp26Glu) and less stable microtubules.
Panobinostat (LBH589)-induced acetylation of tubulin impairs megakaryocyte maturation and platelet formation.
Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-?B inhibition.
Parthenolide inhibits tubulin carboxypeptidase activity.
Past and future of the mitotic spindle as an oncology target.
Pathology of brain parenchyma in meningeal carcinomatosis; immunohistochemical study with astroprotein (GFAP) and tubulin.
PBOX-15 induces apoptosis and improves the efficacy of oxaliplatin in human colorectal cancer cell lines.
Peloruside, Laulimalide, and Noscapine Interactions with Beta-Tubulin.
Perturbation of microtubule polymerization by quercetin through tubulin binding: a novel mechanism of its antiproliferative activity.
Pharmacokinetics, pharmacodynamics and metabolism of a novel anticancer agent for prostate cancer.
Pharmacophore-based virtual screening for identification of potential selective inhibitors of human histone deacetylase 6.
Phase I and pharmacokinetic study of CI-980 in recurrent pediatric solid tumor cases: a Pediatric Oncology Group study.
Phase I and pharmacokinetic trial of the novel taxane BMS-184476 administered as a 1-hour intravenous infusion in combination with cisplatin every 21 days.
Phase I clinical evaluation of ZD6126, a novel vascular-targeting agent, in patients with solid tumors.
Phase I pharmacologic study of a new Vinca alkaloid: navelbine.
Phase I study of TZT-1027, a novel synthetic dolastatin 10 derivative and inhibitor of tubulin polymerization, given weekly to advanced solid tumor patients for 3 weeks.
Phase I study of TZT-1027, a novel synthetic dolastatin 10 derivative and inhibitor of tubulin polymerization, which was administered to patients with advanced solid tumors on days 1 and 8 in 3-week courses.
Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in patients with taxane-resistant metastatic breast cancer.
Phase II Clinical Trial of Ixabepilone in Metastatic Cervical Carcinoma.
Phase II Multicenter Trial of Oral Quisinostat, a Histone Deacetylase Inhibitor, in Patients with Previously Treated Stage IB-IVA Mycosis Fungoides/Sézary Syndrome.
Phase II trial of intravenous CI-980 (NSC 370147) in patients with metastatic colorectal carcinoma. Model for prospective evaluation of neurotoxicity.
Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents-synthesis, antiproliferative activity and inhibition of tubulin polymerization.
Photo-Uncaging of a Microtubule-Targeted Rigidin Analogue in Hypoxic Cancer Cells and in a Xenograft Mouse Model.
Pictorial Imaging-Histopathology Correlation in a Rabbit with Hepatic VX2 Tumor Treated by Transarterial Vascular Disrupting Agent Administration.
Platinum(IV) complexes conjugated with phenstatin analogue as inhibitors of microtubule polymerization and reverser of multidrug resistance.
Plectin is a novel regulator for apical extrusion of RasV12-transformed cells.
Plinabulin, an inhibitor of tubulin polymerization, targets KRAS signaling through disruption of endosomal recycling.
PLK1 (polo like kinase 1)-dependent autophagy facilitates gefitinib-induced hepatotoxicity by degrading COX6A1 (cytochrome c oxidase subunit 6A1).
Plocabulin, a novel tubulin inhibitor, has potent antitumor activity in patient-derived xenograft models of gastrointestinal stromal tumors.
PM060184, a new tubulin binding agent with potent antitumor activity including P-glycoprotein over-expressing tumors.
PMA synergistically enhances apicularen A-induced cytotoxicity by disrupting microtubule networks in HeLa cells.
Podophyllotoxin analogs: effects on DNA topoisomerase II, tubulin polymerization, human tumor KB cells, and their VP-16-resistant variants.
Polyhydroxysteroidal glycosides from the starfish Anthenea chinensis.
Potent colchicine-site ligands with improved intrinsic solubility by replacement of the 3,4,5-trimethoxyphenyl ring with a 2-methylsulfanyl-6-methoxypyridine ring.
Potential role of tubulin tyrosine ligase-like enzymes in tumorigenesis and cancer cell resistance.
PPARgamma Inhibitors as Novel Tubulin-Targeting Agents.
Pre-clinical evaluation of a novel class of anti-cancer agents, the Pyrrolo-1, 5-benzoxazepines.
Preclinical discovery of ixabepilone, a highly active antineoplastic agent.
Preclinical evaluation of a novel antibody-drug conjugate targeting DR5 for lymphoblastic leukemia therapy.
Preclinical evaluation of the antitumour activity of the novel vascular targeting agent Oxi 4503.
Prediction of new chromene-based inhibitors of tubulin using structure-based virtual screening and molecular dynamics simulation methods.
Pretubulysin: from hypothetical biosynthetic intermediate to potential lead in tumor therapy.
Primary endothelial damage is the mechanism of cardiotoxicity of tubulin-binding drugs.
Progress of tubulin polymerization activity detection methods.
Promising Targets in Anti-cancer Drug Development: Recent Updates.
Promoting assembly and bundling of FtsZ as a strategy to inhibit bacterial cell division: a new approach for developing novel antibacterial drugs.
Proteomic alteration of a thermo?sensitive male sterility SP2S in rapeseed (Brassica napus) in response to mild temperature stress
Proteomics indicates modulation of tubulin polymerization by L-menthol inhibiting human epithelial colorectal adenocarcinoma cell proliferation.
Pseudolarix acid B, a new tubulin-binding agent, inhibits angiogenesis by interacting with a novel binding site on tubulin.
Pyridylalanine-containing hydroxamic acids as selective HDAC6 inhibitors.
Quantitative analysis of the effect of tubulin isotype expression on sensitivity of cancer cell lines to a set of novel colchicine derivatives.
Quantitative Proteomics Reveals a Novel Role of Karyopherin Alpha 2 in Cell Migration through the Regulation of Vimentin-pErk Protein Complex Levels in Lung Cancer.
R-253 disrupts microtubule networks in multiple tumor cell lines.
Radioimmunoassay for tubulin: a quantitative comparison of the tubulin content of different established tissue culture cells and tissues.
Randomized phase II study of ixabepilone or paclitaxel plus carboplatin in patients with non-small-cell lung cancer prospectively stratified by beta-3 tubulin status.
Rapid synthesis of 4-arylchromenes from ortho-substituted alkynols: A versatile access to restricted isocombretastatin A-4 analogues as antitumor agents.
RASSF1A Regulates Spindle Organization by Modulating Tubulin Acetylation via SIRT2 and HDAC6 in Mouse Oocytes.
Rationally designed anti-mitotic agents with pro-apoptotic activity.
Recent advances in combretastatin based derivatives and prodrugs as antimitotic agents.
Recent advances in heterocyclic tubulin inhibitors targeting the colchicine binding site.
Recent advances in trimethoxyphenyl (TMP) based tubulin inhibitors targeting the colchicine binding site.
Recent advances of podophyllotoxin/epipodophyllotoxin hybrids in anticancer activity, mode of action, and structure-activity relationship: An update (2010-2020).
Recent anticancer cytotoxic agents.
Recent Developments in Oxazole Derivatives as Anticancer Agents: Review on Synthetic Strategies, Mechanism of Action and SAR studies.
Recent Developments of Target Based Coumarin Derivatives as Potential Anticancer Agents.
Recent progress in structure activity relationship and mechanistic studies of taxol analogues.
Recent Progress on Tubulin Inhibitors with Dual Targeting Capabilities for Cancer Therapy.
Regioselective suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues.
Regioselective synthesis of water-soluble monophosphate derivatives of combretastatin a-1.
Regulation of Tubulin Expression by Micro-RNAs: Implications for Drug Resistance.
Relationship between lipophilicity and inhibitory activity against cancer cell growth of nine kinds of alk(en)yl trisulfides with different side chains.
Reovirus-associated reduction of microRNA-let-7d is related to the increased apoptotic death of cancer cells in clinical samples.
Repurposing L-Menthol for Systems Medicine and Cancer Therapeutics? L-Menthol Induces Apoptosis through Caspase 10 and by Suppressing HSP90.
Restoration of miR-200c to ovarian cancer reduces tumor burden and increases sensitivity to paclitaxel.
Reverse micelles-in-microspheres with sustained release of water-soluble combretastatin A4 phosphate for S180 tumor treatment.
Reversible action of diaminothiazoles in cancer cells is implicated by the induction of a fast conformational change of tubulin and suppression of microtubule dynamics.
Revisiting microtubule targeting agents: ?-Tubulin and the pironetin binding site as unexplored targets for cancer therapeutics.
Ring-Closing Metathesis Approaches towards the Total Synthesis of Rhizoxins.
Role of a novel CAR-induced gene, TUBA8, in hepatocellular carcinoma cell lines.
Role of aneuploidy in the carcinogenic process: Part 3 of the report of the 2017 IWGT workgroup on assessing the risk of aneugens for carcinogenesis and hereditary diseases.
Role of Indole Scaffolds as Pharmacophores in the Development of Anti-Lung Cancer Agents.
Role of tubulin acetylation in cellular functions and diseases.
RTN4 Knockdown Dysregulates the AKT Pathway, Destabilizes the Cytoskeleton, and Enhances Paclitaxel-Induced Cytotoxicity in Cancers.
S-(4-Methoxyphenyl)-4-methoxybenzenesulfonothioate as a Promising Lead Compound for the Development of a Renal Carcinoma Agent.
S9, a novel anticancer agent, exerts its anti-proliferative activity by interfering with both PI3K-Akt-mTOR signaling and microtubule cytoskeleton.
Scleritodermin A, a cytotoxic cyclic peptide from the lithistid sponge Scleritoderma nodosum.
Screening Anti-Cancer Drugs against Tubulin using Catch-and-Release Electrospray Ionization Mass Spectrometry.
Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance.
Second generation benzofuranone ring substituted noscapine analogs: synthesis and biological evaluation.
Selective enhancement of vincristine cytotoxicity in multidrug-resistant tumor cells by dilantin (phenytoin)
Selective induction of G2/M arrest and apoptosis in HL-60 by a potent anticancer agent, HMJ-38.
Selective lead compounds against kinetoplastid tubulin.
Selenium nanoparticles as new strategy to potentiate ?? T cell anti-tumor cytotoxicity through upregulation of tubulin-? acetylation.
Semisynthetic aurones inhibit tubulin polymerization at the colchicine-binding site and repress PC-3 tumor xenografts in nude mice and myc-induced T-ALL in zebrafish.
Septin cooperation with tubulin polyglutamylation contributes to cancer cell adaptation to taxanes.
Sesterterpenes as tubulin tyrosine ligase inhibitors. First insight of structure-activity relationships and discovery of new lead.
Shogaols at proapoptotic concentrations induce G(2)/M arrest and aberrant mitotic cell death associated with tubulin aggregation.
Signaling pathways and intracellular targets of sulforaphane mediating cell cycle arrest and apoptosis.
Silence of TPPP3 suppresses cell proliferation, invasion and migration via inactivating NF-?B/COX2 signal pathway in breast cancer cell.
Simplified Pretubulysin Derivatives and Their Biological Effects on Cancer Cells.
SKLB060 Reversibly Binds to Colchicine Site of Tubulin and Possesses Efficacy in Multidrug-Resistant Cell Lines.
Small-molecule anticancer agents kill cancer cells by harnessing reactive oxygen species in an iron-dependent manner.
Small-Molecule Ferroptotic Agents with Potential to Selectively Target Cancer Stem Cells.
Small-molecule inducer of cancer cell polyploidy promotes apoptosis or senescence: Implications for therapy.
Special Issue "Anticancer Drugs".
SPIKET and COBRA compounds as novel tubulin modulators with potent anticancer activity.
Spongistatins as tubulin targeting agents.
Stereoselective synthesis of 3,3-diarylacrylonitriles as tubulin polymerization inhibitors.
STMN1 is Overexpressed in Adrenocortical Carcinoma and Promotes a More Aggressive Phenotype In Vitro.
Strategy for developing transgenic assays for screening antineoplastic drugs that affect tubulin polymerization.
Structural basis for drug resistance conferred by ?-tubulin mutations: a molecular modeling study on native and mutated tubulin complexes with epothilone B.
Structural basis of microtubule stabilization by laulimalide and peloruside A.
Structural basis of tubulin detyrosination by the vasohibin-SVBP enzyme complex.
Structural basis of tubulin recruitment and assembly by microtubule polymerases with tumor overexpressed gene (TOG) domain arrays.
Structural Determinants of the Dictyostatin Chemotype for Tubulin Binding Affinity and Antitumor Activity Against Taxane- and Epothilone-Resistant Cancer Cells.
Structural interrogation of benzosuberene-based inhibitors of tubulin polymerization.
Structural modification of resveratrol leads to increased anti-tumor activity, but causes profound changes in the mode of action.
Structure-activity relationship studies of discodermolide and its semisynthetic acetylated analogs on microtubule function and cytotoxicity.
Structure-Activity Relationship Study of Novel 6-Aryl-2-benzoyl-pyridines as Tubulin Polymerization Inhibitors with Potent Antiproliferative Properties.
Structure-activity relationships and antiproliferative effects of 1,2,3,4-4H-quinoxaline derivatives as tubulin polymerization inhibitors.
Structure-activity-relationship studies of conformationally restricted analogs of combretastatin A-4 derived from SU5416.
Structure-based design of a novel synthetic spiroketal pyran as a pharmacophore for the marine natural product spongistatin 1.
Structure-based design of novel anticancer agents.
Structure-based discovery of a boronic acid bioisostere of combretastatin A-4.
Structure-Based Pharmacophore Design and Virtual Screening for Novel Tubulin Inhibitors with Potential Anticancer Activity.
Structure-Guided Design, Synthesis, and Biological Evaluation of (2-(1H-Indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl) Methanone (ABI-231) Analogues Targeting the Colchicine Binding Site in Tubulin.
Structures of potent anticancer compounds bound to tubulin.
Studies on indolizines. Evaluation of their biological properties as microtubule-interacting agents and as melanoma targeting compounds.
Studies on phenothiazines: New microtubule-interacting compounds with phenothiazine A-ring as potent antineoplastic agents.
Substituted 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]thiophene derivatives as potent tubulin polymerization inhibitors.
Substitution at the indole 3 position yields highly potent indolecombretastatins against human tumor cells.
Suppression of nuclear oscillations in Saccharomyces cerevisiae expressing Glu tubulin.
Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers.
Survivin deregulation in beta-tubulin mutant ovarian cancer cells underlies their compromised mitotic response to taxol.
Synergistic effects of the combined treatment of U251 and T98G glioma cells with an anti?tubulin tetrahydrothieno[2,3?c]pyridine derivative and a peptide nucleic acid targeting miR?221?3p.
Synergistic interaction of N-3-Br-benzyl-noscapine and docetaxel abrogates oncogenic potential of breast cancer cells.
Syntheses and antiproliferative effects of d-homo- and d-secoestrones.
Syntheses, quantum mechanical modeling, biomolecular interaction and in vitro anticancer - Tubulin activity of thiosemicarbazones.
Synthesis & antitumor activity of epothilones B and D and their analogs.
Synthesis and activity evaluation of benzoylurea derivatives as potential antiproliferative agents.
Synthesis and anticancer activities of new Benzothiadiazinyl Hydrazinecarboxamides and Anilino[1,2,4]triazolo[1,5-b][1,2,4]thiadiazine 5,5-diones.
Synthesis and anticancer activity of 2-benzylidene indanones through inhibiting tubulin polymerization.
Synthesis and anticancer activity of all known (-)-agelastatin alkaloids.
Synthesis and antiproliferative activities of ottelione a analogues.
Synthesis and antitumor activity of epothilones and their analogues.
Synthesis and Antitumor Molecular Mechanism of Agents Based on Amino 2-(3',4',5'-Trimethoxybenzoyl)benzo[b]furan: Inhibition of Tubulin and Induction of Apoptosis.
Synthesis and bioevaluation of N,4-diaryl-1,3-thiazole-2-amines as tubulin inhibitors with potent antiproliferative activity.
Synthesis and bioevaluation of new vascular-targeting and anti-angiogenic thieno[2,3-d]pyrimidin-4(3H)-ones.
Synthesis and biological activities of high affinity taxane-based fluorescent probes.
Synthesis and biological activity of 8-azapurine and pyrazolo[4,3-d]pyrimidine analogues of myoseverin.
Synthesis and biological effects of novel thiocolchicines. 3. Evaluation of N-acyldeacetylthiocolchicines, N-(alkoxycarbonyl) deacetylthiocolchicines, and O-ethyldemethylthiocolchicines. New synthesis of thiodemecolcine and antileukemic effects of 2-demethyl- and 3-demethylthiocolchicine.
Synthesis and Biological Evaluation of 1-(Diarylmethyl)-1H-1,2,4-triazoles and 1-(Diarylmethyl)-1H-imidazoles as a Novel Class of Anti-Mitotic Agent for Activity in Breast Cancer.
Synthesis and Biological Evaluation of 1-Methyl-1H-indole-Pyrazoline Hybrids as Potential Tubulin Polymerization Inhibitors.
Synthesis and biological evaluation of 2,4,5-substituted pyrimidines as a new class of tubulin polymerization inhibitors.
Synthesis and biological evaluation of 2- and 3-aminobenzo[b]thiophene derivatives as antimitotic agents and inhibitors of tubulin polymerization.
Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-aryl/arylaminobenzo[b]thiophene derivatives as a novel class of antiproliferative agents.
Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-N,N-dimethylamino benzo[b]furan derivatives as inhibitors of tubulin polymerization.
Synthesis and Biological Evaluation of 2-(Alkoxycarbonyl)-3-Anilinobenzo[b]thiophenes and Thieno[2,3-b]pyridines as New Potent Anticancer Agents.
Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-6-substituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine derivatives as antimitotic agents and inhibitors of tubulin polymerization.
Synthesis and biological evaluation of 2-amino-7,7-dimethyl 4-substituted-5-oxo-1-(3,4,5-trimethoxy)-1,4,5,6,7,8-hexahydro-quinoline-3-carbonitrile derivatives as potential cytotoxic agents.
Synthesis and biological evaluation of 2-aroyl-4-phenyl-5-hydroxybenzofurans as a new class of antitubulin agents.
Synthesis and Biological Evaluation of 2-Methyl-4,5-Disubstituted Oxazoles as a Novel Class of Highly Potent Antitubulin Agents.
Synthesis and Biological Evaluation of 2-Substituted Benzyl-/Phenylethylamino-4-amino-5-aroylthiazoles as Apoptosis-Inducing Anticancer Agents.
Synthesis and biological evaluation of 3,4-diaryl-5-aminoisoxazole derivatives.
Synthesis and biological evaluation of 3-(trimethoxyphenyl)-2(3H)-thiazole thiones as combretastatin analogs.
Synthesis and biological evaluation of a series of podophyllotoxins derivatives as a class of potent antitubulin agents.
Synthesis and biological evaluation of aryl azide derivatives of combretastatin A-4 as molecular probes for tubulin.
Synthesis and biological evaluation of B-ring analogues of (-)-rhazinilam.
Synthesis and Biological Evaluation of Benzocyclooctene-based and Indene-based Anticancer Agents that Function as Inhibitors of Tubulin Polymerization.
Synthesis and biological evaluation of benzo[b]furo[3,4-e][1,4]diazepin-1-one derivatives as anti-cancer agents.
Synthesis and biological evaluation of epothilone A dimeric compounds.
Synthesis and biological evaluation of fluoro analogues of antimitotic phenstatin.
Synthesis and biological evaluation of indole-based, anti-cancer agents inspired by the vascular disrupting agent 2-(3'-hydroxy-4'-methoxyphenyl)-3-(3?,4?,5?-trimethoxybenzoyl)-6-methoxyindole (OXi8006).
Synthesis and Biological Evaluation of N-[2-(4-Hydroxyphenylamino)-pyridin-3-yl]-4-methoxy-benzenesulfonamide (ABT-751) Tricyclic Analogues as Antimitotic and Antivascular Agents with Potent in Vivo Antitumor Activity.
Synthesis and Biological Evaluation of New Antitubulin Agents Containing 2-(3',4',5'-trimethoxyanilino)-3,6-disubstituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine Scaffold.
Synthesis and biological evaluation of new disubstituted analogues of 6-methoxy-3-(3',4',5'-trimethoxybenzoyl)-1H-indole (BPR0L075), as potential antivascular agents.
Synthesis and biological evaluation of novel 9-functional heterocyclic coupled 7-deoxy-9-dihydropaclitaxel analogue.
Synthesis and biological evaluation of oxazinonaphthalene-3-one derivatives as potential anticancer agents and tubulin inhibitors.
Synthesis and Biological Evaluation of RGD?Cryptophycin Conjugates for Targeted Drug Delivery.
Synthesis and biological evaluation of structurally diverse ?-conformationally restricted chalcones and related analogues.
Synthesis and biological evaluation of structurally highly modified analogues of the antimitotic natural product curacin A.
Synthesis and biological properties of C12,13-cyclopropyl-epothilone A and related epothilones.
Synthesis and cellular uptake of p-[(123) I]-phenyl-amino-thiazole ((123) I-PAT) as a potential agent for targeting tubulin polymerization in tumors.
Synthesis and characterisation of a novel tubulin-directed DO3A-colchicine conjugate with potential theranostic features.
Synthesis and Characterization of a Theranostic Vascular Disrupting Agent for In Vivo MR Imaging.
Synthesis and cytostatic properties of polyfunctionalized furanoallocolchicinoids.
Synthesis and evaluation of a series of benzylaniline hydrochlorides as potential cytotoxic and antimitotic agents acting by inhibition of tubulin polymerization.
Synthesis and evaluation of alpha-hydroxymethylated conjugated nitroalkenes for their anticancer activity: inhibition of cell proliferation by targeting microtubules.
Synthesis and evaluation of analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents.
Synthesis and evaluation of diaryl sulfides and diaryl selenide compounds for antitubulin and cytotoxic activity.
Synthesis and evaluation of new 2-chloro-4-aminopyrimidine and 2,6-dimethyl-4-aminopyrimidine derivatives as tubulin polymerization inhibitors.
Synthesis and investigation of conformationally restricted analogues of lavendustin A as cytotoxic inhibitors of tubulin polymerization.
Synthesis and mechanistic studies of novel spin-labeled combretastatin derivatives as potential antineoplastic agents.
Synthesis and SAR of C12-C13-oxazoline derivatives of epothilone A.
Synthesis and structure-activity relationships of 1,2,4-triazoles as a novel class of potent tubulin polymerization inhibitors.
Synthesis and Structure-Activity Relationships of N-Methyl-5,6,7-trimethoxylindoles as Novel Antimitotic and Vascular Disrupting Agents.
Synthesis of (-)-Dactylolide and 13-Desmethylene-(-)-dactylolide and Their Effects on Tubulin.
Synthesis of ?,?-Unsaturated Carbonyl-Based Compounds, Oxime and Oxime Ether Analogs as Potential Anticancer Agents for Overcoming Cancer Multidrug Resistance by Modulation of Efflux Pumps in Tumor Cells.
Synthesis of analogs of 2-methoxyestradiol with enhanced inhibitory effects on tubulin polymerization and cancer cell growth.
Synthesis of Combretastatin A-4 and 3'-Aminocombretastatin A-4 derivatives with Aminoacid Containing Pendants and Study of Their Interaction with Tubulin and as Downregulators of the VEGF, hTERT and c-Myc Gene Expression.
Synthesis of dihydronaphthalene analogues inspired by combretastatin A-4 and their biological evaluation as anticancer agents.
Synthesis of novel chromene derivatives of expected antitumor activity.
Synthesis of structurally diverse benzosuberene analogues and their biological evaluation as anti-cancer agents.
Synthesis of triazoloquinazolinone based compounds as tubulin polymerization inhibitors and vascular disrupting agents.
Synthesis, and biological evaluation of 3,6-diaryl-[1,2,4]triazolo[4,3-a]pyridine analogues as new potent tubulin polymerization inhibitors.
Synthesis, anticancer activity and molecular modeling studies of 1,2,4-triazole derivatives as EGFR inhibitors.
Synthesis, anticancer activity, and inhibition of tubulin polymerization by conformationally restricted analogues of lavendustin A.
Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site.
Synthesis, biological evaluation and molecular docking of benzimidazole grafted benzsulfamide-containing pyrazole ring derivatives as novel tubulin polymerization inhibitors.
Synthesis, biological evaluation and molecular docking studies of aminochalcone derivatives as potential anticancer agents by targeting tubulin colchicine binding site.
Synthesis, biological evaluation, and molecular docking studies of novel 1-benzene acyl-2-(1-methylindol-3-yl)-benzimidazole derivatives as potential tubulin polymerization inhibitors.
Synthesis, cytotoxic evaluation and target identification of thieno[2,3-d]pyrimidine derivatives with a dithiocarbamate side chain at C2 position.
Synthesis, cytotoxic properties and tubulin polymerization inhibitory activity of novel 2-pyrazoline derivatives.
Synthesis, in vitro, and in vivo evaluation of phosphate ester derivatives of combretastatin A-4.
Synthesis, molecular docking and biological evaluation of 1-phenylsulphonyl-2-(1-methylindol-3-yl)-benzimidazole derivatives as novel potential tubulin assembling inhibitors.
Synthesis, Molecular Targets, and Antitumor Activities of Substituted Tetrahydro-1-oxopyrano[4,3-b][1]benzopyrans and Nanogels for Drug Delivery.
Synthesis, tubulin assembly, and antiproliferative activity against MCF7 and NCI/ADR-RES cancer cells of 10-O-acetyl-5'-hydroxybutitaxel.
Synthetic and Biological Studies of Tubulin Targeting C2-Substituted 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins.
Systemic delivery of nanoparticle formulation of novel tubulin inhibitor for treating metastatic melanoma.
T0070907 inhibits repair of radiation-induced DNA damage by targeting RAD51.
Target identification of a novel unsymmetrical 1,3,4-oxadiazole derivative with antiproliferative properties.
Targeting HER2-positive cancer with dolastatin 15 derivatives conjugated to trastuzumab, novel antibody-drug conjugates.
Targeting microtubules to inhibit angiogenesis and disrupt tumour vasculature: implications for cancer treatment.
Targeting urokinase and the transferrin receptor with novel, anti-mitotic N-alkylisatin cytotoxin conjugates causes selective cancer cell death and reduces tumor growth.
Targets and pathways involved in the antitumor activity of citral and its stereo-isomers.
Tau and PTEN status as predictive markers for response to trastuzumab and paclitaxel in patients with HER2-positive breast cancer.
Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis.
Taxane resistance in castration-resistant prostate cancer: mechanisms and therapeutic strategies.
Taxane- and epothilone-based chemotherapy: from molecule cargo cytoskeletal logistics to management of castration-resistant prostate carcinoma.
Thalidomide as a multi-template for development of biologically active compounds.
The ?-tubulin meshwork assists in the recruitment of PCNA to chromatin in mammalian cells.
The Aneugenicity of Ketone Bodies in Colon Epithelial Cells Is Mediated by Microtubule Hyperacetylation and Is Blocked by Resveratrol.
The anthelmintic drug mebendazole induces mitotic arrest and apoptosis by depolymerizing tubulin in non-small cell lung cancer cells.
The Bat Flower: A Source of Microtubule-Destabilizing and -Stabilizing Compounds with Synergistic Antiproliferative Actions.
The betaII isotype of tubulin is present in the cell nuclei of a variety of cancers.
The biology of the combretastatins as tumour vascular targeting agents.
The chemistry and biology of antimitotic chalcones and related enone systems.
The clinical development of new mitotic inhibitors that stabilize the microtubule.
The complex role of the triphenylmethyl motif in anticancer compounds.
The complexity of mitochondrial outer membrane permeability and VDAC regulation by associated proteins.
The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in ?-tubulin.
The design, synthesis and evaluation of selenium-containing 4-anilinoquinazoline hybrids as anticancer agents and a study of their mechanism.
The development and use of vascular targeted therapy in ovarian cancer.
The effect of exchanging various substituents at the 2-position of 2-methoxyestradiol on cytotoxicity in human cancer cell cultures and inhibition of tubulin polymerization.
The epothilones: translating from the laboratory to the clinic.
The hematopoietic-specific beta1-tubulin is naturally resistant to 2-methoxyestradiol and protects patients from drug-induced myelosuppression.
The high-resolution X-ray structure of vinca-domain inhibitors of microtubules provides a rational approach for drug design.
The in vitro porcine brain tubulin assembly assay: effects of a genotoxic carcinogen (aflatoxin B1), eight tumor promoters and nine miscellaneous substances.
The Interference of Selected Cytotoxic Alkaloids with the Cytoskeleton: An Insight into Their Modes of Action.
The mammalian metabolite, 2-methoxyestradiol, affects P53 levels and apoptosis induction in transformed cells but not in normal cells.
The microtubule-targeting agent T0070907 induces proteasomal degradation of tubulin.
The Novel Antitubulin Agent TR-764 Strongly Reduces Tumor Vasculature and Inhibits HIF-1? Activation.
The novel tubulin polymerization inhibitor MHPT exhibits selective anti-tumor activity against rhabdomyosarcoma in vitro and in vivo.
The Potential of Combining Tubulin-Targeting Anticancer Therapeutics and Immune Therapy.
The pro-oxidant buthionine sulfoximine (BSO) reduces tumor growth of implanted Lewis lung carcinoma in mice associated with increased protein carbonyl, tubulin abundance, and aminopeptidase activity.
The resveratrol analogue trimethoxystilbene inhibits cancer cell growth by inducing multipolar cell mitosis.
The role of shear stress and altered tissue properties on endothelial to mesenchymal transformation and tumor-endothelial cell interaction.
The role of tubulin in the steroidogenic response of murine adrenal and rat Leydig cells.
The roles of cys124 and ser239 in the functional properties of human betaIII tubulin.
The small molecule SI113 hinders epithelial-to-mesenchymal transition and subverts cytoskeletal organization in human cancer cells.
The stilbene and dibenzo[b,f]oxepine derivatives as anticancer compounds.
The synthesis and evaluation of new butadiene derivatives as tubulin polymerization inhibitors.
The synthetic compound CC-5079 is a potent inhibitor of tubulin polymerization and tumor necrosis factor-alpha production with antitumor activity.
The Tubulin Code in Mitosis and Cancer.
The tumor suppressor protein Fhit. A novel interaction with tubulin.
The Unique Binding Mode of Laulimalide to Two Tubulin Protofilaments.
The vascular disrupting agent BNC105 potentiates the efficacy of VEGF and mTOR inhibitors in renal and breast cancer.
The Widely Used Antihelmintic Drug Albendazole is a Potent Inducer of Loss of Heterozygosity.
The XMAP215 family drives microtubule polymerization using a structurally diverse TOG array.
Therapeutic Targeting of Nuclear ?-Tubulin in RB1-Negative Tumors.
Thiophene derivative-loaded nanoparticles mediate anticancer activity through the inhibition of kinases and microtubule assembly.
Three steps to cancer: how phosphorylation of tubulin, tubulin tyrosine ligase and P-glycoprotein may generate and sustain cancer.
Three-dimensional neuroblastoma cell culture: proteomic analysis between monolayer and multicellular tumor spheroids.
Three-dimensional structured illumination microscopy using Lukosz bound apodization reduces pixel negativity at no resolution cost.
Tivantinib (ARQ 197) exhibits antitumor activity by directly interacting with tubulin and overcomes ABC transporter-mediated drug resistance.
Topoisomerases and tubulin inhibitors: a promising combination for cancer treatment.
Total synthesis and evaluation of C26-hydroxyepothilone D derivatives for photoaffinity labeling of beta-tubulin.
Total synthesis of (-)-pseudolaric acid B.
Total synthesis of hypermodified epothilone analogs with potent in vitro antitumor activity.
Total synthesis of taxol.
Toward docking-based virtual screening for discovering antitubulin agents by targeting taxane and colchicine binding sites.
Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors.
TP53INP2 contributes to autophagosome formation by promoting LC3-ATG7 interaction.
TPPP3 inhibits the proliferation, invasion and migration of endometrial carcinoma targeted with miR-1827.
Transformation-resistant mos revertant is unable to activate MAP kinase kinase in response to v-mos or v-raf.
Treatment of patients resistant to paclitaxel therapy.
Triazole tethered C5-curcuminoid-coumarin based molecular hybrids as novel antitubulin agents: Design, synthesis, biological investigation and docking studies.
Tricyclic pyrone analogs: a new class of microtubule-disrupting anticancer drugs effective against murine leukemia cells in vitro.
Tricyclic pyrone analogs: a new synthetic class of bifunctional anticancer drugs that inhibit nucleoside transport, microtubule assembly, the viability of leukemic cells in vitro and the growth of solid tumors in vivo.
Triethylated chromones with substituted naphthalenes as tubulin inhibitors.
TUBA1C expression promotes proliferation by regulating the cell cycle and indicates poor prognosis in glioma.
Tubal origin of 'ovarian' low-grade serous carcinoma.
Tubulin alpha 8 is expressed in hepatic stellate cells and is induced in transformed hepatocytes.
Tubulin Beta3 Serves as a Target of HDAC3 and Mediates Resistance to Microtubule-Targeting Drugs.
Tubulin binding cofactor C (TBCC) suppresses tumor growth and enhances chemosensitivity in human breast cancer cells.
Tubulin detyrosination is a frequent occurrence in breast cancers of poor prognosis.
Tubulin expression in melanocytic skin tumors. An immunohistochemical study.
Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon.
Tubulin heterogeneity regulates functions and dynamics of microtubules and plays a role in the development of drug resistance in cancer.
Tubulin inhibitor AEZS 112 inhibits the growth of experimental human ovarian and endometrial cancers irrespective of caspase inhibition.
Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy.
Tubulin inhibitors as novel anticancer agents: an overview on patents (2013-2018).
Tubulin inhibitors: a patent review.
Tubulin isoform composition tunes microtubule dynamics.
Tubulin isoforms identified in the brain by MALDI in-source decay.
Tubulin Maytansine Site Binding Ligands and Their Applications as MTAs and ADCs for Cancer Therapy.
Tubulin nitration in human gliomas.
Tubulin polymerization-stimulating activity of Ganoderma triterpenoids.
Tubulin Proteins in Cancer Resistance: A review.
Tubulin Resists Degradation by Cereblon-Recruiting PROTACs.
Tubulin targets in the pathobiology and therapy of glioblastoma multiforme. I. class III beta-tubulin.
Tubulin targets in the pathobiology and therapy of glioblastoma multiforme. II. gamma-tubulin.
Tubulin tyrosination is a major factor affecting the recruitment of CAP-Gly proteins at microtubule plus ends.
Tubulin's response to external electric fields by molecular dynamics simulations.
Tubulin-associated proteins: Aurora and Polo-like kinases as therapeutic targets in cancer.
Tubulin-binding drug screening by MALDI-TOFMS.
Tubulin-targeting agents in hybrid drugs.
Tubulin: A Target for Antineoplastic Drugs into the Cancer Cells but also in the Peripheral Nervous System.
Tubulin: Structure, Functions and Roles in Disease.
Tubulins - the target for anticancer therapy.
Tubulins as Therapeutic Targets in Cancer: from Bench to Bedside.
Tumor suppressor RARRES1 links tubulin deglutamylation to mitochondrial metabolism and cell survival.
Understanding the Basis of Drug Resistance of the Mutants of ??-Tubulin Dimer via Molecular Dynamics Simulations.
Unraveling the molecular mechanism of BNC105, a phase II clinical trial vascular disrupting agent, provides insights into drug design.
Up-regulation of cytoskeletal proteins in activated microglia.
Upregulation of DR5 receptor by the diaminothiazole DAT1 [4-amino-5-benzoyl-2-(4-methoxy phenyl amino) thiazole] triggers an independent extrinsic pathway of apoptosis in colon cancer cells with compromised pro and antiapoptotic proteins.
Vascular disrupting activity of combretastatin analogues.
Vascular disrupting activity of tubulin-binding 1,5-diaryl-1H-imidazoles.
Vascular disrupting effect of CKD-516: preclinical study using DCE-MRI.
Vascular targeting in pancreatic cancer: the novel tubulin-binding agent ZD6126 reveals antitumor activity in primary and metastatic tumor models.
Vasohibin-2 plays an essential role in metastasis of pancreatic ductal adenocarcinoma.
VDAC upregulation and ?TAT1?mediated ??tubulin acetylation contribute to tanespimycin?induced apoptosis in Calu?1 cells.
VDAC-Tubulin, an Anti-Warburg Pro-Oxidant Switch.
Versatile synthesis of new cytotoxic agents structurally related to hemiasterlins.
VHL Inactivation Induces HEF1 and Aurora Kinase A.
Vimentin filaments support extension of tubulin-based microtentacles in detached breast tumor cells.
Viriditoxin regulates apoptosis and autophagy via mitotic catastrophe and microtubule formation in human prostate cancer cells.
Viriditoxin Stabilizes Microtubule Polymers in SK-OV-3 Cells and Exhibits Antimitotic and Antimetastatic Potential.
Virtual and experimental high throughput screening of substituted hydrazones on ?-Tubulin polymerization.
Vitamin K3 chloro derivative (VKT-2) inhibits HDAC6, activates autophagy and apoptosis, and inhibits aggresome formation in hepatocellular carcinoma cells.
Vitamin K3 disrupts the microtubule networks by binding to tubulin: a novel mechanism of its antiproliferative activity.
Voltage dependent anion channels modulate mitochondrial metabolism in cancer cells: regulation by free tubulin and erastin.
Warburg revisited: regulation of mitochondrial metabolism by voltage-dependent anion channels in cancer cells.
Wnt-Independent and Wnt-Dependent Effects of APC Loss on the Chemotherapeutic Response.
X-ray Crystal Structure Guided Discovery and Antitumor Efficacy of Dihydroquinoxalinone as Potent Tubulin Polymerization Inhibitors.
X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor.
YHHU0895, a novel synthetic small-molecule microtubule-destabilizing agent, effectively overcomes P-glycoprotein-mediated tumor multidrug resistance.
YY1 targets tubulin polymerisation-promoting protein to inhibit migration, invasion and angiogenesis in pancreatic cancer via p38/MAPK and PI3K/AKT pathways.
Zampanolide and dactylolide: cytotoxic tubulin-assembly agents and promising anticancer leads.
Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss.
Zinc alters cytoskeletal integrity and migration in colon cancer cells.
[4-(imidazol-1-yl)thiazol-2-yl]phenylamines. A novel class of highly potent colchicine site binding tubulin inhibitors: synthesis and cytotoxic activity on selected human cancer cell lines.
[BETA-III TUBULIN AS A POTENTIAL TARGET FOR BLOCKING INVASIVE GROWTH OF MALIGNANT EPITHELIAL TUMORS].
[Decrease in the antimetastatic effect of vinblastine administered in liposomes]
[Efficacy and safety of ixabepilone (BMS-247550), a novel epothilone B analogue]
[Progress in the study of tubulin inhibitors].
[TUBB3 role in the response of tumor cells to epothilones and taxanes].
Neoplasms, Experimental
New anticancer agents: alterations of the carbamate group of ethyl (5-amino-1,2-dihydro-3-phenylpyrido[3,4-b]pyrazin-7-yl)car bamates.
Neoplasms, Neuroepithelial
Expression of tubulin beta II in neuroepithelial tumors: reflection of architectural changes in the developing human brain.
Immunohistochemical Characterization of Canine Neuroepithelial Tumors.
Nephritis
Modulation of antibody-mediated glomerular injury in vivo by interleukin-6.
Nervous System Diseases
Distinct alpha- and beta-tubulin isotypes are required for the positioning, differentiation and survival of neurons: new support for the 'multi-tubulin' hypothesis.
Epileptogenic Brain Malformations and Mutations in Tubulin Genes: A Case Report and Review of the Literature.
Fitting neurological protein aggregation kinetic data via a 2-step, minimal/"Ockham's razor" model: the Finke-Watzky mechanism of nucleation followed by autocatalytic surface growth.
G protein-coupled receptor kinases are associated with Alzheimer's disease pathology.
Interactions of pathological hallmark proteins: Tubulin polymerization promoting protein/p25, {beta}-amyloid and {alpha}-synuclein.
TAPping into the treasures of tubulin using novel protein production methods.
The Expression of Tubb2b Undergoes a Developmental Transition in Murine Cortical Neurons.
The expression of tubb2b undergoes a developmental transition in murine cortical neurons.
TUBB Variants Underlying Different Phenotypes Result in Altered Vesicle Trafficking and Microtubule Dynamics.
Nervous System Neoplasms
Immunohistochemical distribution of tubulin beta II in human normal and neoplastic tissues.
Neuralgia
Interaction of transient receptor potential vanilloid 4 with annexin A2 and tubulin beta 5.
Probiotic DSF counteracts chemotherapy induced neuropathic pain.
Neuroaxonal Dystrophies
Cytoskeletal changes and ubiquitin expression in dystrophic axons of Seitelberger's disease.
Neuroblastoma
1-Benzyl-1,2,3,4-tetrahydroisoquinoline binds with tubulin beta, a substrate of parkin, and reduces its polyubiquitination.
ADP-ribosylation of microtubule proteins as catalyzed by cholera toxin.
Adriamycin promotes neurite outgrowth in the "neurite-minus" N1A-103 mouse neuroblastoma cell line.
Affinity purification of antibodies from diazotized paper blots of heterogeneous protein samples.
Aggregation of microtubule initiation sites preceding neurite outgrowth in mouse neuroblastoma cells.
Analysis of tubulin proteins and peptides in neuronal and non-neuronal tissues using immobilized pH gradients.
Androgen-induced up-regulation of tubulin isoforms in neuroblastoma cells.
Antibody-drug conjugate efficacy in neuroblastoma - role of payload, resistance mechanisms, target density, and antibody internalization.
Biphasic regulation by dibutyryl cyclic AMP of tubulin and actin mRNA levels in neuroblastoma cells.
CacyBP/SIP interacts with tubulin in neuroblastoma NB2a cells and induces formation of globular tubulin assemblies.
Centrosome overduplication induced by rotenone treatment affects the cellular distribution of p53 tumor suppressor protein in the neuroblastoma B65 cell line.
Changes in intracellular organization of tubulin and actin in N-18 neuroblastoma cells during the process of axon extension induced by serum deprivation.
Changes in microtubule-associated tau protein in human neuroblastoma cells after phencyclidine.
Changes in some cytoskeletal proteins during neuroblastoma cell differentiation.
Characterization and intracellular distribution of microtubule-associated protein 2 in differentiating human neuroblastoma cells.
Characterization of STEF, a guanine nucleotide exchange factor for Rac1, required for neurite growth.
Clathrin-mediated endocytosis of m3 muscarinic receptors. Roles for Gbetagamma and tubulin.
Clinical outcome in children with recurrent neuroblastoma treated with ABT-751 and effect of ABT-751 on proliferation of neuroblastoma cell lines and on tubulin polymerization in vitro.
Compartments of tubulin and tubulin-like proteins in differentiating neubroblastoma cells.
Control of isotubulin expression during neuronal differentiation of mouse neuroblastoma and teratocarcinoma cell lines.
Control of tubulin and actin synthesis and assembly during differentiation of neuroblastoma cells.
D-glucose induces microtubular changes in C1300 neuroblastoma cell line through the incorporation of 3-nitro-L-tyrosine into tubulin.
Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress.
Differential association of tau with subsets of microtubules containing posttranslationally-modified tubulin variants in neuroblastoma cells.
Effect of trans-resveratrol on signal transduction pathways involved in paclitaxel-induced apoptosis in human neuroblastoma SH-SY5Y cells.
Effects of insulin and insulin-like growth factors on neurofilament mRNA and tubulin mRNA content in human neuroblastoma SH-SY5Y cells.
Ganglioside GM1 alters neuronal morphology by modulating the association of MAP2 with microtubules and actin filaments.
High molecular weight tau distribution and microtubule stability in neuroblastoma N115 cells.
Identification of a novel aminotetralin class of HDAC6 and HDAC8 selective inhibitors.
Immunohistochemical Characterization of Canine Neuroepithelial Tumors.
In vitro synthesis of mouse neuroblastoma tubulin.
Interaction of receptor-activity-modifying protein1 with tubulin.
Interactions of ? tubulin isotypes with glutathione in differentiated neuroblastoma cells subject to oxidative stress.
Localization of the neurofilament protein in neuroblastoma cells by immunofluorescent staining.
Low expression of human tubulin tyrosine ligase and suppressed tubulin tyrosination/detyrosination cycle are associated with impaired neuronal differentiation in neuroblastomas with poor prognosis.
Mapping the Mechanome-A Protocol for Simultaneous Live Imaging and Quantitative Analysis of Cell Mechanoadaptation and Ingression.
Melatonin prevents cytoskeletal alterations and oxidative stress induced by okadaic acid in N1E-115 cells.
Modification of tubulin by tyrosylation in cells and extracts and its effect on assembly in vitro.
Nerve growth factor modulates tubulin transcript levels in pheochromocytoma PC12 cells.
Neuritogenesis in mouse NB2a/d1 neuroblastoma cells: triggering by calcium influx and involvement of actin and tubulin dynamics.
Properties and synthesis of tubulin in neuroblastoma cells.
Proteins from morphologically differentiated neuroblastoma cells promote tubulin polymerization.
Proteomic Analysis on Anti-Proliferative and Apoptosis Effects of Curcumin Analog, 1,5-bis(4-Hydroxy-3-Methyoxyphenyl)-1,4-Pentadiene-3-One-Treated Human Glioblastoma and Neuroblastoma Cells.
Purification of tubulin from neuroblastoma cells: absence of covalently bound phosphate in tubulin from normal and morphologically differentiated cells.
Quantitation and characterization of antibody binding to tubulin.
Radioimmunoassay for tubulin: a quantitative comparison of the tubulin content of different established tissue culture cells and tissues.
Remarkable reduction of MAP2 in the brains of scrapie-infected rodents and human prion disease possibly correlated with the increase of calpain.
Reversible in vitro polymerization of tubulin from a cultured cell line (rat glial cell clone C6).
RNAi-mediated stathmin suppression reduces lung metastasis in an orthotopic neuroblastoma mouse model.
SCAPER localizes to primary cilia and its mutation affects cilia length, causing Bardet-Biedl syndrome.
Stabilization of tubulin mRNAs by insulin and insulin-like growth factor I during neurite formation.
Stathmin mediates neuroblastoma metastasis in a tubulin-independent manner via RhoA/ROCK signaling and enhanced transendothelial migration.
Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents.
The expression of tubulin and various enzyme activities during neuroblastoma differentiation.
The intracellular organization of actin and tubulin in cultured C-1300 mouse neuroblastoma cells (clone NB41A3).
The quantitation of tubulin in neuroblastoma cells by radioimmunoassay.
The tubulin inhibitor MG-2477 induces autophagy-regulated cell death, ROS accumulation and activation of FOXO3 in neuroblastoma.
Transglutaminase and neuronal differentiation.
Tubulin constancy during morphological differentiation of mouse neuroblastoma cells.
Tubulin microheterogeneity in neuroblastoma and glioma cell lines differs from that of the brain.
Tubulin pools in differentiating neuroblastoma cells.
Tubulin potentiates the interaction of the metalloendopeptidase nardilysin with the neuronal scaffold protein p42IP4/centaurin-?1 (ADAP1).
Two-dimensional gel electrophoresis of human brain proteins. II. Specific proteins and brain subfractions.
Ultrastructure of multiple microtubule initiation sites in mouse neuroblastoma cells.
Neurocysticercosis
Extraparenchymal human neurocysticercosis induces autoantibodies against brain tubulin and MOG35-55 in cerebral spinal fluid.
Neurodegenerative Diseases
A homozygous canonical splice acceptor site mutation in PRUNE1 is responsible for a rare childhood neurodegenerative disease in Manitoba Cree families.
Aberrant molecular properties shared by familial Parkinson's disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1.
Alpha-synuclein promotes early neurite outgrowth in cultured primary neurons.
Analysis of Tubulin Alpha-1A/1B C-Terminal Tail Post-translational Poly-glutamylation Reveals Novel Modification Sites.
Autoantibodies in neurodegenerative diseases: antigen-specific frequencies and intrathecal analysis.
Building the Neuronal Microtubule Cytoskeleton.
Cholesterol derivatives induce dephosphorylation of the histone deacetylases Rpd3/HDAC1 to upregulate autophagy.
Infantile Neurodegenerative Disorder Associated with Mutations in TBCD, an Essential Gene in the Tubulin Heterodimer Assembly Pathway.
Infantile neurodegenerative disorder associated with mutations in TBCD, an essential gene in the tubulin heterodimer assembly pathway.
Insights into the interaction dynamics between volatile anesthetics and tubulin through computational molecular modelling.
Longitudinal Evaluation of Cerebellar Signs of H-ABC Tubulinopathy in a Patient and in the taiep Model.
Loss of tubulin deglutamylase CCP1 causes infantile-onset neurodegeneration.
Microtubule acetylation: A reading key to neural physiology and degeneration.
Microtubule and MAPs: thermodynamics of complex formation by AUC, ITC, fluorescence, and NMR.
Microtubule Dysfunction: A Common Feature of Neurodegenerative Diseases.
Mutation of NEKL-4/NEK10 and TTLL genes suppress neuronal ciliary degeneration caused by loss of CCPP-1 deglutamylase function.
Oxidative species-induced excitonic transport in tubulin aromatic networks: Potential implications for neurodegenerative disease.
Role of tubulin acetylation in cellular functions and diseases.
Shared and Distinct Patterns of Oligodendroglial Response in ?-Synucleinopathies and Tauopathies.
Targeting the interface of the pathological complex of ?-synuclein and TPPP/p25.
The brain-specific protein TPPP/p25 in pathological protein deposits of neurodegenerative diseases.
The cytoskeleton as a novel therapeutic target for old neurodegenerative disorders.
The ins and outs of tubulin acetylation: More than just a post-translational modification?
The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS.
TPPP/p25: from unfolded protein to misfolding disease: prediction and experiments.
Tubulin glutamylation: a skeleton key for neurodegenerative diseases.
Tubulin Resists Degradation by Cereblon-Recruiting PROTACs.
Neuroectodermal Tumors, Primitive
Immunohistochemical Characterization of Canine Neuroepithelial Tumors.
Neuroinflammatory Diseases
Methamphetamine-induced neuroinflammation and neuronal dysfunction in the mice hippocampus: preventive effect of indomethacin.
Novel therapeutic approaches in multiple system atrophy.
Neuroma
Both positive and negative factors regulate gene expression following chronic facial nerve resection.
Neutropenia
Pharmacokinetics of anticancer agents in patients with impaired liver function.
Nevus
Evaluation of tubulin ?-3 as a novel senescence-associated gene in melanocytic malignant transformation.
Expression of cytoskeletal components in melanocytic skin lesions. An immunohistochemical study.
Nevus, Pigmented
BAP1-inactivated melanocytic tumors show prominent centrosome amplification and associated loss of primary cilia.
Tubulin expression in melanocytic skin tumors. An immunohistochemical study.
Non-alcoholic Fatty Liver Disease
Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity.
Obesity, Morbid
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Ocular Motility Disorders
Mutations in the ?-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities.
Oligodendroglioma
Immunohistochemical Characterization of Canine Neuroepithelial Tumors.
Onchocerciasis
Classical ligands interact with native and recombinant tubulin from Onchocerca volvulus with similar rank order of magnitude.
Optic Nerve Injuries
Increased tubulin messenger RNA in the frog retina after optic nerve transection.
Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma.
Tuba1a gene expression is regulated by KLF6/7 and is necessary for CNS development and regeneration in zebrafish.
Optic Neuritis
Autoantibodies in neurodegenerative diseases: antigen-specific frequencies and intrathecal analysis.
Osteoarthritis
Potential protein targets of the peptidylarginine deiminase 2 and peptidylarginine deiminase 4 enzymes in rheumatoid synovial tissue and its possible meaning.
Profiling of Endogenous Peptides in Human Synovial Fluid by NanoLC-MS: Method Validation and Peptide Identification.
Osteochondroma
Expression of tau proteins and tubulin in extraskeletal myxoid chondrosarcoma, chordoma, and other chondroid tumors.
Osteomalacia
Aluminium induced osteomalacia and encephalopathy--an aberration of the tubulin assembly into microtubules (MTs) by Al3+?
Osteoporosis
Depression, osteoporosis, serotonin and cell membrane viscosity between biology and philosophical anthropology.
Osteosarcoma
CircTUBGCP3 Contributes to the Malignant Progression of Rectal Cancer.
Cytotoxicity and antimitotic activity of Rhinella schneideri and Rhinella marina venoms.
Integrating mechanisms of response and resistance against the tubulin binding agent Eribulin in preclinical models of osteosarcoma.
The Interference of Selected Cytotoxic Alkaloids with the Cytoskeleton: An Insight into Their Modes of Action.
Tubulin polymerization promoting protein 1 (TPPP1) increases ?-catenin expression through inhibition of HDAC6 activity in U2OS osteosarcoma cells.
Ovarian Neoplasms
An Amino-Benzosuberene Analogue That Inhibits Tubulin Assembly and Demonstrates Remarkable Cytotoxicity.
Assessment of the trifluoromethyl ketone functionality as an alternative zinc-binding group for selective HDAC6 inhibition.
Bcl-2 down-regulation and tubulin subtype composition are involved in resistance of ovarian cancer cells to vinflunine.
beta tubulin mutations are rare in human ovarian carcinoma.
BRCA1 Regulates g-Tubulin Binding to Centrosomes.
Class III beta-tubulin overexpression is a marker of poor clinical outcome in advanced ovarian cancer patients.
Decreased levels of baseline and drug-induced tubulin polymerisation are hallmarks of resistance to taxanes in ovarian cancer cells and are associated with epithelial-to-mesenchymal transition.
Design and discovery of silybin analogues as antiproliferative compounds using a ring disjunctive - Based, natural product lead optimization approach.
Design, synthesis and biological evaluation of bridged epothilone D analogues.
Dose-intense taxol: high response rate in patients with platinum-resistant recurrent ovarian cancer.
Knockout of vasohibin-2 reduces tubulin carboxypeptidase activity and increases paclitaxel sensitivity in ovarian cancer.
Molecular determinants of epothilone B derivative (BMS 247550) and Apo-2L/TRAIL-induced apoptosis of human ovarian cancer cells.
MT-4 suppresses resistant ovarian cancer growth through targeting tubulin and HSP27.
No significant role for beta tubulin mutations and mismatch repair defects in ovarian cancer resistance to paclitaxel/cisplatin.
Novel chemotypes targeting tubulin at the colchicine binding site and unbiasing P-glycoprotein.
Overexpression of class III beta-tubulin predicts good response to taxane-based chemotherapy in ovarian clear cell adenocarcinoma.
P18/Stathmin1 is regulated by miR-31 in ovarian cancer in response to taxane.
Paclitaxel inhibits expression of heat shock protein 27 in ovarian and uterine cancer cells.
Potent inhibition of tubulin polymerisation and proliferation of paclitaxel-resistant 1A9PTX22 human ovarian cancer cells by albendazole.
Restoration of miR-200c to ovarian cancer reduces tumor burden and increases sensitivity to paclitaxel.
SRC tyrosine kinase and multidrug resistance protein-1 inhibitions act independently but cooperatively to restore paclitaxel sensitivity to paclitaxel-resistant ovarian cancer cells.
Stathmin and tubulin expression and survival of ovarian cancer patients receiving platinum treatment with and without paclitaxel.
Targeting Src and tubulin in mucinous ovarian carcinoma.
Taxol induction of p21WAF1 and p53 requires c-raf-1.
The G-protein-coupled estrogen receptor agonist G-1 suppresses proliferation of ovarian cancer cells by blocking tubulin polymerization.
Tubulin Beta 2C Chain (TBB2C), a Potential Marker of Ovarian Cancer, an Insight from Ovarian Cancer Proteome Profile.
Tubulysin analogs incorporating desmethyl and dimethyl tubuphenylalanine derivatives.
[TUBB3 role in the response of tumor cells to epothilones and taxanes].
Pancreatic Neoplasms
A phase 2 study of oral MKC-1, an inhibitor of importin-?, tubulin, and the mTOR pathway in patients with unresectable or metastatic pancreatic cancer.
Chemical inhibitors: the challenge of finding the right target.
Imidazo[2,1-b]thiazole-Coupled Natural Noscapine Derivatives as Anticancer Agents.
Involvement of the Tubulin Tyrosine Ligase-Like Family Member 4 Polyglutamylase in PELP1 Polyglutamylation and Chromatin Remodeling in Pancreatic Cancer Cells.
Nanoformulation design and therapeutic potential of a novel tubulin inhibitor in pancreatic cancer.
YY1 targets tubulin polymerisation-promoting protein to inhibit migration, invasion and angiogenesis in pancreatic cancer via p38/MAPK and PI3K/AKT pathways.
Pancreatitis
Actin overexpression parallels severity of pancreatic injury.
Pancreatitis, Acute Necrotizing
An evaluation of potential reference genes for stability of expression in two salmonid cell lines after infection with either Piscirickettsia salmonis or IPNV.
Pantothenate Kinase-Associated Neurodegeneration
Impaired Coenzyme A metabolism affects histone and tubulin acetylation in Drosophila and human cell models of pantothenate kinase associated neurodegeneration.
Paralysis
Antigenic characteristics of neurofibrillary tangles in progressive supranuclear palsy.
Neurofibrillary tangles in Alzheimer's disease and progressive supranuclear palsy: antigenic similarities and differences. Microtubule-associated protein tau antigenicity is prominent in all types of tangles.
Parasitemia
Induction of high levels of IgG autoantibodies in mice infected with Plasmodium chabaudi.
Induction of protective immune response in mice by a DNA vaccine encoding Trypanosoma evansi beta tubulin gene.
Parasitic Diseases
Antibodies to tubulin in patients with parasitic infections.
Congeners Derived from Microtubule-Active Phenylpyrimidines Produce a Potent and Long-Lasting Paralysis of Schistosoma mansoni In Vitro.
Microtubules as antifungal and antiparasitic drug targets.
Parkinson Disease
Age-dependent accumulation of oligomeric SNCA/?-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA).
Autoantibodies in neurodegenerative diseases: antigen-specific frequencies and intrathecal analysis.
Challenging drug target for Parkinson's disease: Pathological complex of the chameleon TPPP/p25 and alpha-synuclein proteins.
Drosophila tubulin polymerization promoting protein mutants reveal pathological correlates relevant to human Parkinson's disease.
G protein-coupled receptor kinases are associated with Alzheimer's disease pathology.
Interactions of pathological hallmark proteins: Tubulin polymerization promoting protein/p25, {beta}-amyloid and {alpha}-synuclein.
Irreversible incorporation of L-dopa into the C-terminus of ?-tubulin inhibits binding of molecular motor KIF5B to microtubules and alters mitochondrial traffic along the axon.
Microtubule acetylation: A reading key to neural physiology and degeneration.
Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels.
Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation.
Rotenone induces aggregation of gamma-tubulin protein and subsequent disorganization of the centrosome: relevance to formation of inclusion bodies and neurodegeneration.
Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions.
Zinc-induced structural changes of the disordered tppp/p25 inhibits its degradation by the proteasome.
Parkinsonian Disorders
Aberrant molecular properties shared by familial Parkinson's disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1.
Diminished taxol/GTP-stimulated tubulin polymerization in diseased region of brain from patients with late-onset or inherited Alzheimer's disease or frontotemporal dementia with parkinsonism linked to chromosome-17 but not individuals with mild cognitive impairment.
Docosahexaenoic acid protection in a rotenone induced Parkinson's model: Prevention of tubulin and synaptophysin loss, but no association with mitochondrial function.
The role of tau (MAPT) in frontotemporal dementia and related tauopathies.
Periodontal Diseases
A conserved Ala320 in the FtsZ of Porphyromonas gingivalis is important for cell division.
Peripheral Nervous System Diseases
cis-diamminedichloroplatinum (II) (cisplatin) alters microtubule assembly dynamics.
Design, synthesis and anticancer evaluation of novel series of Indibulin analogues.
Evaluation of tubulin polymerization and chronic inhibition of proteasome as citotoxicity mechanisms in bortezomib-induced peripheral neuropathy.
Lack of neurotoxicity of the vascular targeting agent ZD6126 following repeated i.v. dosing in the rat.
Microtubule and tubulin binding and regulation of microtubule dynamics by the antibody drug conjugate (ADC) payload, monomethyl auristatin E (MMAE): Mechanistic insights into MMAE ADC peripheral neuropathy.
Pathogenic role of delta 2 tubulin in bortezomib-induced peripheral neuropathy.
Proteasome inhibitors increase tubulin polymerization and stabilization in tissue culture cells: a possible mechanism contributing to peripheral neuropathy and cellular toxicity following proteasome inhibition.
TRPV1-tubulin complex: involvement of membrane tubulin in the regulation of chemotherapy-induced peripheral neuropathy.
Persistent Hyperplastic Primary Vitreous
Modulating EGFR-MTORC1-autophagy as a potential therapy for persistent fetal vasculature (PFV) disease.
Phenylketonurias
Experimental phenylketonuria: replacement of carboxyl terminal tyrosine by phenylalanine in infant rat brain tubulin.
Pheochromocytoma
A macromolecular structure favouring microtubule assembly in NGF-differentiated pheochromocytoma cells (PC12).
Absence of 2'-deoxy-GTP in adult brain tubulin.
Charge variants of tubulin, tubulin S, membrane-bound and palmitoylated tubulin from brain and pheochromocytoma cells.
Cytosolic Cl- Affects the Anticancer Activity of Paclitaxel in the Gastric Cancer Cell Line, MKN28 Cell.
I-387, a Novel Antimitotic Indole, Displays a Potent In vitro and In vivo Antitumor Activity with Less Neurotoxicity.
Nerve growth factor modulates tubulin transcript levels in pheochromocytoma PC12 cells.
Neurites induced by staurosporine in PC12 cells are resistant to colchicine and express high levels of tau proteins.
Peptide neuroprotection through specific interaction with brain tubulin.
Plasma membrane localization of palmitoylated tubulin.
Quinazoline-based tricyclic compounds that regulate programmed cell death, induce neuronal differentiation, and are curative in animal models for excitotoxicity and hereditary brain disease.
The ADNP derived peptide, NAP modulates the tubulin pool: implication for neurotrophic and neuroprotective activities.
Tubulin isotype usage in vivo: a unique spatial distribution of the minor neuronal-specific beta-tubulin isotype in pheochromocytoma cells.
Photosensitivity Disorders
Effects of Visible-Light Irradiation of Protoporphyrin?IX on the Self-Assembly of Tubulin Heterodimers.
Pituitary Neoplasms
Neuronal differentiation and expression of neural epitopes in pituitary adenomas.
Pituitary adenoma stem cells.
Plant Diseases
Combretastatin A-4 and Derivatives: Potential Fungicides Targeting Fungal Tubulin.
Plasmacytoma
Restricted immunoglobulin variable region (Ig V) gene expression accompanies secondary rearrangements of light chain Ig V genes in mouse plasmacytomas.
Stimulation by tubulin of an adenylate cyclase from murine plasmacytoma.
Pneumocystis Infections
Characterization of the beta-tubulin gene of Pneumocystis carinii.
Polycystic Kidney Diseases
Mechanism of pancreatic and liver malformations in human fetuses with short-rib polydactyly syndrome.
Microtubule active taxanes inhibit polycystic kidney disease progression in cpk mice.
Polycystic Kidney, Autosomal Dominant
Ganab Haploinsufficiency Does Not Cause Polycystic Kidney Disease or Polycystic Liver Disease in Mice.
Polycystic Kidney, Autosomal Recessive
Mechanism of pancreatic and liver malformations in human fetuses with short-rib polydactyly syndrome.
Polymicrogyria
Beta tubulin isoforms are not interchangeable for rescuing impaired radial migration due to Tubb3 knockdown.
Brain-specific knockin of the pathogenic Tubb5 E401K allele causes defects in motor coordination and prepulse inhibition.
Mutations in ?- and ?-tubulin encoding genes: Implications in brain malformations.
Mutations in the ?-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities.
Recognizable cerebellar dysplasia associated with mutations in multiple tubulin genes.
TUBA1A mutation-associated lissencephaly: case report and review of the literature.
Tubulin-related cortical dysgeneses: microtubule dysfunction underlying neuronal migration defects.
Polyneuropathies
Serum IgM monoclonal autoantibody binding to the 301 to 314 amino acid epitope of beta-tubulin: clinical association with slowly progressive demyelinating polyneuropathy.
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
Anti-alpha- and beta-tubulin IgM antibodies in dysimmune neuropathies.
Serum IgM monoclonal autoantibody binding to the 301 to 314 amino acid epitope of beta-tubulin: clinical association with slowly progressive demyelinating polyneuropathy.
Porcine Reproductive and Respiratory Syndrome
Porcine reproductive and respiratory syndrome virus envelope (E) protein interacts with tubulin.
Pre-Eclampsia
Detyrosinated tubulin is decreased in fetal vessels of preeclampsia placentas.
Differential proteomic analysis of highly purified placental cytotrophoblasts in preeclampsia demonstrates a state of increased oxidative stress and reduced cytotrophoblast antioxidant defense.
Maternal whole blood mRNA signatures identify women at risk of early preeclampsia: a longitudinal study.
Tubulin detyrosination promotes human trophoblast syncytium formation.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
A role for altered microtubule polymer levels in vincristine resistance of childhood acute lymphoblastic leukemia xenografts.
Cytotoxic 3,4,5-trimethoxychalcones as mitotic arresters and cell migration inhibitors.
N-alkylisatin-based microtubule destabilizers bind to the colchicine site on tubulin and retain efficacy in drug resistant acute lymphoblastic leukemia cell lines with less in vitro neurotoxicity.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Mebendazole is a potent inhibitor to chemoresistant T cell acute lymphoblastic leukemia cells.
Semisynthetic aurones inhibit tubulin polymerization at the colchicine-binding site and repress PC-3 tumor xenografts in nude mice and myc-induced T-ALL in zebrafish.
Primary Dysautonomias
Microtubules stability in human peripheral nerves.
Primary Graft Dysfunction
Chronic Lung Allograft Dysfunction: Immune Responses Induced by Circulating Exosomes with Lung-Associated Self-Antigens.
Prion Diseases
Reduction of protein kinase MARK4 in the brains of experimental scrapie rodents and human prion disease correlates with deposits of PrP(Sc).
Prolactinoma
Immunofluorescence demonstration of tubulin and actin in estrogen-induced rat prolactinoma cells in vitro. Alteration of their distribution after bromocriptine, colchicine and cytochalasin B treatments.
Prostatic Hyperplasia
Immunohistochemical analysis of beta-tubulin isotypes in human prostate carcinoma and benign prostatic hypertrophy.
Prostatic Neoplasms
(Z)-1,1-Dichloro-2-(4-methoxyphenyl)-3-phenylcyclopropane induces concentration-dependent growth inhibition, apoptosis, and coordinates regulation of apoptotic genes in TRAMP cells.
2-Phenyl-5-(pyrrolidin-1-yl)-1-(3,4,5-trimethoxybenzyl)-1H-benzimidazole, a benzimidazole derivative, inhibits growth of human prostate cancer cells by affecting tubulin and c-Jun N-terminal kinase.
A phase 2 study of KX2-391, an oral inhibitor of Src kinase and tubulin polymerization, in men with bone-metastatic castration-resistant prostate cancer.
A Phase II study of Paclitaxel and Vinorelbine (Pacl-Vin) in hormone-refractory metastatic prostate cancer: Double Tubulin Targeting.
Activation of membrane androgen receptors potentiates the antiproliferative effects of paclitaxel on human prostate cancer cells.
Antiproliferative benzothiazoles incorporating a trimethoxyphenyl scaffold as novel colchicine site tubulin polymerisation inhibitors.
Beta-tubulin III expression in prostate cancer.
Design, synthesis and biological evaluation of bridged epothilone D analogues.
Diethylstilbestrol and docetaxel: a Phase II study of tubulin active agents in patients with metastatic, androgen-independent prostate cancer.
Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells.
Discovery of 2-chloro-N-(4-methoxyphenyl)-N-methylquinazolin-4-amine (EP128265, MPI-0441138) as a potent inducer of apoptosis with high in vivo activity.
Enzyme-responsive polymeric micelles of cabazitaxel for prostate cancer targeted therapy.
Epothilones: tubulin polymerization as a novel target for prostate cancer therapy.
Estrogen effects on tubulin expression and taxane mediated cytotoxicity in prostate cancer cells.
Estrogen receptor ? and aromatase polymorphisms affect risk, prognosis, and therapeutic outcome in men with castration-resistant prostate cancer treated with docetaxel-based therapy.
Histone deacetylase 3 indirectly modulates tubulin acetylation.
Histone Deacetylase Inhibitor Potentiates Anticancer Effect of Docetaxel via Modulation of Bcl-2 Family Proteins and Tubulin in Hormone Refractory Prostate Cancer Cells.
KUD773, a phenylthiazole derivative, displays anticancer activity in human hormone-refractory prostate cancers through inhibition of tubulin polymerization and anti-Aurora A activity.
Lx2-32c, a novel semi-synthetic taxane, exerts antitumor activity against prostate cancer cells in vitro and in vivo.
Mana-Hox displays anticancer activity against prostate cancer cells through tubulin depolymerization and DNA damage stress.
Phosphorylated LIM kinases colocalize with gamma-tubulin in centrosomes during early stages of mitosis.
Posttranscriptional regulation of T-type Ca(2+) channel expression by interleukin-6 in prostate cancer cells.
Regulation of microtubule, apoptosis, and cell cycle-related genes by taxotere in prostate cancer cells analyzed by microarray.
Reversible inhibition of four important human liver cytochrome P450 enzymes by diethylstilbestrol.
Self-Catalyzed Assembly of Peptide Scaffolded Nanozyme as a Dynamic Biosensing System.
Semisynthetic aurones inhibit tubulin polymerization at the colchicine-binding site and repress PC-3 tumor xenografts in nude mice and myc-induced T-ALL in zebrafish.
Structural Optimization of Indole Derivatives Acting at Colchicine Binding Site as Potential Anticancer Agents.
Structure-Guided Design, Synthesis, and Biological Evaluation of (2-(1H-Indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl) Methanone (ABI-231) Analogues Targeting the Colchicine Binding Site in Tubulin.
Synthesis of 2-anilinopyridyl-triazole conjugates as antimitotic agents.
The novel toluidine sulphonamide EL102 shows pre-clinical in vitro and in vivo activity against prostate cancer and circumvents MDR1 resistance.
The product of the candidate prostate cancer susceptibility gene ELAC2 interacts with the gamma-tubulin complex.
The role of clusterin in prostate cancer: treatment resistance and potential as a therapeutic target.
Tubulin tyrosine ligase like 12, link to prostate cancer through tubulin post-translational modification and chromosome ploidy.
Tubulin-targeting chemotherapy impairs androgen receptor activity in prostate cancer.
Zerumbone, a ginger sesquiterpene, induces apoptosis and autophagy in human hormone-refractory prostate cancers through tubulin binding and crosstalk between endoplasmic reticulum stress and mitochondrial insult.
[Synergic effects of the combination of VEGF-targeted shRNA and taxol on human prostate cancer DU145 both in vitro and in vivo]
Prostatic Neoplasms, Castration-Resistant
Ascleposide, a natural cardenolide, induces anticancer signaling in human castration-resistant prostatic cancer through Na+ /K+ -ATPase internalization and tubulin acetylation.
Proteinuria
Modulation of cytoskeletal organization of podocytes during the course of aminonucleoside nephrosis in rats.
Psoriasis
Immunofluorescence of the tubulin system in human skin fibroblasts in Werner's syndrome, Kaposi sarcoma, and psoriasis.
Tirbanibulin: First Approval.
Pulmonary Arterial Hypertension
Targets of anti-endothelial cell antibodies in pulmonary hypertension and scleroderma.
Purpura, Thrombocytopenic, Idiopathic
The beta 1 tubulin R307H single nucleotide polymorphism is associated with treatment failures in immune thrombocytopenia (ITP).
Reflex, Abnormal
Serum IgM monoclonal autoantibody binding to the 301 to 314 amino acid epitope of beta-tubulin: clinical association with slowly progressive demyelinating polyneuropathy.
Reperfusion Injury
Expression of tubulin folding cofactor B in mouse hepatic ischemia-reperfusion injury.
Retinal Degeneration
Alterations in the balance of tubulin glycylation and glutamylation in photoreceptors leads to retinal degeneration.
Correction: Alterations in the balance of tubulin glycylation and glutamylation in photoreceptors leads to retinal degeneration.
Distribution of microtubules in cultured RPE cells from normal and dystrophic RCS rats.
Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C.
Retinitis Pigmentosa
ASQ2 encodes a TBCC-like protein required for mother-daughter centriole linkage and mitotic spindle orientation.
Crystal structure of the actin binding domain of the cyclase-associated protein.
Retinoblastoma
Growth hormone (GH) action in the developing lung: changes in lung proteins after adenoviral GH overexpression.
Studies of ocular retinoblastomas with immunoperoxidase techniques.
Retinopathy of Prematurity
Pharmacological Interventions for Vascular Targeting in Retinopathy of Prematurity: An Experimental Study.
Rhabdomyosarcoma
The novel tubulin polymerization inhibitor MHPT exhibits selective anti-tumor activity against rhabdomyosarcoma in vitro and in vivo.
Rhabdomyosarcoma, Alveolar
Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health.
Rotavirus Infections
Rotavirus infection of cells in culture induces activation of RhoA and changes in the actin and tubulin cytoskeleton.
Sequestration of free tubulin molecules by the viral protein NSP2 induces microtubule depolymerization during rotavirus infection.
Sarcoidosis
Proteomic Analysis of Kveim Reagent Identifies Targets of Cellular Immunity in Sarcoidosis.
Sarcoma
Determinants of anti-vascular action by combretastatin A-4 phosphate: role of nitric oxide.
Differential expression of tubulin isotypes during the cell cycle.
Protein kinase C delta-mediated cytoskeleton remodeling is involved in aloe-emodin-induced photokilling of human lung cancer cells.
Role of the MAPK/cJun NH2-terminal kinase signaling pathway in starvation-induced autophagy.
Systemic inflammation response index (SIRI) as a predictive factor for overall survival in advanced soft tissue sarcoma treated with eribulin.
Sarcoma 180
Antitumor agents. II: Regio- and stereospecific syntheses of 1-beta-alkyl-1-desoxypodophyllotoxin derivatives and biological activity.
Sarcoma, Avian
Organization of pp60src and selected cytoskeletal proteins within adhesion plaques and junctions of Rous sarcoma virus-transformed rat cells.
Radioimmunoassay for tubulin: a quantitative comparison of the tubulin content of different established tissue culture cells and tissues.
Temperature-sensitive changes in surface modulating assemblies of fibroblasts transformed by mutants of Rous sarcoma virus.
Sarcoma, Kaposi
Immunofluorescence of the tubulin system in human skin fibroblasts in Werner's syndrome, Kaposi sarcoma, and psoriasis.
Sarcoma, Synovial
The synovial sarcoma SYT-SSX2 oncogene remodels the cytoskeleton through activation of the ephrin pathway.
Schizencephaly
Mutations in ?- and ?-tubulin encoding genes: Implications in brain malformations.
Scleroderma, Systemic
Targets of anti-endothelial cell antibodies in pulmonary hypertension and scleroderma.
Seizures
Cell death, gliosis, and synaptic remodeling in the hippocampus of epileptic rats.
Correlation between reactive sprouting and microtubule protein expression in epileptic hippocampus.
De novo pathogenic variant in TUBB2A presenting with arthrogryposis multiplex congenita, brain abnormalities, and severe developmental delay.
Effect of qingyangshen on hippocampal alpha- and beta-tubulin gene expression during kainic acid induced epileptogenesis.
Molecular and cellular cascades in seizure-induced neosynapse formation.
Reversible posterior leukoencephalopathy syndrome induced by vinorelbine.
Tubulin ?-III modulates seizure activity in epilepsy.
Severe Dengue
Differential expression of aldolase, alpha tubulin and thioredoxin peroxidase in peripheral blood mononuclear cells from dengue fever and dengue hemorrhagic fever patients.
Sleep Apnea Syndromes
Neural autoantibodies in patients with neurological symptoms and histories of chemical/mold exposures.
Sleep Deprivation
Increased apoptosis in rat brain after rapid eye movement sleep loss.
Sleep deprivation-induced protein changes in basal forebrain: Implications for synaptic plasticity.
Small Cell Lung Carcinoma
Induction of tubulin by docetaxel is associated with p53 status in human non small cell lung cancer cell lines.
Spinal Cord Injuries
Histone deacetylase 6 inhibition restores autophagic flux to promote functional recovery after spinal cord injury.
Spinocerebellar Ataxias
Tau Tubulin Kinase TTBK2 Sensitivity of Glutamate Receptor GluK2.
Spondylitis, Ankylosing
Genome-wide DNA methylation analysis in ankylosing spondylitis identifies HLA-B*27 dependent and independent DNA methylation changes in whole blood.
Squamous Cell Carcinoma of Head and Neck
?- and ?-Santalols Directly Interact with Tubulin and Cause Mitotic Arrest and Cytotoxicity in Oral Cancer Cells.
Gamma tubulin: a promising indicator of recurrence in squamous cell carcinoma of the larynx.
GAPD and tubulin are suitable internal controls for qPCR analysis of oral squamous cell carcinoma cell lines.
The effects of PC-Spes on chemosensitive and chemoresistant head and neck cancer cells and primary mucosal keratinocytes.
Tubulin ?-6 chain is a stably expressed reference gene in archival samples of normal oral tissue and oral squamous cell carcinoma.
Starvation
An estimation of the soluble tubulin content in Tetrahymena cells of normal and of size-altered phenotype.
Evaluation and validation of experimental condition-specific reference genes for normalization of gene expression in Asia II-I Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae).
MIR145-3p promotes autophagy and enhances bortezomib sensitivity in multiple myeloma by targeting HDAC4.
Reference Gene Validation for Quantitative PCR Under Various Biotic and Abiotic Stress Conditions in Toxoptera citricida (Hemiptera, Aphidiae).
Selection of housekeeping genes and demonstration of RNAi in cotton leafhopper, Amrasca biguttula biguttula (Ishida).
Stomach Neoplasms
Antitumor evaluation of novel phenothiazine derivatives that inhibit migration and tubulin polymerization against gastric cancer MGC-803 cells.
Cytosolic Cl- Affects the Anticancer Activity of Paclitaxel in the Gastric Cancer Cell Line, MKN28 Cell.
Deacetylisovaltratum disrupts microtubule dynamics and causes G2/M-phase arrest in human gastric cancer cells in vitro.
EBV-miR-BART12 accelerates migration and invasion in EBV-associated cancer cells by targeting tubulin polymerization-promoting protein 1.
Effects of valproic acid on the cell cycle and apoptosis through acetylation of histone and tubulin in a scirrhous gastric cancer cell line.
Elevated TUBA1A Might Indicate the Clinical Outcomes of Patients with Gastric Cancer, Being Associated with the Infiltration of Macrophages in the Tumor Immune Microenvironment.
Hispidin induces autophagic and necrotic death in SGC-7901 gastric cancer cells through lysosomal membrane permeabilization by inhibiting tubulin polymerization.
Identification of tubulin beta chain, thymosin beta-4-like protein 3, and cytochrome b-c1 complex subunit 1 as serological diagnostic biomarkers of gastric cancer.
Synthesis and biological evaluation of 2-amino-1-thiazolyl imidazoles as orally active anticancer agents.
Stroke
Colchicine for prevention of vascular inflammation in Non-CardioEmbolic stroke (CONVINCE) - study protocol for a randomised controlled trial.
Direct identification of proteins from T47D cells and murine brain tissue by matrix-assisted laser desorption/ionization post-source decay/collision-induced dissociation.
Growth-associated gene expression after stroke: evidence for a growth-promoting region in peri-infarct cortex.
Low-level laser therapy applied transcranially to rats after induction of stroke significantly reduces long-term neurological deficits.
Supranuclear Palsy, Progressive
Antigenic characteristics of neurofibrillary tangles in progressive supranuclear palsy.
Neurofibrillary tangles in Alzheimer's disease and progressive supranuclear palsy: antigenic similarities and differences. Microtubule-associated protein tau antigenicity is prominent in all types of tangles.
Synovitis
Succinyl-CoA Ligase Deficiency in Pro-inflammatory and Tissue-Invasive T Cells.
Synucleinopathies
Challenging drug target for Parkinson's disease: Pathological complex of the chameleon TPPP/p25 and alpha-synuclein proteins.
Co-Transmission of Alpha-Synuclein and TPPP/p25 Inhibits Their Proteolytic Degradation in Human Cell Models.
Involvement of clusterin and the aggresome in abnormal protein deposits in myofibrillar myopathies and inclusion body myositis.
Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies.
Zinc-induced structural changes of the disordered tppp/p25 inhibits its degradation by the proteasome.
Tachycardia
Role of microtubules in the contractile dysfunction of myocytes from tachycardia-induced dilated cardiomyopathy.
Tauopathies
Activated cofilin exacerbates tau pathology by impairing tau-mediated microtubule dynamics.
Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress.
Imbalanced Expression of Tau and Tubulin Induces Neuronal Dysfunction in C. elegans Models of Tauopathy.
Impaired tau-microtubule interactions are prevalent among pathogenic tau variants arising from missense mutations.
Inhibition of microtubule assembly competent tubulin synthesis leads to accumulation of phosphorylated tau in neuronal cell bodies.
Neuroprotective Approach of Anti-Cancer Microtubule Stabilizers Against Tauopathy Associated Dementia: Current Status of Clinical and Preclinical Findings.
Teratocarcinoma
Actin and tubulin in teratocarcinoma cells. Amount and intracellular organization upon cytodifferentiation.
Control of isotubulin expression during neuronal differentiation of mouse neuroblastoma and teratocarcinoma cell lines.
Teratoma
GRO? regulates human embryonic stem cell self-renewal or adoption of a neuronal fate.
Transfection with pax6 Gene of Mouse Embryonic Stem Cells and Subsequent Cell Cloning Induced Retinal Neuron Progenitors, Including Retinal Ganglion Cell-Like Cells, in vitro.
Tetanus
Buoyant density gradient fractionation and flow cytometric analysis of embryonic rat cortical neurons and progenitor cells.
The cellular function of MASH1 in autonomic neurogenesis.
Thrombocytopenia
?-1 tubulin R307H SNP alters microtubule dynamics and affects severity of a hereditary thrombocytopenia.
Panobinostat (LBH589)-induced acetylation of tubulin impairs megakaryocyte maturation and platelet formation.
Preclinical profile of the HER2-targeting ADC SYD983/SYD985: introduction of a new duocarmycin-based linker-drug platform.
Thrombocytosis
Panobinostat (LBH589)-induced acetylation of tubulin impairs megakaryocyte maturation and platelet formation.
Preliminary investigation about the expression of tubulin in platelets from patients with iron deficiency anemia and thrombocytosis.
Thrombosis
Humanin analogue, HNG, inhibits platelet activation and thrombus formation by stabilizing platelet microtubules.
Thymoma
Cell quality control mechanisms maintain stemness and differentiation potential of P19 embryonic carcinoma cells.
PAQR3 suppresses the growth of non-small cell lung cancer cells via modulation of EGFR-mediated autophagy.
Role of the MAPK/cJun NH2-terminal kinase signaling pathway in starvation-induced autophagy.
Thyroid Carcinoma, Anaplastic
Valproic acid enhances tubulin acetylation and apoptotic activity of paclitaxel on anaplastic thyroid cancer cell lines.
Thyroid Neoplasms
Involvement of centrosomes in nuclear irregularity of thyroid carcinoma cells.
Thyroiditis
Natural antibody status in patients with Hashimoto's thyroiditis.
Tinea
A Molecular Epidemiological Survey of Clinically Important Dermatophytes in Iran Based on Specific RFLP Profiles of Beta-tubulin Gene.
Clinical evaluation of ?-tubulin real-time PCR for rapid diagnosis of dermatophytosis, a comparison with mycological methods.
Tourette Syndrome
Anti-streptococcal, tubulin, and dopamine receptor 2 antibodies in children with PANDAS and Tourette syndrome: Single-point and longitudinal assessments.
Tremor
Developmental consequences of mutations in the 84B alpha-tubulin gene of Drosophila melanogaster.
Trench Fever
Use of the cell division protein FtsZ as a means of differentiating among Bartonella species.
Triple Negative Breast Neoplasms
An Orally Available Tubulin Inhibitor, VERU-111, Suppresses Triple-Negative Breast Cancer Tumor Growth and Metastasis and Bypasses Taxane Resistance.
HDAC6 inhibition enhances the anti-tumor effect of eribulin through tubulin acetylation in triple-negative breast cancer cells.
Neoadjuvant Docetaxel/Cyclophosphamide in Triple-negative Breast Cancer: Predictive Value of Class III-? Tubulin and Non-basal Subtype.
New Colchicine-Derived Triazoles and Their Influence on Cytotoxicity and Microtubule Morphology.
Tektin4 loss promotes triple-negative breast cancer metastasis through HDAC6-mediated tubulin deacetylation and increases sensitivity to HDAC6 inhibitor.
Trypanosomiasis
Antibodies that recognize alpha- and beta-tubulin inhibit in vitro growth of the fish parasite Trypanosoma danilewskyi, Laveran and Mesnil, 1904.
Classical ligands bind tubulin of trypanosomes and inhibit their growth in vitro.
Orally Active and Selective Tubulin Inhibitors as Anti-Trypanosome Agents.
Trypanosomiasis, African
An alternative model for the role of RP2 protein in flagellum assembly in the African trypanosome.
Lead optimization of selective tubulin inhibitors as anti-trypanosomal agents.
Tuberculosis
2-Alkoxycarbonylaminopyridines: inhibitors of Mycobacterium tuberculosis FtsZ.
Computational studies of the properties and activities of selected trisubstituted benzimidazoles as potential antitubercular drugs inhibiting MTB-FtsZ polymerization.
Conformational Flexibility of A Highly Conserved Helix Controls Cryptic Pocket Formation in FtsZ.
Drug discovery targeting cell division proteins, microtubules and FtsZ.
Functional analysis of TPM domain containing Rv2345 of Mycobacterium tuberculosis identifies its phosphatase activity.
Identification of a novel steroid derivative, NSC12983, as a paclitaxel-like tubulin assembly promoter by 3-D virtual screening.
In vitro polymerization of Mycobacterium leprae FtsZ OR Mycobacterium tuberculosis FtsZ is revived or abolished, respectively, by reciprocal mutation of a single residue.
Molecular dynamics analysis of the effects of GTP, GDP, and benzimidazole derivative on structural dynamics of a cell division protein FtsZ from Mycobacterium tuberculosis.
MtFtsX a predicted membrane domain of ABC transporter complex MtFtsEX of Mycobacterium tuberculosis interacts with the cell division protein MtFtsZ.
Mycobacterium tuberculosis cell division protein, FtsE, is an ATPase in dimeric form.
Screening and Development of New Inhibitors of FtsZ from M. Tuberculosis.
Slow polymerization of Mycobacterium tuberculosis FtsZ.
Structure of Mycobacterium tuberculosis FtsZ reveals unexpected, G protein-like conformational switches.
Suprastructures and dynamic properties of Mycobacterium tuberculosis FtsZ.
Tuberous Sclerosis
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
tubulin gtpase deficiency
Gene knockout analysis of two gamma-tubulin isoforms in mice.
Scanning electron microscopy and human sperm pathology.
Uremia
High ammonia levels in brain induce tubulin in cerebrum but not in cerebellum.
[The physiopathologic bases of the neurotoxicity of phosphorus chelating agents containing soluble aluminum salts in patients with renal insufficiency]
Urinary Bladder Neoplasms
Anticancer sulfonamide hybrids that inhibit bladder cancer cells growth and migration as tubulin polymerisation inhibitors.
Uterine Cervical Neoplasms
A semisynthetic taxane Yg-3-46a effectively evades P-glycoprotein and ?-III tubulin mediated tumor drug resistance in vitro.
Benomyl and colchicine synergistically inhibit cell proliferation and mitosis: evidence of distinct binding sites for these agents in tubulin.
Design, synthesis and biological evaluation of a novel library of antimitotic C2-aroyl/arylimino tryptamine derivatives that are also potent inhibitors of indoleamine-2, 3-dioxygenase (IDO).
Expression of class III beta tubulin in cervical cancer patients administered preoperative radiochemotherapy: correlation with response to treatment and clinical outcome.
Innervation of cervical carcinoma is mediated by cancer-derived exosomes.
NMK-BH2, a novel microtubule-depolymerising bis (indolyl)-hydrazide-hydrazone, induces apoptotic and autophagic cell death in cervical cancer cells by binding to tubulin at colchicine - site.
Overexpressed HDAC8 in cervical cancer cells shows functional redundancy of tubulin deacetylation with HDAC6.
Synthesis and anticancer activity studies of alpha-aminoalkylated conjugated nitroalkenes.
Synthesis, Evaluation of Cytotoxicity and Molecular Docking Studies of the 7-Acetamido Substituted 2-Aryl-5-bromo-3-trifluoroacetylindoles as Potential Inhibitors of Tubulin Polymerization.
Targeting of tubulin polymerization and induction of mitotic blockage by Methyl 2-(5-fluoro-2-hydroxyphenyl)-1H-benzo[d]imidazole-5-carboxylate (MBIC) in human cervical cancer HeLa cell.
Uterine Neoplasms
An Investigation to Study the Role of Novel Rhenium Compounds on Endometrial Uterine Cancer Cell Lines.
Paclitaxel inhibits expression of heat shock protein 27 in ovarian and uterine cancer cells.
SQ1274, a novel microtubule inhibitor, inhibits ovarian and uterine cancer cell growth.
Vaccinia
Vaccinia virus infection induces a stress response that leads to association of Hsp70 with viral proteins.
Vascular System Injuries
Investigation into the role of Stmn2 in vascular smooth muscle phenotype transformation during vascular injury via RNA sequencing and experimental validation.
Lesion complexity determines arterial drug distribution after local drug delivery.
Vesicular Stomatitis
An alternative fixation-processing method for preembedding ultrastructural immunocytochemistry of cytoplasmic antigens: the GBS (glutaraldehyde-borohydride-saponin) procedure.
Interaction between tubulin and the viral matrix protein of vesicular stomatitis virus: possible implications in the viral cytopathic effect.
NH2-terminal acidic region of the phosphoprotein of vesicular stomatitis virus can be functionally replaced by tubulin.
Stimulation of vesicular stomatitis virus in vitro RNA synthesis by microtubule-associated proteins.
Tubulin: a factor necessary for the synthesis of both Sendai virus and vesicular stomatitis virus RNAs.
Virus Diseases
Chronic Lung Allograft Dysfunction: Immune Responses Induced by Circulating Exosomes with Lung-Associated Self-Antigens.
Comparative proteomic analyses of two reovirus T3D subtypes and comparison to T1L identifies multiple novel proteins in key cellular pathogenic pathways.
Modulation of cellular macromolecular synthesis by coronavirus: implication for pathogenesis.
Reovirus-associated reduction of microRNA-let-7d is related to the increased apoptotic death of cancer cells in clinical samples.
Waldenstrom Macroglobulinemia
A new tubulin polymerization inhibitor, auristatin PE, induces tumor regression in a human Waldenstrom's macroglobulinemia xenograft model.
Natural antibodies against tubulin, actin myoglobin, thyroglobulin, fetuin, albumin and transferrin are present in normal human sera, and monoclonal immunoglobulins from multiple myeloma and Waldenström's macroglobulinemia may express similar antibody specificities.
Werner Syndrome
Immunofluorescence of the tubulin system in human skin fibroblasts in Werner's syndrome, Kaposi sarcoma, and psoriasis.
Whooping Cough
Adenine nucleotides directly stimulate pertussis toxin.
ADPRibosylation of chicken red cell tubulin and inhibition of microtubule self-assembly in vitro by the NAD(+)-dependent avian ADPRibosyl transferase.
Changes of GTP binding proteins, not neurofilament-associated proteins, in the brain of the neurofilament-deficient quail, "Quiver".
Insulin inhibits pertussis toxin-catalyzed ADP-ribosylation of G-proteins. Evidence for a novel interaction between insulin receptors and G-proteins.
Microtubule protein ADP-ribosylation in vitro leads to assembly inhibition and rapid depolymerization.
Studies of signal transduction in the respiratory burst-associated stimulation of fMet-Leu-Phe-induced tubulin tyrosinolation and phorbol 12-myristate 13-acetate-induced posttranslational incorporation of tyrosine into multiple proteins in activated neutrophils and HL-60 cells.
Wilms Tumor
Immunohistochemical distribution of tubulin beta II in human normal and neoplastic tissues.
The Expression and Potential Role of Tubulin Alpha 1b in Wilms' Tumor.
Wiskott-Aldrich Syndrome
Cdc42-interacting protein-4 functionally links actin and microtubule networks at the cytolytic NK cell immunological synapse.
Role of Rho-GTPases in megakaryopoiesis.
Yellow Fever
Testis-specific expression of the beta2 tubulin promoter of Aedes aegypti and its application as a genetic sex-separation marker.