3.6.5.1: heterotrimeric G-protein GTPase

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For detailed information about heterotrimeric G-protein GTPase, go to the full flat file.

Reaction

Synonyms

cone transducin, EC 3.6.1.46, EF-2, EF-G, elongation factor 2, G alpha i2, G alpha q, G alpha11, G alphaQ, G betagamma, G12, G13, Galpha protein, Galpha-subunit, Galpha16, Galphai1, Galphai3, Galphao, Galphaq, GI, GmGalpha protein, GPA1, Gq, Gs alpha, GTP phosphohydrolase, GTPase, guanosine 5'-triphosphatase, guanosine triphosphatase, heterotrimeric G protein, heterotrimeric G protein alpha subunit, heterotrimeric G protein family, heterotrimeric G protein Gsalpha, heterotrimeric G-protein, heterotrimeric G-protein GTPase, heterotrimeric GTPase, phosphatase, guanosine tri-, photoreceptor-specific G protein, Rab1, Rab1 GTPase, Rab1a, ribosomal GTPase, SsEF-2, transducin, transducin GTPase

ECTree

     3 Hydrolases

         3.6 Acting on acid anhydrides

             3.6.5 Acting on GTP to facilitate cellular and subcellular movement

                3.6.5.1 heterotrimeric G-protein GTPase

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Results	in table
98	Activating Compound
110	AA Sequence
3	Application
1	CAS Registry Number
16	Cloned(Commentary)
4	Crystallization (Commentary)
7114	Disease/ Diagnostics
40	General Information
19	Inhibitors
3	Ki Value [mM]
17	KM Value [mM]
27	Localization
9	Metals/Ions
18	Molecular Weight [Da]
44	Natural Substrates/ Products (Substrates)
114	Organism
22	PDB ID
12	pH Optimum
10	Posttranslational Modification
52	Protein Variants
8	Purification (Commentary)
4	Reaction
24	Reaction Type
89	Reference
97	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
77	Substrates and Products (Substrate)
39	Subunits
112	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
1	Temperature Range [°C]
24	Turnover Number [1/s]

Crystallization

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Crystallization on EC 3.6.5.1 - heterotrimeric G-protein GTPase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

-

Bos taurus

P04896

685385

Galphao-subunit of heterotrimeric G protein in complex with the RGS domain of CG5036, method screening, hanging-drop vapour-diffusion method, mixing of 0.0015 ml of 25 mg/ml protein solution containing 20 mM Tris-HCl pH 7.5, 2 mM MgCl2, 150 mM NaCl, 2 mM DTT, with 0.0015 ml of reservoir solution containing 20% PEG 4000, 100 mM HEPES sodium salt, pH 7.5, and equilibration against 0.3 ml of reservoir solution, 8-10 days, 22°C, X-ray diffraction structure determination and analysis at 2.0 A resolution, model fitting and refinement

Drosophila melanogaster

-

733026

crystal structure of mutant K180P-Galphai1 bound to a GTP analog

Mammalia

-

676767

RGS4 complexed with Gialpha1-Mg2+-GDP-AlF4

Rattus norvegicus

-

644109