3.6.1.B17: ATP-independent RNA helicase

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For detailed information about ATP-independent RNA helicase, go to the full flat file.

Word Map on EC 3.6.1.B17

3.6.1.B17

dengue

nonstructural

unwind

poliovirus

capsid

enteroviruses

replicons

uncoating

encapsidation

anti-denv

picornaviridae

flaviviridae

vp3

Reaction

In vitro the enzyme unwinds double-strandet RNA independently of ATP =

Synonyms

2CATPase, ATP-independent RNA annealing activity, ATP-independent RNA helicase, AtRH57, DEAD-box RNA helicase, DENV helicase, DENV NS3, nonstructural protein 3, NS3, NS3 helicase, p41, protein NS3, Prp28

ECTree

3 Hydrolases

3.6 Acting on acid anhydrides

3.6.1 In phosphorus-containing anhydrides

3.6.1.B17 ATP-independent RNA helicase

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Results	in table
1	Activating Compound
3	AA Sequence
4	Cloned(Commentary)
2	Crystallization (Commentary)
2	Expression
15	General Information
4	Inhibitors
3	KM Value [mM]
4	Localization
5	Metals/Ions
1	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
8	Organism
3	pH Optimum
1	pH Range
8	Protein Variants
4	Purification (Commentary)
1	Reaction
8	Reference
4	Source Tissue
25	Substrates and Products (Substrate)
1	Subunits
22	Synonyms
2	Temperature Optimum [°C]
2	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 3.6.1.B17 - ATP-independent RNA helicase

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Single-stranded RNA

Dengue virus

O09234

viral ATPases, including NS3 from flaviviruses, are stimulated by single-stranded RNA. At RNA saturation, an increase of 13.5fold and 9.6fold is achieved with respect to the basal activities for recombinant mutant NS3-FL and NS3-hel, respectively

735052