3.6.1.66: XTP/dITP diphosphatase
This is an abbreviated version!
For detailed information about XTP/dITP diphosphatase, go to the full flat file.
Reaction
Synonyms
Af2237, dITP/XTP pyrophosphatase, Ec197, hypoxanthine/xanthine dNTP pyrophosphatase, inosine triphosphatase, inosine triphosphate pyrophosphatase, ITPA, Mj0226, PH1917, TM0159
ECTree
Advanced search results
Substrates Products
Substrates Products on EC 3.6.1.66 - XTP/dITP diphosphatase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REACTION DIAGRAM
dITP + H2O
dIMP + diphosphate
the enzyme hydrolyzes the non-canonical nucleotides, dITP and XTP and may have a major role in preventing mutations caused by incorporation of dITP and XTP formed spontaneously in the nucleotide pool into DNA
-
-
?
dITP + H2O
dIMP + diphosphate
i.e. 2'-deoxyinosine 5'-triphosphate
-
-
?
dITP + H2O
dIMP + diphosphate
the enzyme hydrolyzes the non-canonical nucleotides, dITP and XTP and may have a major role in preventing mutations caused by incorporation of dITP and XTP formed spontaneously in the nucleotide pool into DNA
-
-
?
dITP + H2O
dIMP + diphosphate
i.e. 2'-deoxyinosine 5'-triphosphate
-
-
?
dTDP + phosphate
ITP and dITP are slightly preferred over XTP
-
-
?
dITP + H2O
dTDP + phosphate
ITP and dITP are slightly preferred over XTP
-
-
?
IDP + phosphate
ITP and dITP are slightly preferred over XTP
-
-
?
ITP + H2O
IDP + phosphate
ITP and dITP are slightly preferred over XTP
-
-
?
ITP + H2O
IMP + diphosphate
catalytic efficiency (kcat/Km) is about 60% compared to the catalytic efficiency of XTP
-
-
?
ITP + H2O
IMP + diphosphate
catalytic efficiency (kcat/Km) is about 60% compared to the catalytic efficiency of XTP
-
-
?
XDP + phosphate
ITP and dITP are slightly preferred over XTP
-
-
?
XTP + H2O
XDP + phosphate
ITP and dITP are slightly preferred over XTP
-
-
?
XTP + H2O
XMP + diphosphate
the enzyme hydrolyzes the non-canonical nucleotides, dITP and XTP and may have a major role in preventing mutations caused by incorporation of dITP and XTP formed spontaneously in the nucleotide pool into DNA
-
-
?
?
-
reaction rate is less than 1% compared to dITP or XTP with the following substrates: dGTP, dATP, dCTP, dTTP, dUTP
-
-
?
additional information
?
-
-
reaction rate is less than 1% compared to dITP or XTP with the following substrates: dGTP, dATP, dCTP, dTTP, dUTP
-
-
?
additional information
?
-
-
reaction rate is less than 2% compared to dITP or XTP with the following substrates: dGTP, dATP, dCTP, dTTP, dUTP
-
-
?
additional information
?
-
catalytic efficiency (kcat/Km) is less than 1% compared to dITP or XTP with the following substrates: dGTP, GTP, dATP, dCTP, dTTP, dUTP, 8-oxo-dGTP. Neither endonuclease nor 3'-exonuclease activities were detected in this protein
-
-
?
additional information
?
-
-
catalytic efficiency (kcat/Km) is less than 1% compared to dITP or XTP with the following substrates: dGTP, GTP, dATP, dCTP, dTTP, dUTP, 8-oxo-dGTP. Neither endonuclease nor 3'-exonuclease activities were detected in this protein
-
-
?
additional information
?
-
catalytic efficiency (kcat/Km) for GTP, dGTP, ATP, CTP or TTP is less than 1% compared to the catalytic efficiency of XTP
-
-
?
additional information
?
-
-
catalytic efficiency (kcat/Km) for GTP, dGTP, ATP, CTP or TTP is less than 1% compared to the catalytic efficiency of XTP
-
-
?
additional information
?
-
catalytic efficiency (kcat/Km) is less than 1% compared to dITP or XTP with the following substrates: dGTP, GTP, dATP, dCTP, dTTP, dUTP, 8-oxo-dGTP. Neither endonuclease nor 3'-exonuclease activities were detected in this protein
-
-
?
additional information
?
-
catalytic efficiency (kcat/Km) for GTP, dGTP, ATP, CTP or TTP is less than 1% compared to the catalytic efficiency of XTP
-
-
?