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3.6.4.7: peroxisome-assembly ATPase

This is an abbreviated version!
For detailed information about peroxisome-assembly ATPase, go to the full flat file.

Word Map on EC 3.6.4.7

Reaction

ATP
+
H2O
=
ADP
 +
phosphate

Synonyms

AAA protein, AAA+-ATPase, AAA+-type II ATPase, AAA-ATPase, AAA-complex, AFG1, APEM10, AtLon2, ATP-dependent lon protease, ATPase associated with diverse cellular activities, ATPase associated with various cellular activities, Cdc48, Cdc48p, HpPln, lon, lon protease, LON protease 2, lon2, LONP2, Mm-p, Nc-p, NSF, NSF-like ATPase, p97/VCP, PAF-2, PAS1, PAS1p, PAS8, peroxin, peroxin ATPase complex, peroxisomal AAA ATPase complex, peroxisomal AAA complex, peroxisomal Lon protease, peroxisomal Lon-protease, peroxisomal Pex1/Pex6 ATPase complex, peroxisomal protease LON2, peroxisomal receptor export complex, peroxisome assembly factor-2, peroxisome-assembly ATPase, peroxisome-associated ATPase, Pex1, PEX1/6, Pex1/6 AAA+ complex, Pex1/6 type II AAA+ complex, Pex1/6p-complex, Pex1/Pex6, Pex1/Pex6 complex, Pex1p, Pex1p-Pex6p complex, Pex1p-Pex6p-complex, Pex1p/Pex6p, PEX6, Pex6 AAA ATPase, Pex6p, Pln, REM, SEC18p, TBP1, valosin-containing protein, VCP, Yl-p, Zm-p

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.4 Acting on acid anhydrides to facilitate cellular and subcellular movement
                3.6.4.7 peroxisome-assembly ATPase

Reference

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Reference on EC 3.6.4.7 - peroxisome-assembly ATPase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lee, Y.J.; Wickner, R.B.
AFG1, a new member of the SEC18-NSF, PAS1, CDC48-VCP, TBP family of ATPases
Yeast
8
787-790
1992
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Tsukamoto, T.; Miura, S.; Nakai, T.; Yokota, S.; Shimozawa, N.; Suzuki, Y.; Orii, T.; Fujiki, Y.; Sakai, F.; Bogaki, A.
Peroxisome assembly factor-2, a putative ATPase cloned by functional complementation on a peroxisome-deficient mammalian cell mutant
Nature Genet.
11
395-401
1995
Saccharomyces cerevisiae, Cricetulus griseus, Homo sapiens, Komagataella pastoris, Rattus norvegicus
Manually annotated by BRENDA team
Fukuda, S.; Shimozawa, N.; Suzuki, Y.; Zhang, Z.; Tomatsu, S.; Tsukamoto, T.; Hashiguchi, N.; Osumi, T.; Masuno, M.; Imaizumi, K.; Kuroki, Y.; Fujiki, Y.; Orii, T.; Kondo, N.
Human peroxisome assembly factor-2 (PAF-2): a gene responsible for group C peroxisome biogenesis disorder in humans
Am. J. Hum. Genet.
59
1210-1220
1996
Cricetulus griseus, Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Zhang, Z.; Suzuki, Y.; Shimozawa, N.; Fukuda, S.; Imamura, A.; Tsukamoto, T.; Osumi, T.; Fujiki, Y.; Orii, T.; Wanders, R.J.; Barth, P.G.; Moser, H.W.; Paton, B.C.; Besley, G.T.; Kondo, N.
Genomic structure and identification of 11 novel mutations of the PEX6 (peroxisome assembly factor-2) gene in patients with peroxisome biogenesis disorders
Hum. Mutat.
13
487-496
1999
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Kiel, J.A.; Hilbrands, R.E.; van der Klei, I.J.; Rasmussen, S.W.; Salomons, F.A.; van der Heide, M.; Faber, K.N.; Cregg, J.M.; Veenhuis, M.
Hansenula polymorpha Pex1p and Pex6p are peroxisome-associated AAA proteins that functionally and physically interact
Yeast
15
1059-1078
1999
Saccharomyces cerevisiae, Yarrowia lipolytica, Ogataea angusta, Homo sapiens, Komagataella pastoris, Rattus norvegicus
Manually annotated by BRENDA team
Titorenko, V.I.; Chan, H.; Rachubinski, R.A.
Fusion of small peroxisomal vesicles in vitro reconstructs an early step in the in vivo multistep peroxisome assembly pathway of Yarrowia lipolytica
J. Cell Biol.
148
29-44
2000
Saccharomyces cerevisiae, Yarrowia lipolytica, Homo sapiens, Komagataella pastoris
Manually annotated by BRENDA team
Titorenko, V.I.; Rachubinski, R.A.
Peroxisomal membrane fusion requires two AAA family ATPases, Pex1p and Pex6p
J. Cell Biol.
150
881-886
2000
Yarrowia lipolytica, Yarrowia lipolytica E122
Manually annotated by BRENDA team
Tamura, S.; Matsumoto, N.; Imamura, A.; Shimozawa, N.; Suzuki, Y.; Kondo, N.; Fujiki, Y.
Phenotype-genotype relationships in peroxisome biogenesis disorders of PEX1-defective complementation group 1 are defined by Pex1p-Pex6p interaction
Biochem. J.
357
417-426
2001
Homo sapiens
Manually annotated by BRENDA team
Shiozawa, K.; Maita, N.; Tomii, K.; Seto, A.; Goda, N.; Akiyama, Y.; Shimizu, T.; Shirakawa, M.; Hiroaki, H.
Structure of the N-terminal Domain of PEX1 AAA-ATPase: Characterization of a putative adaptor-binding domain
J. Biol. Chem.
279
50060-50068
2004
Mus musculus
Manually annotated by BRENDA team
Shiozawa Kumik, S.K.; Goda Natsuk, G.N.; Shimizu Toshiyuk, S.T.; Mizuguchi Kenj, M.K.; Kondo Naom, K.N.; Shimozawa Nobuyuk, S.N.; Shirakawa Masahir, S.M.; Hiroaki Hidekaz, H.H.
The common phospholipid-binding activity of the N-terminal domains of PEX1 and VCP/p97
FEBS J.
273
4959-4971
2006
Mus musculus
Manually annotated by BRENDA team
Ostersetzer, O.; Kato, Y.; Adam, Z.; Sakamoto, W.
Multiple intracellular locations of Lon protease in Arabidopsis: evidence for the localization of AtLon4 to chloroplasts
Plant Cell Physiol.
48
881-885
2007
Arabidopsis thaliana (O64948)
Manually annotated by BRENDA team
Fujiki, Y.; Miyata, N.; Matsumoto, N.; Tamura, S.
Dynamic and functional assembly of the AAA peroxins, Pex1p and Pex6p, and their membrane receptor Pex26p involved in shuttling of the PTS1 receptor Pex5p in peroxisome biogenesis
Biochem. Soc. Trans.
36
109-113
2008
Homo sapiens
Manually annotated by BRENDA team
Platta, H.W.; Debelyy, M.O.; El Magraoui, F.; Erdmann, R.
The AAA peroxins Pex1p and Pex6p function as dislocases for the ubiquitinated peroxisomal import receptor Pex5p
Biochem. Soc. Trans.
36
99-104
2008
Saccharomyces cerevisiae, Homo sapiens
Manually annotated by BRENDA team
Lingard, M.J.; Monroe-Augustus, M.; Bartel, B.
Peroxisome-associated matrix protein degradation in Arabidopsis
Proc. Natl. Acad. Sci. USA
106
4561-4566
2009
Arabidopsis thaliana
Manually annotated by BRENDA team
Nashiro, C.; Kashiwagi, A.; Matsuzaki, T.; Tamura, S.; Fujiki, Y.
Recruiting mechanism of the AAA peroxins, Pex1p and Pex6p, to Pex26p on the peroxisomal membrane
Traffic
12
774-788
2011
Homo sapiens
Manually annotated by BRENDA team
Miyata, N.; Okumoto, K.; Mukai, S.; Noguchi, M.; Fujiki, Y.
AWP1/ZFAND6 functions in Pex5 export by interacting with cys-monoubiquitinated Pex5 and Pex6 AAA ATPase
Traffic
13
168-183
2012
Homo sapiens
Manually annotated by BRENDA team
Aksam, E.B.; Koek, A.; Kiel, J.A.; Jourdan, S.; Veenhuis, M.; van der Klei, I.J.
A peroxisomal Lon protease and peroxisome degradation by autophagy play key roles in vitality of Hansenula polymorpha cells
Autophagy
3
96-105
2007
Zea mays (P93647), Ogataea angusta (Q2V573), Ogataea angusta, Yarrowia lipolytica (Q6C0L7), Neurospora crassa (Q7SA85), Mus musculus (Q9DBN5), Ogataea angusta NCYC495 (Q2V573)
Manually annotated by BRENDA team
Grimm, I.; Erdmann, R.; Girzalsky, W.
Role of AAA+-proteins in peroxisome biogenesis and function
Biochim. Biophys. Acta
1863
828-837
2016
Penicillium chrysogenum (B6HJQ3), Homo sapiens (O43933), Homo sapiens (Q13608), Arabidopsis thaliana (O64948), Escherichia coli (P0A9M0), Saccharomyces cerevisiae (P24004), Saccharomyces cerevisiae (P33760), Ogataea angusta (Q2V573), Mus musculus (Q5BL07), Mus musculus (Q99LC9)
Manually annotated by BRENDA team
Bartoszewska, M.; Williams, C.; Kikhney, A.; Opalinski, L.; van Roermund, C.W.T.; de Boer, R.; Veenhuis, M.; van der Klei, I.J.
Peroxisomal proteostasis involves a Lon family protein that functions as protease and chaperone
J. Biol. Chem.
287
27380-27395
2012
Penicillium chrysogenum, Rattus norvegicus (Q3MIB4), Penicillium chrysogenum DS54465
Manually annotated by BRENDA team
Gardner, B.M.; Chowdhury, S.; Lander, G.C.; Martin, A.
The Pex1/Pex6 complex is a heterohexameric AAA+ motor with alternating and highly coordinated subunits
J. Mol. Biol.
427
1375-1388
2015
Saccharomyces cerevisiae (P24004), Saccharomyces cerevisiae (P33760), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Saffian, D.; Grimm, I.; Girzalsky, W.; Erdmann, R.
ATP-dependent assembly of the heteromeric Pex1p-Pex6p-complex of the peroxisomal matrix protein import machinery
J. Struct. Biol.
179
126-132
2012
Saccharomyces cerevisiae (P24004), Saccharomyces cerevisiae (P33760), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Ciniawsky, S.; Grimm, I.; Saffian, D.; Girzalsky, W.; Erdmann, R.; Wendler, P.
Molecular snapshots of the Pex1/6 AAA+ complex in action
Nat. Commun.
6
7331
2015
Saccharomyces cerevisiae (P24004), Saccharomyces cerevisiae (P33760), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Goto-Yamada, S.; Mano, S.; Nakamori, C.; Kondo, M.; Yamawaki, R.; Kato, A.; Nishimura, M.
Chaperone and protease functions of LON protease 2 modulate the peroxisomal transition and degradation with autophagy
Plant Cell Physiol.
55
482-496
2014
Arabidopsis thaliana (O64948)
Manually annotated by BRENDA team
Reumann, S.; Ma, C.; Lemke, S.; Babujee, L.
AraPerox. A database of putative Arabidopsis proteins from plant peroxisomes
Plant Physiol.
136
2587-2608
2004
Arabidopsis thaliana (O64948)
Manually annotated by BRENDA team
Blok, N.B.; Tan, D.; Wang, R.Y.; Penczek, P.A.; Baker, D.; DiMaio, F.; Rapoport, T.A.; Walz, T.
Unique double-ring structure of the peroxisomal Pex1/Pex6 ATPase complex revealed by cryo-electron microscopy
Proc. Natl. Acad. Sci. USA
112
E4017-E4025
2015
Saccharomyces cerevisiae (P24004), Saccharomyces cerevisiae (P33760)
Manually annotated by BRENDA team
Law, K.B.; Bronte-Tinkew, D.; Di Pietro, E.; Snowden, A.; Jones, R.O.; Moser, A.; Brumell, J.H.; Braverman, N.; Kim, P.K.
The peroxisomal AAA ATPase complex prevents pexophagy and development of peroxisome biogenesis disorders
Autophagy
13
868-884
2017
Homo sapiens
Manually annotated by BRENDA team
Schwerter, D.P.; Grimm, I.; Platta, H.W.; Erdmann, R.
ATP-driven processes of peroxisomal matrix protein import
Biol. Chem.
398
607-624
2017
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Schwartzkopff, B.; Platta, H.W.; Hasan, S.; Girzalsky, W.; Erdmann, R.
Cysteine-specific ubiquitination protects the peroxisomal import receptor Pex5p against proteasomal degradation
Biosci. Rep.
35
e00215
2015
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Tan, D.; Blok, N.B.; Rapoport, T.A.; Walz, T.
Structures of the double-ring AAA ATPase Pex1/Pex6 involved in peroxisome biogenesis
FEBS J.
283
986-992
2016
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Saffert, P.; Enenkel, C.; Wendler, P.
Structure and function of p97 and Pex1/6 type II AAA+ complexes
Front. Mol. Biosci.
4
33
2017
Saccharomyces cerevisiae, Caenorhabditis elegans
Manually annotated by BRENDA team
Pedrosa, A.G.; Francisco, T.; Ferreira, M.J.; Rodrigues, T.A.; Barros-Barbosa, A.; Azevedo, J.E.
A mechanistic perspective on PEX1 and PEX6, two AAA+ proteins of the peroxisomal protein import machinery
Int. J. Mol. Sci.
20
5246
2019
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Pedrosa, A.G.; Francisco, T.; Bicho, D.; Dias, A.F.; Barros-Barbosa, A.; Hagmann, V.; Dodt, G.; Rodrigues, T.A.; Azevedo, J.E.
Peroxisomal monoubiquitinated PEX5 interacts with the AAA ATPases PEX1 and PEX6 and is unfolded during its dislocation into the cytosol
J. Biol. Chem.
293
11553-11563
2018
Homo sapiens
Manually annotated by BRENDA team
Schwerter, D.; Grimm, I.; Girzalsky, W.; Erdmann, R.
Receptor recognition by the peroxisomal AAA complex depends on the presence of the ubiquitin moiety and is mediated by Pex1p
J. Biol. Chem.
293
15458-15470
2018
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Gardner, B.M.; Castanzo, D.T.; Chowdhury, S.; Stjepanovic, G.; Stefely, M.S.; Hurley, J.H.; Lander, G.C.; Martin, A.
The peroxisomal AAA-ATPase Pex1/Pex6 unfolds substrates by processive threading
Nat. Commun.
9
135
2018
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Gonzalez, K.L.; Fleming, W.A.; Kao, Y.T.; Wright, Z.J.; Venkova, S.V.; Ventura, M.J.; Bartel, B.
Disparate peroxisome-related defects in Arabidopsis pex6 and pex26 mutants link peroxisomal retrotranslocation and oil body utilization
Plant J.
92
110-128
2017
Arabidopsis thaliana (Q9FNP1 and Q8RY16)
Manually annotated by BRENDA team
Grimm, I.; Saffian, D.; Girzalsky, W.; Erdmann, R.
Nucleotide-dependent assembly of the peroxisomal receptor export complex
Sci. Rep.
6
19838
2016
Saccharomyces cerevisiae
Manually annotated by BRENDA team