3.6.5.4: signal-recognition-particle GTPase

This is an abbreviated version!
For detailed information about signal-recognition-particle GTPase, go to the full flat file.

Reaction

Synonyms

54-kDa GTPase, chloroplast signal recognition particle, chloroplast signal recognition particle protein, chloroplast signal recognition particle receptor, chloroplast SRP, cpFtsY, cpSRP, cpSRP43, cpSRP54, CtSR, EC 3.6.1.49, Ffh, FlhF, FtsH, FtsY, FtsY GTPase, GTPase, guanine triphosphatase, guanosine 5'-triphosphatase, guanosine triphosphatase, PAB0955, ribosomal GTPase, signal recognition particle, signal recognition particle 54 kDa protein, signal recognition particle receptor, signal recognition particle receptor beta subunit, signal recognition particle receptor subunit alpha, signal recognition particle receptor subunit beta, signal recognition particle-like GTPase, signal-recognition-particle GTPase, SR, SR GTPase, SRalpha, SRbeta, SRbeta GTPase, SRP, SRP GTPase, SRP GTPase Ffh, SRP receptor, SRP receptor GTPase, SRP14, SRP19, SRP21, SRP54, SRP54 GTPase, Srp72p, SRP:SR GTPase, SRP:SR guanine triphosphatase, SRPRA, SRPRB

ECTree

     3 Hydrolases

         3.6 Acting on acid anhydrides

             3.6.5 Acting on GTP to facilitate cellular and subcellular movement

                3.6.5.4 signal-recognition-particle GTPase

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Results	in table
11	Activating Compound
71	AA Sequence
19	Application
1	CAS Registry Number
45	Cloned(Commentary)
24	Crystallization (Commentary)
252	Disease/ Diagnostics
46	General Information
6	Inhibitors
2	Ki Value [mM]
19	KM Value [mM]
76	Localization
20	Metals/Ions
22	Molecular Weight [Da]
76	Natural Substrates/ Products (Substrates)
260	Organism
7	PDB ID
8	pH Optimum
2	pI Value
5	Posttranslational Modification
127	Protein Variants
42	Purification (Commentary)
3	Reaction
15	Reaction Type
116	Reference
1	Renatured (Commentary)
10	Source Tissue
1	Specific Activity [micromol/min/mg]
114	Substrates and Products (Substrate)
37	Subunits
178	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
8	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 3.6.5.4 - signal-recognition-particle GTPase

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

4.5S RNA

2 entries

-

cpFtsY

Arabidopsis thaliana

P37107

chlorplastic cell division protein FtsY homologue, a signal recognition particle receptor protein, also shows GTPase activity

757189

-

FtsY

3 entries

-

GTP

2 entries

signal recognition particle receptor

Thermus aquaticus

-

SRP and its receptor stimulate each other’s GTPase activity, mechanism of reciprocal activation, substrate twinning activates the signal recognition particle and its receptor

660000

-

signal recognition particle RNA

Escherichia coli

-

SRP RNA, the signal recognition particle RNA distal end triggers GTP hydrolysis in the signal recognition particle protein-SRP receptor GTPase, i.e. Ffh-FtsY GTPase, complex. An intact docking site at the distal end of SRP RNA is required to stimulate GTPase activation. Loop E plays a crucial role in GTPase activation by the SRP RNA

734245

-

additional information

2 entries

-

4.5S RNA

Escherichia coli

-

accelerates the association between Ffh and FtsY 400fold in their GTP-bound form and thereby stimulates GTPase activity

657913

-

4.5S RNA

Escherichia coli

-

stimulates GTPase activity in the SRP-FtsY complex in vitro and is essential for SRP function in vivo

690025

-

FtsY

Escherichia coli

-

GTPase subunit of the bacterial SRP receptor activates Ffh, reciprocal GTPase activation mechanism

660353

-

FtsY

Escherichia coli

-

GTPase subunit of the bacterial SRP receptor, both Ffh and FtsY act as GTPase activating proteins for one another, resulting in a mutual stimulation of GTP hydrolysis by both proteins

657913

-

FtsY

Escherichia coli

-

GTPase subunit of the SRP receptor activates Ffh, Ffh and FtsY reciprocally regulate each other’s GTPase activity

658538

-

GTP

Escherichia coli

-

GTP binding to both the SRP and SR is a prerequisite for the formation of the SRP-SR complex in which GTP hydrolysis is activated in a composite active site

686249

GTP

Thermus aquaticus

-

GTP binding to both the SRP and SR is a prerequisite for the formation of the SRP-SR complex in which GTP hydrolysis is activated in a composite active site

686249

additional information

Escherichia coli

P0AGD7; P10121

the FtsY GTPase is activated by formation of the targeting complex as well as upon membrane interaction, but homodimerization of FtsY also stimulates its GTPase activity

758489

-

additional information

Escherichia coli

-

the FtsY GTPase is activated by formation of the targeting complex as well as upon membrane interaction, but homodimerization of FtsY also stimulates its GTPase activity

758489

-