3.6.5.1: heterotrimeric G-protein GTPase

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For detailed information about heterotrimeric G-protein GTPase, go to the full flat file.

Reaction

Synonyms

cone transducin, EC 3.6.1.46, EF-2, EF-G, elongation factor 2, G alpha i2, G alpha q, G alpha11, G alphaQ, G betagamma, G12, G13, Galpha protein, Galpha-subunit, Galpha16, Galphai1, Galphai3, Galphao, Galphaq, GI, GmGalpha protein, GPA1, Gq, Gs alpha, GTP phosphohydrolase, GTPase, guanosine 5'-triphosphatase, guanosine triphosphatase, heterotrimeric G protein, heterotrimeric G protein alpha subunit, heterotrimeric G protein family, heterotrimeric G protein Gsalpha, heterotrimeric G-protein, heterotrimeric G-protein GTPase, heterotrimeric GTPase, phosphatase, guanosine tri-, photoreceptor-specific G protein, Rab1, Rab1 GTPase, Rab1a, ribosomal GTPase, SsEF-2, transducin, transducin GTPase

ECTree

     3 Hydrolases

         3.6 Acting on acid anhydrides

             3.6.5 Acting on GTP to facilitate cellular and subcellular movement

                3.6.5.1 heterotrimeric G-protein GTPase

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98	Activating Compound
110	AA Sequence
3	Application
1	CAS Registry Number
16	Cloned(Commentary)
4	Crystallization (Commentary)
7114	Disease/ Diagnostics
40	General Information
19	Inhibitors
3	Ki Value [mM]
17	KM Value [mM]
27	Localization
9	Metals/Ions
18	Molecular Weight [Da]
44	Natural Substrates/ Products (Substrates)
114	Organism
22	PDB ID
12	pH Optimum
10	Posttranslational Modification
52	Protein Variants
8	Purification (Commentary)
4	Reaction
24	Reaction Type
89	Reference
97	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
77	Substrates and Products (Substrate)
39	Subunits
112	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
1	Temperature Range [°C]
24	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 3.6.5.1 - heterotrimeric G-protein GTPase

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SYSTEMATIC NAME

IUBMB Comments

GTP phosphohydrolase (signalling)

This group comprises GTP-hydrolysing systems, where GTP and GDP alternate in binding. This group includes stimulatory and inhibitory G-proteins such as Gs, Gi, Go and Golf, targetting adenylate cyclase and/or K+ and Ca2+ channels; Gq stimulating phospholipase C; transducin activating cGMP phosphodiesterase; gustducin activating cAMP phosphodiesterase. Golf is instrumental in odour perception, transducin in vision and gustducin in taste recognition. At least 16 different alpha subunits (39-52 kDa), 5 beta subunits (36 kDa) and 12 gamma subunits (6-9 kDa) are known.