3.6.1.B17: ATP-independent RNA helicase
This is an abbreviated version!
For detailed information about ATP-independent RNA helicase, go to the full flat file.
Word Map on EC 3.6.1.B17
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3.6.1.B17
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dengue
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nonstructural
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unwind
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poliovirus
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capsid
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enteroviruses
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replicons
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uncoating
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encapsidation
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anti-denv
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picornaviridae
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flaviviridae
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vp3
- 3.6.1.B17
- dengue
-
nonstructural
-
unwind
- poliovirus
-
capsid
- enteroviruses
-
replicons
-
uncoating
-
encapsidation
-
anti-denv
- picornaviridae
- flaviviridae
- vp3
Reaction
In vitro the enzyme unwinds double-strandet RNA independently of ATP =
Synonyms
2CATPase, ATP-independent RNA annealing activity, ATP-independent RNA helicase, AtRH57, DEAD-box RNA helicase, DENV helicase, DENV NS3, nonstructural protein 3, NS3, NS3 helicase, p41, protein NS3, Prp28
ECTree
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General Information
General Information on EC 3.6.1.B17 - ATP-independent RNA helicase
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evolution
malfunction
metabolism
physiological function
additional information
enzyme AtRH57 belongs to class II DEAD-box RNA helicase gene family. AtRH57 contains a DESD sequence in motif II and is thus classified into the DExD group
evolution
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enzyme AtRH57 belongs to class II DEAD-box RNA helicase gene family. AtRH57 contains a DESD sequence in motif II and is thus classified into the DExD group
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Arabidopsis thaliana T-DNA insertion mutant rh57-1 exhibits hypersensitivity to glucose and abscisic acid. The other two rh57 mutants also show glucose hypersensitivity similar to rh57-1, strongly suggesting that the Glc-hypersensitive feature of these mutants results from mutation of AtRH57. Mutants rh57-1 and rh57-3 display severely impaired seedling growth when grown in Glc concentrations higher than 3%. Transcripts of Glc-responsive genes are altered in rh57 mutants, rh57 mutants exhibit abscisic acid hypersensitivity and enhanced abscisic acid accumulation by Glc. Decreased processing of pre-rRNA products in rh57 mutants. rh57-1 mutants show resistance to antibiotics, e.g. streptomycin. Phenotypes, overview
malfunction
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when the enzyme helicase activity is impaired, enterovirus 71 RNA replication and virion production are mostly abolished in cells
malfunction
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Arabidopsis thaliana T-DNA insertion mutant rh57-1 exhibits hypersensitivity to glucose and abscisic acid. The other two rh57 mutants also show glucose hypersensitivity similar to rh57-1, strongly suggesting that the Glc-hypersensitive feature of these mutants results from mutation of AtRH57. Mutants rh57-1 and rh57-3 display severely impaired seedling growth when grown in Glc concentrations higher than 3%. Transcripts of Glc-responsive genes are altered in rh57 mutants, rh57 mutants exhibit abscisic acid hypersensitivity and enhanced abscisic acid accumulation by Glc. Decreased processing of pre-rRNA products in rh57 mutants. rh57-1 mutants show resistance to antibiotics, e.g. streptomycin. Phenotypes, overview
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AtRH57 acts in a signaling network downstream of hexokinase 1, HXK1
metabolism
Thermochaetoides thermophila
the enzyme is a spliceosomal DEAD-box helicase which is involved in two steps of spliceosome assembly. It is required for the formation of commitment complex 2 in an ATP-independent manner
metabolism
Thermochaetoides thermophila DSM 1495
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the enzyme is a spliceosomal DEAD-box helicase which is involved in two steps of spliceosome assembly. It is required for the formation of commitment complex 2 in an ATP-independent manner
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metabolism
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AtRH57 acts in a signaling network downstream of hexokinase 1, HXK1
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the participation of enzyme NS3, modulating the folding of cis-acting RNA elements by the dual RNA unwinding/annealing activities, provides an additional biological role for this viral protein
physiological function
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enzyme-mediated RNA remodeling plays a critical role in the enteroviral life cycle
physiological function
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the enzyme plays an important role in norovirus RNA replication
physiological function
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the participation of enzyme NS3, modulating the folding of cis-acting RNA elements by the dual RNA unwinding/annealing activities, provides an additional biological role for this viral protein
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the enzyme NS3 contains the viral serine protease at the N-terminus and ATPase, RTPase, and helicase activities at the C-terminus. Although the helicase domain, comprising amino acids 171 to 618, is an active enzyme, the protease domain has been proposed to have a modulatory role on the helicase and NTPase activities. RNA binding induces a conformational change in the NS3 to a closed form, while no changes in protein structure are observed in different nucleotide-bound states
additional information
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the enzyme NS3 contains the viral serine protease at the N-terminus and ATPase, RTPase, and helicase activities at the C-terminus. Although the helicase domain, comprising amino acids 171 to 618, is an active enzyme, the protease domain has been proposed to have a modulatory role on the helicase and NTPase activities. RNA binding induces a conformational change in the NS3 to a closed form, while no changes in protein structure are observed in different nucleotide-bound states
additional information
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the enzyme NS3 contains the viral serine protease at the N-terminus and ATPase, RTPase, and helicase activities at the C-terminus. Although the helicase domain, comprising amino acids 171 to 618, is an active enzyme, the protease domain has been proposed to have a modulatory role on the helicase and NTPase activities. RNA binding induces a conformational change in the NS3 to a closed form, while no changes in protein structure are observed in different nucleotide-bound states
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