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3.6.4.B10: chaperonin ATPase (protein-folding, protecting from aggregation, protein stabilizing)

This is an abbreviated version!
For detailed information about chaperonin ATPase (protein-folding, protecting from aggregation, protein stabilizing), go to the full flat file.

Word Map on EC 3.6.4.B10

Reaction

ATP
+
H2O
=
ADP
 +
phosphate

Synonyms

alpha/beta-thermosome, ApCpnB, archaeal chaperonin, CCT, CCT ATPase, CCT chaperonin, CCT complex, CCT/TRiC, CCT/TRiC chaperonin, CCT/TRiC complex, CCT2, chaperonin B, chaperonin containing t-complex polypeptide-1, chaperonin containing TCP-1, chaperonin containing TCP1, chaperonin TCP-1 ring complex, chaperonin TRiC, chaperonin TRiC/CCT, chaperonin-containing t-complex polypeptide 1, cPKA, CpkB, CtCCT, cytosolic chaperonin TRiC, eukaryotic chaperone complex, eukaryotic chaperonin, eukaryotic chaperonin TRiC, eukaryotic group II chaperonin, GaTRiC, group II chaperonin, group II chaperonin CCT/TRiC, group II CPN, HsTRiC, Mm-cpn, MmCpn, More, PfCPN, PfTRiC, PhCPN, Plasmodium TRiC, protein P45, T-complex polypeptide-1 ring complex, T-complex protein 1, T-complex protein 1 ring complex, T-complex protein-1 ring complex, TCP-1, TCP-1 ring complex, TCP1, TCP1 ring complex, thermosome, TKS1-CPN, TriC, TRiC chaperonin, TRiC chaperonin complex, TRiC/CCT, type II chaperonin

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.4 Acting on acid anhydrides to facilitate cellular and subcellular movement
                3.6.4.B10 chaperonin ATPase (protein-folding, protecting from aggregation, protein stabilizing)

Expression

Expression on EC 3.6.4.B10 - chaperonin ATPase (protein-folding, protecting from aggregation, protein stabilizing)

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
cardiac-specific upregulation of CCT components under time restricted feeding (TRF)
P12613; Q9W392; P48605; Q9VK69; Q7KKI0; Q9VXQ5; Q9VHL2; Q7K3J0
expression of CCT is not induced by stress conditions
Thermochaetoides thermophila
-
induced when halophilic cells are exposed to a low salt stress
-
possesses two chaperonins, cold-inducible CpkA and heat-inducible CpkB, which are involved in adaptation to low and high temperatures, respectively
role of AKT in regulating TCP1 downstream of FGFR2, Akt inhibition results in downregulation of TCP1 protein as well as reduced levels of Akt and RPS6 phosphorylation
P17987; P78371; P49368; P50991; P48643; P40227; Q99832; P50990
subunit CCT1 is transcriptionally modulated by the driver oncogene, phosphatidylinositide 3-kinases (PI3K)
Q32L40; Q3ZBH0; Q3T0K2; F1N0E5; F1MWD3; Q3MHL7; Q2NKZ1; Q3ZCI9
the TCP1 subunit of TRiC is regulated by fibroblast growth factor receptor 2 (FGFR2), the induction of TCP1 by FGFR2 is inhibited by PD173074, i.e. N-[2-[[4-(diethylamino)butyl]amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea], an ATP-competitive inhibitor. FGFR2 signals through PI3K and Akt to regulate TCP1 expression
P17987; P78371; P49368; P50991; P48643; P40227; Q99832; P50990