3.6.1.B11: multiple site diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase

This is an abbreviated version!
For detailed information about multiple site diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase, go to the full flat file.

Reaction

Synonyms

APS1, diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase

ECTree

     3 Hydrolases

         3.6 Acting on acid anhydrides

             3.6.1 In phosphorus-containing anhydrides

                3.6.1.B11 multiple site diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase

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Results	in table
1	AA Sequence
2	Cloned(Commentary)
6	kcat/KM [mM/s]
6	KM Value [mM]
4	Metals/Ions
1	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
2	Organism
2	pH Optimum
1	pH Range
1	pI Value
1	Protein Variants
2	Purification (Commentary)
1	Reaction
2	Reference
6	Substrates and Products (Substrate)
1	Subunits
3	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
6	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 3.6.1.B11 - multiple site diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

P1,P5-bis(5'-adenosyl)pentaphosphate + H2O

ATP + ADP

2 entries

P1,P6-bis(5'-adenosyl)hexaphosphate + H2O

adenosine 5'-tetraphosphate + ADP

3 entries

additional information

?

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Schizosaccharomyces pombe

Q09790

the enzyme has limited activity on P1,P4-bis(5'-adenosyl)tetraphosphate and negligible activity on P1,P3-bis(5'-adenosyl)triphosphate, ADP-ribose, and NADH. Aps1 catalyzes the hydrolysis of mononucleotides with decreasing activity in order from p5A to AMP

714143

-

-

?

P1,P5-bis(5'-adenosyl)pentaphosphate + H2O

ATP + ADP

Schizosaccharomyces pombe

Q09790

-

714143

-

-

?

P1,P5-bis(5'-adenosyl)pentaphosphate + H2O

ATP + ADP

Schizosaccharomyces pombe

Q09790

P1,P6-bis(5'-adenosyl)hexaphosphate and P1,P5-bis(5'-adenosyl)pentaphosphate being the preferred substrates. 88.7% of the activity with P1,P6-bis(5'-adenosyl)hexaphosphate

714143

-

-

?

P1,P6-bis(5'-adenosyl)hexaphosphate + H2O

adenosine 5'-tetraphosphate + ADP

Schizosaccharomyces pombe

Q09790

-

714143

-

-

?

P1,P6-bis(5'-adenosyl)hexaphosphate + H2O

adenosine 5'-tetraphosphate + ADP

Schizosaccharomyces pombe

-

degrades P1,P6-bis(5'-adenosyl)hexaphosphate and P1,P5-bis(5'-adenosyl)pentaphosphate, in preference to other diadenosine polyphosphates. The initial 31 residues of Aps1 are not involved in substrate binding or catalysis with respect to P1,P6-bis(5'-adenosyl)hexaphosphate

714173

-

-

?

P1,P6-bis(5'-adenosyl)hexaphosphate + H2O

adenosine 5'-tetraphosphate + ADP

Schizosaccharomyces pombe

Q09790

P1,P6-bis(5'-adenosyl)hexaphosphate and P1,P5-bis(5'-adenosyl)pentaphosphate being the preferred substrates

714143

P1,P4-bis(5'-adenosyl)tetraphosphate and ADP are the major products. ATP is a minor product resulting from a direct, symmetrical cleavage of P1,P6-bis(5'-adenosyl)hexaphosphate. No hydrolysis of P1,P6-bis(5'-adenosyl)hexaphosphate to P1,P6-bis(5'-adenosyl)pentaphosphate and AMP. Most of the AMP present in this reaction must arise from the hydrolysis of the initial reaction products

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