3.6.5.1: heterotrimeric G-protein GTPase
This is an abbreviated version!
For detailed information about heterotrimeric G-protein GTPase, go to the full flat file.
Word Map on EC 3.6.5.1
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3.6.5.1
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guanine
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g-proteins
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toxin
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actin
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gdp
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cyclase
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gtp-binding
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rhoa
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cytoskeleton
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retinal
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pertussis
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cdc42
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agonist
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rac1
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rhodopsin
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adp-ribosylation
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photoreceptors
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protein-coupled
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alpha-subunits
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galphas
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phospholipase
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adenylyl
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camp
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endocytosis
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microtubule
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nucleotide-binding
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endosomes
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dynamin
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gdp-bound
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adenylate
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rgs
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fission
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cholera
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endocytic
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gpcrs
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ras-related
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dominant-negative
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cytokine
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phototransduction
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pigmentosa
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diphtheria
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ribosylation
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muscarinic
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toxin-sensitive
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opsin
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gtp-dependent
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gppnhp
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pleckstrin
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dynamin-related
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p21-activated
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medicine
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drug development
- 3.6.5.1
- guanine
- g-proteins
- toxin
- actin
- gdp
- cyclase
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gtp-binding
- rhoa
- cytoskeleton
- retinal
- pertussis
- cdc42
- agonist
- rac1
- rhodopsin
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adp-ribosylation
- photoreceptors
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protein-coupled
- alpha-subunits
- galphas
- phospholipase
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adenylyl
- camp
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endocytosis
- microtubule
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nucleotide-binding
- endosomes
- dynamin
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gdp-bound
- adenylate
- rgs
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fission
- cholera
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endocytic
-
gpcrs
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ras-related
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dominant-negative
- cytokine
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phototransduction
- pigmentosa
- diphtheria
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ribosylation
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muscarinic
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toxin-sensitive
- opsin
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gtp-dependent
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gppnhp
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pleckstrin
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dynamin-related
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p21-activated
- medicine
- drug development
Reaction
Synonyms
cone transducin, EC 3.6.1.46, EF-2, EF-G, elongation factor 2, G alpha i2, G alpha q, G alpha11, G alphaQ, G betagamma, G12, G13, Galpha protein, Galpha-subunit, Galpha16, Galphai1, Galphai3, Galphao, Galphaq, GI, GmGalpha protein, GPA1, Gq, Gs alpha, GTP phosphohydrolase, GTPase, guanosine 5'-triphosphatase, guanosine triphosphatase, heterotrimeric G protein, heterotrimeric G protein alpha subunit, heterotrimeric G protein family, heterotrimeric G protein Gsalpha, heterotrimeric G-protein, heterotrimeric G-protein GTPase, heterotrimeric GTPase, phosphatase, guanosine tri-, photoreceptor-specific G protein, Rab1, Rab1 GTPase, Rab1a, ribosomal GTPase, SsEF-2, transducin, transducin GTPase
ECTree
3.6.5.1 heterotrimeric G-protein GTPaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.6.5.1 - heterotrimeric G-protein GTPase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
GTP + H2O
GDP + phosphate
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Gq/11 is the physiological regulator of phospholipase C-beta1
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?
GTP + H2O
GDP + phosphate
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intrinsic GTPase activity of transducin controls inactivation of the effector enzyme, cGMP phosphodiesterase during turnoff of the visual signal
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?
GTP + H2O
GDP + phosphate
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cycle of G protein activation and deactivation that transmits a signal from receptor to effector: when GDP is bound the alpha subunit associated with the betagamma subunit to form an inactive heterotrimer that binds to the receptor. Both alpha and betagamma subunits can bind to the receptor. When a chemical or physical signal stimulates the receptor, the receptor becomes activated and changes its conformation. The GDP-ligated alpha-subunit responds with a conformational change that decreases GDP affinity, so that GDP is released. Leaving GDP is replaced by GTP. Once ATP is bound, the alpha subunit assumes its activated conformation and dissociates both from the receptor and from betagamma. The activated state lasts until the GTP is hydrolyzed to GDP by the intrinsic GTPase activity of the alpha-subunit. Once GTP is cleaved to GDP, the alpha and betagamma subunits reassociate, become inactive, and return to the receptor. The free alpha and betagamma subunits each activate target effectors. Galphas and Galphaolf, stimulate adenylyl cyclase and regulate Ca2+ channels. Galphai-1, Galphai-2, Galphai-3, Galphao, Galphat-1, Galphat-2, Galphagust and Galphaz inhibit adenylyl cyclase, regulate K+ and Ca2+ channels, and activate cGMP phosphodiesterase. Galphaq, Galpha11, Galpha14, Galppha15 and Galpha16 activate phospholipase C. Galpha12 and Galpha13 regulate Na/K+ exchange. The betagamma subunit is a positive regulator of K+ channels, adenylyl cyclase, phospholipase Cbeta, phospholipase A2, phosphoinositide 3-kinase and beta-adrenergic receptor kinase
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?
GTP + H2O
GDP + phosphate
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Galpha subunits can regulate intracellular effectors, such as adenylyl cyclase, phospholipase Cbeta, K+ and Ca+ channels, and cyclic GMP phosphodiesterase
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?
GTP + H2O
GDP + phosphate
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Gi1alpha, Gi2alpha and Gi3alpha are capable of preventing stimulation of adenylate cyclase by the alpha2A-adrenoceptor
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?
GTP + H2O
GDP + phosphate
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Gi: the G protein that mediates inhibition of adenylate cyclase
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?
GTP + H2O
GDP + phosphate
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GTPase that functions as a component of the rhodopsin-linked, light-activated phosphodiesterase system
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?
additional information
?
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calcium-independent PKCtheta/delta is a potential downstream target of Galpha12
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?
additional information
?
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protein-protein interaction analysis between soybean G-protein subunits, overview. GmGalpha and GmGbeta interact in most of the possible combinations
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?
additional information
?
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Galpha12 and Galpha13 couple with G-protein coupled receptors, GPCRs, for various ligands, e.g. angiotensin II, endothelin, thrombin, bombesin, thromboxane A2, sphingosine-1-phosphate, and lysophosphatidic acid. The coupling specificity between G12 and G13 is usually not strict and most of these ligands can activate both G12 and G13. The RH domain of PDZ-RhoGEF interacts with Galpha13 through multiple intermolecular interfaces. One point of contact is centred on an Ile-Ile-Gly motif found N-terminal to the RGS box. This motif forms multiple contacts with the alpha helical domain of Galpha13, and is conserved in other RH-RhoGEFs. Additionally, Galpha13 interacts with an acidic stretch of residues N-terminal to the core RGS box of PDZ-RhoGEF, overview
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?
