3.6.4.6: vesicle-fusing ATPase

This is an abbreviated version!
For detailed information about vesicle-fusing ATPase, go to the full flat file.

Reaction

Synonyms

AAA ATPase Vps4, AAA-ATPase, ATP phosphohydrolase, ATP6V0D1, ATP6V0D2, ATPase, ATPase N-ethylmaleimide sensitive factor, C06A1.1, C41C4.8, CDC-48.1, CDC-48.2, Cdc48, Cdc48p, Csc1p, Did6p, dNSF, dNSF-1, dNSF1, End13p, Grd13p, Helar-NSF, Hez-NSF, HsPEX1, HsPex1p, HsPex6p, membrane deformation AAA ATPase, N-ethyl maleimide sensitive factor, N-ethylmaleimide sensitive factor, N-ethylmaleimide sensitive fusion protein, N-ethylmaleimide sensitive-factor, N-ethylmaleimide-sensitive factor, N-ethylmaleimide-sensitive fusion protein, N-ethylmeleimide-sensitive factor, NEM-sensitive fusion protein, NSF, NSF ATPase, NSF protein, NSF-1, NSF2, nsfA, NSFII, p97, p97/VCP/Cdc48p, p97/VCP/Cdc48p homologue, p97ATPase, peptide p97, Pex1, Pex1p, pex22, Pex6p, PpPex1p, PpPex6p, rat Pex6p, Sec18, SEC18 gene product, SEC18p, SKD1, SKD1/VPS4B, SKD2, SKD2 protein, Sso0909, SsoVps4, suppresor of potassium transport growth defect, Suppressor of K+ Transport Growth Defect1, triple-A ATPase, V-ATPase, vacular protein sorting 4 B, vacuolar protein sorting 4, vacuolar protein sorting 4 protein, vasolin-containing protein, VCP, vesicle-fusing ATPase, Vesicular-fusion protein NSF, Vpl4p, Vps 4B, Vps4, Vps4 ATPase, VPS4 gene product, Vps4p, Vps4p AAA ATPase, Vpt10p

ECTree

     3 Hydrolases

         3.6 Acting on acid anhydrides

             3.6.4 Acting on acid anhydrides to facilitate cellular and subcellular movement

                3.6.4.6 vesicle-fusing ATPase

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Results	in table
19	Activating Compound
11969	AA Sequence
8	Application
1	CAS Registry Number
30	Cloned(Commentary)
2	Cofactor
11	Crystallization (Commentary)
469	Disease/ Diagnostics
1	Expression
29	General Information
7	Inhibitors
2	KM Value [mM]
66	Localization
16	Metals/Ions
22	Molecular Weight [Da]
93	Natural Substrates/ Products (Substrates)
177	Organism
562	PDB ID
6	pH Optimum
1	pH Range
3	Posttranslational Modification
54	Protein Variants
23	Purification (Commentary)
35	Reaction
19	Reaction Type
104	Reference
51	Source Tissue
5	Specific Activity [micromol/min/mg]
109	Substrates and Products (Substrate)
35	Subunits
200	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
1	Turnover Number [1/s]

Synonyms

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Synonyms on EC 3.6.4.6 - vesicle-fusing ATPase

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

AAA ATPase Vps4

4 entries

AAA-ATPase

Saccharomyces cerevisiae

P52917

-

699526

ATP phosphohydrolase

2 entries

ATP6V0D1

Mus musculus

-

subunit

755920

ATP6V0D2

Mus musculus

-

subunit

755920

ATPase

2 entries

ATPase N-ethylmaleimide sensitive factor

2 entries

C06A1.1

Caenorhabditis elegans

-

-

667441

C41C4.8

Caenorhabditis elegans

-

-

667441

CDC-48.1

Caenorhabditis elegans

-

-

667441

CDC-48.2

Caenorhabditis elegans

-

-

667441

Cdc48

5 entries

Cdc48p

Saccharomyces cerevisiae

-

-

210582, 210584

Csc1p

Saccharomyces cerevisiae

-

-

668565

Did6p

Saccharomyces cerevisiae

-

-

668565

dNSF

Drosophila melanogaster

-

-

210576

dNSF-1

Drosophila melanogaster

-

-

656585, 657180

dNSF1

2 entries

End13p

Saccharomyces cerevisiae

-

-

668565

Grd13p

Saccharomyces cerevisiae

-

-

668565

Helar-NSF

Helicoverpa armigera

-

-

668945

Hez-NSF

Helicoverpa zea

-

-

667820

HsPEX1

Homo sapiens

-

-

210581

HsPex1p

Homo sapiens

-

-

669490

HsPex6p

Homo sapiens

-

-

210580, 210581, 669490

membrane deformation AAA ATPase

Saccharomyces cerevisiae

-

-

724447

N-ethyl maleimide sensitive factor

Cricetulus griseus

-

-

656763

N-ethylmaleimide sensitive factor

7 entries

N-ethylmaleimide sensitive fusion protein

2 entries

N-ethylmaleimide sensitive-factor

2 entries

N-ethylmaleimide-sensitive factor

4 entries

N-ethylmaleimide-sensitive fusion protein

5 entries

N-ethylmeleimide-sensitive factor

Rattus norvegicus

-

-

656874

NEM-sensitive fusion protein

2 entries

NSF

11 entries

NSF ATPase

Cricetulus griseus

-

-

734226

NSF protein

4 entries

NSF-1

Caenorhabditis elegans

-

there are two NSF-1 isoforms, which are expressed in distinct tissues through two separate promoters

668367

NSF2

Drosophila sp. (in: flies)

-

-

668742

nsfA

Dictyostelium discoideum

Q75JI3

gen ename

756637

NSFII

Drosophila melanogaster

P54351

-

210579

p97

9 entries

p97/VCP/Cdc48p

Caenorhabditis elegans

-

-

670042

p97/VCP/Cdc48p homologue

Caenorhabditis elegans

-

-

667441

p97ATPase

2 entries

peptide p97

Rattus norvegicus

P46462

essential chaperone in endoplasmic reticulum-associated degradation and organelle biogenesis, contains two ATPases associated with various cellular activities domains (D1 and D2)

698750

Pex1

Mus musculus

-

-

667040, 668578

Pex1p

4 entries

pex22

Komagataella pastoris

-

-

210586

Pex6p

3 entries

PpPex1p

Komagataella pastoris

-

-

210580

PpPex6p

Komagataella pastoris

-

-

210580

rat Pex6p

Rattus norvegicus

-

-

210581

Sec18

Saccharomyces cerevisiae

-

-

654648

SEC18 gene product

2 entries

SEC18p

Homo sapiens

-

-

685048

SKD1

4 entries

SKD1/VPS4B

Mus musculus

P46467

-

701337

SKD2

Mus musculus

-

-

210576, 210579

SKD2 protein

-

-

-

-

Sso0909

2 entries

SsoVps4

2 entries

suppresor of potassium transport growth defect

Mus musculus

-

-

656346

Suppressor of K+ Transport Growth Defect1

Arabidopsis thaliana

Q9ZNT0

-

734975

triple-A ATPase

2 entries

V-ATPase

Mus musculus

-

-

755920

vacular protein sorting 4 B

Mus musculus

-

-

656346

vacuolar protein sorting 4

4 entries

vacuolar protein sorting 4 protein

Saccharomyces cerevisiae

P52917

-

699526

vasolin-containing protein

Rattus norvegicus

P46462

-

698750

VCP

8 entries

vesicle-fusing ATPase

2 entries

Vesicular-fusion protein NSF

-

-

-

-

Vpl4p

Saccharomyces cerevisiae

-

-

668565

Vps 4B

Mus musculus

-

-

656346

Vps4

4 entries

Vps4 ATPase

Saccharomyces cerevisiae

P52917

-

734303

VPS4 gene product

Saccharomyces cerevisiae

-

-

210577, 210579

Vps4p

4 entries

Vps4p AAA ATPase

2 entries

Vpt10p

Saccharomyces cerevisiae

-

-

668565

AAA ATPase Vps4

Saccharolobus solfataricus

Q97ZJ7

-

725724

AAA ATPase Vps4

Saccharolobus solfataricus P2

Q97ZJ7

-

-

AAA ATPase Vps4

Saccharomyces cerevisiae

-

-

725724

AAA ATPase Vps4

Saccharomyces cerevisiae

P52917

-

734303

ATP phosphohydrolase

Mus musculus

-

-

687629

ATP phosphohydrolase

Rattus norvegicus

-

-

686701

ATPase

Dictyostelium discoideum

Q75JI3

-

756637

ATPase

Homo sapiens

P55072

-

756637

ATPase N-ethylmaleimide sensitive factor

Bos taurus

-

-

667294

ATPase N-ethylmaleimide sensitive factor

Mus musculus

-

-

667294

Cdc48

Arabidopsis thaliana

-

-

688690

Cdc48

Archaea

-

-

688690

Cdc48

Drosophila melanogaster

-

-

688690

Cdc48

protozoa

-

-

688690

Cdc48

Saccharomyces cerevisiae

-

-

688690

dNSF1

Drosophila melanogaster

-

isoform 1

686724

dNSF1

Drosophila melanogaster

P46461

isoform 2

686724

N-ethylmaleimide sensitive factor

Danio rerio

-

-

668336

N-ethylmaleimide sensitive factor

Drosophila melanogaster

P46461

-

686724

N-ethylmaleimide sensitive factor

Drosophila sp. (in: flies)

-

-

668742

N-ethylmaleimide sensitive factor

Homo sapiens

-

-

685048

N-ethylmaleimide sensitive factor

Mammalia

-

-

686724

N-ethylmaleimide sensitive factor

Rattus norvegicus

-

-

686724

N-ethylmaleimide sensitive factor

Saccharomyces cerevisiae

-

-

686724

N-ethylmaleimide sensitive fusion protein

-

-

-

-

N-ethylmaleimide sensitive fusion protein

Rattus norvegicus

-

-

669601

N-ethylmaleimide sensitive-factor

Mus musculus

-

-

687629

N-ethylmaleimide sensitive-factor

Rattus norvegicus

-

-

686701

N-ethylmaleimide-sensitive factor

Cricetinae

-

-

720534

N-ethylmaleimide-sensitive factor

Cricetulus griseus

-

-

734226

N-ethylmaleimide-sensitive factor

Helicoverpa armigera

-

-

689343

N-ethylmaleimide-sensitive factor

Mus musculus

-

-

670662

N-ethylmaleimide-sensitive fusion protein

Helicoverpa armigera

-

-

689343

N-ethylmaleimide-sensitive fusion protein

Helicoverpa zea

-

-

667820

N-ethylmaleimide-sensitive fusion protein

Mammalia

-

-

688499

N-ethylmaleimide-sensitive fusion protein

Mus musculus

-

-

687536

N-ethylmaleimide-sensitive fusion protein

Rattus norvegicus

-

-

687536

NEM-sensitive fusion protein

-

-

-

-

NEM-sensitive fusion protein

Drosophila melanogaster

-

-

656585

NSF

Bos taurus

-

-

667294

NSF

Cricetinae

-

-

720534

NSF

Cricetulus griseus

-

-

656763, 734226

NSF

Danio rerio

-

-

668336

NSF

Drosophila melanogaster

P46461

-

686724

NSF

Helicoverpa armigera

-

-

689343

NSF

Homo sapiens

-

-

656661, 685048

NSF

Mammalia

-

-

686724, 688499

NSF

Mus musculus

-

-

667294, 669996, 687536, 687629

NSF

Rattus norvegicus

-

-

656874, 669601, 686724, 687536

NSF

Saccharomyces cerevisiae

-

-

686724

NSF protein

Drosophila melanogaster

-

N-ethyl-maleimide-sensitive fusion protein

210576

NSF protein

Homo sapiens

-

-

210577

NSF protein

Homo sapiens

-

N-ethyl-maleimide-sensitive fusion protein

210576

NSF protein

Saccharomyces cerevisiae

-

-

210576, 210577, 210582, 210584

p97

Arabidopsis thaliana

-

-

688690

p97

Archaea

-

-

688690

p97

Dictyostelium discoideum

Q75JI3

-

756637

p97

Drosophila melanogaster

-

-

688690

p97

Homo sapiens

-

-

699411, 720048

p97

Homo sapiens

P55072

-

756637

p97

protozoa

-

-

688690

p97

Rattus norvegicus

-

-

656341, 686380

p97

Saccharomyces cerevisiae

-

-

688690

p97ATPase

Rattus norvegicus

-

-

210584, 210585

p97ATPase

Xenopus laevis

-

-

210576, 210584

Pex1p

Cricetulus griseus

-

-

667439

Pex1p

Homo sapiens

-

-

685048

Pex1p

Komagataella pastoris

-

-

210586

Pex1p

Saccharomyces cerevisiae

-

-

210579, 668571

Pex6p

Homo sapiens

-

-

685048

Pex6p

Komagataella pastoris

-

-

210586

Pex6p

Saccharomyces cerevisiae

-

-

210579, 668571

SEC18 gene product

Candida albicans

-

-

210576

SEC18 gene product

Saccharomyces cerevisiae

-

-

210576, 210579, 210582, 210584

SKD1

Arabidopsis thaliana

-

-

689461

SKD1

Arabidopsis thaliana

Q9ZNT0

-

734975

SKD1

Mus musculus

-

-

210577, 210585, 656346

SKD1

Schizosaccharomyces pombe

-

-

210577

Sso0909

Saccharolobus solfataricus

Q97ZJ7

locus name

725724

Sso0909

Saccharolobus solfataricus P2

Q97ZJ7

locus name

-

SsoVps4

Saccharolobus solfataricus

Q97ZJ7

-

725724

SsoVps4

Saccharolobus solfataricus P2

Q97ZJ7

-

-

triple-A ATPase

Dictyostelium discoideum

Q75JI3

-

756637

triple-A ATPase

Homo sapiens

P55072

-

756637

vacuolar protein sorting 4

Drosophila melanogaster

Q9Y162

-

733702

vacuolar protein sorting 4

Saccharolobus solfataricus

Q97ZJ7

-

725724

vacuolar protein sorting 4

Saccharolobus solfataricus P2

Q97ZJ7

-

-

vacuolar protein sorting 4

Saccharomyces cerevisiae

-

-

725724

VCP

Arabidopsis thaliana

-

-

688690

VCP

Archaea

-

-

688690

VCP

Dictyostelium discoideum

Q75JI3

-

756637

VCP

Drosophila melanogaster

-

-

688690

VCP

Homo sapiens

P55072

-

756637

VCP

protozoa

-

-

688690

VCP

Rattus norvegicus

P46462

-

698750

VCP

Saccharomyces cerevisiae

-

-

688690

vesicle-fusing ATPase

Mus musculus

-

-

687629

vesicle-fusing ATPase

Rattus norvegicus

-

-

686701

Vps4

Drosophila melanogaster

Q9Y162

-

733702

Vps4

Homo sapiens

-

-

756027, 758466

Vps4

Homo sapiens

-

vacuolar protein sorting 4

756698

Vps4

Saccharomyces cerevisiae

-

-

757152

Vps4p

Saccharomyces cerevisiae

-

-

210578, 210582, 210585, 656345, 668565, 735147

Vps4p

Saccharomyces cerevisiae

-

a type I ATPase associated with a variety of cellular activities ATPase

699527

Vps4p

Saccharomyces cerevisiae

P52917

-

699526, 734303

Vps4p

Saccharomyces cerevisiae BY4741

-

-

-

Vps4p AAA ATPase

Saccharomyces cerevisiae

-

-

210582, 735147

Vps4p AAA ATPase

Saccharomyces cerevisiae BY4741

-

-

-